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Journal of Harbin Institute of Technology(New Series) 2024年第1期31卷 26-37页

作者： k.masamudram Bhavya Sai Rishi raghu Sai Surya Varshith Nuk.la Jayashree Jayaraman Vijayashree Jayaraman School of Computer Science and Engineering Vellore Institute of TechnologyVellore 632014India

For years,foot ulcers link.d with diabetes mellitus and neuropathy have significantly impacted diabetic patients’ health-related quality of life(HRQoL). Diabetes foot ulcers impact15% of all diabetic patients at some point in their lives. The facilities and resources used for DFU detection and treatment are only available at hospitals and clinics,which results in the unavailability of feasible and timely detection at an early stage. This necessitates the development of an at-home DFU detection system that enables timely predictions and seamless communication with users,thereby preventing amputations due to neglect and severity. This paper proposes a feasible system consisting of three major modules:an IoT device that work. to sense foot nodes to send vibrations onto a foot sole,a machine learning model based on supervised learning which predicts the level of severity of the DFU using four different classification techniques including XGBoost,k.SVM,Random Forest,and Decision tree,and a mobile application that acts as an interface between the sensors and the patient. Based on the severity levels,necessary steps for prevention,treatment,and medications are recommended via the application.

关键词： diabetic foot ulcer podiatry diabetes mellitus healthcare footcare internet of things machine learning human⁃computer interaction

Amelioration of Aluminium Toxicity in Pigeon Pea [Cajanus cajan (L.) Millsp.] Plant by 24-Epibrassinolide

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American Journal of Plant Sciences 2016年第12期7卷 1618-1628页

作者： N. Divya Sri M. Madhan Mohan k. Mahesh k. raghu S. Seeta Ram Rao Department of Botany Osmania University Hyderabad India

The effect of 24-epibrassinolide on growth of pigeon pea [Cajanus cajan (L.) Millsp.] under aluminium toxicity was studied. 24-EBL reduced the impact of Al stress on plant growth. Particularly 24-EBL reduced the inhibitory impact of aluminium toxicity on root growth which was further manifested in overall improvement of vegetative growth. Application of 24-epibrassinolide removed the inhibitory influence of Al nodulation. The growth stimulation in Cajanus plants by 24-EBL under Al stress was associated with elevated levels of chlorophylls, nucleic acids and soluble proteins. 24-Epibrassinolide application enhanced proline content in Al3+ stressed Cajanus plants. Further, the supplementation of 24-epibrassinolide to Al stress treatments increased the activities of antioxidative enzymes viz., catalase [EC 1.***.1.6];peroxidase [EC 1.***.1.7];superoxide dismutase [EC 1.***.1.1] and ascorbate peroxidase [EC 1.***.1.11]. Lipid peroxidation induced by Al was found reduced with the supplementation of 24-epibrassinolide. The present studies demonstrated the ameliorating capability of 24-epibrassinolide on the Al induced inhibition of plant growth of C. cajan.

关键词： Aluminium Toxicity 24-Epibrassinolide Cajanus cajan Antioxidative Enzymes

Recognition and Anticipation of Diabetic Foot Ulcer in Type Ⅱ Diabetic Patients using Multi-layered Fuzzy Model

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Journal of Harbin Institute of Technology(New Series) 2024年第4期31卷 13-23页

作者： Sai Surya Varshith Nuk.la Jayashree Jayaraman Vijayashree Jayaraman Rishi raghu School of Computer Science and Engineering Vellore Institute of TechnologyVellore 632014Tamil NaduIndia

Diabetes mellitus is associated with foot ulcers,which frequently pave the way to lower-extremity ***,trauma,deformity,high plantar pressures,and peripheral vascular disease are the most common underlying *** 15%of diabetic patients are affected by diabetic foot ulcer in their lifetime.64 million people are affected by diabetics in India and 40000 amputations are done every *** ulcers are evaluated and classified in a systematic and thorough manner to assist in determining the best course of *** paper proposes a novel model which predicts the threat of diabetic foot ulcer using independent agents for various input values and a combination of fuzzy expert *** proposed model uses a classification system to distinguish between each fuzzy framework.and its *** on the severity levels necessary prevention,treatment,and medication are *** the results of all the fuzzy framework. derived from its constituent parameters,a risk.specific medication is *** work.also has higher accuracy when compared to other related models.

关键词： diabetic ulcer typeⅡdiabetic fuzzy model

Energy Efficient Hyperparameter Tuned Deep Neural Network.to Improve Accuracy of Near-Threshold Processor

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Intelligent Automation & Soft Computing 2023年第7期37卷 471-489页

作者： k.Chanthirasek.ran raghu Gundaala Department of Electronics and Communication Engineering Saveetha School of EngineeringSaveetha Institute of Medical and Technical SciencesChennai602105TamilnaduIndia

When it comes to decreasing margins and increasing energy effi-ciency in near-threshold and sub-threshold processors,timing error resilience may be viewed as a potentially lucrative alternative to *** the other hand,the currently employed approaches have certain restrictions,including high levels of design complexity,severe time constraints on error consolidation and propagation,and uncontaminated architectural registers(ARs).The design of near-threshold circuits,often k.own as NT circuits,is becoming the approach of choice for the construction of energy-efficient digital *** a result of the exponentially decreased driving current,there was a reduction in performance,which was one of the *** studies have advised the use of NT techniques to chip multiprocessors as a means to preserve outstanding energy efficiency while minimising performance *** the past several years,there has been a clear growth in interest in the development of artificial intelligence hardware with low energy consumption(AI).This has resulted in both large corporations and start-ups producing items that compete on the basis of varying degrees of performance and energy *** technology’s ultimate goal was to provide levels of efficiency and performance that could not be achieved with graphics processing units or general-purpose *** achieve this objective,the technology was created to integrate several processing units into a single *** accomplish this purpose,the hardware was designed with a number of unique *** this study,an Energy Effi-cient Hyperparameter Tuned Deep Neural Network.EEHPT-DNN)model for Variation-Tolerant Near-Threshold Processor was *** order to improve the energy efficiency of artificial intelligence(AI),the EEHPT-DNN model employs several AI *** notion focuses mostly on the repercussions of embedded technologies positioned at the network.s *** presented model employs a deep stack.d sparse autoencod

关键词： Deep learning hyperparameter tuning artificial intelligence near-threshold processor embedded system

Assessment of the binding interactions of SARS-CoV-2 spik. glycoprotein variants

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Journal of Pharmaceutical Analysis 2022年第1期12卷 58-64页

作者： Deepa raghu Pamela Hamill Arpitha Banaji Amy McLaren Yu-Ting Hsu Product Characterization MilliporeSigmaRockvilleMD20850USA Product Characterization MilliporeSigmaStirlingFK94NFUK Process and Analytical Development MilliporeSigmaSt.LouisMO63118USA

Severe acute respiratory syndrome-associated coronavirus 2 is a major global health issue and is driving the need for new *** surface spik. protein,which plays a central role in virus infection,is currently the target for vaccines and neutralizing *** emergence of novel variants with multiple mutations in the spik. protein may reduce the effectiveness of neutralizing antibodies by altering the binding activity of the protein with angiotensin-converting enzyme 2(ACE2).To understand the impact of spik. protein mutations on the binding interactions required for virus infection and the effectiveness of neutralizing monoclonal antibody(mAb)therapies,the binding activities of the original spik. protein receptor binding domain(RBD)sequence and the reported spik. protein variants were investigated using surface plasmon *** addition,the interactions of the ACE2 receptor,an antispik. mAb(mAb1),a neutralizing mAb(mAb2),the original spik. RBD sequence,and mutants D614G,N501Y,N439k.Y453F,and E484k.were *** to the original RBD,the Y453F and N501Y mutants displayed a significant increase in ACE2 binding affinity,whereas D614G had a substantial reduction in binding *** mAb-RBD mutant proteins displayed a reduction in binding affinities relative to the original RBD,except for the E484k.mAb1 *** potential neutralizing capability of mAb1 and mAb2 was ***,mAb1 failed to inhibit the ACE2-RBD interaction while mAb2 inhibited the ACE2-RBD interactions for all RBD mutants,except mutant E484k.which only displayed partial block.ng.

关键词： Surface plasmon resonance SARS-CoV-2 Monoclonal antibody RBD ACE2

印度的非正式资源回收体系推动社会走向循环建造

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世界建筑 2024年第1期 56-57页

作者：迪皮卡·拉古凯瑟琳·德·沃尔夫母卓尔(译) 苏黎世联邦理工学院不详

在发展中国家迅速崛起的过程中,建筑和建材废料都呈指数级增长,原来线性的建材废料管理体系必须向循环利用的体系转变。在印度,从事建材回收再利用的企业虽然主要是未正式注册的地方性企业,但它们为国家的经济增长做出了巨大贡献。本文... 详细信息

在发展中国家迅速崛起的过程中,建筑和建材废料都呈指数级增长,原来线性的建材废料管理体系必须向循环利用的体系转变。在印度,从事建材回收再利用的企业虽然主要是未正式注册的地方性企业,但它们为国家的经济增长做出了巨大贡献。本文研究了孟买和班加罗尔的建材回收行业涉及的利益相关方和回收流程,重点关注这两座城市目前的建材资源采购和贸易模式。

关键词：班加罗尔贸易模式利益相关方回收行业回收体系回收再利用建材资源循环利用

Deregulated miRNA clusters in ovarian cancer:Imperative implications in personalized medicine

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Genes & Diseases 2022年第6期9卷 1443-1465页

作者： Amoolya k.ndettu Divya Adiga Vasudha Devi Padmanaban SSuresh Sanjiban Chak.abarty raghu Radhak.ishnan Shama Prasada k.bek.odu Department of Cell and Molecular Biology Manipal School of Life SciencesManipal Academy of Higher EducationManipalKarnataka 576104India Department of Pharmacology Centre for Cardiovascular PharmacologyMelaka Manipal Medical CollegeManipal Academy of Higher EducationManipal CampusManipalKarnataka 576104India School of Biotechnology National Institute of TechnologyCalicutKerala 673601India Department of Oral Pathology Manipal College of Dental SciencesManipal Academy of Higher EducationManipalKarnataka 576104India Center for DNA Repair and Genome Stability(CDRGS) Manipal Academy of Higher EducationManipalKarnataka 576104India

Ovarian cancer(OC)is one of the most common and fatal types of gynecological *** is usually detected at the advanced stages of the disease,mak.ng it highly *** are single-stranded,small non-coding RNAs with an approximate size ranging around 22 ***,a considerable proportion of miRNAs are organized in clusters with miRNA genes placed adjacent to one another,getting transcribed together to result in miRNA clusters(MCs).MCs comprise two or more miRNAs that follow the same orientation during *** expression of the miRNA cluster has been identified as one of the k.y drivers in *** exists both as tumor-suppressive and oncogenic clusters and has a significant role in OC pathogenesis by facilitating cancer cells to acquire various *** present review summarizes the regulation and biological function of MCs in *** review also highlights the utility of abnormally expressed MCs in the clinical management of OC.

关键词： Diagnosis Drug resistance miRNA clusters Ovarian cancer Prognosis Regulation

Spray Characteristics of Biodiesel Fuel in Constant Volume Chamber using Multi-response Optimization Technique

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Journal of Thermal Science 2016年第6期25卷 581-588页

作者： P.raghu N.Nallusamy Sri Venk.teswara College of Engineering Department of Mechanical Engineering SSN College of Engineering Department of Mechanical Engineering

This study discusses about the optimization of spray characteristics of biodiesel fuel in a spray *** factors namely,fuel injection pressure,fuel temperature and fuel blends were chosen as the influencing factor for the set *** levels were chosen in each factor and spray tip penetration,spray cone angle and Sauter mean diameter(SMD) were tak.n as the response *** were designed by employing design of experiments method and Taguchi full factorial array was used to conduct the tests with different levels of the chosen *** Response Signal to Noise ratio(MRSN) was calculated for the response variables and the optimum combination level of factors was obtained simultaneously using Taguchi's parametric *** experiments were conducted for the obtained optimum combination level of factors and the results were compared with the normal operating conditions and significant improvement were observed in the response variables.

关键词： Taguchi 实验的设计喷洒尖端穿入喷洒锥角度 ANOVA

On the contribution of boundaries towards strength in oxygen free high conductivity copper subjected to repetitive upsetting–extrusion

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Progress in Natural Science:Materials International 2016年第6期26卷 621-629页

作者： k.Sahithya I.Balasundar Vajinder Singh P.Ghosal T.raghu Near Net Shape Group Aeronautical Materials Division Defence Metallurgical Research Laboratory Kanchanbagh Post Electron Microscopy Group Material Science Division Defence Metallurgical Research Laboratory Kanchanbagh Post

Oxygen free high conductivity(OFHC) copper was subjected to 1, 5, 10, 15 and 20 cycles of repetitive upsetting and extrusion(RUE) process at room temperature. Microstructure and microhardness in the RUE processed material were evaluated at specific locations and correlated with the equivalent plastic strain. The microhardness of the material was found to be independent of strain or number of RUE cycles at certain locations whereas it exhibited strain softening behaviour at certain locations even though significant grain refinement was achieved. This difference in behaviour is attributed to the varied strength contribution from different types of boundaries present in the material after deformation.

关键词： Severe plastic deformation OFHC Copper RUE EBSD

Enhancement of current density using effective membranes electrode assemblies for water electrolyser system

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Journal of Energy Chemistry 2016年第1期25卷 77-84页

作者： Swaminathan Seetharaman Subash Chandrabose raghu k.mbiz Ansari Mahabadi Institute of Materials Research & Engineering A*STAR (Agency for Science Technology and Research) 3 Research Link Singapore 117 602 Singapore School of Civil and Environmental Engineering Nanyang Technological University Block N1 Nanyang Avenue Singapore 639 798 Singapore

The goal of this study was to develop and design a composite proton exchange membrane（PEM） and membrane electrode assembly（MEA） that are suitable for the PEM based water electrolysis system. In particular,it focuses on the development of sulphonated polyether ether k.tone（SPEEk. based membranes and caesium salt of silico-tungstic acid（Cs Si WA） matrix compared with one of the transition metal oxides such as titanium dioxide（TiO2）, silicon dioxide（SiO2） and zirconium dioxide（ZrO2）. The resultant membranes have been characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, ion exchange capacity（IEC）, water uptak. and atomic force microscopy. Comparative studies on the performance of MEAs were also conducted utilizing impregnation-reduction and conventional brush coating methods. The PEM electrolysis performance of SPEEk.Cs Si WA-ZrO2 composite membrane was more superior than that of other membranes involved in this study. Electrochemical characterization shows that a maximum current density of 1.4 A/cm^2 was achieved at 60 °C, explained by an increased concentration of protonic sites available at the interface.

关键词： Composite membrane Membrane electrode assembly Impregnation reduction method Brush coating method Electrolysis