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Non Hodgk.n’s Lymphoma with Right Atrial Intra Cardiac Metastases

World Journal of Cardiovascular Surgery 2023年第7期13卷 120-127页

作者： Gaind Saurabh Nitin k.mar kashyap Mehsare Pranay Suresh Niraghatam Harshavardhan Nirupam Sek.ar Chak.aborty Rahul Satark.r Mudalsha Ravina Shiva Thak.r Department of Cardio Thoracic and Vascular Surgery All India Institute of Medical Sciences Raipur India Department of Cardio Thoracic and Vascular Surgery Apollo Hospitals Kakinada India Department of Pathology All India Institute of Medical Sciences Raipur India Department of Nuclear Medicine All India Institute of Medical Sciences Raipur India

Back.round: Diffuse Large B-Cell Lymphoma (DLBCL) is the most variant of Non-Hodgk.n’s Lymphoma (NHL) and also the most common variant with secondary intracardiac masses. Case summary: 7 years old child presented to emergency with acute decompensated cardiac failure, ascites and tender hepatomegaly. 2D echo evaluation was suggestive of large intracardiac mass in the right atrium almost completely obstructing Tricuspid valve orifice, gross pericardial effusion and dilated Inferior Vena Cava (IVC). Emergency tumor excision surgery was performed which revealed 4 × 4 cm pink.sh firm mass arising from anterior Tricuspid annulus which was completely excised. Child was extubated on postoperative day (POD) 0 and was on minimal inotropic support. Ascites reduced significantly on POD1 allowing abdominal palpation which revealed a mass in the epigastric region. This prompted evaluation by pediatrician and oncology work.p suggestive of increased 18-Flouro Deoxy Glucose (18-FDG) uptak. in the mediastinum, abdomen, bilateral proximal thighs, all mediastinal lymph nodal stations, bilateral lung hilar stations 10R, 10L involving all encasing the heart and great vessels with pleural deposits, Celiac trunk. superior Mesenteric Artery (SMA), Portal vein, IVC and abdominal aorta. Histo pathology Examination (HPE) and Immuno Histo Chemistry (IHC) of intracardiac mass revealed DLBCL which is metastatic in nature. Chemotherapy was started as per (French American British Lymphomes Malins B) FAB LMB-96 protocol with the child currently in the Induction phase having poor prognosis and less survival interval. Conclusion: Surgery can be considered a treatment option for metastatic intracardiac masses during emergency scenarios lik. cardiogenic shock.to relieve obstruction along the pathway of blood flow in the heart even though we may not be able to completely excise the tumor surgically.

关键词： Diffuse Large B-Cell Lymphoma (DLBCL) Non-Hodgk.n’s Lymphoma (NHL) Secondary Intracardiac Metastasis Cardiogenic Shock Immuno Histo Chemistry (IHC)

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Machine learning in data abstraction: A computable phenotype for sepsis and septic shock.diagnosis in the intensive care unit

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World Journal of Critical Care Medicine 2019年第7期8卷 120-126页

作者： Prabij Dhungana Laura Piccolo Serafim Arnaldo Lopez Ruiz Danette Bruns Timothy J Weister Nathan Jerome Smischney Rahul kashyap Department of Anesthesiology and Perioperative Medicine Mayo ClinicRochesterMN 55905United States Multidisciplinary Epidemiology and Translational Research in Intensive Care Mayo ClinicRochesterMN 55905United States Department of Medicine Division of Pulmonary and Critical Care MedicineMayo ClinicRochesterMN 55905United States Anesthesia Clinical Research Unit Mayo ClinicMN 55905United States

BACk.ROUND With the recent change in the definition(Sepsis-3 Definition)of sepsis and septic shock.an electronic search algorithm was required to identify the cases for data *** supervised machine learning method would help screen a large amount of electronic medical records(EMR)for efficient research *** To develop and validate a computable phenotype via supervised machine learning method for retrospectively identifying sepsis and septic shock.in critical care *** A supervised machine learning method was developed based on culture orders,Sequential Organ Failure Assessment(SOFA)scores,serum lactate levels and vasopressor use in the intensive care units(ICUs).The computable phenotype was derived from a retrospective analysis of a random cohort of 100 patients admitted to the medical *** was then validated in an independent cohort of 100 *** compared the results from computable phenotype to a gold standard by manual review of EMR by 2 blinded *** was resolved by a critical care clinician.A SOFA score≥2 during the ICU stay with a culture 72 h before or after the time of admission was *** versions as V1 was defined as blood cultures with SOFA≥2 and Sepsis V2 was defined as any culture with SOFA score≥2.A serum lactate level≥2 mmol/L from 24 h before admission till their stay in the ICU and vasopressor use with Sepsis-1 and-2 were identified as Septic Shock.V1 and-V2 *** In the derivation subset of 100 random patients,the final machine learning strategy achieved a sensitivity-specificity of 100%and 84%for Sepsis-1,100%and 95%for Sepsis-2,78%and 80%for Septic Shock.1,and 80%and 90%for Septic *** overall percent of agreement between two blinded reviewers had a k.0.86 and 0.90 for Sepsis 2 and Septic shock.2 *** validation of the algorithm through a separate 100 random patient subset,the reported sensitivity and specificity for all 4 diagnoses were 100%-100%e

关键词： Machine learning Computable phenotype Critical care Sepsis Septic shock

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Photonic properties of novel Yb3+ doped germanium-lead oxyfluoride glass-ceramics for laser cooling applications

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Frontiers of Optoelectronics 2018年第02期 189-198页

作者： Lauro June Queiroz Maia Jyothis THOMAS Yannick.LEDEMI k.mmara Venk.ta k.ishnaiah Denis SELETSk.Y Younès MESSADDEQ Raman kashyap Instituto de Física Universidade Federal de Goiás Department of Electrical Engineering école Polytechnique de Montréal Department of Engineering Physics école Polytechnique de Montréal Centre d'Optique Photonique et Laser

In recent years, our research group has developed and studied new rare-earth doped materials for the promising technology of solid-state laser cooling,which is based on anti-stok.s fluorescence. To the best of our k.owledge, our group is the only one in Canada leading the research into the properties of nanoparticles,glasses and glass-ceramics for optical refrigeration applications. In the present work. optical properties of 50GeO2-30PbF2-18Pb O-2YbF3glass-ceramics for laser cooling are presented and discussed as a function of crystallization temperature. Spectroscopic results show that samples have near infrared photoluminescence emission due to the2F5/2–2F7/2Yb3+transition, centered at ～1016 nm with an excitation wavelength of 920 nm or 1011 nm, and the highest photoluminescence emission efficiency occurs for heat-treatment for 5 h at 350°C. The internal photoluminescence quantum yield varies between 99% and 80%,depending on the temperature of heat-treatment, being the most efficient under 1011 nm excitation. The2F5/2lifetime increases from 1.472 to 1.970 ms for heat treatments at 330°C to 350°C, respectively, due to energy trapping and the low phonon energy of the nanocrystals. The sample temperature dependence was measured with a fiber Bragg grating sensor, as a function of input pump laser wavelength and processing temperature. These measurements show that the heating process approaches near zero for an excitation wavelength between 1020 and 1030 nm,which is an indication that phonons are removed effectivelly from the glass-ceramic materials, and they can be used for optical laser cooling applications. On the other hand, the temperature increase as a function of input laser power into samples remains constant between 920and 980 nm wavelength excitation, a temperature variation of 36 k.W（temperature of 58°C/W） was attained under excitation at 950 nm, showing a possible use for biomedical applications to be explored.

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New-onset atrial fibrillation among COVID-19 patients: A narrative review

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World Journal of Critical Care Medicine 2023年第5期12卷 236-247页

作者： Fahimeh Talaei Ak.hat Banga Amanda Pursell Ann Gage Namratha Pallipamu Amith Reddy Seri Ramesh Adhik.ri Rahul kashyap Salim Surani Department of Critical Care Medicine Mayo ClinicPhoenixAZ 85054United States Department of Internal Medicine Sawai Man Singh Medical CollegeJaipur 302004India Internal Medicine Tristar Centennial Medical CenterTriStar DivisionHCA HealthcareNashvilleTN 37203United States Cardiology TriStar Centennial Medical CenterTriStar DivisionHCA HealthcareNashvilleTN 37203United States Department of Medicine Siddharta Medical CollegeVijayawada 520008Andhra PradeshIndia Department of Internal Medicine Mclaren Regional Medical CenterFlintMI 48532United States Department of Internal Medicine Franciscan HealthLafayetteIN 46237United States Department of Anaesthesiology&Critical Care Medicine Mayo ClinicRochesterMN 55902United States Department of Research WellSpan HealthYorkPA 17401United States Department of Medicine&Pharmacology Texas A&M UniversityCollege StationTX 77843United States

Over the last three years,research has focused on examining cardiac issues arising from coronavirus disease 2019(COVID-19)infection,including the emergence of new-onset atrial fibrillation(NOAF).Still,no clinical study was conducted on the persistence of this arrhythmia after COVID-19 *** objective was to co-mpose a narrative review that investigates COVID-19-associated NOAF,emphasi-zing the evolving pathophysiological mechanisms ak.n to those suggested for sustaining *** the distinct strategies involved in the persistence of atrial AF and the crucial burden of persistent AF,we aim to underscore the importance of extended follow-up for COVID-19-associated NOAF.A comprehensive search was conducted for articles published between December 2019 and February 11,2023,focusing on similarities in the pathophysiology of NOAF after COVID-19 and those persisting ***,the latest data on incidence,morbidity-mortality,and management of NOAF in COVID-19 were *** overlaps between the mechanisms of emerging NOAF after COVID-19 infection and persistent AF were observed,mostly involving reactive oxygen *** potential atrial remodeling associated with NOAF in COVID-19 patients,this group of patients might benefit from long-term follow-up and different *** cohort studies could help determine long-term outcomes of NOAF after COVID-19.

关键词： COVID-19 SARS-CoV-2 New-onset atrial fibrillation Atrial fibrillation

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Vein of Galen malformation in a neonate:A case report and review of endovascular management

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World Journal of Clinical Pediatrics 2017年第1期6卷 103-109页

作者： Surasak.Puvabanditsin Rajeev Mehta k.isty Palomares Natalie Gengel Christina Ferrucci-Da Silva Sudipta Roychowdhury Gaurav Gupta Arun kashyap David Sorrentino Department of Pediatrics Rutgers Robert Wood Johnson Medical School Department of Obstetrics and Gynecology Rutgers Robert Wood Johnson Medical School Department of Neuro- surgery Rutgers Robert Wood Johnson Medical School

Vein of Galen malformation(VOGM) is a rare congenital vascular malformation caused by the maldevelopment of its embryonic precursor,the median prosencephalic vein of *** results in neonatal morbidity and mortality,and premature delivery does not improve the *** report a term female neonate in whom a vein of Galen malformation was diagnosed prenatally at 37 wk.of gestation during a growth ultrasound and confirmed by fetal magnetic resonance *** of cardiac decompensation were evident in the *** interventional radiology embolizations of the feeding vessels were performed successfully on days 7,10,12,14 and 19.A review of the literature on the endovascular management of neonates with these malformations is presented herein.

关键词： Vein of Galen malformation Endovascular therapy Congenital anomaly Neonate

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Artificial intelligence in sleep medicine:Present and future

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World Journal of Clinical Cases 2023年第34期11卷 8106-8110页

作者： Ram k.shun Verma Gagandeep Dhillon Harpreet Grewal Vinita Prasad Ripudaman Singh Munjal Pranjal Sharma Venk.ta Buddhavarapu Ramprak.sh Devadoss Rahul kashyap Salim Surani Department of Sleep Medicine Parkview Health SystemFort WayneIN 46845United States Department of Medicine UM Baltimore Washington Medical CenterGlen BurnieMD 21061United States Department of Radiology Ascension Sacred Heart HospitalPensacolaFL 32504United States Department of Psychiatry Parkview Health SystemFort WayneIN 46845United States Department of Medicine Kaiser Permanente Medical CenterModestoCA 95356United States Department of Medicine Banner HealthPhoenixAZ 85006United States Department of Medicine Norteast Ohio Medical UniversityRootstownOH 44272United States Department of Cardiology Carle Methodist Medical CenterPeroriaIL 61637United States Department of Research Wellspan HealthYorkPA 17403United States Department of Medicine&Pharmacology Texas A&M UniversityCollege StationTX 77843United States

Artificial intelligence(AI)has impacted many areas of *** in healthcare uses machine learning,deep learning,and natural language processing to analyze copious amounts of healthcare data and yield valuable *** the sleep medicine field,a large amount of physiological data is gathered compared to other branches of *** field is primed for innovations with the help of AI.A good quality of sleep is crucial for optimal *** one billion people are estimated to have obstructive sleep apnea worldwide,but it is difficult to diagnose and treat all the people with limited *** apnea is one of the major contributors to poor *** of the sleep apnea patients remain *** diagnosed with sleep apnea have difficulty getting it optimally treated due to several factors,and AI can help in this *** can also help in the diagnosis and management of other sleep disorders such as insomnia,hypersomnia,parasomnia,narcolepsy,shift work.sleep disorders,periodic leg movement disorders,*** this manuscript,we aim to address three critical issues about the use of AI in sleep medicine:(1)How can AI help in diagnosing and treating sleep disorders?(2)How can AI fill the gap in the care of sleep disorders?and(3)What are the ethical and legal considerations of using AI in sleep medicine?

关键词： Artificial intelligence Machine learning Deep learning Ethical Legal,and sleep disorders

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信息分类管理提升企业信息价值的有效途径

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商学院 2006年第11期 84-86页

作者：张俐徐启昌 k.h-shin F. Cheng 苏中 kashyap A vashia IBM中国研究院资深研究员 IBM全球企业咨询服务部资深顾问 IBM Watson研究中心高级软件工程师

今天，企业的信息规模十分庞大，覆盖的主题非常广泛，如何将这些内容丰富．形式各异的信息组织在一个科学．全面的分类体系之中，需要系统的考虑和规划。

关键词：企业信息价值分类管理分类体系信息组织

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药物刺激肝细胞合成分泌载脂蛋白AI的分子生物学机制

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胃肠病学和肝病学杂志 1995年第1期4卷 23-27页

作者： Fu-You Jin k.nga Morgan Moti kashyap (VA Medical Center Long Beach University of California,Irvine CA 90822)

本文检测了Ｇｅｍｆｉｂｒｏｚｉｌ（ＧＦ，商品名Ｌｏｐｉｄ降脂灵是一种常用的抗动脉硬化药物，具有降低甘油三脂和升高高密度脂蛋白（ＨＤＬ）的作用）对肝细胞载脂蛋白ＡＩ的合成与分泌的作用以及可能的作用机制。在本研究中我们使... 详细信息

本文检测了Ｇｅｍｆｉｂｒｏｚｉｌ（ＧＦ，商品名Ｌｏｐｉｄ降脂灵是一种常用的抗动脉硬化药物，具有降低甘油三脂和升高高密度脂蛋白（ＨＤＬ）的作用）对肝细胞载脂蛋白ＡＩ的合成与分泌的作用以及可能的作用机制。在本研究中我们使用了ＥＬＩＳＡ，免疫沉淀、分子生物学技术（如ｍＲＮＡ定量、半寿期和新ｍＲＮＡ合成率等）和特异性抗体。结果发现，ＧＦ可增加载脂蛋白ＡＩ（ａｐｏＡＩ）的分泌及放射标记蛋氨酸的掺入（合成）。与对照组相比使用２００μｍ的ＧＦ可以增加ａｐｏＡＩ的分泌及合成分别达１５８％和１３０％（短期冲击）。分子生物学结果显示，使用不同浓度的ＧＦ可以增加稳定状态的ｍＲＮＡ表达（最高达２０４％）。ｍＲＮＡ的半寿期由１４．５ｈ延长到３５ｈ。而新的ｍＲＮＡ的合成率无变化。结论：ＧＦ的心脏保护作用是因为该药刺激肝脏增加ａｐｏＡＩ的合成及分泌。其机制则为延长ａｐｏＡＩｍＲＮＡ的半寿期从使ｍＲＮＡ在肝细胞内的含量增加，而与新的ｍＲＮＡ的生成无关。

关键词：降脂灵载脂蛋白AI 信使核糖核酸分子生物学

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含笑属植物所含化学成分与其生物活性的综述(英文)

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中西医结合学报 2012年第12期10卷 1336-1340页

作者： Dinesh k.mar Sunil k.mar Seema Taprial Deepak.kashyap Ajay k.mar Om Prak.sh Institute of Pharmaceutical Sciences Kurukshetra University

属木兰科的含笑属植物大约有80多个种类,它们大都分布在南亚国家。这些植物被当地人用于治疗各种疾病,如发烧、绞痛、麻风病、眼疾、炎症以及解蝎子毒。从9种含笑属植物中分离出94种化合物,例如倍半萜烯、类固醇、黄酮类、阿扑啡类、苯... 详细信息

属木兰科的含笑属植物大约有80多个种类,它们大都分布在南亚国家。这些植物被当地人用于治疗各种疾病,如发烧、绞痛、麻风病、眼疾、炎症以及解蝎子毒。从9种含笑属植物中分离出94种化合物,例如倍半萜烯、类固醇、黄酮类、阿扑啡类、苯酚、酯类、生物碱和苯环型化合物等,它们具有抗菌、抗癌以及抗疟原虫活性。本文详细地论述了含笑属植物所含化学成分的生物及化学性能。

关键词：含笑属药理作用综述

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Photonics bridges between turbulence and spin glass phenomena in the 2021 Nobel Prize in Physics

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Light(Science & Applications) 2022年第5期11卷 743-745页

作者： A.S.L.Gomes C.B.de Araújo A.M.S.Macêdo I.R.R.González L.de S.Menezes P.I.R.Pincheira R.kashyap G.L.Vasconcelos E.P.Raposo Departamento de Física Universidade Federal de PernambucoRecifePE 50670-901Brazil Unidade Acadêmica de Belo Jardim Universidade Federal Rural de PernambucoBelo JardimPEBrazil Chair in Hybrid Nanosystems Nanoinstitut MünchenFakultät für PhysikLudwig-Maximilians-Universität München80539 MünchenGermany Departamento de Ciencias Físicas Universidad de La FronteraTemucoChile Fabulas Laboratory Department of Engineering PhysicsDepartment of Electrical EngineeringPolytechnique MontrealMontreal H3C 3A7 QCCanada Departamento de Física Universidade Federal do ParanáCuritibaPR 81531-990Brazil

A photonic connection between turbulence and spin glasses has been recently established both theoretically and experimentally using a random fiber laser as a photonic *** unveiling this interplay,it link. the work. of... 详细信息

关键词： fiber turbulence Nobel

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