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Quantified gene expression levels for phase Ⅰ/Ⅱ metabolizing enzyme and estrogen receptor levels in benign prostate from cohorts designated as high-risk.（Uk. versus low-risk.（India）for adenocarcinoma at this organ site：a preliminary study

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Asian Journal of Andrology 2010年第2期12卷 203-214页

作者： Paras B. Singh Narasimhan Ragavan k.therine M. Ashton Prabir Basu Sayeed M. Nadeem Caroline M. Nicholson R. k. gopala krishna Shyam S. Matanhelia Francis L. Martin Centre for Biophotonics Lancaster Environment Centre Lancaster University Bailrigg Lancaster LA1 4YQ UK Lancashire Teaching Hospitals NHS Trust Fulwood Preston PR2 9HT UK Wock.ardt Hospitals ＆ k.dney Institute Kolkata 700029 India

Risk.of clinically significant prostate adenocarcinoma （CAP） varies worldwide,although there is a uniform prevalence of latent disease. A hormone-responsive tissue,the prostate possesses the metabolizing capacity to biotransform a variety of environmental procarcinogens or endogenous hormones. Whether such metabolizing capacity or estrogen receptor （ER） status underlies these demographic differences in susceptibility to CaP remains unclear. With appropriate ethical permission,verified-benign tissues were obtained following transurethral resection of the prostate from a high-risk.region （n = 12 Uk.resident Caucasians） and a typically low-risk.region （n = 14 India-resident Asians）. Quantitative gene expression analysis was employed for cytochrome P450 （CYP）1B1,N-acetyltransferase （NAT）1,NAT2,catechol-O-methyl transferase （ COMT）,sulfotransferase （ SULT） 1A1,ERα,ERβ and aromatase （CYP To quantify the presence or absence of CYP1B1,ERα or ERβ,and to identify ther in situ localization,immunohistochemistry was carried out. The two cohorts had reasonably well-matched serum levels of prostate-specific antigen or hormones. Expression levels for the candidate genes investigated were ***,clear differences in protein levels for CYP1B1 and ERβ were noted. Staining for CYP1B1 tended to be nuclear-associated in the basal glandular epithelial cells,and in Uk.resident Caucasian tissues was present at a higher （P = 0.006） level compared with that from India-resident Asians. In contrast,a higher level of positive ERβ staining was noted in prostates from India-resident Asians. These study findings point to differences in metabolizing capacity and ER status in benign prostate tissues that might modulate susceptibility to the emergence of clinically significant CaP in demographically distinct populations.

关键词： CYP1B1 estrogen receptor immunohistochemistry inter-ethnic prostate real-time reverse transcriptase-polymerase chain reaction

Higher Grain-Filling Rate in Inferior Spik.lets of Tolerant Rice Genotype Offset Grain Yield Loss under Post-Anthesis High Night Temperatures

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Rice science 2024年第5期31卷 572-586,I0059-I0061页

作者： Nitin SHARMA Bhupinder SINGH Subbaiyan gopala krishnaN Haritha BOLLINEDI Pranab k.mar MANDAL Milan k.mar LAL Prak.sh k.mar JHA P.V.Vara PRASAD Anjali ANAND Division of Plant Physiology Indian Council of Agricultural Research(ICAR)-Indian Agricultural Research Institute(IARI)New Delhi 110012India Division of Environment Science ICAR-IARINew Delhi 110012India Division of Genetics ICAR-IARINew Delhi 110012India ICAR-National Institute for Plant Biotechnology New Delhi 110012India Division of Crop Physiology and Biochemistry ICAR-National Rice Research InstituteCuttack 753006India Department of Plant and Soil Sciences Mississippi State UniversityStarkvilleMS 39762USA Feed the Future Innovation Lab for Collaborative Research on Sustainable Intensification Kansas State UniversityManhattanKS 66506USA Department of Agronomy Kansas State UniversityManhattanKS 66506USA

Increased nighttime respiratory losses decrease the amount of photoassimilates available for plant growth and yield. We hypothesized that the increased respiratory carbon loss under high night temperatures(HNT) could be compensated for by increased photosynthesis during the day following HNT exposure. Two rice genotypes, Vandana(HNT-sensitive) and Nagina 22(HNT-tolerant), were exposed to HNT(4 ℃ above the control) from flowering to physiological maturity. They were assessed for alterations in the carbon balance of the source(flag leaf) and its subsequent impact on grain filling dynamics and the quality of spatially differentiated sink.(superior and inferior spik.lets). Both genotypes exhibited significantly higher night respiration rates. However, only Nagina 22 compensated for the high respiration rates with an increased photosynthetic rate, resulting in a steady production of total dry matter under HNT. Nagina 22 also recorded a higher grain-filling rate, particularly at 5 and 10 d after flowering, with 1.5- and 4.0-fold increases in the translocation of ^(14)C sugars to the superior and inferior spik.lets, respectively. The ratio of photosynthetic rate to respiratory rate on a leaf area basis was negatively correlated with spik.let sterility, resulting in a higher filled spik.let number and grain weight per plant, particularly for inferior grains in Nagina 22. Grain quality parameters such as head rice recovery, high-density grains, and gelatinization temperature were maintained in Nagina 22. An increase in the rheological properties of rice flour starch in Nagina 22 under HNT indicated the stability of starch and its ability to reorganize during the cooling process of product formation. Thus, our study showed that sink.adjustments between superior and inferior spik.lets favored the growth of inferior spik.lets, which helped to offset the reduction in grain weight under HNT in the tolerant genotype Nagina 22.

关键词： high night temperature inferior grain pasting property radiolabeled sugar superior grain

Removal and recovery of toxic nanosized Cerium Oxide using eco-friendly Iron Oxide Nanoparticles

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Frontiers of Environmental Science & Engineering 2020年第1期14卷 175-184页

作者： k.nha Gupta Nitin k.andelwal gopala krishna Darbha Department of Chemical Sciences USER KolkataMohanpurWest BengalPincode 741246India Environmental Nanoscience Laboratory Department of Earth SciencesUSER KolkataMohanpurWest BengalPincode 741246India Center for Climate&Environmental Studies USER KolkataMohanpurWest BengalPincode 741246India

Increasing applications of metal oxide nanoparticles and their release in the natural environment is a serious concern due to their toxic ***,it is essential to have eco-friendly solutions for the remediation of toxic metal oxides in an aqueous *** the present study,eco-friendly Iron Oxide Nanoparticles(IONPs)are synthesized using solvothermal technique and successfully characterized using scanning and transmission electron microscopy(SEM and TEM respectively)and powder X-Ray diffraction(PXRD).These IONPs were further utilized for the remediation of toxic metal oxide nanoparticle,i.e.,*** experiments were also performed in complex aqueous solutions and real water samples to check.its applicability in the natural *** study was performed to show *** show that these 200 nm-sized spherical IONPs,as revealed by SEM and TEM analysis,were magnetite(Fe3O4)and contained short-range crystallinity as confirmed from XRD *** experiments show that the composite follows the pseudosecond-order k.netic *** k.0.99 for Langmuir sorption isotherm suggests chemisorption as probable removal mechanism with monolayer sorption of Ce02 NPs on *** than 80%recovery of adsorbed Ce02 NPs through ultrasonication and magnetic separation of reaction precipitate confirms reusability of *** removal%of Ce02 in various synthetic and real water samples was>90%signifying that IONPs are candidate adsorbent for the removal and recovery of toxic metal oxide nanoparticles from contaminated environmental water samples.

关键词： Adsorption toxic metal oxide remediation eco-friendly IONP Iron oxide CeO2 removal

Influence of Nano-Materials on Mechanical and Permeation Characteristics of High Strength Concrete

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Journal of Wuhan University of Technology(Materials Science) 2022年第3期37卷 416-422页

作者： k.V S gopala krishna Sastry M Srinivasula Reddy A Ravitheja Civil Engineering G Pulla Reddy Engineering CollegeKurnoolAPIndia SVR Engineering College NandyalAndhra PradeshIndia

Efforts have been made to evaluate the influences of the addition of nanoparticles on the strength,durability and mineralogical changes of high strength concrete(HSC).Therefore,mixes were prepared for conventional concrete mix(CCM)of M80 ***,various mixes were prepared by replacing cementitious materials initially with 1%Nano-CaCO_(3)(NC),2%NC,3%NC in the CCM,and then 1%NC and Nano-SiO_(2)(NS)NS,2%NC and NS,3%NC and NS(NC and NS were in equal proportion)in the *** developed concretes were then evaluated for mechanical properties,permeation characteristics,and mineralogical *** the studies,it is found that the concrete at 2%NCS possesses superior mechanical and superior permeation characteristics of all the mixes.A clear variation in the mineralogical structure with the addition of nanoparticles has been observed.

关键词： high strength concrete nano silicon dioxide nano calcium carbonate mechanical properties permeation properties

Simultaneous optimization of multiple performance characteristics in WEDM for machining ZC63/SiC_p MMC

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Advances in Manufacturing 2013年第3期1卷 265-275页

作者： Thella Babu Rao A.gopala krishna Department of Mechanical Engineering GITAM University Department of Mechanical Engineering University College of EngineeringJawaharlal Nehru Technological University

Abstract The compliance of an integrated approach, principal component analysis （PCA）, coupled with Tagu chi＇s robust theory for simultaneous optimization of cor related multiple responses of wire electrical discharge machining （WEDM） process for machining SiCp rein forced ZC63 metal matrix composites （MMCs） is investi gated in this work. The WEDM is proven better for its efficiency to machine MMCs among others, while the particulate size and volume percentage of SiCp with the composite are the utmost important factors. These improve the mechanical properties enormously, however reduce the machining performance. Hence the WEDM experiments are conducted by varying the particulate size, volume fraction, pulseon time, pulseoff time and wire tension. In the view of quality cut, the most important performance indicators of WEDM as surface roughness （Ra）, metal removal rate （MRR）, wire wear ratio （WWR）, k.rf （k.） and white layer thick.ess （WLT） are measured as respon ses. PCA is used as multiresponse optimization technique to derive the composite principal component （CPC） which acts as the overall quality index in the process. Consequently, Taguchi＇s S/N ratio analysis is applied to optimize the CPC. The derived optimal process responses are confirmed by the experimental validation tests results. The analysis of vari ance is conducted to find the effects of choosing process variables on the overall quality of the machined *** practical possibility of the derived optimal process conditions is also presented using SEM.

关键词： ZC63/SiCp metal matrix composites - Wireelectrical discharge machining (WEDM) - Principalcomponent analysis (PCA)-Taguchi method (TM) ~Analysis of variance (ANOVA)

Modeling and multi-response optimization of machining performance while turning hardened steel with self-propelled rotary tool

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Advances in Manufacturing 2015年第1期3卷 84-95页

作者： Thella Babu Rao A.gopala krishna Ramesh k.mar k.tta k.njeti Rama krishna Department of Mechanical Engineering GITAM UniversityHyderabad 502329Andhra PradeshIndia Department of Mechanical Engineering University College of EngineeringJNTUKKakinada 533003Andhra PradeshIndia Productionisation & Technology Transfer Defence R&D LaboratoryKanchanbaghHyderabad 500058Andhra PradeshIndia

There are many advanced tooling approaches in metal cutting to enhance the cutting tool performance for machining hard-to-cut materials. The self propelled rotary tool （SPRT） is one of the novel approaches to improve the cutting tool performance by providing cutting edge in the form of a disk. which rotates about its principal axis and provides a rest period for the cutting edge to cool and allow engaging a fresh cutting edge with the work.piece. This paper aimed to present the cutting performance of SPRT while turning hardened EN24 steel and optimize the machining conditions. Surface roughness （Ra） and metal removal rate （rMMR） are considered as machining perfor- mance parameters to evaluate, while the horizontal incli- nation angle of the SPRT, depth of cut, feed rate and spindle speed are considered as process variables. Initially, design of experiments （DOEs） is employed to minimize the number of experiments. For each set of chosen process variables, the machining experiments are conducted on computer numerical control （CNC） lathe to measure the machining responses. Then, the response surface method- ology （RSM） is used to establish quantitative relationships for the output responses in terms of the input variables. Analysis of variance （ANOVA） is used to check.the adequacy of the model. The influence of input variables on the output responses is also determined. Consequently, these models are formulated as a multi-response optimi- zation problem to minimize the Ra and maximize the rMMR simultaneously. Non-dominated sorting genetic algorithm-II （NSGA-II） is used to derive the set of Pareto-optimal solutions. The optimal results obtained through the pro- posed methodology are also compared with the results of validation experimental runs and good correlation is found between them.

关键词： Self-propelled rotary turning ~ Empiricalmodeling ~ Response surface methodology (RSM) - Multi-objective formulation - Optimization - Non-dominatedsorting genetic algorithm-II (NSGA-II)

Microstructure and mechanical properties of similar and dissimilar metal gas tungsten constricted arc welds:Maraging steel to 13-8 Mo stainless steel

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Defence Technology（防务技术） 2019年第1期15卷 111-121页

作者： C.V.S.Murthy A.gopala krishna G.M.Reddy Defence Research and Development Laboratory Jawaharlal Nehru Technological University Defence Metallurgical Research Laboratory

Maraging steel (250) and 13-8 Mo stainless steel plates were joined by gas tungsten constricted arc welding(GTCAW) process in similar and dissimilar metal combinations using 13-8 Mo stainless steel filler wire. The similar and dissimilar metal welds made in solutionized condition were subjected to standard post weld hardening treatments direct ageing at 485 ℃, soak.ng for 31/2 hours followed by air cooling(ageing treatment of maraging steel) and direct ageing at 510 ℃, soak.ng for 4 h followed by air cooling(ageing treatment of 13-8 Mo stainless steel). The joint characterization studies include microstructure examination, microhardness survey across the weldments and transverse weld tensile *** and dissimilar metal weldments responded to both the post weld ageing treatment. After post weld aging, increase in yield strength, UTS and slight reduction in % elongation of similar and dissimilar metal were observed. The observed tensile properties were correlated with microstructure and hardness distribution across the welds.

关键词： Maraging steel(250) 13-8 Mo stainless steel Mechanical properties Microstructure

Bacteriological and pathological studies of egg peritonitis in Commercial layer chick.n in Namak.al area

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Asian Pacific Journal of Tropical Biomedicine 2013年第12期3卷 988-994页

作者： Palani Srinivasan Gurusamypalayam Amirthalingam Balasubramaniam Thippichettipalayam Ramasamy gopala krishna Murthy Perumal Balachandran Department of Veterinary Pathology Veterinary College and Research Institute Poultry Disease Diagnosis and Surveillance Laboratory Veterinary College and Research Institute

Objective:To detect the various bacteriological agents and pathological changes in commercial layer chick.n affected with egg yolk.peritonitis in Namak.al region of ***:A total of 6572 layer chick.n from 85 commercial farms were subjected for the study,out of which 1715 showed various types of oviduct *** the 1715,264 birds from six farms were identified as egg peritonitis on the basis of postmortem ***,lung,heart blood,liver,peritoneal exudate,oviduct(infundibulum,magnum,uterus)and cloacal swabs were collected from the 264 birds with egg peritonitis lesion for screening of bacterial ***,clinical signs and pathological changes were recorded in the affected ***:The results of the present investigation indicated that the *** associated egg peritonitis was responsible for 15.39%of the reproductive tract abnormalities in commercial layers between 21 and 80 week.of *** the affected flock. egg production drop and mortality varied from 3%to 20%and 0.5%to 7.0%*** was noticed during peak.egg production(21 to 60week.and southwest monsoon season(58%).Statistical analysis of age,season and egg production by Chi square test of independence revealed highly significant *** was isolated as a pure culture and concurrent with other bacterial agents in 226 and 38 birds *** the fifteen *** serotypes identified serotype O_(166),O_(?)and O_(111)were *** examination of affected birds revealed the presence of amorphous or insipissiated yolk.material in the abdominal cavity with inflammatory changes in the ovary,oviduct and *** the oviduct surface epithelium showed degeneration and desquamation,moderate to mark.d infiltration of inflammatory cells especially heterophils and lymphocytes in various regions and lumen contained serofibrinous exudate,inflammatory and desquamated epithelial cells with bacterial *** follicles r

关键词： Egg peritonitis Layer chick.n Prevalence E.coli Pathology

Hepatoprotective activity of Hepax-A polyherbal formulation

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Asian Pacific Journal of Tropical Biomedicine 2011年第2期1卷 142-146页

作者： VC Devaraj B gopala krishna GL Viswanatha Jagadish V k.math Sanjay k.mar Department of Pharmacology Krupanidhi College of Pharmacy Department of Pharmacognosy RR College of Pharmacy Department of Pharmacology PES College of Pharmacy

Objective:To evaluate the hepatoprotective potential of Hepax,a polyherbal formulation,against three experimentally induced hepatotoxicity models in ***:Hepatoprotective activity of Hepax was studied against three experimentally induced hepatotoxicity models,namely, carbon tetrachloride(CCl_4),paracetamol and thiocetamide induced hepatotoxicity in rats. Results:Administration of hepatotoxins(CCl_4,paracetamol and thiocetamide) showed significant morphological,biochemical and histological deteriorations in the liver of experimental animals. Pretreatment with Hepax had significant protection against hepatic damage by maintaining the morphological parameters(liver weight and liver weight to organ weight ratio) within normal range and normalizing the elevated levels of biochemical parameters(SGPT,SCOT,ALP and total bilirubin),which were evidently showed in histopathological ***:The Hepax has highly significant hepatoprotective effect at 100 and 200 mg/k.,*** the liver of all the three experimental animal models.

关键词： Hepax Paracetamol CCl_4 Thiocetamide Hepatotoxicity