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Genes link.d to obesity-related infertility:bridging the k.owledge gap

Reproductive and Developmental Medicine 2024年第2期8卷 121-129页

作者： Praveen k.mar chandra sekar Ramak.ishnan Veerabathiran Human Cytogenetics and Genomics Laboratory Faculty of Allied Health SciencesChettinad Academy of Research and EducationKelambakkamTamil Nadu 603103India

Genetic factors play a pivotal role in the complex relationship between obesity and *** article delves into the genetics of obesity-related infertility,focusing on the essential genes and mechanisms in both *** explored infertility factors in obese females,focusing on polycystic ovary syndrome(PCOS)and the influence of genes lik. insulin receptor(INSR),androgen receptor(AR),and follicle-stimulating hormone receptor(FSHR).Epigenetic changes are believed to contribute to PCOS-related *** impact of adipok.nes and inflammation on obesity-related infertility has been discussed,with genes such as fat mass and obesity(FTO)and melanocortin-4-receptor(MC4R)playing significant *** factors affecting sperm quality and function,including nuclear receptor subfamily 3 group C member 1(NR3C1)and methylenetetrahydrofolate reductase(MTHFR),have been investigated in obesity-related infertility in *** dysregulation influenced by genetic mark.rs,such as leptin receptor(LEPR),tumor necrosis factor-alpha(TNF-α),and interleuk.n-6(IL-6),was also *** factors play a vital role in obesity-related infertility in both *** involved in metabolism,hormonal regulation,and inflammation contribute to the complex association between obesity and *** changes further complicate the *** these genetic mechanisms is essential to address obesity-related infertility and develop personalized interventions.

关键词： Obesity Infertility PCOS DNA methylation Epigenetics

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Invasive Alien Plants of Indian Himalayan Region—Diversity and Implication

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American Journal of Plant Sciences 2012年第2期3卷 177-184页

作者： k. chandra sekar G. B. Pant Institute of Himalayan Environment & Development Kosi-Katarmal Almora India.

The present study deals with comprehensive list of Invasive alien plants of Indian Himalayan Region with back.round information on family, habit and nativity. A total of 190 invasive alien species under 112 genera, belonging to 47 families have been recorded. Among these, the dicotyledons represent by 40 families, 95 genera and 170 species;monocotyledons represent by 7 families, 17 genera and 20 species. The analysis of invasive species reveals that 18 species have been introduced intentionally, while the remaining species established unintentionally through trade. In terms of nativity, amongst 13 geographic regions, the majority of invasive plants reported from American continent (73%). While in life form analysis, the herbs (148 species) are dominant, followed by shrubs (19 species), Grass (11 species), Trees (4 species), sedges and climber (3 species each). Most of the invasive species are annual habit (63%). Apart from these, 90 species (47%) are being used by locals for medicinal purposes. A better planning is needed for early detection to control and reporting of infestations of spread of new and naturalized weeds to be monitored.

关键词： Invasive Alien Species Indian Himalayan Region Nativity India

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Rhododendrons in Indian Himalayan Region: Diversity and Conservation

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American Journal of Plant Sciences 2010年第2期1卷 131-137页

作者： k. chandra sekar Sunil k.mar Srivastava 不详

The genus Rhododendron of Indian Himalayan Region (IHR) has been enumerated in the present paper. A total of 87 species, 12 subspecies and 8 varieties of Rhododendrons recorded in IHR, among these 6 species and one subspecies are reported from Western Himalaya. The maximum concentration of 86% observed in Arunachal Pradesh (75 species). The species of Rhododendrons exhibit significant diversity in habit and broad range of distribution from the altitude of 800-6000 m. and the best range is observed in 3001-3500 m altitudes. In analysis revealed 20 taxa are endemic, 30 are rare, 24 are threatened / endangered, 3 are vulnerable and 47 taxa have to be assessed. The major threats to rhododendrons are deforestation and unsustainable extraction for firewood and incense by local people has been discussed.

关键词： Rhododendrons Indian Himalayan Region Ericaceae India

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The present status and future prospects of forest vegetation in part of Nanda Devi Biosphere Reserve(a World Heritage Site),India

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Journal of Forestry Research 2015年第4期26卷 897-904页

作者： Balwant Rawat Sanjay Gairola k.chandra sekar Ranbeer S.Rawal G.B.Pant Institute of Himalayan Environment and Development Kosi-KatarmalAlmoraUttarakhand 263643India Forest Ecology and Environment Division Forest Research InstituteDehradunUttarakhand 248006India Society for the Conservation of Nature Parnkuti Anantpur University RoadRewaMadhya PradeshIndia

We studied forest vegetation at Lata-Tolma- Phagti, a protected area and part of Nanda Devi Biosphere Reserve in the western Himalaya. We analyzed community composition, population structure, regeneration patterns, and projected development of future compositional patterns. We sampled ten 10 x 10 m quadrat for tree species in each of 30 forest stands. We sampled shrubs in ten 5 x 5 m quadrat, and herbs in twenty 1 x 1 m quadrat within each forest stand. We recorded 248 plant species from 8 forest communities. Broadly the demographic profiles at study sites exhibited progressive structures suggesting long term persistence of the communities/species. Density--diameter distribution revealed greater proportions of seedlings and a significant decline （P 〈 0.05） in the proportion of trees in older age/size classes. Of the 23 recorded tree species, 13.0 % showed good, 52.2 % fair, 26.1% poor and 8.7 % no regeneration. Differences in regeneration by species are indicative of future foreststructure and dynamics. Assessment of changes in structure of forest types provides baseline data for development of priorities for conservation of other representative land- scapes in the reserve as well as in the Himalaya.

关键词： Regeneration pattern Population structure Compositional changes

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An Effective Mannosylated Chitosan Nanoparticle DNA Vaccine for FMD Virus

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Virologica Sinica 2012年第6期27卷 373-376页

作者： Raj k.shore Nanda Bedaso Mammo Edao Irshad Ahmad Hajam Shanmugam chandra sekar k.ndabattula Ganesh Veerak.athappa Bhanuprak.sh Subodh k.shore FMD Quality Control and Quality Assurance Laboratory Indian Veterinary Research InstituteH A FarmHebbalBangalore 560024KarnatakaIndia

Dear Editor,We are reporting you an effective DNA vaccine for FMD virus,and it was prepared using mannosylated chitosan (MC) nanoparticles to form the FMDVpVAC-VP1-OmpA complex *** particles were characterized for their physical properties lik. morphology,size and charge prior evaluating the actual vaccine delivery effect of *** immunological evaluation indicated that the 20

关键词：复合纳米粒子猪口蹄疫病毒 DNA疫苗壳聚糖糖化 ELISA法物理性质中和抗体

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