检索结果-南通市图书馆

World Journal of Traditional Chinese Medicine 2024年第2期10卷 149-158页

作者： Eric wei Chiang chan Hung Tuck chan Siu kuin Wong Department of Food Science and Nutrition Faculty of Applied SciencesUCSI UniversityCherasKuala LumpurMalaysia Secretariat of International Society for Mangrove Ecosystems Faculty of AgricultureUniversity of the RyukyusOkinawaJapan School of Foundation Studies Xiamen University MalaysiaSepangSelangorMalaysia

The rich chemical constituents and diverse pharmacological properties of Ramulus Mori(RM) or the twig of Morus alba with evidence supported by clinical trials and patents are reviewed. known as Sangzhi in Chinese, RM is widely used in traditional Chinese medicine to treat gout, arthritis, and rheumatism. Chemical constituents include flavonoids, benzofurans, alkaloids, stilbenes, chalcones, phenolic acids, and coumarins. Bioactivities of RM include antidiabetic, anti-obesity, anti-inflammatory, antityrosinase, neuroprotective, antioxidant, hepatoprotective, cytoprotective, renoprotective, antihyperuricemic, analgesic, antifungal, DNA protective, anticancer, gastroprotective, cardioprotective, anti-hair aging, anti-arthritic, and antiplatelet aggregation properties. The most active compounds from RM are mulberrin, oxyresveratrol, and mulberroside A. All four clinical trials on RM are focused on the treatment of diabetes. The patents entail using RM extracts as cosmetics for skin whitening and as agents for hypoglycemia. Topics for further research on RM are suggested.

关键词： Clinical trials mulberrin mulberroside A oxyresveratrol patents Sangzhi

Carbon-based nanomaterials cause toxicity by oxidative stress to the liver and brain in Sprague-Dawley rats

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2024年第6期35卷 54-64页

作者： Ying-Ying Xu chan Jin Meng Wu Jian-Ye Zhou Hui-Ling wei Department of Gastroenterology China-Japan Friendship HospitalBeijing 100029China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Institute of Particle and Nuclear Physics College of PhysicsHenan Normal UniversityXinxiang 453007China

Carbon-based nanomaterials have important research significance in various disciplines,such as composite materials,nanoelectronic devices,biosensors,biological imaging,and drug ***,the human and ecological risks associated with carbon-based nanomaterials have received increasing ***,the biological safety of carbon based nanomaterials has not been systematically *** this study,we used different types of carbon materials,namely,graphene oxide(GO),single-walled carbon nanotubes(SWCNTs),and multiwalled carbon nanotubes(MWCNTs),as models to observe their distribution and oxidative damage in *** results of Histopathological and ultrastructural examinations indicated that the liver and lungs were the main accumulation targets of these ***-μ-XRF analysis revealed that SWCNTs and MWCNTs might be present in the *** shows that the three types of carbon-based nanomaterials could cross the gas-blood barrier and eventually reach the liver *** addition,SWCNTs and MWCNTs could cross the blood-brain barrier and accumulate in the cerebral *** increase in ROS and MDA levels and the decrease in GSH,SOD,and CAT levels indicated that the three types of nanomaterials might cause oxidative stress in the *** suggests that direct instillation of these carbon-based nanomaterials into rats could induce ROS *** addition,iron(Fe)contaminants in these nanomaterials were a definite source of free ***,these nanomaterials did not cause obvious damage to the rat brain *** deposition of selenoprotein in the rat brain was found to be related to oxidative stress and Fe *** information may support the development of secure and reasonable applications of the studied carbon-based nanomaterials.

关键词： Carbon-based nanomaterials Oxidative stress Trace element distribution TEM SR-μ-XRF

key Technologies and Prospects for Electric Vehicles Within Emerging Power Systems: Insights from Five Aspects

在线全文

学校读者我要写书评

暂无评论

CSEE Journal of Power and Energy Systems 2024年第2期10卷 439-447页

作者： Yalun Li Minggao Ouyang C.C.chan Xueliang Sun Yonghua Song wei Cai Yilin Xie Yuqiong Mao Department of Electrical Engineering and School of Vehicle and MobilityTsinghua UniversityBeijing 100084China School of Vehicle and Mobility Tsinghua UniversityBeijing 100084China Department of Electrical and Electronic Engineering The University of Hong KongHong Kong 999077China Department of Mechanical and Materials Engineering University of Western OntarioLondonON N6A 3K7Canada State key Laboratory of Internet of Things for Smart City University of MacaoTaipaMacao 999078China Department of Electrical Engineering Tsinghua UniversityBeijing 100084China School of Electrical and Electronic Engineering Harbin University of Science and TechnologyHarbin 150080China

The energy revolution requires coordination in energy consumption, supply, storage and institutional *** energy generation technologies, along with their associated costs, are already fully equipped for large-scale ***, energy storage remains a bottleneck, and solutions areneeded through the use of electric vehicles, which traditionallyplay the role of energy consumption in power systems. Toclarify the key technologies and institutions that support EVsas terminals for energy use, storage, and feedback, the CSEEJPES forum assembled renowned experts and scholars in relevantfields to deliver keynote reports and engage in discussions ontopics such as vehicle–grid integration technology, advancedsolid-state battery technology, high-performance electric motortechnology, and institutional innovation in the industry *** experts also provided prospects for energy storage andutilization technologies capable of decarbonizing new powersystems.

关键词： Electric vehicles engineering philosophy highpower density motor new power system solid state batteries vehicle grid integration.

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

抛弃型水凝胶接触镜的细菌定植

国际眼科杂志 2008年第9期8卷 1749-1752页

作者： Bakiah Shaharuddin k wei chan Siti Suraiya Mohd Noor Zunaina Embong 马来西亚理科大学医学院眼科马来西亚吉兰丹州古邦阁亮16150 马来西亚理科大学医学院微生物与寄生虫学系马来西亚吉兰丹州古邦阁亮16150

目的:确定抛弃型水凝胶接触镜及其护理液细菌定植的比率,并确定污染的病原体。方法:按目的抽样进行横断面研究。从马来西亚Sains大学健康校园的本科学生接触镜配戴者中收集100片水凝胶接触镜。所有的镜片和护理液均送微生物培养和革兰... 详细信息

目的:确定抛弃型水凝胶接触镜及其护理液细菌定植的比率,并确定污染的病原体。方法:按目的抽样进行横断面研究。从马来西亚Sains大学健康校园的本科学生接触镜配戴者中收集100片水凝胶接触镜。所有的镜片和护理液均送微生物培养和革兰氏染色。结果:大多数的研究参与者为女性(98%)。平均年龄21.36±1.63岁。41片接触镜(82%)呈现阳性细菌定植,32%的护理液可见阳性细菌定植。最常见的病原体是凝固酶阴性葡萄球菌、金黄色葡萄球菌和链球菌,而在接触镜中能更频繁地分离出假单胞菌和沙雷氏菌。结论:配戴接触镜有导致镜片和护理液细菌定植的潜在危险。建议在镜片护理和配戴过程中采取最大程度的预防措施并严格遵守卫生做法。

关键词：水凝胶接触镜细菌定植大学学生的接触镜配戴

2SWUNet: small window SWin UNet based on tansformer for building extraction from high-resolution remote sensing images

在线全文

学校读者我要写书评

暂无评论

Optoelectronics Letters 2024年第10期20卷 599-606页

作者： YU Jiamin chan Sixian LEI Yanjing WU wei WANG Yuan ZHOU Xiaolong College of Computer Science and Technology Zhejiang University of Technology key Laboratory of Meteorological Disaster(kLME) Ministry of Education & Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD) Nanjing University of Information Science &Technology College of Geographic Information Modern Industry Zhejiang University of Technology College of Electrical and Information Engineering Quzhou University

Models dedicated to building long-range dependencies often exhibit degraded performance when transferred to remote sensing images. Vision transformer(Vi T) is a new paradigm in computer vision that uses multi-head self-attention(MSA) rather than convolution as the main computational module, with global modeling capabilities. However, its performance on small datasets is usually far inferior to that of convolutional neural networks(CNNs). In this work, we propose a small window SWin UNet(2SWUNet) for building extraction from high-resolution remote sensing images. Firstly, the 2SWUNet is trained based on swin transformer by designing a fully symmetric encoder-decoder U-shaped architecture. Secondly, to construct a reasonable U-shaped architecture for building extraction from high-resolution remote sensing images, different forms of patch expansion are explored to simulate up-sampling operations and recover feature map resolution. Then, the small window-based multi-head self-attention(W-MSA) is designed to reduce the computational and memory burden, which is more appropriate for the features of remote sensing images. Meanwhile, the pre-training mechanism is advanced to make up for the lack of decoder parameters. Finally, comparison experiments with other mainstream CNNs and Vi Ts validate the superiority of the proposed model.

关键词： A

Engineering a high-barrier d-f single-molecule magnet centered with hexagonal bipyramidal Dy(Ⅲ)unit

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2024年第10期67卷 3291-3298页

作者： wei Deng chan-Ying Yao Yan-Cong Chen Ying-Qian Zhou Shan-Nan Du Jun-Liang Liu Ming-Liang Tong key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education School of ChemistryInstitute of Green Chemistry and Molecular EngineeringGuangdong Basic Research Center of Excellence for Functional Molecular EngineeringSun Yat-sen UniversityGuangzhou 510006China

In the pursuit of high-performance single-molecule magnets(SMMs),incorporating intramolecular magnetic coupling emerges as a pivotal *** these,d-f SMMs have garnered significant attention due to their remarkable versatility,which lies in their ability to tune coordination environments and facilely substitute metal ***,achieving performance-centric d-f SMMs through the synergistic interplay between highly anisotropic f ions and d-f magnetic interactions remains a formidable *** mononuclear hexagonal bipyramidal(D_(6h))Dy^(Ⅲ)SMMs have been successfully isolated,the exploration of d-f SMMs featuring D_(6h)-lanthanide metal centers remains uncharted *** this study,we employed planar bipodal ligands in conjunction with“staple-like”axial phenoxide ligands to synthesize the first hexagonal bipyramidal d-f ***,this compound exhibits alternating-current magnetic susceptibilities peaking up to 68 k with an energy barrier surpassing 1,200 k,thus establishing a new benchmark within the heterometallic d-f SMM landscape inclusive of complexes with diamagnetic d metals and paramagnetic f ***,the ferromagnetic interaction at the d-f sites engenders oscillating relaxation times contingent on the magnetic field—a characteristic distinct from mononuclear *** findings shed light on a deliberate design approach for d-f SMMs,emphasizing the cooperative utilization of high-barrier lanthanide modules alongside d ions through magnetic *** synergy significantly enhances and diversifies the magnetic dynamics of these intriguing molecular systems.

关键词： single-molecule magnets magnetic coupling crystal engineering hexagonal bipyramid energy barrier

Antimony oxides-protected ultrathin Ir-Sb nanowires as bifunctional hydrogen electrocatalysts

在线全文

学校读者我要写书评

暂无评论

Nano Research 2024年第3期17卷 1042-1049页

作者： Bingyan Xu Xuan Huang Shangheng Liu Zhiwei Hu Cheng-wei kao Ting-Shan chan Hongbo Geng Ying Zhang Xiaoqing Huang Country State key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Max Planck Institute for Chemical Physics of Solids Dresden 01187Germany “National Synchrotron Radiation Research Center” Hsinchu 30076TaiwanChina School of Materials Engineering Changshu Institute of TechnologyChangshu 215500China Institute for Carbon Neutralization College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035China

Developing electrocatalysts with fast kinetics and long-term stability for alkaline hydrogen oxidation reaction(HOR)and hydrogen evolution reaction(HER)is of considerable importance for the industrial production of green and sustainable ***,an ultrathin Ir-Sb nanowires(Ir-Sb NWs)protected by antimony oxides(SbO_(x))was synthesized as an efficient bifunctional catalyst for both HOR and HER under alkaline *** from the much higher mass activities of Ir-Sb nanowires than those of Ir nanowires(Ir NWs)and commercial Pt/C,the SbO_(x) protective layer also contributes to the maintenance of morphology and anti-CO poisoning ability,leading to the long-term cycling performance in the presence of ***,the Ir-Sb NW/SbO_(x) exhibits the highest catalytic activities,which are about 3.5 and 4.8 times to those of Ir NW/C and commercial Pt/C toward HOR,*** work provides that the ultrathin morphology and H_(2)O-occupied Sb sites can exert the intrinsic high activity of Ir and effectively optimize the absorption of OH*both in alkaline HER/HOR electrolysis.

关键词： Ir nanowire amorphous antimony oxides bifunctional mechanism hydrogen evolution reaction hydrogen oxidation reaction

Cellular zinc metabolism and zinc signaling:from biological functions to diseases and therapeutic targets

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第2期9卷 401-441页

作者： Bonan Chen Peiyao Yu Wai Nok chan Fuda Xie Yigan Zhang Li Liang kam Tong Leung kwok Wai Lo Jun Yu Gary M.k.Tse wei kang ka Fai To Department of Anatomical and Cellular Pathology State Key Laboratory of Translational OncologyPrince of Wales HospitalThe Chinese University of Hong KongHong KongChina State key Laboratory of Digestive Disease Institute of Digestive DiseaseThe Chinese University of Hong KongHong KongChina CUHk-Shenzhen Research Institute The Chinese University of Hong KongShenzhenChina Department of Pathology Nanfang Hospital and Basic Medical CollegeSouthern Medical UniversityGuangdong Province Key Laboratory of Molecular Tumor PathologyGuangzhouChina Institute of Biomedical Research Taihe HospitalHubei University of MedicineShiyanChina Department of Pediatrics The Chinese University of Hong KongHong KongChina Department of Medicine and Therapeutics The Chinese University of Hong KongHong KongChina

Zinc metabolism at the cellular level is critical for many biological processes in the body.A key observation is the disruption of cellular homeostasis,often coinciding with disease *** an essential factor in maintaining cellular equilibrium,cellular zinc has been increasingly spotlighted in the context of disease *** research suggests zinc’s involvement in promoting malignancy and invasion in cancer cells,despite its low tissue *** has led to a growing body of literature investigating zinc’s cellular metabolism,particularly the functions of zinc transporters and storage mechanisms during cancer *** transportation is under the control of two major transporter families:SLC30(ZnT)for the excretion of zinc and SLC39(ZIP)for the zinc ***,the storage of this essential element is predominantly mediated by metallothioneins(MTs).This review consolidates knowledge on the critical functions of cellular zinc signaling and underscores potential molecular pathways linking zinc metabolism to disease progression,with a special focus on *** also compile a summary of clinical trials involving zinc *** the main localization of zinc transporters at the cell membrane,the potential for targeted therapies,including small molecules and monoclonal antibodies,offers promising avenues for future exploration.

关键词： metabolism invasion involvement

Automatic fovea detection and choroid segmentation for choroidal thickness assessment in optical coherence tomography

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2024年第10期17卷 1763-1771页

作者： Chen Yu Lin Hung Ju Chen Yi kit chan wei Ping Hsia Yu Len Huang Chia Jen chang Department of Ophthalmology Taichung Veterans General HospitalTaichung 407TaiwanChina Department of Computer Science Tunghai UniversityTaichung 407TaiwanChina

AIM:To develop an automated model for subfoveal choroidal thickness(SFCT)detection in optical coherence tomography(OCT)images,addressing manual fovea location and choroidal contour ***:Two procedures were proposed:defining the fovea and segmenting the *** localization from B-scan OCT image sequence with three-dimensional reconstruction(LocBscan-3D)predicted fovea location using central foveal depression features,and fovea localization from two-dimensional en-face OCT(LocEN-2D)used a mask region-based convolutional neural network(Mask R-CNN)model for optic disc detection,and determined the fovea location based on optic disc relative *** segmentation also employed Mask ***:For 53 eyes in 28 healthy subjects,LocBscan-3D’s mean difference between manual and predicted fovea locations was 170.0μm,LocEN-2D yielded 675.9μ***-2D performed better in non-high myopia group(P=0.02).SFCT measurements from Mask R-CNN aligned with manual ***:Our models accurately predict SFCT in OCT ***-3D excels in precise fovea localization even with high ***-2D shows high detection rates but lower accuracy especially in the high myopia *** both models offers a robust SFCT assessment approach,promising efficiency and accuracy for large-scale studies and clinical use.

关键词： subfoveal choroidal thickness optical coherence tomography automatic foveal detection automatic choroid segmentation

Association between Exposure of Rare Earth Elements and Outcomes of In Vitro Fertilization-Embryo Transfer in Beijing

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2024年第8期37卷 876-886页

作者： Yutong Wang Jing Li Shirong Xu Shengli Lin Zhenchen Hou Linlin Wang Yali Huang Yue Sun wei Guo Lailai Yan Ying Wang chan Tian State key Laboratory of Female Fertility Promotion Center for Reproductive MedicineDepartment of Obstetrics and Gynecology Peking University Third HospitalBeijing 100191China Department of Medical Genetics Peking UniversityBeijing 100191China National Clinical Research Center for Obstetrics and Gynecology Peking University Third HospitalBeijing 100191China key Laboratory of Assisted Reproduction(Peking University) Ministry of EducationBeijing 100191China Beijing key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology Beijing 100191China Central Laboratory of School of Public Health Peking UniversityBeijing 100191China School of Basic Medical Sciences Peking UniversityBeijing 100191China

Objective The study aimed to investigate the impact of rare earth elements(REEs)exposure on pregnancy outcomes of in vitro fertilization-embryo transfer(IVF-ET)by analyzing samples from *** A total of 141 couples were *** and follicular fluid from the wives and semen plasma from the husbands,were analyzed for REEs using inductively coupled plasma mass spectrometry(ICP-MS).Spearman's correlation coefficients and the Mann–Whitney U test were used to assess correlations and compare REE concentrations among three types of samples,*** models were utilized to estimate the individual REE effect on IVF-ET outcomes,while BkMR and WQS models explored the mixture of REE interaction effects on IVF-ET *** Higher La concentration in semen(median 0.089 ng/mL,P=0.03)was associated with a lower fertilization ***,this effect was not observed after artificial selection intervention through intracytoplasmic sperm injection(ICSI)(P=0.27).In semen,the REEs mixture did not exhibit any significant association with clinical *** Our study revealed a potential association between high La exposure in semen and a decline in fertilization rate,but not clinical pregnancy *** is the first to report REEs concentrations in follicular fluid with La,Ce,Pr,and Nd found at significantly lower concentrations than in serum,suggesting that these four REEs may not accumulate in the female reproductive ***,at the current exposure levels,mixed REEs exposure did not exhibit reproductive toxicity.

关键词： Rare earth elements In vitro fertilization Pregnancy outcomes Mixture exposure analysis