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脑CT诊断后颅窝小卒中:脑CT迭代重建算法对检测性能的影响

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国际医学放射学杂志 2017年第6期 733-734页

作者： T.Inoue T.Nakaura M.Yoshida k.Yokoyama k.hirata M.kidoh 张毓婧 Department of Radiology Amakusa Medical Center

摘要目的本研究旨在确定脑CT全模型迭代重建(IMR-neuro)能否提高脑CT对后颅窝脑卒中的诊断准确性。方法纳入37例后颅窝缺血性脑卒中病人和37例无脑卒中

关键词：后颅窝梗死区域缺血性脑卒中 CT

由ODP Leg191布设的海底井下宽频带地震仪系统

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世界地震译丛 2004年第6期35卷 80-82页

作者： M．Shinohara E．Araki T．kanazawa M．Mochizuki k．hirata k．Suyehiro H．Mikada T．Yamada Y．kaiho 周公威郝春月吕春来不详中国地震局地球物理研究所

名为WP-2的新井下地震观测站由ODP Leg191成功地布设在西北太平洋海盆的ODP1179E钻孔。为了研究地球构造,WP-2台站被安置在一个独特的点位。两套宽频带地震仪用水泥固定在玄武岩层内,通过ROV号潜艇来驱动系统并检查系统的工作状态。ROV... 详细信息

名为WP-2的新井下地震观测站由ODP Leg191成功地布设在西北太平洋海盆的ODP1179E钻孔。为了研究地球构造,WP-2台站被安置在一个独特的点位。两套宽频带地震仪用水泥固定在玄武岩层内,通过ROV号潜艇来驱动系统并检查系统的工作状态。ROV也用于回收初始数据。WP-2台站的地震噪声水平对地震观测而言是足够低的。

关键词：井下地震观测站北太平洋宽频带地震仪噪声处理安装操作

Regression analysis of squeezing-induced hybrid nanofluid flow in Darcy-Forchheimer porous medium

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 193-208页

作者： k.MUHAMMAD M.SARFRAZ Department of Humanities and Sciences School of Electrical Engineering and Computer Science National University of Sciences and Technology Department of Mathematics Quaid-i-Azam University

This article presents a mathematical model addressing a scenario involving a hybrid nanofluid flow between two infinite parallel plates. One plate remains stationary, while the other moves downward at a squeezing velocity. The space between these plates contains a Darcy-Forchheimer porous medium. A mixture of water-based fluid with gold(Au) and silicon dioxide(Si O2) nanoparticles is formulated. In contrast to the conventional Fourier's heat flux equation, this study employs the Cattaneo-Christov heat flux equation. A uniform magnetic field is applied perpendicular to the flow direction, invoking magnetohydrodynamic(MHD) effects. Further, the model accounts for Joule heating, which is the heat generated when an electric current passes through the fluid. The problem is solved via NDSolve in MATHEMATICA. Numerical and statistical analyses are conducted to provide insights into the behavior of the nanomaterials between the parallel plates with respect to the flow, energy transport, and skin *** findings of this study have potential applications in enhancing cooling systems and optimizing thermal management strategies. It is observed that the squeezing motion generates additional pressure gradients within the fluid, which enhances the flow rate but reduces the frictional drag. Consequently, the fluid is pushed more vigorously between the plates, increasing the flow velocity. As the fluid experiences higher flow rates due to the increased squeezing effect, it spends less time in the region between the plates. The thermal relaxation, however, abruptly changes the temperature, leading to a decrease in the temperature fluctuations.

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Magnetic Pair-Breaking in Y1-xHoxNi2B2C （x = 0, 0.25, 0.5, 0.75） Single Crystals

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Chinese Physics Letters 2006年第4期23卷 975-977页

作者：赵松睿沈静琴许祝安 Takeya H hirata k Department of Physics Zhejiang University Hangzhou 310027 National Institute for Materials Science 1-2-1 Sengen Tsukuba Ibaraki 305-0047 Japan

Temperature-dependent resistivity and magnetic susceptibility were studied for quaternary borocarbide intermetallic compounds Y1-xHoxNi2B2C （x = 0, 0.25, 0.5, 0. 75）, which show coexistence of superconductivity with magnetism. In a normal state, the compounds exhibit conventional metallic behaviour. The Debye temperature θD is derived by fitting the temperature dependence of resistivity to the Bloch-Gruneisen expression, i.e. θD scales with M^-0.5 （M is the averaged atomic mass on the Y^3＋ site）, which means that the acoustic mode of the lattice vibrating spectrum is influenced by the Y^3＋ site atoms. Fitting the temperature-dependent magnetic susceptibility above TN to the Curie-Weiss law, effective magnetic moment μeff is deduced, and then de Gennes factor dG is calculated. It is found that as Ho content increases, μeff as well as dG increases and Tc decreases. Moreover, the decrease of Tc scales with dG, i.e., △Te ∝ -nI^2 N （EF ）dG, which is consistent with the prediction of the Abrikosov-Gor＇kov theory. We suggest that pair-breaking effect of magnetic Ho^3＋ ions. The significant impact on To. the depression of Tc could be mainly ascribed to the magnetic change of Debye temperature with Ho content may not have significant impact on Tc.

关键词： ANTIFERROMAGNETIC SUPERCONDUCTOR HONI2B2C ORDER TRANSPORT METALS

Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

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Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad Al kabbani Christoph köhler Hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-kO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

Increased prevalence of intestinal inflammation in patients with liver cirrhosis

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World Journal of Gastroenterology 1999年第5期5卷 391-396页

作者： Saitoh O Sugi k Lojima k Matsumoto H Nakagawa k kayazawa M Tanaka S Teranishi T hirata I katsu ki k Second Department of Internal Medicine Osaka Medical College Takatsuki Japan Department of Gastroenterology Ijinkai Takeda General Hospital Kyoto Japan

AIM To investigate the pathophysiology of the digestive tract in patients with liver *** In 42 cirrhotic patients and 20control subjects, the following fecal proteinswere measured by enzyme-linkedimmunosorb6nt assay: albumin (Alb ),transferrin (Tf), and al-antitrypsin (a,-AT) as amarker for intestinal protein l0ss, hemoglobin(Hb) for bleeding, PMN-eIastase for intestinalinflammation, and secretory lgA for *** The fecaI concentrations of Hb, Alb,Tf, al-AT, and PMN’eIastase were increased in13 (3l%), 8(19%), l0(24%), 6(14%), and 1l(26%) cases among 42 patients, resPectiveIy.F6cal concentration of secretory IgA wasdecreased in 7 (l7%) of 42 patients. However,these fecal concentrations were not related tothe severity or etiology of liver cirrhosis. Theserum Alb level was significantIy decreased inpatients with intestinal protein Ioss c0mpared tothat in patients without intestinal protein *** These findings suggest that: rob6sides the weIl’known pathological conditions,Such as bleeding and protein loss, intestinaIinflammati0n and decreased intestinaI immunityare found in cirrhotic patients, @ intestinalprotein loss contributes to hypoalbuminemia incirrhotic patients, and @ intestinaI inflammationshouId not b6 0verlooked in cirrhotic patients,since it may contribute to or cause intestinalprotein Ioss and oth6r various pathologicalconditions.

关键词： liver cirrhosis intestinal inflammation secretory IgA fecal proteins

Physicochemical properties of Li_(3)Ba_(2)La_(3)(MoO_(4))_(8):Eu,Tb red-emitting phosphor for solid state white lamps

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Journal of Rare Earths 2023年第9期41卷 1279-1287,I0001页

作者： kora Lu Rojas Baldivia Gustavo A.hirata Center for Scientific Research and Higher Education of Ensenada Ensenada Baja California 22860Mexico Center for Nanoscience and Nanotechnology National Autonomous University of Mexico EnsenadaBaja Califomia 22860Mex

In this work,combustion synthesis was used for the first time to fabricate a phosphor material with red emission for applications in solid-state white-light *** synthesized a material with emission wavelength at λ_(em)=617 nm,excited under long UV-blue wavelength based on Eu^(3+),Tb^(3+)-activated molybdates Li_(3)Ba_(2)(La_(1-x-y)Eu_(x)Tb_(y))_(3)(MoO_(4))_(8) with 0 ≤ x ≤1 and 0 ≤ y ≤ 1.A series of powder samples were produced by the combustion method and post-annealed at 800℃ in *** crystalline phase formation was investigated by X-ray diffraction,which reveals the monoclinic C2/c(15) space *** is observed that crystalline structure and morphology are preserved when the host lattice is doped with Eu^(3+) or Tb^(3+) single ions and co-doped with both ions at different doping concentrations.A detailed characterization by scanning electron microscopy(SEM) and transmission electron microscopy(TEM)shows a similar morphology in all samples:rather large(1-7 μm) agglomerate particles with irregular shapes and surrounded by smaller nanoparticles of 50 nm in ***-visible absorption spectra confirm the presence of Eu^(3+) and Tb^(3+) *** luminescent properties of the obtained phosphors were studied in *** measurements indicate that the best emission intensity is for Eu^(3+):Tb^(3+)doping ratios of 80:0,90:0 and 20:*** the other hand,samples with 80:0,60:40,and 20:80 doping ratios show the highest intensity in a detailed photoluminescence analysis and they exhibit the highest quantum yield values.A complete and efficient energy transfer from the sensitizer Tb^(3+) to the activator Eu^(3+) is observed in all co-doped phosphors post-annealed at 800℃ for 4 ***,the Li_(3)Ba_(2)La_(3)(MaO_(4))_(8):Eu^(3+),Tb^(3+) materials fabricated by combustion synthesis are excellent phosphors for being applied as red-emitting component in solid-state white-light lamps due to an improved color rendering index(CRI) that can be obtained under lo

关键词： Molybdate Europium Terbium Luminescence Phosphor-converted LED Rare earths

Characteristics and predictors of gastric cancer after Helicobacter pylori eradication

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World Journal of Gastroenterology 2018年第20期24卷 2163-2172页

作者： Satoki Shichijo Yoshihiro hirata Department of Gastrointestinal Oncology Osaka International Cancer Institute Division of Advanced Genome Medicine The Institute of Medical Science The University of Tokyo

Helicobacter pylori(H. pylori) eradication can reduce gastric cancer. However, gastric cancer still develops after eradication, and cases who received eradication therapy are increasing. In this study, we have reviewed the characteristics and predictors of primary gastric cancer developing after H. pylori eradication. In terms of the characteristics, endoscopic, histologic, and molecular characteristics are reported. Endoscopically, gastric cancer after eradication is often depressedtype and shows a gastritis-like appearance, which sometimes makes the diagnosis difficult. Histologically, most gastric cancer after eradication is intestinal type, and non-neoplastic epithelium, also called epithelium with low-grade atypia, is frequently seen over the tumor, which is presumably the cause of the endoscopic gastritis-like appearance. As for molecular characteristics, some markers, such as ki67, MUC2, and Wnt5a expression, are lower in cancer from patients in whom H. pylori has been eradicated. In terms of predictors, several Japanese studies have reported that severe endoscopic atrophy at eradication is a risk factor for gastric cancer development. Histologic intestinal metaplasia, especially in the corpus, and long-term use of proton pump inhibitors, are also reported as risk factors for gastric cancer after H. pylori eradication. These studies on the characteristics and predictors of gastric cancer development will become the cornerstone for establishing a novel surveillance program based on the gastric cancer risk stratification specific to H. pylori-eradicated patients.

关键词： gastric cancer eradication characteristic Helicobacter pylori predictor

Human endogenous retrovirus type-W and multiple sclerosis–related smoldering neuroinflammation

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Neural Regeneration Research 2025年第3期20卷 813-814页

作者： Joel Gruchot Laura Reiche Andrew Chan Robert Hoepner Patrick küry Department of Neurology Medical Faculty and University Hospital DüsseldorfHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neurology InselspitalBern University Hospital and University of BernBernSwitzerland

Introduction to human endogenous retrovirus type-W(HERV-W): Genomic inheritance from the past includes retroviral sequences that have been stably incorporated into our genomes and account for up to 8% of human DNA.

关键词： endogenous inflammation Human