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International Journal of Digital Earth 2023年第1期16卷 3810-3837页

作者： Nicola Montaldo andrea Gaspa Roberto Corona Dipartimento di Ingegneria civile ambientale e architetturaUniversita di CagliariCagliariItaly

Periodic observations of vegetation index,such as the normalized difference vegetation index(NDVI),can be used for data assimilation in heterogenous ***,the new Sentinel 2 Multispectral instrument and Landsat 8 Operational Land Imager sensor data are available at such high temporal and spatial resolutions that can be used to detect the patches of the main vegetation components(grass and trees)of heterogenous ecosystems,and capture their *** demonstrate the possibility to merge grass and tree NDVI observations and models,to optimally provide robust predictions of grass and tree leaf area *** proposed assimilation approach assimilates NDVI data through the Ensemble kalman filter(EnkF)and dynamically calibrates a key vegetation dynamic model parameter,the maintenance respiration coeffcient(ma).In the presence of large bias of the grass and tree ma base values,only the use of the proposed assimilation approach removes the large bias in the biomass balance,dynamically calibrating maintenance respiration coefficients,and corrects the *** performance of a land surface-vegetation model was improved by assimilating observations of *** effective impact of the proposed assimilation approach on the evapotranspiration and CO_(2) uptake predictions in the heterogenous ecosystem is also demonstrated.

关键词： Data assimilation leaf area index heterogenous ecosystem vegetation dynamic model Landsat 8 Sentinel 2

Peripancreatic paraganglioma:Lesson from a round table

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World Journal of Gastroenterology 2022年第21期28卷 2396-2402页

作者： Federica Petrelli Geri Fratini andrea Sbrozzi-Vanni andrea Giusti Raffele Manta Claudio Vignali Gabriella Nesi andrea Amorosi andrea Cavazzana Marco Arganini Maria Raffaella Ambrosio Pathology Unit Azienda Sanitaria Toscana Nord OvestPisa 56121Italy Surgery Unit Azienda Sanitaria Toscana Nord OvestPisa 56121Italy Endoscopic Unit Azienda Sanitaria Toscana Nord OvestPisa 56121Italy Endoscopic Unit Santa Maria Misericordia HospitalPerugia 06122Italy Interventional Radiology Unit Azienda Sanitaria Toscana Nord OvestPisa 56121Italy Department of Health Sciences University of FlorenceFlorence 50139Italy Pathology Unit UniversitàMagna GraeciaCatanzaro 88100Italy

We described the case of a peripancreatic paraganglioma(PGL)misdiagnosed as pancreatic *** exploration revealed an unremarkable pancreas and a large well-defined cystic mass originating at the mesocolon *** enucleation of the mass was performed,preserving the pancreatic ***,a diagnosis of PGL was ***,two previously unreported mutations,one affecting the kDR gene in exon 7 and another on the JAk3 gene in exon 4 were *** mutations are known to be *** and cytologic findings were blindly reviewed by an expert panel of clinicians,radiologists,and pathologists to identify possible causes of the *** major issue was lack of evidence of a cleavage plane from the pancreas at imaging,which prompted radiologists to establish an intraparenchymal *** blinded revision shifted the diagnosis towards an extrapancreatic lesion,as the pancreatic parenchyma showed no structural alterations and no dislocation of the Wirsung *** post,the identified biases were the emergency setting of the radiologic examination and the very thin mesocolon sheet,which hindered clear definition of the lesion *** endoscopic ultrasonography diagnosis was confirmed,emphasizing the intrinsic limit of this technique in detecting large ***,pathologic review favored a diagnosis of PGL due to the morphological features and immonohistochemical *** months after tumor excision,the patient is asymptomatic with no disease relapse evident by either radiology or laboratory *** report strongly highlights the difficulties in rendering an accurate preoperative diagnosis of PGL.

关键词： Peripancreatic paraganglioma Pancreatic neuroendocrine tumor Solid pseudopapillary neoplasm S100 Succinate dehydrogenase subunit B gene and expression Fine needle biopsy

Dynamical interactions of dark energy and dark matter:Yang-Mills condensate and QCD axions

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Chinese Physics C 2018年第7期42卷 103-112页

作者： andrea Addazi Pietro Donà Antonino Marcianò Department of Physics&Center for Field Theory and Particle Physics Fudan University200433 ShanghaiChina Institute for Gravitation and the Cosmos&Physics Department Penn StateUniversity ParkPA 16802USA

We analyze a model of cold axion dark matter weakly coupled with a dark gluon condensate, reproducing dark energy. We first review how to recover the dark energy behavior using the functional renormalization group approach, and ground our study in the properties of the effective Lagrangian, to be determined non-perturbatively. Then, within the context of GSM×SU（2）D×U（1）PQ, we consider Yang-Mills condensate （YMC） interactions with QCD axions. We predict a transfer of dark energy density into dark matter density, that can be tested in the next generation of experiments dedicated to dark energy measurements. We obtain new bounds on the interactions between the Yang-Mills condensate and axion dark matter from Planck data：the new physics interaction scale related to the axion/gluon condensate mixing is constrained to be higher than the 106 GeV energy scale.

关键词： dark matter dark energy axion peccei-quinn

Salt Stress in Arabidopsis： Lipid Transfer Protein AZI1 and Its Control by Mitogen-Activated Protein kinase MPk3

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Molecular Plant 2014年第4期7卷 722-738页

作者： andrea Pitzschke Sneha Datta Helene Persak Department of Applied Genetics and Cell Biology University of Natural Resources and Life Sciences Muthgasse 18 1190 Vienna Austria

A plant＇s capability to cope with environmental challenges largely relies on signal transmission through mitogen-activated protein kinase （MAPk） cascades. In Arabidopsis thaliana, MPk3 is particularly strongly associated with numerous abiotic and biotic stress responses. Identification of MPk3 substrates is a milestone towards improving stress resistance in plants. Here, we characterize AZI1, a lipid transfer protein （LTP）-related hybrid proline-rich protein （HyPRP）, as a novel target of MPk3. AZI1 is phosphorylated by MPk3 in vitro. As documented by co-immunoprecipitation and bimolecular fluorescence complementation experiments, AZI1 interacts with MPk3 to form protein complexes in planta. Furthermore, null mutants of azil are hypersensitive to salt stress, while AZIl-overexpressing lines are markedly more tolerant. AZI1 overexpression in the mpk3 genetic background partially alleviates the salt-hypersensitive phenotype of this mutant, but functional MPk3 appears to be required for the full extent of AZIl-conferred robustness. Notably, this robustness does not come at the expense of normal development. Immunoblot and RT-PCR data point to a role of MPk3 as positive regulator of AZI1 abundance.

关键词： salt stress Arabidopsis MAPk MPk3 lipid transfer protein AZI1 phosphorylation in vivo interaction.

Sharing the post-earthquake situation for emergency response management in transborder areas: The e-Atlas tool

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Journal of Safety Science and Resilience 2022年第1期3卷 72-86页

作者： Stefano Grimaz Petra Malisan andrea Pividori SPrinT-Lab Polytechnic Department of Engineering and ArchitectureUniversity of Udine33100UdineItaly

Usually,the response after a disastrous event requires decision-makers in emergency operative rooms to quickly outline and understand the current post-event situation,for planning and defining strategies for a contextualized ***,in many cases,disastrous events affect cross-border territories and/or involve multiple orga-nizations in responding to the demand generated by the *** cases require a harmonized and coordinated response by all the institutions/subjects involved in emergency *** address this challenge,this pa-per proposes the e-Atlas(emergency atlas)tool for showing and sharing information that embraces a response management perspective to explicitly support decision-makers in managing the criticalities of a post-earthquake *** e-Atlas has been designed and tested to:i)acquire sensible information for allowing decision-makers to understand in almost real-time the post-earthquake situational picture,and ii)share the representation of the situational picture among different users,allowing each of them to use it according to its specific *** of the tool are illustrated,to show how it is used in a transborder context in the North-East area of Italy.

关键词： Emergency response management GIS Seismic emergency Decision-making support e-Atlas

An overview of the anti-SARS-CoV-2 properties of Artemisia annua, its antiviral action, protein-associated mechanisms, and repurposing for COVID-19 treatment

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Journal of Integrative Medicine 2021年第5期19卷 375-388页

作者： andrea D.Fuzimoto Holistic Sync-Holistic Integrative Medicine USA/Brazil

Artemisia annua and its phytocompounds have a rich history in the research and treatment of malaria,rheumatoid arthritis, systemic lupus erythematosus, and other diseases. Currently, the World Health Organization recommends artemisinin-based combination therapy as the first-line treatment for multi-drug-resistant malaria. Due to the various research articles on the use of antimalarial drugs to treat coronaviruses, a question is raised: would A. annua and its compounds provide anti-severe acute respiratory syndrome coronavirus-2(SARS-CoV-2) properties? PubMed/MEDLINE, Scopus, and Google Scholar were searched for peer-reviewed articles that investigated the antiviral effects and mechanisms of A. annua and its phytochemicals against SARS-CoVs. Particularly, articles that evidenced the herb’s role in inhibiting the coronavirus-host proteins were favored. Nineteen studies were retrieved. From these,fourteen in silico molecular docking studies demonstrated potential inhibitory properties of artemisinins against coronavirus-host proteins including 3 CL^(PRO), S protein, N protein, E protein, cathepsin-L, helicase protein, nonstructural protein 3(nsp3), nsp10, nsp14, nsp15, and glucose-regulated protein 78 ***, A. annua constituents may impede the SARS-CoV-2 attachment, membrane fusion, internalization into the host cells, and hinder the viral replication and transcription process. This is the first comprehensive overview of the application of compounds from A. annua against SARS-CoV-2/coronavirus disease 2019(COVID-19) describing all target proteins. A. annua’s biological properties, the signaling pathways implicated in the COVID-19, and the advantages and disadvantages for repurposing A. annua compounds are discussed. The combination of A. annua’s biological properties, action on different signaling pathways and target proteins, and a multi-drug combined-therapy approach may synergistically inhibit SARS-CoV-2 and assist in the COVID-19 treatment. Also, A

关键词： COVID-19 SARS-CoV-2 Artemisia annua Artemisinin Main protease Spike protein

Preparation of coemissive luminescent nanoparticles in continuous-flow microreactors for efficient light-harvesting systems

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Aggregate 2022年第6期3卷 3-4页

作者： andrea Pucci Department of Chemistry and Industrial Chemistry University of PisaPisaItaly

To address the energy challenges,scientists have designed various artificial light-harvesting systems inspired by ***,for light-harvesting systems,an energytransfer efficiency close to 100%with an antenna effect greater than 10 is generally considered a good application criterion.[1]Today,building an efficient light-harvesting system at a low cost is still demanding.

关键词： CEAA dyes FRET light-harvesting microreactor

Soybean Ferritin:Isolation,Characterization,and Free Radical Generation

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Journal of Integrative Plant Biology 2012年第1期54卷 45-54页

作者： andrea Galatro Elizabeth Robello Susana Puntarulo Physical Chemistry-PRALIB School of Pharmacy and BiochemistryUniversity of Buenos Aires

The main aim of this work was to assess the multi-task role of ferritin （Ft） in the oxidative metabolism of soybean （Glycine max）. Soybean seeds incubated for 24 h yielded 41 4- 5μg Ft/g fresh weight. The rate of in vitro incorporation of iron （Fe） into Ft was tested by supplementing the reaction medium with physiological Fe chelators. The control rate, observed in the presence of 100μM Fe, was not significantly different from the values observed in the presence of 100 μM Fe-his. However, it was significantly higher in the presence of 100 μM Fe-citrate （approximately 4.5-fold） or of 100 μM Fe-ATP （approximately 14-fold）. Moreover, a substantial decrease in the Trp-dependent fluorescence of the Ft protein was determined during Fe uptake from Fe-citrate, as compared with the control. On the other hand, Ft addition to homogenates from soybean embryonic axes reduced endogenously generated ascorbyl radical, according to its capacity for Fe uptake. The data presented here suggest that Ft could be involved in the generation of free radicals, such as hydroxyl radical, by Fe-catalyzed reactions. Moreover, the scavenging of these radicals by Ft itself could then lead to protein damage. However, Ft could also prevent cellular damage by the uptake of catalytically active Fe.

关键词： ferritin free radical iron soybean.

Female-borne cues affecting Psyttalia concolor （Hymenoptera： Braconidae） male behavior during courtship and mating

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Insect Science 2013年第3期20卷 379-384页

作者： Angelo Canale Giovanni Benelli andrea Lucchi Department of Tree Science Entomology and Plant Pathology University of Pisa Pisa Italy

knowledge of the mechanisms that regulate courtship and mating behavior in Psyttalia concolor （Sz6pligeti）-a koinobiont endophagous solitary parasitoid of the olive fruit fly, Bactrocera oleae （Rossi）, and of other fruit flies-is essential to its mass rearing and management, Augmentative releases ofP. concolor for olive fruit fly control started in the Mediterranean areas in the 1950s and still continue with limited success. We determined the influence of visual and chemical cues on courtship and mating behavior of this braconid and the possible effect of the mating status of males and females in the perception of these cues. Our results suggest that integration of visual and chemical stimuli are fundamental for mate location and courtship. Indeed, the optimal response of the male was achieved when physical and chemical cues were simultaneously presented and vision and olfaction worked synergistically.

关键词： Bactrocera oleae biological control Ceratitis capitata IPM Opiinae sexual communication

Characterization of machine tools and measurement system for micromilling

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Nanotechnology and Precision Engineering 2019年第1期2卷 23-28页

作者： andrea Abeni Matteo Lancini Aldo Attansio Department of Mechanical and Industrial Engineering University of Brescia

Technological progress has led to increased demand for small components with tiny features, which cannot be achieved through conventional machining. Industrial application of processes based on microcutting is limited by some issues concerning the geometrical scale. The process performance is significantly affected by milling machine, tool holder, tool, workpiece material microstructure, workpiece fixtures, and process parameters. At present, an ultimate micromachining assessment procedure is not available. This study aims to propose and conduct an experiment on a testing procedure for micromilling. The set up to be implemented and the output to be considered are defined and described. Three major stages are identified: estimation of the effective bandwidth of the load cell–tool holder system, the milling machine natural frequency measurement, and micromilling test execution. The entire procedure is performed, and its robustness is demonstrated.

关键词： Micromilling Machine tool performance test Tool run-out Force analysis Modal analysis