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A Novel Approach to Breast Tumor Detection: Enhanced speckle Reduction and Hybrid Classification in Ultrasound Imaging

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Computers, Materials & Continua 2024年第5期79卷 1875-1901页

作者： K.Umapathi s.shobana Anand Nayyar judith justin R.Vanithamani Miguel Villagómez Galindo Mushtaq Ahmad Ansari Hitesh Panchal Department of Biomedical Engineering KIT-Kalaignarkarunanidhi Institute of TechnologyCoimbatore641402India Graduate school Faculty of Information TechnologyDuy Tan UniversityDa Nang550000Viet Nam Department of Biomedical and Instrumentation Engineering Avinashilingam Institute for Home Science and Higher Education forWomenCoimbatore641043India UniversidadMichoacana de sanNicolás de HidalgoAvenida Francisco j.Múgica s/N Ciudad Universitaria MoreliaCP58030Mexico Department of Pharmacology and Toxicology College of PharmacyKing Saud UniversityRiyadh11451Saudi Arabia Department of Mechanical Engineering Gujarat Technological UniveristyNigam NagarChandkhedaAhmedabadGujarat382424India

Breast cancer detection heavily relies on medical imaging, particularly ultrasound, for early diagnosis and effectivetreatment. This research addresses the challenges associated with computer-aided diagnosis (CAD) of breastcancer fromultrasound images. The primary challenge is accurately distinguishing between malignant and benigntumors, complicated by factors such as speckle noise, variable image quality, and the need for precise segmentationand classification. The main objective of the research paper is to develop an advanced methodology for breastultrasound image classification, focusing on speckle noise reduction, precise segmentation, feature extraction, andmachine learning-based classification. A unique approach is introduced that combines Enhanced speckle ReducedAnisotropic Diffusion (sRAD) filters for speckle noise reduction, U-NET-based segmentation, Genetic Algorithm(GA)-based feature selection, and Random Forest and Bagging Tree classifiers, resulting in a novel and efficientmodel. To test and validate the hybrid model, rigorous experimentations were performed and results state thatthe proposed hybrid model achieved accuracy rate of 99.9%, outperforming other existing techniques, and alsosignificantly reducing computational time. This enhanced accuracy, along with improved sensitivity and specificity,makes the proposed hybrid model a valuable addition to CAD systems in breast cancer diagnosis, ultimatelyenhancing diagnostic accuracy in clinical applications.

关键词： Ultrasound images breast cancer tumor classification segmentation deep learning lesion detection

Elucidating regulatory processes of intense physical activity by multi-omics analysis

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Military Medical Research 2024年第4期 479-499页

作者： Ernesto s.Nakayasu Marina A.Gritsenko Young-Mo Kim jennifer E.Kyle Kelly G.stratton Carrie D.Nicora Nathalie Munoz Kathleen M. Navarro Daniel Claborne Yuqian Gao Karl K.Weitz Vanessa L. Paurus Kent j. Bloodsworth Kelsey A. Allen Lisa M. Bramer Fernando Montes Kathleen A. Clark Grant Tietje justin Teeguarden Kristin E.Burnum-johnson Biological sciences Division Pacific Northwest National Laboratory Environmental and Molecular sciences Division Pacific Northwest National Laboratory Centers for Disease Control and Prevention National Institute for Occupational Safety and Health Western States Division Computational Analytics Division Pacific Northwest National Laboratory National security Directorate Pacific Northwest National Laboratory Los Angeles County Fire Department Centers for Disease Control and Prevention National Institute for Occupational Safety and Health Respiratory Health Division Environmental and Molecular Toxicology Oregon State University

Background: Physiological and biochemical processes across tissues of the body are regulated in response to the high demands of intense physical activity in several occupations, such as firefighting, law enforcement, military, and sports. A better understanding of such processes can ultimately help improve human performance and prevent illnesses in the work ***: To study regulatory processes in intense physical activity simulating real-life conditions, we performed a multi-omics analysis of 3 biofluids(blood plasma, urine, and saliva) collected from 11 wildland firefighters before and after a 45 min, intense exercise regimen. Omics profiles post-vs. pre-exercise were compared by student's t-test followed by pathway analysis and comparison between the different omics ***: Our multi-omics analysis identified and quantified 3835 proteins, 730 lipids and 182 metabolites combining the 3 different types of samples. The blood plasma analysis revealed signatures of tissue damage and acute repair response accompanied by enhanced carbon metabolism to meet energy demands. The urine analysis showed a strong, concomitant regulation of 6 out of 8 identified proteins from the renin-angiotensin system supporting increased excretion of catabolites, reabsorption of nutrients and maintenance of fluid balance. In saliva, we observed a decrease in 3 pro-inflammatory cytokines and an increase in 8 antimicrobial peptides. A systematic literature review identified 6 papers that support an altered susceptibility to respiratory ***: This study shows simultaneous regulatory signatures in biofluids indicative of homeostatic maintenance during intense physical activity with possible effects on increased infection susceptibility, suggesting that caution against respiratory diseases could benefit workers on highly physical demanding jobs.

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Ubiquitin homeostasis disruption, a common cause of proteostasis collapse in amyotrophic lateral sclerosis?

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Neural Regeneration Research 2022年第10期17卷 2218-2220页

作者： Christen G.Chisholm jeremy s.Lum Natalie E.Farrawell justin j.Yerbury Illawarra Health and Medical Research Institute/Molecular Horizons and school of Chemistry and Molecular Bioscience Science Medicine and Health FacultyUniversity of WollongongNorthfields AveWollongongNSWAustralia

Amyotrophic lateral sclerosis(ALs)is associated with proteostasis collapse:ALs is an unrelenting neurodegenerative disease that is characterized by the loss of motor neurons in the brain and spinal cord,resulting in the progressive atrophy,and eventual paralysis,of skeletal *** due to respiratory failure usually occurs within 2-5 years from symptom *** 90%of ALs cases are of unknown etiology and are termed sporadic ALs(sALs).The remaining 10%of ALs cases present with a family history(familial ALs;fALs)and are associated with genetic mutations in a range of over 20 functionally heterogeneous *** of disease origin,the pathological hallmark of ALs is the accumulation of ubiquitylated protein inclusions in motor neurons and surrounding glial *** presence of these inclusions,compromised largely of misfolded and aggregated proteins,implies a collapse in *** refers to the maintenance of the proteome in a state of balance or equilibrium so that a cell can perform its proper function.

关键词： stasis homeostasis collapse

Psychological, social, and sexual challenges affecting men receiving male infertility treatment: a systematic review and implications for clinical care

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Asian journal of Andrology 2023年第4期25卷 448-453页

作者： Winston Wu justin La Kathryn M schubach Daniel Lantsberg Darren j Katz Department of Urology Western HealthSt AlbansVIC 3021Australia Department of Urology Kaiser Permanente San Rafael Medical CenterSan RafaelCA 94903USA Men’s Health Melbourne MelbourneVIC 3000Australia Reproductive services Unit The Royal Women’s HospitalParkvilleVIC 3052Australia Melbourne IVF East MelbourneVIC 3002Australia Department of surgery Western PrecinctUniversity of MelbourneParkvilleVIC 3010Australia

In recent years, social research surrounding the consequences of infertility has increasingly focused on the male perspective;however, a gap exists in the understanding of men’s experiences of male infertility treatment. This review aims to synthesize theexisting evidence concerning the psychological, social, and sexual burden of male infertility treatment on men, as well as patientneeds during clinical care. A systematic search identified 12 studies that are diverse in design, setting, and methods. Psychologicalevaluations have found that urological surgery may have a lasting impact on infertility-specific stress, and treatment failure canlead to feelings of depression, grief, and inadequacy. Men tended to have an avoidant coping mechanism throughout fertilitytreatment, and their self-esteem, relationship quality, and sexual functions can be tied to outcomes of treatment. Partner bonds canbe strengthened by mutual support and enhanced communication;couple separation, however, has been noted as a predominantreason for discontinuing male infertility treatment and may be associated with difficult circumstances surrounding severe maleinfertility. surgical treatments can affect the sexual functioning of infertile men;however, the impact of testicular sperm extractionoutcomes appears to be psychologically driven whereas the improvements after microsurgical varicocelectomy are only evident inhypogonadal men. Clinically, there is a need for better inclusion, communication, education, and resource provision, to addressreported issues of marginalization and uncertainty in men. Routine psychosocial screening in cases of severe male infertility andfollow-up in cases of surgical treatment failure are likely beneficial.

关键词： male infertility male infertility treatment patient experience patient-centered care psychosocial sexual

Hyperparameter Optimization Based Deep Belief Network for Clean Buses Using solar Energy Model

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Intelligent Automation & soft Computing 2023年第7期37卷 1091-1109页

作者： shekaina justin Wafaa saleh Tasneem Al Ghamdi j.shermina College of Engineering Princess Nourah Bint Abdulrahman UniversityRiyadh 84428Kingdom of Saudi Arabia Transport Engineering school of Engineering and The Built Environment Edinburgh Napier UniversityEdinburgh EH105DUK Department of Computing Muscat CollegeUniversity of SterlingUK

Renewable energy has become a solution to the world’s energy concerns in recent ***(PV)technology is the fastest technique to convert solar radiation into ***-powered buses,metros,and cars use PV *** technologies are always *** in the parameters that need to be analysed and examined include PV capabilities,vehicle power requirements,utility patterns,acceleration and deceleration rates,and storage module type and capacity,among *** is intermit-tent and *** forecasting and modelling of PV sys-tem output power are key to managing storage,delivery,and smart *** unparalleled data granularity,a data-driven system could better anticipate solar *** learning(DL)models have gained popularity due to their capacity to handle complex datasets and increase computing *** article introduces the Galactic swarm Optimization with Deep Belief Network(GsODBN-PPGF)*** GsODBN-PPGF model predicts PV power *** GsODBN-PPGF model normalises data using data *** is used to forecast PV power *** GsO algorithm boosts the DBN model’s predicted ***-PPGF projected 0.002 after 40 h but observed *** GsODBN-PPGF model validation is compared to existing *** showed that the GsODBN-PPGF model outperformed recent *** shows that the proposed model is better at forecasting than other models and can be used to predict the PV power output for the next day.

关键词： Photovoltaic systems solar energy power generation prediction model deep learning

Physical fitness before and during the COVID-19 pandemic:Results of annual national physical fitness surveillance among 16,647,699 japanese children and adolescents between 2013 and 2021

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journal of sport and Health science 2023年第2期12卷 246-254页

作者： Tetsuhiro Kidokoro Grant R.Tomkinson justin jLang Koya suzuki Research Institute for Health and sport science Nippon Sport Science UniversityTokyo 158-8508Japan Graduate school of Health and sports science Juntendo UniversityInzai City 270-1695Japan Alliance for Research in Exercise Nutrition and Activity(ARENA)University of South AustraliaAdelaideSA 5000Australia Centre for surveillance and Applied Research Public Health Agency of CanadaOttawaON K1A 0K9Canada school of Epidemiology and Public Health University of OttawaOttawaON K1H 8M5Canada Healthy Active Living and Obesity Research Group Children’s Hospital of Eastern Ontario Research InstituteOttawaON K1H 8L1Canada

Background:Limited nationally representative evidence is available on temporal trends in physical fitness(PF)for children and adolescents during the coronavirus disease 2019(COVID-19)*** primary aim was to examine the temporal trends in PF for japanese children and adolescents before and during the COVID-19 *** secondary aim was to estimate the concurrent trends in body size(measured as body mass and height)and movement behaviors(exercise,screen,and sleep time).Methods:Census PF data for children in Grade 5(aged 10-11 years)and adolescents in Grade 8(aged 13-14 years)were obtained for the years 2013-2021 from the National survey of Physical Fitness,Athletic Performance,and Exercise Habits in japan(n=16,647,699).PF and body size were objectively measured,and movement behaviors were *** sample-weighted linear regression,temporal trends in mean PF were calculated before the pandemic(2013-2019)and during the pandemic(2019-2021)with adjustments for age,sex,body size,and exercise ***:When adjusted for age,sex,body size,and exercise time,there were significant declines in PF during the pandemic,with the largest declines observed in 20-m shuttle run(standardized(Cohen’s)effect size(Es)=-0.109 per annum(p.a.))and sit-ups performance(Es=-0.133p.a.).The magnitude of the declines in 20-m shuttle run and sit-ups performances were 18-and 15-fold larger,respectively,than the improvements seen before the pandemic(2013-2019),after adjusting for age,sex,body size,and exercise *** the pandemic,both body mass and screen time significantly increased,and exercise time ***:Declines in 20-m shuttle run and sit-ups performances suggest corresponding declines in population health during the COVID-19pandemic.

关键词： Census Physical inactivity Public health Temporal trends Youth

Mixed-phase composites derived from cobalt terephthalate as efficient battery-type electrodes for high-performance supercapattery

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journal of Materials science & Technology 2023年第26期157卷 220-233页

作者： Ramu Manikandan Antonysamy Dennyson savariraj Goli Nagaraju A.M.Kale j.Puigdollers Hyejin Park Hyun-soo Kim jae-Min Oh C.justin Raj Byung Chul Kim Department of Energy and Materials Engineering Dongguk University-SeoulSeoul 04620Republic of Korea Advanced Functional Nanohybrid Material Laboratory Department of ChemistryDongguk University Seoul-CampusJung-guSeoul04620Republic of Korea Department of Materials Imperial College LondonLondon SW72AZUnited Kingdom Department of Advanced Components and Materials Engineering Sunchon National University255Jungang-roSuncheon-siJellanamdo57922Republic of Korea Department of Enginyeria Electrònica Universitat Politècnica CatalunyaBarcelona 08034Spain Next Generation Battery Research Center Korea Electrotechnology Research Institute(KERI)Changwon51543Republic of Korea Physics Division School of Advanced SciencesVellore Institute of Technology(VIT)Chennai CampusChennai600127Tamil NaduIndia

Interfacial engineering of two-dimensional(2D)monometallic phosphides enables remarkable structural and electrochemical properties in energy storage ***,2D nanosheets(Nss)of FeP_(2)/Co_(2) P were grown on Ni-foam(FCP)using a solution-based and phosphorization approach to be used as freestanding for high-performance energy storage *** effective phosphorization strategy is successfully de-veloped to improve the overall crystalline phase,tailor the morphology,and boost the electrochemical performances of *** FCP Nss electrode exhibits a battery-type redox behavior with a maxi-mum high areal capacity of 1.96 C cm^(-2) at 4 mA cm^(-2) in 6 M KOH aqueous electrolyte compared to the other *** superior electrochemical performance was achieved by increasing the electroac-tive sites and high conductivity via surface tailoring and fast redox ***,a supercapattery was assembled utilizing FCP and activated carbon(AC)electrodes and it revealed maximum specific en-ergy(E_(s))and specific power(P_(s))of 41.2 Wh kg^(-1) and 7578 W kg^(-1) with good cycling stability of 91%after 10,000 cycles at 5 A g^(-1).Eventually,the supercapattery has been explored in practical applications by lighting up light-emitting diodes(LEDs),representing the real-time performance of superior energy storage devices.

关键词： 2D nanosheet Monometallic phosphide Battery-type material supercapattery Energy storage

Monohalogenated acetamide-induced cellular stress and genotoxicity are related to electrophilic softness and thiol/thiolate reactivity

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journal of Environmental sciences 2017年第8期29卷 224-230页

作者： justin A.Pals Elizabeth D.Wagner Michael j.Plewa Menghang Xia Matias s.Attene-Ramos Department of Crop sciences University of Illinois at Urbana-Champaign Urbana IL United States Department of Environmental and Occupational Health Milken Institute School of Public Health George Washington University Washington DC United States safe Global Water Institute University of Illinois at Urbana-Champaign Urbana IL United States National Center for Advancing Translational sciences National Institutes of Health (NIH) Department of Health and Human Services (DHHS) Bethesda MD United States

Haloacetamides（HAMs） are cytotoxic, genotoxic, and mutagenic byproducts of drinking water disinfection. They are soft electrophilic compounds that form covalent bonds with the free thiol/thiolate in cysteine residues through an s_N2 reaction *** of the monohalogenated HAMs（iodoacetamide, IAM; bromoacetamide, BAM;or chloroacetamide, CAM） varied depending on the halogen substituent. The aim of this research was to investigate how the halogen atom affects the reactivity and toxicological properties of HAMs, measured as induction of oxidative/electrophilic stress response and genotoxicity. Additionally, we wanted to determine how well in silico estimates of electrophilic softness matched thiol/thiolate reactivity and in vitro toxicological *** of the HAMs significantly induced nuclear Rad51 accumulation and ARE signaling activity compared to a negative control. The rank order of effect was IAM 〉 BAM 〉 CAM for Rad51, and BAM ≈ IAM 〉 CAM for ARE. In general, electrophilic softness and in chemico thiol/thiolate reactivity provided a qualitative indicator of toxicity, as the softer electrophiles IAM and BAM were more thiol/thiolate reactive and were more toxic than CAM.

关键词： Drinking water disinfection byproducts Haloacetamide Toxicity soft electrophile Oxidative stress DNA damage

Growth, Optical, Mechanical, Dielectric and Theoretical studies on Potassium Pentaborate Tetrahydrate (KB_5O_8·4H_2O) single Crystal by Modified sankaranarayanan-Ramasamy Method

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journal of Materials science & Technology 2009年第6期25卷 745-748页

作者： C. justin Raj s. Krishnan s. Dinakaran j. Mary Linet R. Uthrakumar R. Robert s. jerome Das Department of Physics FET Saveetha University Department of Physics RMK Engineering College Department of Physics Loyola College

A nonlinear optical single crystal of potassium pentaborate tetrahydrate （KB5O8·4H2O） has been grown from aqueous solution by using unidirectional crystal growth method of sankaranarayanan-Ramasamy （sR） with a due modification in the growth assembly. Potassium pentaborate crystal of 60 mm length and 10 mm diameter has been grown along （100） plane with a growth rate of 3 mm per day within a period of 20 days. The grown crystal was subjected to single crystal X-ray diffraction analysis to confirm that the crystal belongs to the orthorhombic system. some fundamental data such as valance electron plasma energy, Penn gap, Fermi energy and electronic polarizability of the grown crystal were calculated. The presence of borate in the grown crystal was confirmed by Fourier transform infrared （FTIR） spectroscopy. The optical transmission property of the grown crystal was analyzed using ultra violet （UV） visible spectral analysis. surface morphology of the growth plane was observed using scanning electron microscopy （sEM）. The mechanical strength of the crystals was found out using Vickers microhardness test along the growth axis. Frequency dependent dielectric constant of the grown crystal was studied for various temperatures along （100） plane.

关键词： Crystal growth Characterization Nonlinear optic materials