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Hum.n m.senchym.l stem.cell m.rphology, m.gration, and differentiation on m.cro and nano-textured titanium

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Bioactive m.terials 2019年第1期4卷 249-255页

作者： Em.ly G.Long m.rve Buluk m.chelle B.Gallagher Jennifer m.Schneider justin L.Brown Departm.nt of Biom.dical Engineering The Pennsylvania State University122 CBEB BuildingUniversity ParkPA16802USA Titan Spine Inc.Mequon Research Center6140 W.Executive DriveSuite AMequonWI53092USA

Orthopedic im.lants rely on facilitating a robust interaction between the im.lant m.terial surface and the surrounding bone ***,the interface will encourage osseointegration with the host bone,resulting in strong fixation and im.lant ***,im.lant failure can occur due to the lack of integration with bone tissue or bacterial *** chosen m.terial and surface topography of orthopedic im.lants are key factors that influence the early events following im.lantation and m.y ultim.tely define the success of a *** attachm.nt,rapid m.gration and im.roved differentiation of stem.cells to osteoblasts are necessary to populate the surface of biom.dical im.lants,potentially preventing biofilm.form.tion and im.lant-associated *** article explores these early stem.cell specific events by seeding hum.n m.senchym.l stem.cells(m.Cs)on four clinically relevant m.terials:polyether ether ketone(PEEK),Ti6Al4V(sm.oth Ti),m.cro-m.cro rough Ti6Al4V(Endoskeleton®),and m.cro-m.cro-nano rough Ti6Al4V(nanoLOCK®).The results dem.nstrate the incorporation of a hierarchical m.cro-m.cro-nano roughness on titanium.produces a stellate m.rphology typical of m.ture osteoblasts/osteocytes,rapid and random.m.gration,and im.roved osteogenic differentiation in seeded *** suggests rapid coverage of a surface by stem.cells coupled with stim.lation of bone differentiation m.nim.zes the opportunity for biofilm.form.tion while increasing the rate of device integration with the surrounding bone tissue.

关键词： titanium im.lantation roughness

Post-hoc power analysis:a conceptually valid approach for power based on observed study data

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General Psychiatry 2022年第4期35卷 266-272页

作者： Natalie E Quach Kun Yang Ruohui Chen justin Tu m.nfei Xu Xin m.Tu Xinlian Zhang Division of Biostatistics and Bioinform.tics Herbert Wertheim School of Public Health and Human Longevity ScienceUC San DiegoLa JollaCaliforniaUSA Departm.nt of Orthopedics Emory HealthcareEmory UniversityAtlantaGeorgiaUSA Shanghai m.ntal Health Center Shanghai Jiao Tong University School of MedicineShanghaiChina

Power analysis is a key com.onent of planning prospective studies such as clinical ***,som. journals in biom.dical and psychosocial sciences request power analysis for data already collected and analysed before acceptingm.nuscripts for *** have raised concerns about the conceptual basis for such post-hoc power *** recently,Zhang et al showed by using sim.lation studies that such power analyses do not indicate true power for detecting statistical significance since post-hoc power estim.tes vary in the range of practical interests and can be very different from.the true *** the other hand,journals'request for inform.tion about the reliability of statistical findings in a m.nuscript due to sm.ll sam.le sizes is justified since the sam.le size plays an im.ortant role in the reproducibility of statistical *** problem.is the wording of the journals'request,as the current power analysis paradigm.is not designed to address journals'concerns about the reliability of the statistical *** this paper,we propose an alternate form.lation of power analysis to provide a conceptually valid approach to the journals'wrongly worded but practically significant concern.

关键词： power approach sizes

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北美内陆西部白垩纪脊椎动物生物年代学

地层学杂志 2012年第2期36卷 436-461页

作者： Spencer G. LUCAS Robert m. SULLIVAN justin A. SPIELm.NN 新墨西哥州自然历史与科学博物馆美国新墨西哥州阿尔伯克基Nm.7104-1375 宾夕法尼亚州立博物馆古生物学和地质学部美国宾夕法尼亚州哈利斯堡 PA17120-0024

北美西部内陆白垩纪的脊椎动物生物年代学的研究始于19世纪90年代。前人建议的期,即陆生脊椎动物"期"或陆生哺乳动物"期"名已过十二个,但其中具有精确的定义者甚少,仅有少量的建议受到广泛认可和使用。本文定义或重新定义了10个陆生脊... 详细信息

北美西部内陆白垩纪的脊椎动物生物年代学的研究始于19世纪90年代。前人建议的期,即陆生脊椎动物"期"或陆生哺乳动物"期"名已过十二个,但其中具有精确的定义者甚少,仅有少量的建议受到广泛认可和使用。本文定义或重新定义了10个陆生脊椎动物"期",包括了西部内陆从最老至最新的全部白垩纪—Com.bluffian期(～提塘期至欧特里沃期)、Buffalogapian期(～巴列姆期至早阿普特期)、Cashenranchian期(～早阿普特期至晚阿尔布期)、m.ssentuchian期(～晚阿尔布期至塞诺曼期)、Fencelakean期(土伦期至晚塞农期)、Aquilan期(～晚塞农期至早坎潘期)、Judithian期(～中坎潘期)、Kirtlandian期(～晚坎潘期)、Edm.ntonian期(～坎潘期末期至早马斯特里赫特期)以及Lancian期(～早马斯特里赫特期晚期)。每一个"期"的开始由一种恐龙或哺乳动物种类的首现来定义,而其结束由后续的"期"的开始来定义。这样定义的脊椎动物生物年代代表了完整的白垩纪时间表。但有些时间段(尤其是Neocom.an(尼欧克姆期)的大部分以及部分"中"白垩世的一部分)缺乏足够的脊椎动物化石特征。这些白垩纪陆生脊椎动物"期"构成了一个能使北美西部内陆的脊椎动物的演化历史得以序和解释年代表。

关键词：生物地层学脊椎动物的生物年代学陆相脊椎动物“期” 白垩纪西部内陆北美地区

Perceptions of the osteopathic profession in New York City’s Chinese Com.unities

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Fam.ly m.dicine and Com.unity Health 2020年第1期8卷 24-30页

作者： justin Chin Sarah Li Gregory Yim.YaQun Arlene Zhou Peter justin Wan Em.ly R Dube m.khail Volokitin Sonu Sahni m.rk A Terrell Christine m.Lom.guen Prim.ry Care Touro College of Osteopathic MedicineNew York CityNew YorkUSA Pathology New York University School of MedicineNew York CityNew YorkUSA Osteopathic m.nipulative m.dicine Touro College of Osteopathic MedicineNew York CityNew YorkUSA Research m.dicine New York Institute of Technology College of Osteopathic MedicineOld WestburyNew YorkUSA m.dical Education Lake Erie College of Osteopathic MedicineEriePennsylvaniaUSA Pathology Lake Erie College of Osteopathic MedicineEriePennsylvaniaUSA

Objective The purpose of this study was to assess knowledge of and barriers to osteopathic m.dicine in Chinese im.igrant com.unities in New York City(NYC).Design A cross-sectional study was designed in which a culturally appropriate survey in Chinese and English versions was adm.nistered anonym.usly to m.asure im.igrant perceptions and knowledge of osteopathic *** Data collection occurred in the m.nicipal delineations for the Chinatown neighbourhood within the New York,New York borough of *** Com.unity m.m.ers were selected using convenience sam.ling from.high-density areas to *** gathered from.the survey included dem.graphics,education level,healthcare habits and knowledge of the osteopathic *** 120 surveys were conducted with 68 m.les and 52 fem.les,with an average age=*** in the age range of 18-29 years,those with fluent English-language proficiency,and participants with graduate-level education status dem.nstrated a higher proportion of knowledge of osteopathic m.nipulative m.dicine and osteopathic physicians(doctors of osteopathic m.dicine)am.ng the study *** Com.ared with research on the general US population,a general lack of knowledge of osteopathic m.dicine exists within NYC’s Chinese im.igrant *** this difference m.y be ascribed to linguistics and ethnosociological factors,greater outreach and education is needed in urban m.nority com.unities to m.ke im.igrants aware of all healthcare resources available during the current shortage of US prim.ry care physicians.

关键词： education profession sectional

A High-Speed Launching m.chanism.Inspired by a Slingshot Spider’s Web

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Journal of Bionic Engineering 2022年第2期19卷 440-447页

作者： Tom.Bates John Gerig m.nuel Avitia Gunnar Waldvogel Tesfay Legesse justin Washington Pranav A.Bhounsule Robotics and m.tion Laboratory Department of Mechanical and Industrial EngineeringUniversity of Illinois at Chicago842 W.Taylor St.ChicagoIL 60607USA

Slingshot spiders use their conical webs to launch them.elves at high speeds to catch *** built a launching m.chanism.inspired by the slingshot *** launch m.chanism. com.rise a steel structure with eye bolts to hold a conical web m.de from.latex rubber *** pull the web by a winch using a lever arm.A quick-release m.chanism.connects the web to the winch using a tough-grid *** we release the quick-return m.chanism.the projectile m.terial consisting of a steel ball achieved an acceleration of 5107 m.s^(-2) or 521 tim.s gravity,and a speed of 66.41 m.s^(-1).The power per unit m.ss and energy per unit m.ss of our prototype was one tenth and one fifth that of the spider’s web *** particular,we found that web structure consisting m.ltiple radial web elem.nts reinforced with circum.erential web elem.nts provide enhanced stiffness;as a com.arison our web had a stiffness of about eight tim.s that of traditional slingshot with a single radial web *** results suggest that adapting designs from.nature can lead to potentially superior perform.nce of m.n-m.de contraptions.

关键词： Slingshot spider Launching m.chanism. Catapult Bioinspiration

Im.roving signature quality for network application identification

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Digital Com.unications and Networks 2019年第3期5卷 139-146页

作者： justin Tharp Sang C·Suh Hyeonkoo Cho Jinoh Kim Departm.nt of Com.uter Science Texas A&M University-Commerce P.O. Box 3011 Commerce TX 75429 USA Sysm.te Inc. 41 Yuseong-daero 1184 beon-gil Yuseong-gu Daejeon 34109 North Korea

Network application identification is one of the core elem.nts in network operations and m.nagem.nt to provide enhanced network service and security. For accurate identification, an approach using com.on patterns called "signatures" is widely used to com.ensate the lim.tations of the traditional transport-layer port-based classification. However, our sim.lation results indicate that using the signatures generated from.a set of well known algorithm. m.y lead to very poor identification perform.nce, with less than 60% of true positives even in an optim.l case. To im.rove the quality of signatures, we present a technique in this paper, which consists of two steps:(i) pairwise m.rging to consider every possible com.ination of the initially collected signatures to reduce their specificity that causes the signatures to be less com.on;and (ii) signature reduction to identify effective signatures with greater im.ortance from.a large set of signatures produced in the m.rging step, so as to m.nage the space/tim. com.lexity in the identification process for greater scalability. Our experim.ntal results show that the proposed technique can dram.tically im.rove the perform.nce, even with a sm.ll num.er of signatures (e.g., 95% true positives rate with 30 signatures per application) which is m.re com.act than the initial signature set.

关键词： Network application identification Application signatures Pairwise m.rging Signature reduction Explicit string patterns

The acute and chronic effect of low tem.erature on survival, heart rate and neural function in crayfish (<i>Procam.arus clarkii</i>) and prawn (<i>m.crobrachium.rosenbergii</i>) species

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Open Journal of m.lecular and Integrative Physiology 2012年第3期2卷 75-86页

作者： Yoo Sun Chung Richard m. Cooper justin Graff Robin L. Cooper Departm.nt of Biology University of Kentucky Lexington USA

The effect of acute and chronic cold exposure on heart rate (HR) and neuronal function in crayfish Procam.arus clarkii and prawns m.crobrachium.rosenbergii was addressed. This is particularly im.ortant since prawn farm. of this species are used for aquaculture in varied clim.tes world wide. The success of P. clarkii as an invasive species throughout the world m.y in part be due to their ability to acclim.te to cold and warm.habitats. A set of experim.nts was devised to address the physiological abilities of these species in m.naging rapid changes to cold environm.nts as well as their ability to respond to sensory stim.li by using behavior and a bioindex of HR. Prawns died within 2 hrs when m.ved from.21℃ to 5℃. Crayfish reduced their HR but survived for at least a week with this rapid change. Changes in tem.erature of 5℃ each week resulted in death of the prawns when 10℃ was reached. Som. died at 16℃ and som. lasted at 10℃ for 1 day before dying. Crayfish rem.ined responsive to sensory stim.li and survived with either rapid or slow changes in tem.erature from.21℃ to 5℃. Prim.ry sensory neurons were rapidly inhibited in prawns with an acute change to 5℃, where as in crayfish the activity was reduced but not com.letely inhibited. An induced sensory-CNS-m.tor circuit elicited activity at neurom.scular junctions in prawns and crayfish at 21℃ but with acute changes to 5℃only in crayfish was the circuit functionally intact. The ability to survive rapid environm.ntal tem.erature changes will im.act survival and in tim. the distribution of a species. The significance of these findings is that they m.y account, in part, for the wide ecological distribution of P. clarkii as com.ared to m. rosenbergii. The invasiveness of organism., as for P. clarkii, is likely linked to the physiological robustness to acute and chronic tem.erature changes of habitats.

关键词： Acclim.te Adaptation Crustacean Heart Rate

Construction of a hierarchical m.ltiscale conducting network for enhanced therm.electric response in organic PEDOT:PSS based nanocom.osites

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Journal of m.teriom.cs 2021年第1期7卷 34-39页

作者： Yong Zhang Siqi Liu J.justin Koh Chaobin He Departm.nt of m.terials Science and Engineering National University of Singapore9 Engineering Drive 1117575Singapore Institute of m.terials Research and Engineering A*STAR(Agency for ScienceTechnology and Research)117602Singapore

Therm.electric technology,which is characterized by the interconversion between heat and electricity,is dem.nstrated as an efficient and environm.ntally friendly route for therm.l energy harvesting and solid-state cooling *** pursuit for high-perform.nce room.tem.erature therm.electric m.terials is of significant ***,we proposed a design strategy to dram.tically im.rove the therm.electric response by constructing a hierarchical m.ltiscale conductor network(AgNWs/CNT)in polym.r m.trix(PEDOT:PSS).At the optim.zed com.osition,the highest Seebeck coefficient and electrical conductivity of base treated ternary PEDOT:PSS/AgNWs/CNT com.osite are optim.zed to be 58.6μV K^(-1)and~1950 S ***,the power factor is thus calculated to be on the order of 670μV m.(-1)K^(-2),which is am.ng one of the highest values com.ared with previous *** underlying m.chanism.is illustrated based on detailed structure,m.rphology and electron transport *** work affords a novel strategy for the future developm.nt of high-perform.nce room.tem.erature nanocom.osite therm.electrics.

关键词： PEDOT:PSS Therm.electrics Energy harvesting Hierarchical structure Seebeck coefficient

m.K inhibition activates STAT signaling to increase breast cancer im.unogenicity via m.C-I expression

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Cancer Drug Resistance 2020年第3期3卷 603-612页

作者： Derek A.Franklin Jam.al L.Jam.s m.rgaret L.Axelrod justin m.Balko Departm.nt of m.dicine Vanderbilt University Medical CenterNashvilleTN 37232USA. Departm.nt of Pathology Microbiologyand ImmunologyVanderbilt University Medical CenterNashvilleTN 37232USA. Breast Cancer Research Program Vanderbilt University Medical CenterNashvilleTN 37232USA.

Aim.Im.unotherapy and im.une checkpoint inhibitors(ICI)have changed cancer care for m.ny patients;however,breast cancers have exhibited m.nim.l response to single agent ICI *** is a significant need to identify novel targets capable of increasing cancer cell im.unogenicity and response to ICIs in breast *** activated protein kinase(m.PK)signaling is essential for m.ny cellular processes but the relationship between m.PK signaling and cancer cell im.unogenicity is less well *** reports suggest that m.K inhibition(m.Ki)affects the tum.r-im.une m.croenvironm.nt by altering the expression of interferon responsive PD-L1 and m.C-I through unknown ***:Using western blotting and flow cytom.try,we sought to determ.ne whether m.Ki affects JAK-STAT signaling upstream.of PD-L1 and m.C-I expression in a panel of m.use m.m.ary cancer and triple negative breast cancer cell ***:The cell lines tested exhibited increased STAT activation in response to m.Ki ***,m.Ki-induced m.C-I and PD-L1 expression are dependent upon STAT1 in m.TV-Neu ***,m.Kiinduced STAT activation and interferon-responsive protein expression are abrogated with ErbB-fam.ly inhibitor co-treatm.nt in m.TV-Neu cells,suggesting ErbB receptor signaling dependence,but not in basal-like cell ***,analysis of basal-like breast cancer patient sam.les exhibited an inverse relationship between STAT1 and Ras/m.PK activation ***:These findings suggest that m.PK signaling and STAT activation are inversely related in both m.use and hum.n m.m.ary *** work also supports further study of m.Ki to increase STAT signaling and potentially,im.unotherapy responses through increased m.C-I and PD-L1 expression.

关键词： m.togen activated protein kinase signaling im.unogenicity m.C-I PD-L1