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Aberrant expression of enzymes regulating m^6A mRNA methylation: implication in cancer

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Cancer Biology & Medicine 2018年第4期15卷 323-334页

作者： Natalia Pinello Stephanie Sun justin Jong-Leong Wong Epigenetics and RNA Biology Program Centenary Institute The University of Sydney Sydney Medical School The University of Sydney

N^6-methyladenosine(m^6 A) is an essential RNA modification that regulates key cellular processes, including stem cell renewal,cellular differentiation, and response to DNA damage. Unsurprisingly, aberrant m^6 A methylation has been implicated in the development and maintenance of diverse human cancers. Altered m^6 A levels affect RNA processing, mRNA degradation, and translation of mRNAs into proteins, thereby disrupting gene expression regulation and promoting tumorigenesis. Recent studies have reported that the abnormal expression of m^6 A regulatory enzymes affects m^6 A abundance and consequently dysregulates the expression of tumor suppressor genes and oncogenes, including MYC, SOCS2, ADAM19, and PTEN. In this review, we discuss the specific roles of m^6 A missing space "writers", "erasers", and "readers" in normal physiology and how their altered expression promotes tumorigenesis. We also describe the potential of exploiting the aberrant expression of these enzymes for cancer diagnosis, prognosis, and the development of novel therapies.

关键词： RNA modification N^6-methyladenosine (m^6A) cancer tumor suppressor oncogene

China's Growth Deceleration: Causes and Future Growth Prospect

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Frontiers of Economics in China-Selected Publications from Chinese Universities 2019年第1期14卷 26-52页

作者： justin Yifu Lin Institute of New Structural Economics Peking University Beijing 100871 China Institute of South-South Cooperation and Development Peking University Beijing 100871 China National School of Development Peking University Beijing 100871 China

China's growth decelerated substantially after 2010. This paper argues that the main cause for the deceleration is external and cyclical, China has a potential growth rate of 8%, the economy has good investment opportunities and resources, and China is likely to achieve a medium-high growth rate of around 6.5% in the coming years. The paper also examines the various structural reforms that can help China to release its growth potential and complete the transition to a well-functioning market economy.

关键词： China economic growth deceleration causes countermeasures external factors cyclical factors structural reforms growth potential wellfunctioning market econmy hig-growth rate medium-high growth

Laparoscopic pancreaticoduodenectomy: a descriptive and comparative review

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Chinese Journal of Cancer Research 2015年第4期27卷 368-375页

作者： justin Merkow Alessandro Paniccia Barish H.Edil Department of Surgery University Of Colorado

Laparoscopic pancreaticoduodenectomy（LPD） is an extremely challenging surgery. First described in 1994, it has been slow to gain in popularity. Recently, however, we have seen an increase in the number of centers performing this operation, including our own institution, as well as an increase in the quantity of published data. The purpose of this review is to describe the current status of LPD as described in the literature. We performed a literature search in the Pub Med database using Me SH terms ＂laparoscopy＂ and ＂pancreaticoduodenectomy＂. We then identified articles in the English language with over 20 patients that focused on LPD only. Review articles were excluded and only one article per institution was used for descriptive analysis in order to avoid overlap. There were a total of eight articles meeting review criteria, consisting of 492 patients. On descriptive analysis we found that percent of LPD due to high-grade malignancy averaged 47% over all articles. Average operative time was 452 minutes, blood loss 369 cc＇s, pancreatic leak rate 15%, delayed gastric emptying 8.6%, length of hospital stay 9.4 days, and short term mortality 2.3%. Comparison studies between open pancreaticoduodenectomy（OPD） and LPD suggested decreased blood loss, longer operative time, similar post-operative complication rate, decreased pain, and shorter hospital length of stay for LPD. There was also increased number of lymph nodes harvested and similar margin free resections with LPD in the majority of studies. LPD is a safe surgery, providing many of the advantages typically associated with laparoscopic procedures. We expect this operation to continue to gain in popularity as well as be offered in increasingly more complex cases. In future studies, it will be beneficial to look further at the oncologic outcome data of LPD including survival.

关键词： Laparoscopic laparoscopy pancreaticoduodenectomy whipple review laparoscopic vs.open

Egg rejection behavior does not explain the lack of cowbird parasitism on an eastern North American population of Red-winged Blackbirds

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Avian Research 2019年第4期10卷 431-440页

作者： justin J.Reel Todd J.Underwood Department of Biology Kutztown University

Background:Red-winged Blackbirds(Agelaius phoeniceus),hereafter red-wings,are much less frequently parasitized by Brown-headed Cowbirds(Molothrus ater)in eastern North America than in central North America and had not been recorded as hosts in our study area in southeastern *** hosts of Old World cuckoos(Cuculidae)often show geographic variation in egg rejection behavior,cowbird hosts typically exhibit uniform responses of all acceptance or all rejection of cowbird ***,geographic variation in cowbird parasitism frequencies might reflect a different behavioral response to parasitism by hosts where only some populations reject *** this study,we tested whether egg rejection behavior may explain the lack of parasitism observed in our eastern red-wing population,which may provide insight into low parasitism levels across eastern North ***:We parasitized red-wing nests with model cowbird eggs to determine their response to *** were tested across three nest stages and compared to control nests with no *** rejection differed significantly by stage,we compared responses separately for each nest *** also monitored other songbird nests to identify parasitism frequencies on all potential ***:Red-wings showed significantly more rejections during the building stage,but not for the laying and incubation *** during nest building involved mostly egg burials,which likely represent a continuation of the nest building process rather than true rejection of the cowbird *** these responses,red-wings rejected 15%of cowbird eggs,which is similar to rejection levels from other studies and *** overall parasitism frequency on 11 species surveyed in our study area was only 7.4%.Conclusions:Egg rejection behavior does not explain the lack of parasitism on red-wings in our eastern ***,we suggest that cowbird preference for other hosts and the low abu

关键词： Brood parasitism Brown-headed Cowbird Egg rejection Geographic variation Red-winged Blackbird

Dual Circulation and China's Development

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Frontiers of Economics in China-Selected Publications from Chinese Universities 2021年第1期16卷 30-34页

作者： justin Yifu Lin Institute of New Structural Economics Peking UniversityBeijing 100871China Institute of South-South Cooperation and Development Peking UniversityBeijing 100871China National School of Development Peking UniversityBeijing 100871China

In 2020,China proposed a new development paradigm centered on domestic circulation with a"dual circulation"model in which domestic circulation and international circulation promote each *** new paradigm reflects a clear understanding of China's development trend that saw its share of exports in the GDP declining steadily since ***,the new paradigm does not necessarily mean that China should change its past policy of fully utilizing domestic and international markets and resources in economic *** of large economies of scale in modern manufacturing sector,China should continue to make full use of international markets.

关键词： China dual circulation domestic circulation international circulation economic development

Eigenvalues of Elliptic Systems for the Mixed Problem in Perturbations of Lipschitz Domains with Nonhomogeneous Neumann Boundary Conditions

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Journal of Partial Differential Equations 2020年第1期33卷 48-63页

作者： MIYAZAKI Kohei TAYLOR justin L. Department of Mathematics&Statistics Murray State UniversityMurrayKentuckyU.S.A

We study eigenvalues of an elliptic operator with mixed boundary conditions on very general decompositions of the *** impose nonhomogeneous conditions on the part of the boundary where the Neumann term lies in a certain Sobolev or Lp *** work compares the behavior of and gives a relationship between the eigenvalues and eigenfunctions on the unperturbed and perturbed domains,respectively.

关键词： Eigenvalues elliptic systems mixed problem perturbed domains

Corporate spinoffs and executive compensation

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Frontiers of Business Research in China 2018年第4期12卷 399-423页

作者： justin Law Wayne Yu School of Accounting and Finance The Hong Kong Polytechnic UniversityHung HomHong KongChina College of Business City University of Hong KongKowloon TongHong KongChina

This paper investigates the impact of corporate spinoffs on executive compensation. We find no significant association between executive compensation and stock returns prior to spinoffs, but a significant positive association between the two afterwards. We also find evidence that corporate governance generally improves after the spinoff. In addition, the positive association between executive compensation and stock returns is more pronounced for firms with greater improvements in their corporate governance. Overall, our findings support the notion that spinoffs create value by reducing agency costs.

关键词： Spinoffs Corporate governance CEO compensation

Twist deformation and buckling behavior of veins

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医用生物力学 2013年第S1期28卷 25-28页

作者： justin Garcia Haichao Han The University of Texas at San Antonio Department of Mechanical Engineering/Biomedical Engineering Program

Introduction Twisted arteries and veins disrupt normal blood flow and elevate the risk for clinical complications such as thrombosis,heart attack,stroke,and organ *** should remain mechanically stable for normal ***,compared to arteries,veins are more vulnerable to collapse because they are thin-walled and under lower lumen *** veins have been shown to occur with head turning or after inadvertent twist during various vascular *** vivo and cadaver studies have demonstrated that turning the head to one side can result in torsion and compression of the internal jugular vein and can compromise cranial drain-

关键词： veins buckling jugular arteries compromise disrupt torsion walled vulnerable torque

Spirotetramat reduces fitness of the spotted-wing Drosophila,Drosophila suzukii

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Insect Science 2024年第4期31卷 1222-1230页

作者： Jing Yang justin Flaven-Pouchon Yiwen Wang Bernard Moussian Section of Animal Genetics Interfaculty Institute of Cell BiologyUniversity of TübingenTübingenGermany School of Pharmaceutical Science and Technology Tianjin UniversityTianjinChina INRAE CNRSUniversitéCôte d'AzurInstitut Sophia AgrobiotechSophia AntipolisFrance

With climate change,the spotted-wing Drosophila(SWD,Drosophila suzukii)invades a great number of fruit production regions worldwide.A plethora of insecticides are being applied for management of this *** expected,SWD develops resistance against some potent insecticides or is rather insensitive to some ***,there is an urgent need to identify and characterize alternative insecticides to control SWD ***,we have studied the effects of the orally applied inhibitor of the fatty acid synthesis pathway spirotetramat on SWD fitness with respect to fecundity and surface barrier function at different *** our experiments,we applied spirotetramat mixed with baker's yeast and showed that females and males were not repelled by effective concentrations of this *** found that spirotetramat,by trend,lowers egg numbers laid by fed *** eggs rapidly desiccate,and only a few larvae *** is lethal to larvae and reduces survival of adult flies under low-humidity *** together,based on our data,we propose to use yeast supplemented with spirotetramat and additional SWD-specific attractants in traps in non-crop areas in order to eradicate SWD populations before they infest crop production sites.

关键词： desiccation Drosophila suzuki insecticide lipids