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Outcome following incomplete surgical cytoreduction combined with intraperitoneal chemotherapy for colorectal peritoneal metastases

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World Journal of Gastrointestinal Oncology 2015年第12期7卷 445-454页

作者： Roisin Mary Heaney Conor Shields jurgen mulsow Peritoneal Malignancy Institute Mater Misericordiae University Hospital

Cytoreductive surgery combined with intraperitoneal chemotherapy can improve survival in appropriately selected patients with colorectal peritoneal metastases. Outcomes are best in those patients in whom a complete cytoreduction can be achieved. Unresectabledisease is however encountered in approximately one-quarter of patients at laparotomy. The merits, or otherwise, of proceeding with an incomplete cytoreduction in this setting are unclear. We performed a review of published outcomes following incomplete cytoreduction for colorectal peritoneal metastases. Using the electronic databases, Pub Med and MEDLINE, a systematic search of available literature published during the period January 1997 to September 2014 was conducted. Following application of exclusion criteria, 19 papers were identified and included in this review. These comprised fifteen case series, 3 case control studies and one randomised control trial. In the nineteen studies included in this review, 2790 patients underwent cytoreductive surgery with or without intraperitoneal chemotherapy for peritoneal metastases of colorectal origin. Of these, 1732(62%) underwent a complete cytoreduction while 986(35%) patients underwent an incomplete cytoreduction. Median survival in the complete cytoreduction group ranged from 11 to 62 mo while survival in the latter group ranged from 2.4 to 32 mo. Of the 986 patients with an incomplete cytoreduction, 331 patients received intraperitoneal chemotherapy and survival in this cohort ranged from 4.5 to 32 mo. An incomplete cytoreduction, with or without intraperitoneal chemotherapy, does not appear to confer a survival benefit. The limited available data points to a palliative benefit in a subset of patients. In the absence of high quality data, the decision as to whether or not to proceed with surgery should be made on an individual patient basis.

关键词： Colorectal carcinoma Peritoneal metastases Carcino

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Non-surgical factors influencing lymph node yield in colon cancer

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World Journal of Gastrointestinal Oncology 2016年第5期8卷 466-473页

作者： Patrick Wood Colin Peirce jurgen mulsow Department of Colorectal Surgery Mater Misericordiae University Hospital

There are numerous factors which can affect the lymph node(LN) yield in colon cancer *** aim of this paper was to identify both modifiable and nonmodifiable factors that have been demonstrated toaffect colonic resection specimen LN yield and to summarise the pertinent literature on these topics.A literature review of Pub Med was performed to identify the potential factors which may influence the LN yield in colon cancer resection *** terms used for the search were:LN,lymphadenectomy,LN yield,LN harvest,LN number,colon cancer and colorectal *** nonmodifiable and modifiable factors were *** review identified fifteen non-surgical factors:(13 nonmodifiable,2 modifiable) which may influence LN *** yield is frequently reduced in older,obese patients and those with male sex and increased in patients with right sided,large,and poorly differentiated *** ethnicity and lower socioeconomic class may negatively influence LN ***-operative tumour tattooing appears to increase LN *** are many factors that potentially influence the LN yield,although the strength of the association between the two varies *** oncological resection and pathological analysis remain the cornerstones to achieving good quality and quantity LN yields in patients with colon cancer.

关键词： Lymph node Number Factors Yield Colon cancer

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中国虎甲科名录(鞘翅目:肉食亚目)

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东北林业大学学报 2024年第9期52卷 132-144页

作者：王可意李成德 jurgen Wiesner Fabian A.Botzl 东北林业大学哈尔滨150040 德国·迈讷瑞典农业科学大学瑞典乌普萨拉

通过整理文献资料和标本材料,总结更新了中国虎甲科名录。中国现已知虎甲科昆虫共计27属208种,记述了各个种在中国的分布情况。对现有文献中的可疑和错误记录进行了说明和修订。

关键词：虎甲科分类学昆虫名录中国

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Sphincter preservation for distal rectal cancer - a goal worth achieving at all costs?

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World Journal of Gastroenterology 2011年第7期17卷 855-861页

作者： Jürgen mulsow Des C Winter Institute for Clinical Outcomes Research and Education St. Vincent’s University Hospital

To assess the merits of currently available treatment options in the management of patients with low rectal cancer, a review of the medical literature pertaining to the operative and non-operative management of low rectal cancer was performed, with particular emphasis on sphincter preservation, oncological outcome, functional outcome, morbidity, quality of life, and patient preference. Low anterior resection (AR) is technically feasible in an increasing proportion of patients with low rectal cancer. The cost of sphincter preservation is the risk of morbidity and poor functional outcome in a significant proportion of patients. Transanal and endoscopic surgery are attractive options in selected patients that can provide satisfactory oncological outcomes while avoiding the morbidity and functional sequelae of open total mesorectal excision. In complete responders to neo-adjuvant chemoradiotherapy, a non-operative approach may prove to be an option. Abdominoperineal excision (APE) imposes a permanent stoma and is associated with significant incidence of perineal morbidity but avoids the risk of poor functional outcome following AR. Quality of life following AR and APE is comparable. Given the choice, most patients will choose AR over APE, however patients following APE positively appraise this option. In striving toward sphincter preservation the challenge is not only to achieve the best possible oncological outcome, but also to ensure that patients with low rectal cancer have realistic and accurate expectations of their treatment choice so that the best possible overall outcome can be obtained by each individual.

关键词： Rectal cancer Survival Local recurrence Morbidity Anorectal function Quality of life Patient preference

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Action of aluminum on high voltage-dependent calcium current and its modulation by ginkgolide B

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Acta Pharmacologica Sinica 2005年第5期26卷 539-545页

作者： jurgen HESCHLER Cologne D-50931 Germany Neurophysiology University of Cologne

Aim:To investigate the effect of aluminum(Al)on high voltage-dependent cal-cium current(IHVA)and its modulation by ginkgolide B(Gin B).Methods:Thewhole-cell,patch-clamp technique was used to record IHVAfrom acutely isolatedhippocampal CA1 pyramydal neurons in ***:A1 0.1 mmol/L(lowconcentration)reduced IHVA;A1 0.75 and 1.0 mmol/L(high concentrations)in-creased IHVA,and Al decreased and increased IHVAat intermediate concentrationsof 0.25 and 0.5 mmol/*** increase of IHVAby Al 1.0 mmol/L was enhanced by theadenylyl cyclase(AC)agonist forskolin and was partly abolished by the cyclicadenosine monophosphate(cAMP)-dependent protein kinase A(PKA)antago-nist H-89,whereas the decrease observed with Al 0.1 mmol/L was neither reversedby forskolin nor affected by *** B had no effect on IHVAin normal neurons,but canceled the increase in IHVAby 1.0 mmol/L ***:The resultsindicate that the mechanism of Al affecting IHVAdiffers at different concentrations,and this may be attributed to its complex *** B could prevent neuronsfrom injury by inhibiting calcium influx.

关键词： hippocampus aluminum voltage-dependent calcium channels ginkgolide B patch-clamp technique

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A Numerical Investigation for a Model of the Solid-Gas Phase in a Crystal Growth Apparatus

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Communications in Computational Physics 2008年第4期3卷 913-934页

作者： jurgen Geiser Humboldt-Universitat zu Berlin Department of Mathematics Unter den Linden 6D-10099 BerlinGermany.

We present discretization and solver methods for a model of the solid-gas phase in a crystal growth *** model equations are coupled Eulerian and heat-transfer equations with flux boundary *** a more detailed discussion we consider simpler equations and present time-and space-decomposition methods as solver methods to decouple the multi-physics *** present the error analysis for the discretization and solver *** experiments are performed for the Eulerian and heat-transfer equation using decomposition *** present a real-life application of a crystal growth apparatus,based on underlying stationary heat *** we discuss further error analysis and application to a more complex model of crystal growth.

关键词： Decomposition methods finite-volume discretization error analysis heat equation crystal growth.

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3nce upon a Time- Chloroplast Protein Imporl Research from Infancy to Future Challenges

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Molecular Plant 2016年第6期9卷 798-812页

作者： Bettina Bolter jurgen Soill Department Biotogie I-Botanik Ludwig-Maximilians-Universitat GroBhaderner Stral3e 2-4 82152 Planegg-Martinsried Germany Munich Center for Integrated Protein Science CiPSM Ludwig-Maximilians-Universitat Feodor-Lynen-Strasse 25 81377 Munich Germany

Protein import into chloroplasts has been a focus of research for several decades. The first publications dealing with this fascinating topic appeared in the 1970s. From the initial realization that many plastid proteins are being encoded for in the nucleus and require transport into their target organelle to the identification of import components in the cytosol, chloroplast envelopes, and stroma, as well as elucidation of some mechanistic details, more fascinating aspects are still being unraveled. With this overview, we present a survey of the beginnings of chloroplast protein import research, the first steps on this winding road, and end with a glimpse into the future.

关键词： chloroplast protein import historical perspective Toc Tic evolution envelope membranes

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Nutrient retention and release in coarse woody debris of three important central European tree species and the use of NIRS to determine deadwood chemical properties

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Forest Ecosystems 2018年第3期5卷 296-310页

作者： Steffen Herrmann jurgen Bauhus Faculty of Environment and Natural Resources University of Freiburg Tennenbacherstr.4D-79106Freiburg i.Br.Germany Thunen Institute of Forest Ecosystems Alfred-M611er-Strabe 1Haus41/4216225EberswaldeGermany

Background: Coarse woody debris(CWD) is very important for forest ecosystems, particularly for biodiversity and carbon storage. Its relevance as a possible reservoir and source of nutrients is less clear, especially in central ***: Based on a chronosequence of known ages of logs, we analyzed the nutrients stored in CWD of Fagus sylvatica, Picea abies, and Pinus sylvestris at different sites in Germany. To quantify nutrient concentrations, we assessed the use of Near Infrared Reflectance Spectroscopy(NIRS) to determine the chemical properties of ***: NIRS models were suitable to predict concentrations of C, N, P, lignin and extractives. Concentrations of most nutrients increased with mass loss, with the exception of potassium, which decreased for beech and pine and remained relatively constant for spruce. The highest nutrient concentrations(N, P, S, Ca and Mn, except Mg and K) were generally observed in highly decomposed spruce logs. The net effect of decreasing CWD mass and increasing nutrient concentrations was either a decreasing(N, P and K in beech; P, Mg, K and Mn in pine), constant(S, Ca and Mg in beech; N, S and Ca in pine) or increasing amount of nutrients(N, P, S and Ca in spruce; Mn in beech) in the logsover the course of decomposition. The C/N ratio decreased for all tree species, most markedly for spruce from ca. 1000 at the beginning of the decomposition process to 180 at 36 years. The N/P ratio converged to a value of about 30 forall three species. Lignin concentrations increased for spruce and beech and remained constant for ***: Our results indicate that most nutrients remain in CWD for long periods. Nutrients may be used and cycled by microorganisms within CWD, but with the exception of P(in beech), Mg(in pine) and K(in beech and pine), there appears to be little net nutrient export until two thirds of the mass is lost. Instead, N, P, S and Ca were accumulated in spruce logs, indicating that CWD became a net sink rathe

关键词： CWD NIRS Decay Carbon F.sylvatica P.abies P.sylvestris

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Between fighting and tolerance： reproductive biology of wingless males in the ant Cardiocondyla venustula

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Insect Science 2017年第5期24卷 818-828页

作者： Susanne Jacobs jurgen Heinze LS ZoologielEvolutionsbiologie Universitat Regensburg Regensburg Germany

Male reproductive tactics vary widely across the species of the ant genus Cardiocondyla, from obligatory lethal combat among co-occurring males to complete mutual tolerance. The African species C. venustula Wheeler, 1908 has an intermediate phylogenetic position between taxa with fighting males and taxa with tolerant males and also shows an intermediate male behavior. Males from 2 native populations in South Africa and a population introduced to Puerto Rico attacked and killed freshly eclosing rivals but rarely engaged in deadly fights with adult competitors, Instead, several males per colony established small ＂territories＂ in their natal nests and defended them against other males. Males with a stable territory had more contact with female sexuals than nonterritorial males and more frequently engaged in mating attempts. In controlled choice experiments, female sexuals did not show any preference for particular males. We suggest that male territoriality in C. venustula is an adaptation to the seasonal production of large numbers of female sexuals by multiple mothers.

关键词： Cardiocondyla ergatoid males Formicidae male competition sexual selection territoriality

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Extent and chronology of Quaternary glaciation

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Episodes 2008年第2期31卷 211-218页

作者： jurgen Ehlers Philip Gibbard Geologisches Landesamt Billstrasse 84. D-20539 Hamburg Germany Cambndge Quaternary Department Of Geography University of cambridge Downing Street Cambridge CB2 3EN England.

In a recent INQUA project the extent of Pleistocene glaciations has been digitally mapped and the chronology of events reviewed. The onset of the present Ice Age in both hemispheres dates back to the Palaeogene. In Greenland, Iceland, North America and southernmost South America sizeable ice sheets formed well before 2.6 ka BP. In Alaska and on Tierra del Fuego the ice advanced further than in any later glaciations. Evidence for Early Pleistocene glaciation （2.6-0. 78 Ma） has been reported from many parts of the world, but in most cases dating remains problematic, and the size of the glaciers and ice sheets is unknown.

关键词：第四纪地质时代冰川范围年代

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