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Non-surgical factors influencing lymph node yield in colon cancer

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World Journal of Gastrointestinal Oncology 2016年第5期8卷 466-473页

作者： Patrick Wood Colin Peirce jurgen Mulsow Department of Colorectal Surgery Mater Misericordiae University Hospital

There are numerous factors which can affect the lymph node(LN) yield in colon cancer *** aim of this paper was to identify both modifiable and nonmodifiable factors that have been demonstrated toaffect colonic resection specimen LN yield and to summarise the pertinent literature on these topics.A literature review of Pub Med was performed to identify the potential factors which may influence the LN yield in colon cancer resection *** terms used for the search were:LN,lymphadenectomy,LN yield,LN harvest,LN number,colon cancer and colorectal *** nonmodifiable and modifiable factors were *** review identified fifteen non-surgical factors:(13 nonmodifiable,2 modifiable) which may influence LN *** yield is frequently reduced in older,obese patients and those with male sex and increased in patients with right sided,large,and poorly differentiated *** ethnicity and lower socioeconomic class may negatively influence LN ***-operative tumour tattooing appears to increase LN *** are many factors that potentially influence the LN yield,although the strength of the association between the two varies *** oncological resection and pathological analysis remain the cornerstones to achieving good quality and quantity LN yields in patients with colon cancer.

关键词： Lymph node Number Factors Yield Colon cancer

Single-drive high-speed lumped depletion-type modulators toward 10 fJ/bit energy consumption

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Photonics Research 2017年第2期5卷 134-142页

作者： XINBAI LI FENGHE YANG FANG ZHONG QINGZHONG DENG jurgen MICHEL ZHIPING ZHOU State Key Laboratory of Advanced Optical Communication Systems and Networks School of Electronics Engineering and Computer SciencePeking University MIT Microphotonics Center Massachusetts Institute of Technology

Reduction of modulator energy consumption to 10 fJ∕bit is essential for the sustainable development of communication *** modulators might be a viable solution if instructed by a complete theory ***,we present a complete analytical electro-optic response theory,energy consumption analysis,and eye diagrams on absolute scales for lumped *** the speed limitation is understood and alleviated by single-drive configuration,and comprehensive knowledge into the energy dependence on structural parameters significantly reduces energy *** results show that silicon modulation energy as low as 80.8 and 21.5 fJ∕bit can be achieved at 28 Gbd under 50 and 10 Ω impedance drivers,respectively.A 50 Gbd modulation is also shown to be *** analytical models can be extended to lumped modulators on other material platforms and offer a promising solution to the current challenges of modulation energy reduction.

关键词： length type high

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鸡群发生呼吸道疾病的原因

中国家禽 2002年第7期24卷 33-38页

作者： jurgen Emele 陈鸿军译扬州大学预防兽医系江苏扬州225009

产蛋鸡和肉用鸡中发生的呼吸道疾病会造成可观的经济损失。但许多有效的饲养管理措施却不适用于蛋鸡,或者由于呼吸道疾病的消退期太长,感染鸡群的治疗一直是长期存在的问题。本文对其临床症状、分离方法、预防和治疗进行浅要的阐述。

关键词：病毒性疾病鸡群呼吸道疾病原因

Graphene-based optical phase modulation of waveguide transverse electric modes

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Photonics Research 2014年第3期2卷 S0034-S0040页

作者： Michele Midrio Paola Galli Marco Romagnoli Lionel C.Kimerling jurgen Michel Dipartimento di Ingegneria Elettrica Gestionale e Meccanica Universitàdegli Studi di Udine33100 UdineItaly Bell Labs Alcatel-Lucentvia Trento 3020871 Vimercate(MB)Italy CNIT National Laboratory of Photonic Networks 56124 PisaItaly Massachusetts Institute of Technology 77 Massachusetts Ave.CambridgeMassachusetts 02139USA

In this paper we report TE-mode phase modulation obtained by inducing a capacitive charge on graphene layers embedded in the core of a *** is a biasing regime in which graphene absorption is negligible but large index variations can be achieved with a voltage–length product as small as V_(π)L_(π)≃0.07 V cm for straight waveguides and V_(π)L_(π)≃0.0024 V cm for 12μm radius microring *** phase modulation device uniquely enables a small signal amplitude<1 V with a micrometer-sized footprint for compatibility with CMOS circuit *** of phase-induced changes are computed for straight waveguides and for microring resonators,showing the possibility of implementing several optoelectronic functionalities as modulators,tunable filters,and switches.

关键词： waveguide optoelectronic phase

Generation of Interactive Questionnaires Using YAWL-based Workflow Models

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Management Studies 2015年第6期3卷 273-280页

作者： Raimond Wust Stephan Butikofer jurgen Spielberger Jorg Sigrist Zurich University of Applied Sciences (ZHAW) Winterthur Switzerland AM-TEC Switzerland AG (AM-TEC) Rafz Switzerland

A concept is introduced in this article which has strong practical impact for computer aided system configuration. System configuration is a cumbersome and fault sensitive task while setting up systems in a broad range of business applications like ERP （enterprise resource planning） and other workflow-systems. Given a generic process or workflow model in YAWL-notation （yet another workflow language） or any other process modeling language like business process model and notation or WFMC （workflow management coalition）, it could be stated that, by using a set of reduction rules as introduced, it is possible to generate a hierarchically structured tree of sub graphs of the workflow graph-representation. According to the notation used, authors call these sub graphs facts. The tree structure of the graph-representation on one hand and the logical relation between the branches and leafs of the tree on the other can be utilized to create a set of constraints and dependencies among the single facts. Some researchers showed that the nested branches can be associated to （predefined） questions with respect to the configuration of a workflow management system, for instance an ERP-application. They presented an algorithm which dynamically sorts the questions and answers in a maximum efficient configuration path, while working through the corresponding questionnaire. By combining the different elements as facts, constraints on questions, and configuration space, it is thus possible to algorithmically generate the efficient structured and interactive questionnaire for the configuration of workflow systems and algorithmically check the consistency （dead lock free, free of synchronization structural conflict） of the underlying workflow model. The concept was tested in the prototype of the interactive questionnaire for configuration of the web-service based ERP-Application Posity.

关键词： workflow modeling interactive questionnaire algorithmic process analysis workflow graph reduction formal workflow consistence ERP-system setup system automation

Outcome following incomplete surgical cytoreduction combined with intraperitoneal chemotherapy for colorectal peritoneal metastases

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World Journal of Gastrointestinal Oncology 2015年第12期7卷 445-454页

作者： Roisin Mary Heaney Conor Shields jurgen Mulsow Peritoneal Malignancy Institute Mater Misericordiae University Hospital

Cytoreductive surgery combined with intraperitoneal chemotherapy can improve survival in appropriately selected patients with colorectal peritoneal metastases. Outcomes are best in those patients in whom a complete cytoreduction can be achieved. Unresectabledisease is however encountered in approximately one-quarter of patients at laparotomy. The merits, or otherwise, of proceeding with an incomplete cytoreduction in this setting are unclear. We performed a review of published outcomes following incomplete cytoreduction for colorectal peritoneal metastases. Using the electronic databases, Pub Med and MEDLINE, a systematic search of available literature published during the period January 1997 to September 2014 was conducted. Following application of exclusion criteria, 19 papers were identified and included in this review. These comprised fifteen case series, 3 case control studies and one randomised control trial. In the nineteen studies included in this review, 2790 patients underwent cytoreductive surgery with or without intraperitoneal chemotherapy for peritoneal metastases of colorectal origin. Of these, 1732(62%) underwent a complete cytoreduction while 986(35%) patients underwent an incomplete cytoreduction. Median survival in the complete cytoreduction group ranged from 11 to 62 mo while survival in the latter group ranged from 2.4 to 32 mo. Of the 986 patients with an incomplete cytoreduction, 331 patients received intraperitoneal chemotherapy and survival in this cohort ranged from 4.5 to 32 mo. An incomplete cytoreduction, with or without intraperitoneal chemotherapy, does not appear to confer a survival benefit. The limited available data points to a palliative benefit in a subset of patients. In the absence of high quality data, the decision as to whether or not to proceed with surgery should be made on an individual patient basis.

关键词： Colorectal carcinoma Peritoneal metastases Carcino

Glans ischemia after circumcision in children:Two case reports

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World Journal of Clinical Pediatrics 2021年第4期10卷 79-83页

作者： Daniela Codrich Alessandro Boscarelli Alessia Cerrina Maria-Grazia Scarpa Marianna Iaquinto Damiana Olenik Edoardo Guida jurgen Schleef Department of Pediatric Surgery and Urology Institute for maternal and child health-IRCCS Burlo GarofoloTrieste 34137Italy

Circumcision refers to the removal of the skin covering the tip of the penis and is one of the most common surgical procedures performed in *** though circumcision is a well-standardized operation,several minor and major complications may be experienced by paediatric *** ischemia(GI)has been widely reported in the paediatric literature as a complication following ***,etiopathogenesis of GI is not well defined and management guidelines are *** SUMMARY We describe our experience with this rare and scary complication using subcutaneous enoxaparin alone or in association with a topical *** Hypothetical causes and different management strategies are discussed.

关键词： Circumcision Children Complications Glans penis Ischemia Case report

Post-Translational Derepression of Invertase Activity in Source Leaves via Down-Regulation of Invertase Inhibitor Expression Is Part of the Plant Defense Response

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Molecular Plant 2010年第6期3卷 1037-1048页

作者： Katharina B. Bonfig Andrea Gabler Uwe K. Simon Nora Luschin-Ebengreuth Martina Hatz Susanne Berger Naseem Muhammad jurgen Zeier Alok K. Sinha Thomas Roitsch Julius-von-Sachs-Institut fuer Biowissenschaften Lehrstuhl for Pharmazeutische Biologie Universitaet Wuerzburg Julius-von-Sachs-Platz 2 97082 Wuerzburg Germany Institute of Plant Sciences Department of Plant Physiology University of Graz 8010 Graz Austria Zentrum for rnedizinische Grundlagenforschung (ZMF) Medizinische Universitat Graz Stiftingtalstraβe 24 A-8010 Graz Department of Biology Plant Biology Section University of Fribourg Route Albert Gockel 3 CH-1700 Fribourg Switzerland National Institute for Plant Genome Research Aruna Asaf Ali Road New Delhi 110067 India

There is increasing evidence that pathogens do not only elicit direct defense responses, but also cause pronounced changes in primary carbohydrate metabolism. Cell-wall-bound invertases belong to the key regulators of carbohydrate partitioning and source-sink relations. Whereas studies have focused so far only on the transcriptional induction of invertase genes in response to pathogen infection, the role of post-translational regulation of invertase activity has been neglected and was the focus of the present study. Expression analyses revealed that the high mRNA level of one out of three proteinaceous invertase inhibitors in source leaves of Arabidopsis thaliana is strongly repressed upon infection by a virulent strain of Pseudomonas syringae pv. tomato DC3000. This repression is paralleled by a decrease in invertase inhibitor activity. The physiological role of this regulatory mechanism is revealed by the finding that in situ invertase activity was detectable only upon infection by P. syringae. In contrast, a high invertase activity could be measured in vitro in crude and cell wall extracts prepared from both infected and non-infected leaves. The discrepancy between the in situ and in vitro invertase activity of control leaves and the high in situ invertase activity in infected leaves can be explained by the pathogen-dependent repression of invertase inhibitor expression and a concomitant reduction in invertase inhibitor activity. The functional importance of the release of invertase from post-translational inhibition for the defense response was substantiated by the application of the competitive chemical invertase inhibitor acarbose. Posttranslational inhibition of extracellular invertase activity by infiltration of acarbose in leaves was shown to increase the susceptibility to P. syringae. The impact of invertase inhibition on spatial and temporal dynamics of the repression of photosynthesis and promotion of bacterial growth during pathogen infection supports a

关键词： Acarbose Arabidopsis defense responses invertase inhibitor protein invertase plant-microbe interactions Pseudomonas syringae.

β1/β2肾上腺素能受体基因缺失对肾脏球旁器颗粒细胞肾素分泌的影响

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中华肾脏病杂志 2007年第11期23卷 722-727页

作者：陈丽萌黄宇宁 jurgen Schnermann 中国医学科学院北京协和医院肾内科北京100730 美国国立卫生研究院

目的观察β肾上腺素能受体对肾脏球旁器颗粒（JG）细胞肾素分泌的调节作用。方法密度梯度离心原代分离野生型和131／132肾上腺素受体基因敲除小鼠肾小球球旁器（JGA）颗粒细胞（JGC）。实时PCR明确JG细胞上存在β1/β2肾上腺素能受体基... 详细信息

目的观察β肾上腺素能受体对肾脏球旁器颗粒（JG）细胞肾素分泌的调节作用。方法密度梯度离心原代分离野生型和131／132肾上腺素受体基因敲除小鼠肾小球球旁器（JGA）颗粒细胞（JGC）。实时PCR明确JG细胞上存在β1/β2肾上腺素能受体基因表达。激光共聚焦显微镜下动态观察喹林和LysoTracker-Red染色条件下异丙肾上腺素促使JG活细胞分泌肾素的动态过程。尾静脉取血，用放射免疫方法测定清醒状态野生型和β1/β2肾上腺素能受体基因敲除小鼠基础肾素水平。不同浓度前列腺素E2（PGE2）、异丙肾上腺素和福斯高林刺激野生型和β1/β2肾上腺素能受体基因缺失小鼠JG细胞，放免法测定细胞内和上清中肾素活性。实时PCR测定肾皮质及JG细胞中肾素mRNA水平，以及不同浓度福斯高林对JG细胞内cAMP浓度的影响。结果成功分离的JG细胞上存在13肾上腺素能受体基因表达。激光共聚焦显微镜能观察到异丙肾上腺素明显刺激JG细胞分泌包含肾素的酸性颗粒。β1/β2肾上腺素能受体基因敲除小鼠血浆基础肾素降低，与肾脏皮质肾素mRNA降低平行。原代培养的β1/β2肾上腺素能受体基因敲除小鼠的JG细胞，肾素产生和分泌都明显降低，肾素mRNA也降低。PGE2、异丙肾上腺素和福斯高林呈剂量依赖性增加野生型小鼠JG细胞肾素转录、合成和分泌。β1/β2肾上腺素能受体基因敲除小鼠JG细胞对13肾上腺素能受体激动剂没有反应，而大剂量福斯高林能刺激其肾素分泌。福斯高林呈剂量依赖性上调JG细胞内cAMP水平。结论JG细胞上存在的肾上腺素能β受体，通过上调JG细胞内cAMP，促使JG细胞合成和分泌肾素。

关键词：受体肾上腺素能β 肾素肾小球旁器颗粒细胞