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Advances in 3D printing scaffolds for peripheral nerve and spinal cord injury repair

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International Journal of Extreme Manufacturing 2023年第3期5卷 264-300页

作者： juqing song Baiheng Lv Wencong Chen Peng Ding Yong He School of Mechanical Engineering Dongguan University of TechnologyDongguan 523808People’s Republic of China China Nuclear Power Technology Research Institute Co. LtdShenzhen 518000People’sRepublicof China School of Mechanical Engineering Zhejiang UniversityHangzhou310058People’s Republic of China

Because of the complex nerve anatomy and limited regeneration ability of natural tissue,the current treatment effect for long-distance peripheral nerve regeneration and spinal cord injury(SCI)repair is not *** an alternative method,tissue engineering is a promising method to regenerate peripheral nerve and spinal cord,and can provide structures and functions similar to natural tissues through scaffold materials and seed ***,the rapid development of 3D printing technology enables researchers to create novel 3D constructs with sophisticated structures and diverse functions to achieve high bionics of structures and *** this review,we first outlined the anatomy of peripheral nerve and spinal cord,as well as the current treatment strategies for the peripheral nerve injury and SCI in *** that,the design considerations of peripheral nerve and spinal cord tissue engineering were discussed,and various 3D printing technologies applicable to neural tissue engineering were elaborated,including inkjet,extrusion-based,stereolithography,projection-based,and emerging printing ***,we focused on the application of 3D printing technology in peripheral nerve regeneration and spinal cord repair,as well as the challenges and prospects in this research field.

关键词： peripheral nerve regeneration spinal cord repair 3D printing construct bionic structure bionic function

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骨膜组织工程的研究进展

中国材料进展 2016年第6期35卷 461-465页

作者：宋菊青施雪涛王迎军华南理工大学国家人体组织功能重建与修复中心广州广东510641 华南理工大学材料科学与工程学院广州广东510641

一直以来,由创伤、肿瘤切除和先天畸形引起的临界性骨缺损的临床治疗都存在极大的挑战,包括自体骨移植在内的传统骨缺损治疗方法,由于供体不足和免疫排斥反应等问题,已经不足以满足临床需求。而组织工程的发展改变了骨修复的传统治疗模... 详细信息

一直以来,由创伤、肿瘤切除和先天畸形引起的临界性骨缺损的临床治疗都存在极大的挑战,包括自体骨移植在内的传统骨缺损治疗方法,由于供体不足和免疫排斥反应等问题,已经不足以满足临床需求。而组织工程的发展改变了骨修复的传统治疗模式,基于人工和天然生物材料的各种组织工程复合支架被用于修复受损骨。与此同时,也有越来越多的学者认识到骨膜在骨缺损修复中的重要作用,尤其是组织工程支架的整合性和血管化。除了自体或异体骨膜移植,研究者将组织工程的理念融入到骨膜修复中,从结构和功能上模拟天然骨膜。从组织工程骨膜的不同设计理念出发,简单回顾了4类组织工程骨膜的研究进展,包括结构仿生型、微观结构仿生型、血管化型和外力刺激型,这些将为骨组织工程构建和骨膜深入研究提供理论基础并开启新的思路和方法。

关键词：骨缺损治疗骨膜组织工程微图案化血管化

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参数化流动传热问题的模型降阶方法研究

原子能科学技术 2024年第7期58卷 1440-1451页

作者：杨迪段承杰丁鹏宋菊青宋子凡张纯禹中山大学中法核工程与技术学院广东珠海519082 中广核研究院有限公司广东深圳518028 东莞理工学院机械学院广东东莞523808

高精度的数值模型是构建反应堆堆芯数字孪生的基础,但传统的高分辨率数值模型的计算效率无法满足数字孪生的需求。为显著提高计算效率,综合利用伽辽金投影法和径向基函数插值法构造了参数化流动传热问题的降阶模型。该模型以典型的数值... 详细信息

高精度的数值模型是构建反应堆堆芯数字孪生的基础,但传统的高分辨率数值模型的计算效率无法满足数字孪生的需求。为显著提高计算效率,综合利用伽辽金投影法和径向基函数插值法构造了参数化流动传热问题的降阶模型。该模型以典型的数值解作为学习样本,通过本征正交分解获得各物理场分布的主模态作为缩减基,然后将控制方程在缩减基张成的空间上进行投影以获得自由度个数显著降低的降阶模型。螺旋十字型燃料冷却剂的测试算例表明,相较于全阶模型,该降阶模型可实现高达3~4个数量级的加速效果,降阶模型的速度场与压力场的相对误差均小于10%。

关键词：流动传热降阶模型本征正交分解径向基函数插值

老年永久性肠造口患者居家自我护理问题的质性研究

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老年医学与保健 2019年第2期25卷 227-229,246页

作者：宋巨庆戴爱兰陈凌蔡海燕上海市虹口区四川北路街道社区卫生服务中心上海200080

目的探索老年永久性肠造口患者在居家自我护理过程中存在的问题,为其他患者转归社区后的疾病自我管理与肠造口健康教育提供借鉴。方法采用质性研究中的现象学研究方法,用目的抽样法选取10例老年永久性肠造口患者,采用半结构式访谈法收... 详细信息

目的探索老年永久性肠造口患者在居家自我护理过程中存在的问题,为其他患者转归社区后的疾病自我管理与肠造口健康教育提供借鉴。方法采用质性研究中的现象学研究方法,用目的抽样法选取10例老年永久性肠造口患者,采用半结构式访谈法收集资料,Colaizzi内容分析法分析资料并形成主题。结果老年永久性肠造口患者在居家自我护理过程中主要存在以下5个方面的问题,即并发症处理问题、心理问题、造口用物问题、睡眠问题与饮食问题。结论为了提高老年肠造口患者转归社区后的居家自我护理能力,应当在全面了解老年肠造口患者居家自我护理问题的基础上,加强针对性的健康宣教,争取更广泛的社会支持资源,进而帮助老年肠造口患者提升自我护理能力,提高生活质量。

关键词：老年肠造口自我护理质性研究

Hyperspectral imaging for one-step growth simulation of Brochothrix thermosphacta in chilled beef during storage

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Food Science and Human Wellness 2024年

作者： Xiaohua Liu Binjing Zhou Jin song Kang Tu Jing Peng Weijie Lan Jing Xu Jie Wu juqing Wu Leiqing Pan College of Food Science and Technology， Nanjing Agricultural University College of Artificial Intelligence， Nanjing Agricultural University School of Food and Biological Engineering， Bengbu University

In this work， one-step growth models using hyperspectral imaging (HSI) (400–1 000) nm were successfully developed in order to estimate the microbial loads， minimum growth temperature (Tmin) and maximum specific growth rate (μmax) of Brochothrix thermosphacta in chilled beef at isothermal temperatures (4–25) ℃. Three different methods were compared for model development， particularly using (Model I) the predicted microbial loads from partial least squares regression of the whole spectral variables; (Model II) the selected spectral variables related to microbial loads; and (Model III) the first principal scores of HSI spectra by principal component analysis. Consequently， Model I showed the best ability to predict the microbial loads of B. thermosphacta， with the coefficient of determination (Rv2) and root mean square error in internal validation (RMSEV) of 0.921 and 0.498 (lg (CFU/g)). The Tmin(–12.32 ℃) and μmaxcan be well estimated with R2and RMSE of 0.971 and 0.276 (lg (CFU/g))， respectively. The upward trend of μmaxwith temperature was similar to that of the plate count method. HSI technique thus can be used as a simple method for one-step growth simulation of B. thermosphacta in chilled beef during storage.

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Simultaneous sludge reduction and nutrient removal(SSRNR) with interaction between Tubificidae and microorganisms: A full-scale study

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Simultaneous sludge reduction and nutrient removal(SSRNR) wi...

Inhibition of free ammonia to the granule-based enhanced biological phosphorus removal system and the recoverability

浙江省环境科学学会2014年学术年会

作者： juqing Lou Peide Sun Maoxin Guo Ge Wu Yingqi song School of Environmental Science and Engineering Zhejiang Gongshang University

A symbiotic ecosystem between Tubificidae and microorganisms was established at a full-scale wastewater treatment plant(WWTP). In this ecosystem Tubificidae were inoculated, and then adhered to the outer layers of carrier materials in an oxidation tank. During the long-term treatment of sewage volumes of 20,000 m3dà1, the excess sludge production rate was reduced from 0.21 to 0.051 kg mà3and sludge settleability was significantly improved. When the influent concentrations of COD, NH+4–N, POà4–P,and SS were in the ranges of 130.0–459.0 mg Là1, 14.2–27.5 mg Là1, 1.6–7.0 mg Là1, and 60.0–466.0 mg Là1, respectively, the COD and SS removal efficiency was increased by 8.7% and 13.6% within the symbiotic system compared to the control without Tubificidae. In addition, NH+4–N and phosphorus removal efficiency can also be improved. The results showed that both sludge reduction and nutrient removal were enhanced simultaneously significantly within the system utilizing the symbiotic interactions of Tubificidae and microorganisms.

关键词： Simultaneous sludge reduction and nutrient removal(SSRNR) Symbiotic system Tubificidae Full-scale study WWTP

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Inhibition of free ammonia to the granule-based enhanced bio...

The long-term effect of nitrite on the granule-based enhanced biological phosphorus removal system and the reversibility

浙江省环境科学学会2014年学术年会

作者： Xiongliu Zheng Peide Sun juqing Lou Jing Cai Yingqi song Shenjing Yu Xuanyu Lu School of Environmental Science and Engineering Zhejiang Gongshang University

The inhibition of free ammonia(FA) to the granule-based enhanced biological phosphorus removal(EBPR) system and the recoverability from macro- to micro-scale were investigated in this study. FA was found to seriously deteriorate the EBPR performance and sludge characteristic(settleability and morphology). The FA inhibitory threshold of 17.76 mg N L 1was established. Acclimation phenomenon took place when poly-phosphate accumulating organisms(PAOs) were exposed for long time to constant FA concentration(8.88 mg N L 1). The repressed polysaccharides excretion could lead to breaking the stability and integrity of the granules. Therefore, the reduced particle size and granule disintegration were observed. The molecular analysis revealed that FA had a significant influence on the microbial communities and FA inhibition may provide a competitive advantage to glycogen accumulating organisms(GAOs) over PAOs. Interestingly, the community composition was found irreversible by recovery(Dice coefficients, 36.3%), although good EBPR performance was re-achieved.

关键词： Free ammonia Granule-based enhanced biological phosphorus removal system Microbial activity Microbial community structure Recoverability

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The long-term effect of nitrite on the granule-based enhance...

“水蚯蚓-微生物共生系统”细观机理模型(T-FCASM)建立及校验

浙江省环境科学学会2014年学术年会

作者： Xiongliu Zheng Peide Sun juqing Lou Zhiguo Fang Maoxin Guo Yingqi song Xiudi Tang Tao Jiang School of Environmental Science and Engineering Zhejiang Gongshang University Zhejiang Provincial Key Laboratory of Solid Waste Treatment and Recycling

This study investigated the long-term effect of nitrite on the granule-based enhanced biological phosphorus removal(EBPR) system and the reversibility from macro- to micro-scale. Nitrite was found to seriously deteriorate the EBPR performance and result in severe sludge bulking. The inhibited polysaccharides excretion could lead to breaking the stability and integrity of the granules. Therefore,the reduced particle size and granule disintegration were observed. In this study, granules with lower ratio of proteins to polysaccharides(1.76) had better structure and function than the higher(3.84). Experimental results demonstrated that the microbial community structure was largely changed due to the presence of nitrite. In comparison, glycogen accumulating organisms(GAOs) had stronger resistibility and higher recovery rate than poly-phosphate accumulating organisms(PAOs). Interestingly, the community composition was unable to recover(Dice coefficients, 33.0%), although good EBPR performance was achieved only by propagating other types of PAOs.

关键词： Granule-based enhanced biological phosphorus removal system Nitrite Extracellular polymeric substances Microbial community structure Reversibility

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环境科学学报 2009年第12期29卷 2492-2503页

作者：孙培德吴革郭茂新王如意宋英琦楼菊青浙江工商大学环境科学与工程学院杭州310012

基于浙江省诸暨市菲达宏宇污水处理厂新型氧化沟工艺的现场长期观察和试验研究,提出"水蚯蚓-微生物共生系统"的新技术原理,获得了"水蚯蚓-微生物共生系统"中污染物输入量与输出量随时间的动态变化规律,并建立了水蚯蚓作用的传递函数,从... 详细信息

基于浙江省诸暨市菲达宏宇污水处理厂新型氧化沟工艺的现场长期观察和试验研究,提出"水蚯蚓-微生物共生系统"的新技术原理,获得了"水蚯蚓-微生物共生系统"中污染物输入量与输出量随时间的动态变化规律,并建立了水蚯蚓作用的传递函数,从而实现水蚯蚓在污水处理和污泥降解过程中对污染物去除作用的模拟.以全耦合活性污泥模型(FCASM3)为基础平台,结合水蚯蚓作用的传递函数,最终建立了污水厂"水蚯蚓-微生物共生系统"细观机理模型(T-FCASM).利用对该污水处理厂常规水质指标测定和进水模型组分分析等试验结果,完成了对"水蚯蚓-微生物共生系统"细观机理模型(T-FCASM)的校验工作.动态模拟结果表明:T-FCASM实现了对回流污泥浓度的准确模拟;同时该模型能够对污水处理厂生物去除有机物及脱氮过程进行较准确的模拟,而对生物除磷过程的模拟,由于该污水处理厂低磷进水的原因,与实测值存在一定的偏差.

关键词：水蚯蚓-微生物共生系统传递函数细观机理模型污水处理厂现场校验污泥减量