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Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

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Neural Regeneration Research 2025年第10期20卷 2838-2854页

作者： Lu Guan Mengting Qiu Na Li Zhengxiang Zhou Ru Ye Liyan Zhong Yashuang Xu Junhui Ren Yi Liang Xiaomei Shao Jianqiao Fang Junfan Fang junying du Department of Neurobiology and Acupuncture Research Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Key Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Fuchun Community Health Service Center of Fuyang District HangzhouZhejiang ProvinceChina

Pain is often comorbid with emotional disorders such as anxiety and *** of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid *** review primarily aims to outline the main circuitry(including the input and output connectivity)of the anterior cingulate cortex and classification and functions of different gamma-aminobutyric acidergic neurons;it also describes the neurotransmitters/neuromodulators affecting these neurons,their intercommunication with other neurons,and their importance in mental comorbidities associated with chronic pain *** understanding on their role in pain-related mental comorbidities may facilitate the development of more effective treatments for these ***,the mechanisms that regulate gamma-aminobutyric acidergic systems remain *** is also unclear as to whether the mechanisms are presynaptic or *** exploration of the complexities of this system may reveal new pathways for research and drug development.

关键词： anterior cingulate cortex anxiety chronic pain circuit communication comorbidity depression gamma-aminobutyric acidergic neurons parvalbumin neurons synaptic transmission

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Electroacupuncture Alleviates Anxiety-like Behavior in Pain Aversion Rats by Attenuating the Expression of Neuropeptide Y in Anterior Cingulate Cortex

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Clinical Complementary Medicine and Pharmacology 2022年第2期2卷 10-18页

作者： Fangbing Shao junying du Sisi Wang Rok Cerne Junfan Fang Xiaomei Shao Xiaoming Jin Jianqiao Fang Department of Neurobiology and Acupuncture Research the Third School of Clinical MedicineZhejiang Chinese Medical University.Hangzhou 310053ZhejiangChina Indiana Spinal Cord and Brain Injury Research Group Stark Neuroscience Research Institute&Department of AnatomyCell Biology and PhysiologyIndiana University School of MedicineIndianapolis 46202IndianaUSA

Background:Pain is considered as a multidimensional conscious experience that includes a sensory component and a negative affective-motivational ***(EA)is widely used to treat pain and paininduced negative emotions,however,little is known about the mechanisms underlying the effect of ***:This study investigated the effect of EA on alleviating the anxiety-like behaviors in pain aversion rats and its anterior cingulate cortex(ACC)regulation ***:After a Freund’s complete adjuvant(CFA)-conditioned place aversion(C-CPA)model was established in rats,EA treatment(2/100 Hz,30 min,once/day,4 days totally)was applied at bilateral Zusanli(ST36)and Kunlun(BL60)*** Frey filaments were used to measure changes of pain withdrawal threshold(PWT)at indicated time *** zero maze(EZM)was used to investigate the changes of pain-related anxiety and CPA was used to investigate the changes of pain *** protein expression levels of GAD67,PV,and NPY in ACC were detected by Western ***:Compared with the control group,the staying time in the"CFA-paired compartment"was significantly reduced,and the PWT was decreased in model *** the EZM assessment,the distance and the time in open arm,as well as the number of open arm entries of model group were significantly lower than those in the control *** the CPA assessment,the time spent in the"CFA-paired compartment"was significantly decreased in model group compared with control group,and EA reversed the changes in pain sensation and in pain-related *** blotting showed that the NPY level,but not the levels of GAD67 and PV,was significantly increased in the ACC of the model group compared to that of the control *** increased expression of NPY in the ACC was significantly downregulated by EA,while sham EA produced no such ***:EA can effectively relieve the pain and pain-related emotions,and its mechanism may be achieved by

关键词： Electroacupuncture Chronic pain Anterior cingulate cortex Aversion Anxiety Neuropeptide Y

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上海社会力量参与社区教育的现状及对策

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职业技术教育 2017年第33期38卷 62-66页

作者：李珺杜君英上海市教育科学研究院职业教育与成人教育研究所上海行健职业学院

建设服务型政府的背景下,国家鼓励社会力量参与社会公共事业。社区教育作为一项社会公共事业,其壮大与发展仅靠政府的力量远远不够,需要吸纳各种社会力量广泛参与,不断提高公共产品供给的质量和效率,满足人们多元化的、更高层次的学习... 详细信息

建设服务型政府的背景下,国家鼓励社会力量参与社会公共事业。社区教育作为一项社会公共事业,其壮大与发展仅靠政府的力量远远不够,需要吸纳各种社会力量广泛参与,不断提高公共产品供给的质量和效率,满足人们多元化的、更高层次的学习需求。在相关政策的大力倡导和推动下,上海社会力量参与社区教育实践无论从数量、方式、类型、途径方面都有了初步成效,但从目前总体情况来看,还存在着社会力量参与程度不均衡,参与积极性不高等诸多问题,需要政策上的支持、机制上的突破以及制度上的进一步明确。

关键词：社会力量终身教育上海社区教育

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媒体融合背景下短视频新闻发展的机遇与挑战

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卫星电视与宽带多媒体 2020年第9期 105-107页

作者：杜俊颖衡水日报社河北衡水053000

伴随新媒体发展与传播技术进步,媒体融合现已成为媒体领域发展的主流态势,为新闻信息传播塑造了崭新的舞台。同时,媒体融合的持续演进与受众群体习惯的变化,短视频精简的模式更能顺应受众消费习惯,而短视频的诞生为新闻联播发展带来无... 详细信息

伴随新媒体发展与传播技术进步,媒体融合现已成为媒体领域发展的主流态势,为新闻信息传播塑造了崭新的舞台。同时,媒体融合的持续演进与受众群体习惯的变化,短视频精简的模式更能顺应受众消费习惯,而短视频的诞生为新闻联播发展带来无限可能。本研究阐述了媒体融合背景下短视频新闻发展迎来的机遇,分析了媒体融合背景下短视频新闻发展面临的挑战,并提出媒体融合背景下短视频新闻发展的有效路径。

关键词：媒体融合短视频新闻挑战机遇

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成人学习动机的培养和激发

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西北成人教育学院学报 2003年第4期 15-18页

作者：杜君英华东师范大学职业教育与成人教育研究所上海200062

本文基于成人学习活动中重要性的客观事实,提出了五点相应的培养与激发的措施。同时,又注意到在实际的培养与激发活动中,须把握动机激起的“度”,恰当控制动机激起水平,避免走向极端,适得其反。

关键词：成人学习动机培养激发

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社区教育课程现状分析

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陕西师范大学继续教育学报 2006年第3期23卷 24-25,29页

作者：杜君英上海行健职业学院助教上海200072

从地域和学习者维度分析，现有的社区教育课程呈现趋同化倾向，缺少独特性；适应老年群体的课程较多，适应中青年群体的课程偏少。

关键词：社区教育课程浦东新区

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The Activation Mode of Spinal Cord Dorsal Horn TRPV1 at Maintenanceof SNI-Induced Neuropathic Pain and The Effect of Electroacupuncture with Low Frequency

The Activation Mode of Spinal Cord Dorsal Horn TRPV1 at Main...

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2016中国中西医结合麻醉学会[CSIA]年会暨第三届全国中西医结合麻醉学术研讨会、河南省中西医结合学会麻醉专业委员会成立大会

作者： Yan Sisi Jiang Yongliang Ye Jiayu He Xiaofen du junying Chen Lifang Chen Xiaojun Zhao Wensheng Fang Jianqiao The Third Clinical Medical College Zhejiang Chinese Medical University

[Objective]To investigate the activation modes of spinal cord dorsal horn(SCDH)transient receptor potential vanilloid type1(TRPV1) at maintenance period of neuropathic pain and the effect of electroacupuncture(EA) with low frequency.[Methods]SD rats were randomly divided into Normal,Sham spared nerve injury(SNI),SNI and SNI + EA groups,8 animals per *** neuropathic pain model was established with SNI.2Hz EA was administered at ipsilateral points Zusanli(ST36) and Kunlun(BL60)once every day for consecutive 14 *** withdrawal threshold(PWT)was tested to determine mechanical *** levels of TRPV1,p-TRPV1 and protein kinase C(PKC) in ipsilateral(SCDH)were tested by western ***1 and PKC expressions were measured by immunofluorescence.[Results]Rats in SNI group developed spontaneous pain at maintenance period of neuropathic pain and showed a significant reduction in PWT(P0.05).Rats in sham SNI group had no obvious changes.2Hz EA up-regulated SNI rats PWT(PO.01),reduced ipsilateral(SCDH) TRPVl level and PKC level.[Conclusion]SCDH TRPVl activation is mainly through its enhancement of *** with low frequency could alleviate neuropathic pain during the maintenance period,which may be related to the down-regulation of TRPVl signal transduction pathway which mediated by PKC.

关键词： Neuropathic pain Electroacupuncture TRPVl p-TRPV1 PKC

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Map activation of various brain regions using different frequencies of electroacupuncture ST36,utilizing the FosCreER strategy

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Acupuncture and Herbal Medicine 2024年第3期4卷 386-398页

作者： Zi Guo Naixuan Wei Ru Ye Tiancheng Sun Shuang Qiu Xiaomei Shao Xiaochang Ge Lu Guan Junfan Fang Jianqiao Fang junying du Department of Neurobiology and Acupuncture Research The Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouChina Key Laboratory of Acupuncture and Neurology of Zhejiang Province Zhejiang Chinese Medical UniversityHangzhouChina Key Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases Zhejiang Chinese Medical UniversityHangzhouChina Departments of Neurobiology and Anesthesiology of Second Affiliated Hospital Zhejiang University School of MedicineHangzhouChina

Objective:Electroacupuncture(EA)is an alternative treatment option for *** frequencies of EA have different painrelieving effects;however,the central mechanism is still not well ***:The Fos2A-iCreER(TRAP):Ai9 mice were divided into three groups(sham,2 Hz,and 100 Hz).The mice were intraperitoneally injected with 4-hydroxytamoxifen(4-OHT)immediately after EA at Zusanli(ST36)for 30 min to record the activated *** week later,the mice were sacrificed,and the number of TRAP-treated neurons activated by EA in the thalamus,amygdala,cortex,and hypothalamus was ***:In the cortex,2 Hz EA activated more TRAP-treated neurons than 100 Hz EA did in the cingulate cortex area 1(Cg1)and primary somatosensory cortex(S1),and 2 and 100 Hz EAs did not differ from sham ***-treated neurons activated by 2 Hz EA were upregulated in the insular cortex(IC)and secondary somatosensory cortex(S2)compared with those activated by 100 Hz and sham *** the thalamus,the number of TRAP-treated neurons activated by 2 Hz EA was elevated in the paraventricular thalamic nucleus(PV)compared with those activated by sham *** the ventrolateral thalamic nucleus(VL),the number of TRAPtreated neurons activated by 2 Hz EA was significantly upregulated compared with those activated by 100 Hz EA,and sham EA showed no difference compared with 2 or 100 Hz ***-treated neurons were more frequently activated in the ventral posterolateral thalamic nucleus(VPL)by 2 Hz EA than by 100 Hz or sham ***:Low-frequency EA ST36 effectively activates neurons in the Cg1,S1,S2,IC,VPL,PV,and *** enhanced excitability of the aforementioned nuclei induced by low-frequency EA may be related to its superior efficacy in the treatment of neuropathological pain.

关键词： Amygdala Cortex EA-TRAPed neurons Electroacupuncture Frequency Hypothalamus Thalamus

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Effect of electroacupuncture on expression of GABAA receptor mRNA in different brain regions in rats with chronic inflammatory pain

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China Medical Abstracts(Internal Medicine) 2020年第2期37卷 66-66页

作者： du junying 3rd Coll Clin Med Zhejiang Chin Med UnivHangzhou 310053

Objective To observe the expression of GABA_A receptor mRNA in different brain regions of the central nervous system in chronic inflammatory pain rats and the intervention effect of electroacupuncture (EA).Methods A total of 48 SPF male SD rats were randomly divided into a blank control group,a model control group,an EA group and a sham EA group,12 rats in each *** model of chronic inflammatory pain was established by injecting Freund’s complete adjuvant into their feet.

关键词： pain rats electroacupuncture

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让音乐成为中学作文教学的媒介

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厦门教育学院学报 2011年第2期13卷 74-77页

作者：杜俊英厦门集美上塘中学福建厦门361023

在急功近利思想的主导下,中学作文教与学显得心浮气躁,学生的想象力、创造力受到严重的挫伤。在音乐中捕捉灵感,在音乐中陶冶情操,作文课应积极把握这一特点,让优美的旋律流注课堂,让音乐欣赏成为作文教学的媒介,让作文教学绽放绚丽的... 详细信息

在急功近利思想的主导下,中学作文教与学显得心浮气躁,学生的想象力、创造力受到严重的挫伤。在音乐中捕捉灵感,在音乐中陶冶情操,作文课应积极把握这一特点,让优美的旋律流注课堂,让音乐欣赏成为作文教学的媒介,让作文教学绽放绚丽的光彩。

关键词：中学语文作文音乐

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