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Fish scale-derived scaffolds with MSCs loading for photothermal therapy of bone defect

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Nano Research 2023年第5期16卷 7383-7392页

作者： Siyu Shen Rui Liu Chuanhui Song Tao Shen Yiwen Zhou junxia guo Bin Kong Qing Jiang State Key Laboratory of Pharmaceutical Biotechnology Division of Sports Medicine and Adult Reconstructive SurgeryDepartment of Orthopedic SurgeryNanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China Branch of National Clinical Research Center for Orthopedics Sports Medicine and RehabilitationNanjing 210008China The Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing 210008China Department of Orthodontics Nanjing Stomatological HospitalMedical School of Nanjing UniversityNanjing 210008China Department of Sports Medicine and Adult Reconstructive Surgery Nanjing Drum Tower HospitalClinical College of Nanjing Medical UniversityNanjing 210008China Department of Biomedical Engineering School of MedicineShenzhen UniversityShenzhen 518060China

Tissue engineering scaffolds have presented effective value in bone repair.However,the integration of the diverse components,complex structures,multifunction to impart the scaffolds with improved applicability is still a challenge.Here,we propose a novel fish-derived scaffold combined with photothermal therapy and mesenchymal stem cells(MSCs)to promote bone regeneration.The fish-derived scaffold is composed of the decellularized fish scale and gelatin methacrylate synthesized from fish gelatin(fGelMA),which can promote the proliferation and osteogenesis of MSCs with no obvious immunological rejection.Furthermore,the black phosphorus(BP)nanosheets are incorporated into the fGelMA hydrogel network,which can endow the hydrogel with the capacity of photothermal conversion stimulated by near-infrared(NIR)light.The fish-derived scaffold can promote the osteogenesis process of MSCs with higher expression of osteogenic markers and higher mineralization assisted by the NIR light in vitro.The regeneration of mice calvarial defect has also been accelerated by the scaffold with photothermal therapy and MSCs.These results suggest that the fish-derived scaffold,photothermal therapy,MSCs-based regenerative therapy is a promising clinical strategy in bone regeneration.

关键词： fish scale GelMA photothermal therapy mesenchymal stem cell bone regeneration

Flexible, Porous, and Metal–Heteroatom?Doped Carbon Nanofibers as Efficient ORR Electrocatalysts for Zn–Air Battery

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Nano-Micro Letters 2019年第1期11卷 147-163页

作者： Qijian Niu Binling Chen junxia guo Jun Nie Xindong guo Guiping Ma Key Laboratory of carbon Fiber and Functional Polymers Ministry of Education Beijing University of Chemical Technology State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology College of Engineering Mathematics and Physical Sciences University of Exeter

Developing an e cient and durable oxygen reduction electrocatalyst is critical for clean-energy technology, such as fuel cells and metal–air batteries. In this study, we developed a facile strategy for the preparation of flexible, porous, and well-dispersed metal–heteroatom-doped carbon nanofibers by direct carbonization of electrospun Zn/Co-ZIFs/PAN nanofibers(Zn/Co-ZIFs/PAN). The obtained Zn/Co and N co-doped porous carbon nanofibers carbonized at 800 °C(Zn/Co–N@PCNFs-800) presented a good flexibility, a continuous porous structure, and a superior oxygen reduction reaction(ORR) catalytic activity to that of commercial 20 wt% Pt/C, in terms of its onset potential(0.98 V vs. RHE), half-wave potential(0.89 V vs. RHE), and limiting current density(-5.26 mA cm^(-2)). In addition, we tested the suitability and durability of Zn/Co–N@PCNFs-800 as the oxygen cathode for a rechargeable Zn–air battery. The prepared Zn–air batteries exhibited a higher power density(83.5 mW cm^(-2)), a higher specific capacity(640.3 mAh g^(-1)), an excellent reversibility, and a better cycling life than the commercial 20 wt% Pt/C + RuO_2 catalysts. This design strategy of flexible porous non-precious metal-doped ORR electrocatalysts obtained from electrospun ZIFs/polymer nanofibers could be extended to fabricate other novel, stable, and easy-to-use multi-functional electrocatalysts for clean-energy technology.

关键词： Electrospinning Zn/Co-ZIFs Carbon nanofibers Flexible porous structure ORR Zn–air battery

Behavior Model Construction for Client Side of Modern Web Applications

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Tsinghua Science and Technology 2021年第1期26卷 112-134页

作者： Weiwei Wang junxia guo Zheng Li Ruilian Zhao the College of Information Science and Technology Beijing University of Chemical TechnologyBeijing 100029China

Most of the behavior models with respect to Web applications focus on sequencing of events,without regard for the changes of parameters or elements and the relationship between trigger conditions of events and Web pages.As a result,these models are not sufficient to effectively represent the dynamic behavior of the Web2.0 application.Therefore,in this paper,to appropriately describe the dynamic behavior of the client side of Web applications,we define a novel Client-side Behavior Model(CBM)for Web applications and present a user behavior trace-based modeling method to automatically generate and optimize CBMs.To verify the effectiveness of our method,we conduct a series of experiments on six Web applications according to three types of user behavior traces.The experimental results show that our modeling method can construct CBMs automatically and effectively,and the CBMs built are more precise to represent the dynamic behavior of Web applications.

关键词： web applications client-side behavior model user behavior trace

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低秩张量填充的循环算法

工程数学学报 2024年第1期41卷 111-126页

作者：王俊霞郭雄伟王川龙太原师范学院数学与统计学院晋中030619 智能优化计算与区块链技术山西省重点实验室晋中030619 北京交通大学数学与统计学院北京100044

针对张量填充问题,提出一种低秩张量填充的循环算法。以交替方向乘子法为基础,对子问题循环更新,有效地减少了算法在迭代过程中张量展开、矩阵折叠以及奇异值分解的计算花费。同时,在合理的假设条件下,给出了算法的收敛性分析。最后,通... 详细信息

针对张量填充问题,提出一种低秩张量填充的循环算法。以交替方向乘子法为基础,对子问题循环更新,有效地减少了算法在迭代过程中张量展开、矩阵折叠以及奇异值分解的计算花费。同时,在合理的假设条件下,给出了算法的收敛性分析。最后,通过数值实验与HaLRTC算法、DR-TR算法及LRTC-Logdet算法的对比,验证了算法相对其它方法的有效性。

关键词：张量填充循环更新交替方向乘子法

环指蛋白213基因变异与血管相关疾病关系的研究进展

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中国脑血管病杂志 2024年第5期21卷 341-348页

作者：曹芳刘珺宇郭雨欣严俊霞中南大学湘雅公共卫生学院流行病与卫生统计学系长沙410013

环指蛋白213(RNF213)为烟雾病的易感基因,也与颅内动脉闭塞或狭窄、缺血性卒中、颅内动脉瘤、脑动静脉畸形等多种血管相关疾病有关。作者对RNF213基因变异与血管相关疾病的关系及其可能的机制进行综述,以期为该类疾病的预防、诊断和治... 详细信息

环指蛋白213(RNF213)为烟雾病的易感基因,也与颅内动脉闭塞或狭窄、缺血性卒中、颅内动脉瘤、脑动静脉畸形等多种血管相关疾病有关。作者对RNF213基因变异与血管相关疾病的关系及其可能的机制进行综述,以期为该类疾病的预防、诊断和治疗提供参考。

关键词：环指蛋白213基因血管疾病综述

Investigation on the Tribology of Co Implanted Stainless Steel Using Metal Vapor Vacuum Arc Ion Source

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Journal of Materials Science & Technology 2004年第3期20卷 265-268页

作者： junxia guo Xun CAI Qiulong CHEN Key Lab for High Temperature Materials and Testing, Shanghai Jiao Tong University, Shanghai 200030, China Lab. for High Temp. Mat. and Testing Shanghai Jiaotong Univ. Shanghai 200030 China

AISI 304 stainless steel was ion implanted with Co, and the tribological property on the surface of the stainless steelwas investigated. The Co ion implantation was carried out using a metal vapor vacuum arc (Mevva) broad-beam ionsource with an extraction voltage of 40 kV, implantation doses of 3×10^(17)/cm^2 and 5×10^(17)/cm^2, and ion currentdensities of 13, 22 and 32μA/cm^2. The results showed that the near-surface hardness of Co-implanted stainless steelsample was increased by 50% or more, and it increased with increasing ion current density at first and then declined.The friction coefficient decreased from 0.74 to 0.20 after Co implantation. The wear rate after Co implantationreduced by 25% or more as compared to the unimplanted sample. The wear rate initially decreased with increasingion current density and then an increase was observed. Within the range of experimental parameters, there existsa critical ion current density for the Co-implanted stainless steel, at which the wear rate decreased with increasingretained dose, going through a minimum and then increased. The critical ion current density in this paper is about22μA/cm^2.

关键词： Tribology Metal vapor vacuum arc Cobalt Implanted stainless steel

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基于VMD和排列熵的海缆振动信号降噪方法

光通信技术 2024年第2期48卷 84-89页

作者：郭家兴钱君霞闫安心赵盛杰江苏科能电力工程咨询有限公司南京210036

为了有效去除信号中的噪声,提出了基于变分模态分解(VMD)和排列熵(PE)的海缆振动信号降噪方法。该方法首先使用VMD将信号分解成从高频到低频的数个本征模态函数,然后计算各模态分量的PE值定量表征其随机性程度。接着,对含噪声信息较多... 详细信息

为了有效去除信号中的噪声,提出了基于变分模态分解(VMD)和排列熵(PE)的海缆振动信号降噪方法。该方法首先使用VMD将信号分解成从高频到低频的数个本征模态函数,然后计算各模态分量的PE值定量表征其随机性程度。接着,对含噪声信息较多的本征模函数(IMF)分量进行小波阈值降噪,并通过信号重构得到降噪后的海缆振动信号。为了验证该方法的有效性,搭建了基于布里渊光时域分析(BOTDA)的海底电缆(海缆)振动信号监测模拟实验系统,通过实验获得了冲刷、摩擦、锚砸3种工况下的海缆振动信号。实验结果表明:所提方法能有效去除海缆振动信号中的高频噪声,其冲刷、摩擦及锚砸3类信号的信噪比分别提升至30.2578 dB、29.6354 dB、38.7862 dB,且标准差较低。

关键词：海底电缆降噪布里渊光时域分析振动监测

Development of Novel Phosphino-Oxazoline Ligands and Their Application in Asymmetric Alkynlylation of Benzylic Halides

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Chinese Journal of Chemistry 2022年第11期40卷 1337-1345页

作者： Rui guo Jiale Sang Haijing Xiao junxia Li guozhu Zhang State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryCenter for Excellence in Molecular SynthesisUniversity of Chinese Academy of SciencesChinese Academy of Sciences345 Lingling RoadShanghai 200032China CCNU-uOttawa Joint Research Centre Key Laboratory of Pesticides&Chemical Biology Ministry of EducationInternational Joint Research Center for Intelligent Biosensing Technology and HealthCollege of ChemistryCentral China Normal University(CCNU)152 Luoyu RoadWuhanHubei 430079China

A new set of stereochemically diverse phosphino-oxazoline ligands derived from simple L-amino acids and 2-(diphenylphosphaneyl)-benzoic acid were developed.Those mono anionic tridentated N,N,P-ligands promote the Cu-catalyzed enantioselective radical cou-pling of terminal alkynes with a broad range of benzylic halides including benzo-fused cyclicα-halides andα-silyl benzyl halides in high yield and excellent enantioselectivity under mild reaction conditions.With multi distinct sites for structural modification,a di-verse pool of chiral N,N,P-ligands is readily accessed,allowing for rapid optimization of the ligand structure for a specific substrate.Notably,the enantioselective alkynlylation of benzylic halides bonds in benzo-cyclic molecules has also been realized for the first time.

关键词： Copper catalysis Phosphino-oxazoline ligands Cross-coupling Benzylic halides Alkynes

基于高通量测序中江丹参“发汗”过程中优势微生物群落与主要药效成分相关性研究

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中草药 2024年第2期55卷 420-433页

作者：王晓宇张松林王颖郭俊霞吴萍李青苗四川省中医药科学院四川成都610041 四川省道地药材系统开发工程技术研究中心四川成都610041 中药材品质及创新中药研究四川省重点实验室四川成都610041 资阳市食品药品检验检测中心四川资阳641399

目的探究中江丹参Salvia miltiorrhiza“发汗”过程中主要微生物群落及变化特征,以及优势微生物群落与主要药效成分之间的关系,以科学阐释传统“发汗”加工方式对中江丹参品质的影响。方法采用高通量测序技术对“发汗”过程中江丹参的... 详细信息

目的探究中江丹参Salvia miltiorrhiza“发汗”过程中主要微生物群落及变化特征,以及优势微生物群落与主要药效成分之间的关系,以科学阐释传统“发汗”加工方式对中江丹参品质的影响。方法采用高通量测序技术对“发汗”过程中江丹参的微生物多样性进行研究,结合化学品质分析,将优势微生物群落丰度与“发汗”丹参主要药效成分含量相关联,以期进一步判定“发汗”过程中影响中江丹参药材品质的主要微生物群落。结果21个中江丹参“发汗”样品共检出221个真菌菌属,677个细菌菌属。“发汗”过程中始终存在的优势真菌有小戴卫霉属Davidiella、轮枝菌属Verticillium;优势细菌有绿菌门未归类菌属Chloroplast_unclassified和根瘤菌属未归类菌属Mitochondria_unclassified 2个未归类菌属,已知细菌有节细菌属Arthrobacter、链霉菌属Streptomyces等。同时,相关性研究表明,真菌小戴卫霉属与样品中紫草酸含量呈显著负相关;子囊菌门未归类霉属Ascomycota_unclassified与丹参酮ⅡA含量呈显著正相关。细菌绿菌门未归类菌属绿菌门未归类与样品中迷迭香酸、水溶性成分含量呈显著正相关;与丹酚酸B含量呈极显著正相关;与丹参酮I含量呈显著负相关。根瘤菌属菌群Allorhizobium-Neorhizobium-Pararhizobium-Rhizobium与紫草酸含量呈显著正相关。结论影响“发汗”中江丹参品质的微生物群落可能为真菌小戴卫霉属,子囊菌门未归类霉属及细菌绿菌门未归类菌属,为探究中江丹参“发汗”过程中微生物的群落特征提供了实验依据,为进一步筛选分离“发汗”过程中影响中江丹参品质的优势微生物奠定了基础。

关键词：高通量测序发汗中江丹参微生物群落药效成分相关性微生物多样性真菌细菌紫草酸丹参酮Ⅱ_(A) 迷迭香酸丹酚酸B 丹参酮Ⅰ