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Multiporphyrinic architectures:Advances in structural design for photodynamic therapy

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Aggregate 2024年第1期5卷 67-84页

作者： Yuwei Gao Yan Li Zhengwei Xu Shuangjiang Yu junqiu liu Hongcheng Sun College of Material Chemistry and Chemical EngineeringKey Laboratory of Organosilicon Chemistry and Material TechnologyMinistry of EducationHangzhou Normal UniversityHangzhouChina

Rationally designed multiporphyrinic architectures for boosting photodynamic therapy(PDT)have attracted significant attentions recently years due to their great potential for light-mediated generation of reactive oxygen ***,there is still a gap between the structure design and their PDT performance for biomedical *** tutorial review provides a historical overview on(i)the basic concept of PDT for deeply understanding the porphyrin-mediated PDT reactions,(ii)developing strategies for constructing porphyrinic architectures,like nanorings,boxes,metal-organic frameworks(MOFs),covalent-organic frameworks(COFs),vesicles,etc.,where we classified into the following three categories:multiporphyrin arrays,porphyrinic frameworks,and others porphyrin assemblies,(iii)the various application scenarios for clinical cancer therapy and antibacterial ***,the existing challenges and future perspectives on the innovation of porphyrinic architectures for clinical PDT applications are mentioned in the end ***,the porphyrinic nanomaterials with atomically precise architectures provide an ideal platform for investigating the relationship between structures and PDT outputs,design of personalized“all-in-one”theranostic agents,and the popularization and application in wider biomedical fields.

关键词： covalent-organic frameworks(COFs) metal-organic frameworks(MOFs) multiporphyrin arrays photodynamic therapy(PDT) porphyrinic architectures

A wideband,high-resolution vector spectrum analyzer for integrated photonics

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Light(Science & Applications) 2024年第4期13卷 760-771页

作者： Yi-Han Luo Baoqi Shi Wei Sun Ruiyang Chen Sanli Huang Zhongkai Wang Jinbao Long Chen Shen Zhichao Ye Hairun Guo junqiu liu International Quantum Academy 518048 ShenzhenChina. Shenzhen Institute for Quantum Science and Engineering Southern University of Science and Technology518055 ShenzhenChina. Department of Optics and Optical Engineering University of Science and Technology of China230026 HefeiChina. Hefei National Laboratory University of Science and Technology of China230088 HefeiChina. Qaleido Photonics 518048 ShenzhenChina. Key Laboratory of Specialty Fiber Optics and Optical Access Networks Shanghai University200444 ShanghaiChina

The analysis of optical spectra—emission or absorption—has been arguably the most powerful approach for discovering and understanding *** invention and development of many kinds of spectrometers have equipped us with versatile yet ultra-sensitive diagnostic tools for trace gas detection,isotope analysis,and resolving hyperfine structures of atoms and *** proliferating data and information,urgent and demanding requirements have been placed today on spectrum analysis with ever-increasing spectral bandwidth and frequency *** requirements are especially stringent for broadband laser sources that carry massive information and for dispersive devices used in information processing *** addition,spectrum analyzers are expected to probe the device’s phase response where extra information is *** we demonstrate a novel vector spectrum analyzer(VSA)that is capable of characterizing passive devices and active laser sources in one *** a dual-mode VSA can measure loss,phase response,and dispersion properties of passive *** also can coherently map a broadband laser spectrum into the RF *** VSA features a bandwidth of 55.1 THz(1260–1640 nm),a frequency resolution of 471 kHz,and a dynamic range of 56 ***,our fiber-based VSA is compact and *** requires neither high-speed modulators and photodetectors nor any active feedback ***,we employ our VSA for applications including characterization of integrated dispersive waveguides,mapping frequency comb spectra,and coherent light detection and ranging(LiDAR).Our VSA presents an innovative approach for device analysis and laser spectroscopy,and can play a critical role in future photonic systems and applications for sensing,communication,imaging,and quantum information processing.

关键词： spectrum resolution coherent

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基于天顶轴速度零点的行人步数检测

测绘地理信息 2024年第1期49卷 118-123页

作者：刘俊求夏林元中山大学地理科学与规划学院广东广州511400

针对现有峰值检测算法适用性较低和深度学习方法算力要求较高的问题,研究和完整阐述了步态规律和数据特征,通过分析步态规律提出了基于天顶轴速度零值的行人步数检测算法。通过将载体坐标系下的加速度计数据转换到地理坐标系下,使用经... 详细信息

针对现有峰值检测算法适用性较低和深度学习方法算力要求较高的问题,研究和完整阐述了步态规律和数据特征,通过分析步态规律提出了基于天顶轴速度零值的行人步数检测算法。通过将载体坐标系下的加速度计数据转换到地理坐标系下,使用经验模态分解、趋势项剔除等方法提取出每一步中的有效天顶轴速度零点,统计有效零点的个数作为步数。在多种行走状态下的实验表明,相比改进的峰值检测模型,本模型的准确率与可靠性有明显提升,在行人过快或过慢行走时提升效果更为显著。

关键词：步数检测多行走状态加速度计天顶轴速度经验模态分解

Ion transporters: emerging agents for anticancer therapy

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Science China Chemistry 2022年第7期65卷 1265-1278页

作者： Tengfei Yan Xin Zheng Shengda liu Yingping Zou junqiu liu State Key Laboratory of Powder Metallurgy College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China College of Material Chemistry and Chemical EngineeringKey Laboratory of Organosilicon Chemistry and Material TechnologyMinistry of EducationKey Laboratory of Organosilicon Material Technology of Zhejiang ProvinceHangzhou Normal UniversityHangzhou 311121China

Natural ion channels are pore-forming proteins that allow ions to pass through biomembranes, playing pivotal roles in almost all facets of cellular physiological functions. Biomimetic ion transporters were initially investigated for the purpose of treating lifethreatening channelopathies. Recent studies have indicated that membrane-active synthetic ionophores possess desirable anticancer bioactivity against diverse cancer cell lines by disturbing intracellular ion homeostasis, triggering oxidative stress, and inducing apoptosis in tumors. Recent progress on ionophore-related antitumor therapeutics is comprehensively summarized in this review, including the molecular design principles, functional mechanisms, and characterization methods. Finally, we conclude this review by discussing the future opportunities and challenges in this field. It is anticipated that this review will provide an existing panoramic sketch and future directions toward the construction of novel ion transporters with simplified preparation procedures, enhanced biocompatibility, and desirable anti-proliferative activities, which may further accelerate their therapeutic applications in clinical treatments.

关键词： ion transporter ion homeostasis apoptosis anticancer treatment

Artificial Photosynthesis(AP):From Molecular Catalysts to Heterogeneous Materials

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Chemical Research in Chinese Universities 2022年第3期38卷 688-697页

作者： JI Yuancheng XU Jiayun SUN Hongcheng liu junqiu State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun130012P.R.China College of Material Chemistry and Chemical EngineeringKey Laboratory of Organosilicon Chemistry and Material TechnologyMinistry of EducationKey Laboratory of Organosilicon Material Technology of Zhejing ProvinceHangzhou Normal UniversityHangzhou311121P.R.China

The development of green and renewable energy sources is in high demand due to energy shortage and productivity *** photosynthesis(AP)is one of the most effective ways to address the energy shortage and the greenhouse effect by converting solar energy into hydrogen and other carbon-based high value-added products through the understanding of the mechanism,structural analysis,and functional simulation of natural *** this review,the development of AP from natural catalysts to artificial catalysts is described,and the processes of oxygen production,hydrogen production,and carbon fixation are sorted out to understand the properties and correlations of the core functional components in natural photosynthesis,to provide a better rational design and optimization for further development of advanced heterogeneous materials.

关键词： Artificial photosynthesis Oxygen evolution reaction Hydrogen evolution reaction CO_(2)reduction reaction Heterogeneous material

Self-assembled Supramolecular Artificial Transmembrane Ion Channels:Recent Progress and Application

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Chemical Research in Chinese Universities 2023年第1期39卷 3-12页

作者： LUO Yichen ZHU Canhong ZHANG Tianlong YAN Tengfei liu junqiu College of Material Chemistry and Chemical EngineeringKey Laboratory of Organosilicon Chemistry and Material TechnologyMinistry of EducationKey Laboratory of Organosilicon Material TechnologyHangzhou Normal UniversityHangzhou311121P.R.China

Natural protein channels have evolved with fantastic spatial structures,which play pivotal physiological functions in all living *** from nature,chemical scientists have developed a myriad of artificial transmembrane ion channels by using various chemical strategies,among which the non-covalent supramolecular ion channels exhibit remarkable advantages over other forms(e.g.,single-molecule ion channel),which exhibited facile preparation methods,easier structural modification and *** this review,we have systematically summarized the recent progress of supramolecular self-assembled artificial transmembrane ion channels,which were classified by different self-assembly mechanisms,such as hydrogen bonds,π-πinteractions,*** preparation process and self-assembly strategies of the supramolecular ion channels have been ***,potential biomedical applications of the supramolecular ion channels have also been carefully discussed in this ***,future opportunities and challenges facing this field were also elaborately *** is anticipated that this review could provide a panoramic sketch and future directions towards the construction of novel artificial ion channels with novel functions and biomedical applications.

关键词： Self-assembly Supramolecular Artificial ion channel Biomedical application

芒柄花素诱导肺癌细胞焦亡并抑制PD-L1介导的免疫逃逸

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药物评价研究 2024年第5期47卷 971-981页

作者：张振勇李肖李保宏邹艺璇刘君秋陈子超张振山东中医药大学中医药创新研究院山东济南250355 山东中医药大学实验中心山东济南250355

目的探究芒柄花素抑制非小细胞肺癌(NSCLC)A549细胞的作用机制。方法MTT法、细胞划痕和克隆形成实验考察芒柄花素(20~100μmol·L^(−1))对A549细胞增殖、迁移和克隆形成的抑制作用;A549细胞预孵育芒柄花素24 h后,使用Hoechst 33342细胞... 详细信息

目的探究芒柄花素抑制非小细胞肺癌(NSCLC)A549细胞的作用机制。方法MTT法、细胞划痕和克隆形成实验考察芒柄花素(20~100μmol·L^(−1))对A549细胞增殖、迁移和克隆形成的抑制作用;A549细胞预孵育芒柄花素24 h后,使用Hoechst 33342细胞核染色定位,加入经过Dil标记的Jurkat细胞(人T淋巴细胞白血病细胞)共培养30 min,使用激光共聚焦拍摄2种细胞的共定位图像;建立A549-Jurkat细胞共培养模型,MTT和结晶紫染色法检测芒柄花素对A549细胞活性的影响;试剂盒法检测A549细胞线粒体膜电位(JC-1染色)和谷胱甘肽(GSH)水平探究芒柄花素对线粒体应激的诱导作用;Western blotting法考察芒柄花素对A549细胞线粒体应激后非经典焦亡相关蛋白和PD-L1蛋白表达的影响。结果与对照组比较,芒柄花素显著抑制A549细胞的增殖、迁移和克隆形成能力(P<0.01、0.001),增强细胞共培养模型中T细胞的募集和杀伤作用(P<0.01、0.001);芒柄花素可诱导A549细胞线粒体应激,诱导线粒体膜电位下降,显著降低细胞GSH水平(P<0.05、0.01),显著上调bcl-2相关x蛋白(BAX)、裂解的半胱氨酸-天冬氨酸蛋白酶-3(cleaved-Caspase-3)、穿孔素蛋白E(Gasdermin E)-N蛋白表达诱导细胞焦亡(P<0.01、0.001),同时显著下调p-磷酸化磷脂酰肌醇3激酶(p-PI3K)、蛋白激酶B(Akt)、核因子κB(NF-κB)、细胞程序性死亡-配体1(PD-L1)蛋白表达抑制免疫逃逸(P<0.05、0.001)。结论芒柄花素具有诱导NSCLC细胞焦亡并阻断免疫逃逸的作用,其机制为一方面可通过诱导A549细胞线粒体应激,促进细胞焦亡招募T细胞,增强肿瘤免疫;另一方面抑制p-PI3K/Akt/NF-κB信号轴,进而降低PD-L1蛋白表达,抑制A549细胞免疫逃逸。

关键词：芒柄花素非小细胞肺癌线粒体应激细胞焦亡细胞程序性死亡-配体1(PD-L1) 免疫逃逸

Regulation of artificial supramolecular transmembrane signal transduction by selenium-containing artificial enzyme receptors

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Nano Research 2023年第1期16卷 964-969页

作者： Shengda liu Yunpeng Xing Tengfei Yan Yijia Li Ruizhen Tian Jinxing Hou Jiayun Xu Tingting Wang junqiu liu Key Laboratory of Organosilicon Chemistry and Material Technology Ministry of EducationCollege of MaterialChemistry and Chemical EngineeringHangzhou Normal UniversityHangzhou 311121China State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012China

Signal transduction across lipid bilayers is of profound importance in biological *** biological systems,natural enzymes mediate biochemical effects by binding to substrates and facilitating the conversion of external signals into physiological *** transmission of biological signals from one enzyme to the next promotes signal transduction with feedforward and feedback *** these processes in an artificial system provides potential applications and offers a new way to understand fundamental biological processes in ***,the design of artificial signal transduction systems regulated by artificial enzyme receptors in a predictable and intelligent manner remains a ***,benefiting from the polarity-regulated characteristics of Se-containing compounds with artificial glutathione peroxidase(GPx)activity,we constructed an artificial transmembrane signaling receptor with a Se-containing GPx-like recognition head group,a membrane-anchoring group,and a pre-enzyme end *** artificial supramolecular signal transduction system containing such signal transduction receptors extends the range of signaling systems based on enzyme regulation,which provides a new way to study natural signal processes in cells and artificially regulated biological processes.

关键词： signal transduction supramolecular introduction selenium-containing glutathione peroxidase(GPx)-like receptors artificial enzyme

Protein assembly:Controllable design strategies and applications in biology

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聚集体(英文)

聚集体(英文) 2023年第3期4卷 19-35页

作者： Yijia Li Ruizhen Tian Haolu Shi Jiayun Xu Tingting Wang junqiu liu College of Material Chemistry and Chemical EngineeringKey Laboratory of Organosilicon Chemistry and Material TechnologyMinistry of EducationKey Laboratory of Organosilicon Material TechnologyZhejiang ProvinceHangzhou Normal UniversityHangzhouChina

Protein assembly is the structural basis for the collaboration between proteins to accomplish life activities due to its realization of the domain-limited and precise spatial arrangement of ***,artificial manipulation of protein selfassembly has profound implications in areas such as exploring the mysteries of life and developing *** this review,we not only summarize the classical assembly strategies and the structures of exquisite protein assemblies,but also aim to generalize the flexible and controllable assembly tools and the“interaction”between the assembled protein-based materials and the external *** the basis of this,the application,challenges and further development of protein assembly in biology are reviewed.

关键词： biomaterials controllable construction strategies protein nanostructures protein self-assembly