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Retrospective analysis of patients with rare-site and metastatic giant cell tumor

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Chinese Journal of Cancer Research 2013年第5期25卷 585-592页

作者： junling liu Han Yang Rui Sun Zhijun Yang Zhihua Zhu State Key Laboratory of Oncology in South China Department of Medical Oncology Sun Yat-sen University Cancer Center Department of Thoracic Surgery Sun Yat-sen University Cancer Center Department of Nasopharyngeal Carcinoma Sun Yat-sen University Cancer Center

A giant cell tumor occurs mainly in the proximal tibia,humerus,distal radius bone and the pelvic *** is rarely observed in such sites as the ribs and the temporal *** condition is primarily treated with surgical excision and functional *** effect of chemotherapy on lung metastases and locally advanced giant cell tumors has remained *** collected and analyzed the data of six patients with rare giant cell tumors located in the head and neck *** an average follow-up of 42.6 months after surgery （14 to 90 months）,no local recurrence or metastasis was *** also collected and analyzed the data of five patients with metastatic giant cell tumors who were undergoing surgery for the primary tumor before; of three patients who had experienced multiple chemotherapy cycles,one had spontaneous regression,and one survived for long timer despite *** other two patients had their major metastatic lesions resected by surgery,and presented long-term survival during the follow *** addition,this study reports one patient with locally advanced giant cell tumor of the rib,who has undergone successful surgical resection following two cycles of chemotherapy with ifosfamide and liposomal *** resection of the lesion at the head and neck is the key to relapse-free *** prognosis of lung metastases in patients with giant cell tumors is relatively *** chemotherapy is also conducive to the surgery for locally advanced lesions and improvement of the quality of life.

关键词： Giant cell tumor neoadjuvant chemotherapy ifosfamide liposomal doxorubicin

Correlation between the cumulative analgesic effect of electroacupuncture intervention and synaptic plasticity of hypothalamic paraventricular nucleus neurons in rats with sciatica

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Neural Regeneration Research 2013年第3期8卷 218-225页

作者： Qiuling Xu Tao liu Shuping Chen Yonghui Gao Junying Wang Lina Qiao junling liu Hainan Medical University Institute of Acu-moxibustion China Academy of Chinese Medical Sciences

In the present study, a rat model of chronic neuropathic pain was established by ligation of the sciatic nerve and a model of learning and memory impairment was established by ovariectomy to investigate the analgesic effect of repeated electroacupuncture stimulation at bilateral Zusanfi （ST36） and Yanglingquan （GB34）. In addition, associated synaptic changes in neurons in the paraventricular nucleus of the hypothalamus were examined. Results indicate that the thermal pain threshold （paw withdrawal latency） was significantly increased in rats subjected to 2-week electroacupuncture intervention compared with 2-day electroacupuncture, but the analgesic effect was weakened remarkably in ovariectomized rats with chronic constrictive injury. 2-week electroacupuncture intervention substantially reversed the chronic constrictive injury-induced increase in the synaptic cleft width and thinning of the postsynaptic density. These findings indicate that repeated electroacupuncture at bilateral Zusanfi and Yanglingquan has a cumulative analgesic effect and can effectively relieve chronic neuropathic pain by remodeling the synaptic structure of the hypothalamic paraventricular nucleus.

关键词： neural regeneration acupuncture and moxibustion Chronic neuropathic pain electroacupuncture acupuncture analgesia cumulative effect synaptic plasticity hypothalamus learning and memory neurobiology grants-supported paper photographs-containing paper neuroregeneration

The cumulative analgesic effect of repeated electroacupuncture involves synaptic remodeling in the hippocampal CA3 region

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Neural Regeneration Research 2012年第18期7卷 1378-1385页

作者： Qiulinq Xu Tao liu Shuping Chen Yonghui Gao Junying Wang Lina Qiao junling liu Hainan Medical University Haikou 571101 Hainan Province China Institute of Acupuncture and Moxibustion China Academy of Chinese Medical Sciences Beijing 100700 China

In the present study, we examined the analgesic effect of repeated electroacupuncture at bilateral Zusanfi （ST36） and Yanglingquan （GB34） once a day for 14 consecutive days in a rat model of chronic sciatic nerve constriction injury-induced neuropathic pain. In addition, concomitant changes in calcium/calmodulin-dependent protein kinase II expression and synaptic ultrastructure of neurons in the hippocampal CA3 region were examined. The thermal pain threshold （paw withdrawal latency） was increased significantly in both groups at 2 weeks after electroacupuncture intervention compared with 2 days of electroacupuncture. In ovariectomized rats with chronic constriction injury, the analgesic effect was significantly reduced. Electroacupuncture for 2 weeks significantly diminished the injury-induced increase in synaptJc cleft width and thinning of the postsynaptJc density, and it significantly suppressed the down-regulation of intracellular calcium/ calmodulin-dependent protein kinase II expression in the hippocampal CA3 region. Repeated electroacupuncture intervention had a cumulative analgesic effect on injury-induced neuropathic pain reactions, and it led to synaptic remodeling of hippocampal neurons and upregulated calcium/calmodulin-dependent protein kJnase II expression in the hippocampal CA3 region.

关键词： chronic neuropathic pain acupuncture analgesia cumulative effect synaptic plasticity hippocampal CA3 region calcium/calmodulin-dependent protein kinase II neurobiology electroacupuncture neural regeneration

Acupuncture effects on the hippocampal cholinergic system in a rat model of neuropathic pain

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Neural Regeneration Research 2012年第3期7卷 212-218页

作者： Junying Wang junling liu Shuping Chen Yonghui Gao Fanying Meng Lina Qiao Institute of Acu-moxibustion China Academy of Chinese Medical Sciences Beijing 100700 China

The present study observed the effects of repeated electroacupuncture of Zusanli （ST36） and Yanglingquan （GB34） on expression of hippocampal acetylcholinesterase, vesicular acetylcholine transporter, and muscarinic M1 receptor mRNA in chronic constrictive injury （neuropathic pain） and/or ovariotomy rats. Results demonstrated increased expression of hippocampal acetylcholinesterase, vesicular acetylcholine transporter, and muscarinic M1 receptor mRNA, as well as decreased pain threshold, in a rat model of chronic neuropathic pain after electroacupuncture. The effects of electroacupuncture increased with prolonged time, but the above-mentioned effects decreased in memory-deficient animals. Results indicated that repeated electroacupuncture has a cumulative analgesic effect, which is closely associated with upregulation of acetylcholinesterase and vesicular acetylcholine transporter activity, as well as M1 receptor mRNA expression and memory.

关键词： acetylcholinesterase chronic pain cumulative effect electroacupuncture analgesia hippocampus M1R mRNA expression vesicular acetylcholine transporter

Seasonal variations of tris (2-chloroethyl) phosphate and cytotoxicity of organic extracts in water samples from Wuhan, China

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Journal of Environmental Sciences 2019年第2期31卷 299-309页

作者： Youjian Zhang Wenjuan Zhang Jian Hou Xian Wang Wenhong Lu Hongyan Zheng Wei Xiong junling liu Jing Yuan Department of Occupational and Environmental Health Huazhong University of Science and Technology Key Laboratory of Environment and Health Ministry of Education & Ministry of Environmental ProtectionState Key Laboratory of Environmental Health (Incubating)School of Public HealthTongji Medical CollegeHuazhong University of Science and Technology Wuhan Centers for Disease Control and Prevention

Tris(2-chloroethyl) phosphate(TCEP) is a typical phosphate flame retardant. Its potential adverse health effects have recently aroused concern. We investigated the seasonal variations of TCEP concentrations in the raw, finished and tap water samples from two drinking water treatment plants(DWTPs) in China, and evaluated the cytotoxicity and apoptosis/necrosis of organic extracts(OEs) in water samples. We enriched TCEP and OEs in water samples by solid-phase extraction method. The TCEP concentrations in water samples were determined by gas chromatography–mass spectrometry. Normal human liver cell line L02 was treated with OEs in the water samples, and then the cytotoxicity and apoptosis/necrosis were measured by 3-(4, 5-dimethyithiazol-2-yl)-2,5-diphenyl-tetrazolium bromide assay and flow cytometry, respectively. The results showed that cytotoxicities of OEs in raw water samples from both DWTPs in summer and winter were stronger than those in spring and autumn, cytotoxicity of OEs in finished and tap water samples from both DWTPs in summer and autumn were stronger than those in spring and winter. In all seasons, the maximal concentrations(100 mL water/mL cell culture) of OEs in the raw water samples from both DWTPs induced late apoptosis/necrosis. The reasons for seasonal variations of TCEP in water samples and potential toxic effects of other pollutants in the water samples need to be further investigated.

关键词： Tris (2-chloroethyl) phosphate Cytotoxicity Organic extract Apoptosis Necrosis

Deficiency of the G protein Gαq ameliorates experimental autoimmune encephalomyelitis with impaired DC-derived IL-6 production and Th17 differentiation

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Cellular & Molecular Immunology 2017年第6期14卷 557-567页

作者： Weiming Lai Yingying Cai Jinfeng Zhou Shuai Chen Chaoyan Qin Cuixia Yang junling liu Xin Xie Changsheng Du Department of Central Laboratory Shanghai Tenth People's Hospital of Tongji University School of Life Sciences and Technology Tongji University Shanghai 200092 China Department of Biochemistry and Molecular Cell Biology Shanghai Jiao Tong University School of Medicine Shanghai 200025 China National Center for Drug Screening CAS Key Laboratory of Receptor Research Chinese Academy of Sciences Shanghai Institute of Materia Medica Shanghai 201203 China Shanghai Key Laboratory of Signaling and Disease Research School of Life Sciences and Technology Tongji University Shanghai 200092 China

Many G protein-coupled receptors （GPCRs） are reported to be involved in the pathogenesis of multiple sclerosis （MS）, and -40% of all identified GPCRs rely on the Gaq/11 G protein family to stimulate inositol lipid signaling. However, the function of Ga subunits in MS pathogenesis is still unknown. In this study, we attempted to determine the role of Gaq in the pathogenesis of experimental autoimmune encephalomyelitis （EAE）, a well-known mouse model of MS. We discovered that compared with wild-type mice, Gaq-knockout mice exhibited less severe EAE symptoms, with lower clinical scores, reduced leukocyte infiltration and less extensive demyelination. Moreover, a significantly lower percentage of Th17 cells, one of the key players in MS pathogenesis, was observed in Gaq-knockout EAE mice. Studies in vitro demonstrated that deficiency of Gaq in CD4＋ T cells directly impaired Th17 differentiation. In addition, deficiency of Gaq significantly impaired DC-derived IL-6 production, thus inhibiting Th17 differentiation and the Gaq-PLCβ-PKC and Gaq-MAPKs signaling pathways involved in the reduced IL-6 production by DCs. In summary, our data highlighted the critical role of Gaq in regulating Th17 differentiation and MS oathogenesis.

关键词： Dendritic cells EAE Gαq IL-6 Th17 differentiation MS

INFLUENCE OF ACUPUNCTURE ON THE DISCHARGE OF PHA NEURONS IN THE RABBIT

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针刺研究 1992年第1期17卷 21-25页

作者： Cao Qingshu, liu junling, Han Zhenjing, Wang Hongwei (Institute of Acupuncture and Moxibustion, China Academy of TCM, Beijing, 100700) Institute of Acupuncture and Moxibustion China Academy of TCM Beijing.

This paper deals with whether the posterior hypothalamus area(PHA) can receive signals from electroacupuncture(EA) at "Neiguan", and whether a relative specificity does exist between acupoints or acupoint and non-acupoint The neuron activity was recorded extracellularly for analyzing the influence of EA at different acupoints and nonacupoint on the discharge of PHA neurons.

关键词： PHA AT EA INFLUENCE OF ACUPUNCTURE ON THE DISCHARGE OF PHA NEURONS IN THE RABBIT

Mechanisms　on　Correlation　between　the　Pericardium　Meridian　and　Heart　Effects　of　Electroacupuncture　at　Neiguan　and　Other　Acupo

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中国针灸 1995年第S2期15卷 242-243页

作者： Cao Qingshu liu junling Wen Shen liu Rutting Zhuang Ding(Institute of Acupuncture and Moxibustion, China Academyof Traditional Chinese Medicine, Beijing 100700)

ＭｅｃｈａｎｉｓｍｓｏｎＣｏｒｒｅｌａｔｉｏｎｂｅｔｗｅｅｎｔｈｅＰｅｒｉｃａｒｄｉｕｍＭｅｒｉｄｉａｎａｎｄＨｅａｒｔＥｆｆｅｃｔｓｏｆＥｌｅｃｔｒｏａｃｕｐｕｎｃｔｕｒｅａｔＮｅｉｇｕａｎａｎｄＯｔｈｅｒＡｃｕｐ... 详细信息

ＭｅｃｈａｎｉｓｍｓｏｎＣｏｒｒｅｌａｔｉｏｎｂｅｔｗｅｅｎｔｈｅＰｅｒｉｃａｒｄｉｕｍＭｅｒｉｄｉａｎａｎｄＨｅａｒｔＥｆｆｅｃｔｓｏｆＥｌｅｃｔｒｏａｃｕｐｕｎｃｔｕｒｅａｔＮｅｉｇｕａｎａｎｄＯｔｈｅｒＡｃｕｐｏｉｎｔｓｏｎＡｃｕｔｅＭｙｏｃａ...

关键词： Acupo Effects Heart Mechanisms Meridian Neiguan Other Pericardium and at

Effect of Maotai liquor on P53 gene in primary hepatocellular carcinoma induced by compound factors in rats

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Chinese Medical Journal 2014年第2期127卷 378-380页

作者： Zhao Xueke Cheng Mingliang Mu Mao liu junling He Chang Zhang Quan Department of Infectious Disease Affiliated Hospital of Guiyang Medical College Guiyang Guizhou 550004 China Department of Pathology Guiyang Medical College Guiyang Guizhou 550004 China

In China, the morbidity of alcoholic liver diseases （ALD） is increasing, which is the second cause of liver diseases after viral hepatitis. An epidemiological survey of 99 subjects in Kweichow Maotai Distillery who have drunk a lot of Maotai liquor for a long time showed that fatty livers were predominate and the incidence of hepatic fibrosis and cirrhosis was relatively low. Now, we carried out an animal experiment to investigate the mutation of P53 gene in liver tissues of primary hepatocellular carcinoma （HCC） induced by compound factors.

关键词： primary hepatocellular carcinoma Maotai liquor P53