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Applications,of fluorescence lifetime imaging in clinical medicine

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Journal of Innovative Optical Health Sciences 2018年第1期11卷 106-122页

作者： Zhanwen Wang Yanping Zheng Deqiang Zhao Ziwei Zhao Lixin Liu Artem Pliss Feiqi Zhu Jun Liu junle qu Ping Luan Shenzhen University Health Science Center Shenzhen 518060 P.R.China Department of Neurology Nanfang Hospital of Southern Medical University Guangzhou Guangdong 510515P.R.China Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province Shenzhen University Shenzhen 518060P.R.China School of Physics and Optoelectronic Engineering Xidian University Xi'an 710071P.R.China Institutue for Laser Photonics and Biophotonics State University of New YorkBuffaloNew YorkUSA Cognitive Impairment Ward of Neurology Department The 3rd A±liated Hospital of Shenzhen University Shenzhen 518001 P.R.China Department of Neurodegenerative Diseases and Aging Sun Yat-Sen Memorial Hospital Sun Yat-Sen University GuangdongP.R.China

Fluorescence lifetime is not only associated with the molecular structure f fuorophores,but alsostrongly depends on the environment around them,which llows fuorescence lifetime imagingmicroscopy(FLIM)to be used as a tool for precise measurement of the cell or tisue microenvironment,This review introduces the basic principle of fuorescence lifetime imagingtechnology and its application in clinical medicine,including research and diagnosis of diseases inskin,brain,eyes,mouth,bone,blood vessels and cavity organs,and drug *** anoninvasive,nontoxic and nonionizing radiation technique,FLIM demonstrates excellent per-formance with high sensitivity and specificity,which allows to determine precise position of thelesion and,thus,has good potential for application in biomedical research and clinical diagnosis.

关键词： Fluorescence lifetime fluorescence lifetime imaging microscopy clinical medicine

In vivo mice brain microcirculation monitoring based on contrast-enhanced SD-OCT

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Journal of Innovative Optical Health Sciences 2019年第1期12卷 62-71页

作者： Shaozhuang Yang Liwei Liu Yixin Chang Ningning Zhang Kun Liu Liang Hong Bingling Chen Yue Zhao Rui Hu junle qu Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province Shenzhen University Shenzhen 518060P.R.China State Key Laboratory of Supramolecular Structure and Materials Jilin University Changchun 130012P.R.China

In this paper,we proposed a contrast-enhanced homemade spectral domain optical coherence tomography(SD-OCT)method for monitoring of brain *** used the polyethylene glycol(PEG)-ylated gold nanorods(GNRs)as a contrast-enhanced agent,obtained clearly 2D and 3D OCT images of blood vessels and dynamic changes of probes in mouse blood *** to high scattering of the PEG-GNRs,more tiny blood vessels can be imaged and the OCT signal can be enhanced by 5.87 dB after injection of PEG-GNRs for 20 min,the enhancement then declined gradually for 60 *** results demonstrate an effective technique for the enhanced imaging of blood vessels in vivo,especially for studies of the brain microcirculation,which could be serviced for disease mechanism research and therapeutic drug monitoring.

关键词： Optical coherence tomography brain microcirculation cerebral blood vessels gold nanorods

Observations of intracellular second-harmonic generation imaging in black phosphorus nanosheets

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Journal of Innovative Optical Health Sciences 2021年第2期4卷 11-18页

作者： Xiao Peng Yiwan Song Zheng Peng Kaixuan Nie Hao Liu Yingxin Zhou Feifan Zhou Yufeng Yuan Jun Song junle qu Center for Biomedical Optics and Photonics(CBOP)&College of Physics and Optoelectronic Engineering Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province Shenzhen University Shenzhen 518060P.R.China

Functionalized black phosphorus(BP)nanosheets have been considered as promising nanoagents in cancer therapy due to their excellent photothermal conversion ***,it is still difficult to visually monitor the dynamic localization of BP nanoagents in cancer *** this paper,we systematically studied the second-harmonic generation(SHG)signals originating from exfoliated BP ***,under the excitation of a high frequency pulsed laser at 950 nm,the SHG signals of BP nanosheets in vitro are almost undetectable because of their poor ***,the intracellular SHG signals from BP nanosheets could be measured by in vivo optical imaging due to the efficient enrichment of living HeLa ***,the SHG signal intensity from BP nanosheets increases with the prolonged incubation *** can be expected that the BP nanosheets could be a promising intracellular SHG nanoprobe employed for visually in vivo biomedical imaging in practical cancer photothermal therapy(PIT).

关键词： Second harmonic generation nanoprobe black phosphorus nanosheets in vivo im-aging HeLa cells visual monitoring

Intermolecular hydrogen-bonding as a robust tool toward significantly improving the photothermal conversion efficiency of a NIR-II squaraine dye

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Chinese Chemical Letters 2024年第4期35卷 310-315页

作者： Songtao Cai Liuying Wu Yuan Li Soham Samanta Jinying Wang Bing Liu Feihu Wu Kaitao Lai Yingchao Liu junle qu Zhigang Yang Center for Biomedical Photonics&Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China

The photothermal therapy(PTT) has come across as a promising noninvasive therapeutic strategy for tumor treatment. However, low photothermal conversion efficiency(PCE) and hydrophobicity may impede the therapeutic efficacy of organic photothermal agents and an efficient PTT-agent must overcome these two major challenges. In this work, we developed a new strategy to promote higher PCE wherein the intermolecular hydrogen-bonding interaction between the single dye molecule and water facilitated the transformation of the absorbed energy into the heat. A hydrophilic squaraine dye(SCy1) with the second near-infrared region(NIR-II) absorption and extremely low emission were designed to exhibit much higher PCE than that of the analogues of pentamethine-dyes(PCy1, PCy2). The presence of the ‘–O-' at middle of squaric cycle enabled the intermolecular H-bonding formation between the SCy1 and water to promote the energy dissipation channel. Moreover, the introduction of long-chain phenylsulfonate groups helped in to improve the water solubility apart from serving as an additional means of further enhancing PCE through fluorescence quenching. Therefore, SCy1 with a squaraine backbone and long-chain sulfonate moieties revealed outstanding photothermal stability and anti-aggregation activity apart from showing exceptionally high PCE(74%) in water. SCy1 demonstrated excellent therapeutic efficacy when applied in the PTT treatment of tumor-bearing mice under a laser irradiation of 915 nm.

关键词： Squaraine-based cyanine Hydrogen bonds High PCE Anti-aggregation Photothermal therapy

Recent progress of electronic materials based on 2,1,3-benzothiadiazole and its derivatives:synthesis and their application in organic light-emitting diodes

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Science China Chemistry 2021年第3期64卷 341-357页

作者： Youming Zhang Jun Song Junie qu Peng-Cheng Qian Wai-Yeung Wong Department of Applied Biology and Chemical Technology and Research Institute for Smart Energy1 The Hong Kong Polytechnic University(PolyU)Hung HomHong KongChina PolyU Shenzhen Research Institute Shenzhen 518057China College of Materials Science and Engineering Shenzhen UniversityShenzhen 518060China Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic Engineering.Shenzhen UniversityShenzhen 518060China Key Laboratoty of Environmental Functional Materials Technology and Application of Wenzhou City Institute of New Materials&IndustiyCollege of Chemistry&Materials Engineering.Wenzhou UniversityWenzhou 325035China

2,1,3-Benzothiadiazole(BT)and its derivatives are very important acceptor units used in the development of photoluminescent compounds and are applicable for the molecular construction of organic light-emitting diodes,organic solar cells and organic field-effect *** to their strong electron-withdrawing ability,construction of molecules with the unit core of BT and its derivatives can usually improve the electronic properties of the resulting organic *** this contribution,we review the synthesis of various polymers,small molecules and metal complexes with BT and its derivatives and their applications in organic light-emitting ***,the molecular design rules based on these cores are discussed.

关键词： 2,1,3-benzothiadiazole organic light-emitting diodes synthesis electronic properties photoluminescence

Establishment of the fundamental phase-to-polarization link in(ft)classical optics

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Fundamental Research 2021年第5期1卷 649-654页

作者： Xiaoyu Weng Xiumin Gao Guorong Sui Qiang Song Xiangmei Dong junle qu Songlin Zhuang Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China Engineering Research Center of Optical Instrument and System Ministry of EducationShanghai Key Lab of Modem Optical SystemSchool of Optical-Electrical and Computer Engineering University of Shanghai for Science and Technology516 Jungong RoadShanghai 200093China

Vector polarization induced by a change in the scalar phase is far beyond our understanding of the relationship between polarization and phase in classical optics due to the entanglement of the inherent polarized modes of light *** overcome this limitation,we establish this miraculous relationship by the principle of phase vectorization,which can transform three particular phases into linear,circular and elliptical polarizations.A polarized-spatial light modulator based on the principle of phase vectorization can be achieved using a phase-only spatial light modulator,which not only enables pixel-level polarization manipulation of light beams in a real-time dynamic way but also simultaneously retains complete phase *** work demonstrates the phase-to-polarization link and reports the creation of a polarized-spatial light modulator,which will transform our view of the natural properties of light beams and pave the way for the era of vector optics.

关键词： Polarization Vector optics Polarized-spatial light modulator

Editorial for Special Issue on Frontiers in Optical Bioimaging

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Chinese Optics Letters 2010年第10期8卷 925-925页

作者： Niu, Hanben Cheng, Ya qu, junle Shenzhen Univ Inst Optoelect Shenzhen 518060 Peoples R China Chinese Acad Sci Shanghai Inst Opt & Fine Mech Shanghai 201800 Peoples R China Shenzhen Univ Inst Optoelect Shenzhen 518060 Peoples R China

Optical bioimaging has become a very important tool in life science because it is noninvasive, of high specificity, capable of performing multi-parameter measurement,

关键词： Editorial for Special Issue on Frontiers in Optical Bioimaging

Advances in inorganic nanoparticles trapping stiffness measurement:A promising tool for energy and environmental study

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Energy Reviews 2023年第2期2卷 13-31页

作者： Xiaolin Chen Jiajie Chen Jianxing Zhou Xiaoqi Dai Yuhang Peng Yili Zhong Ho-Pui Ho Bruce Zhi Gao Han Zhang junle qu Yonghong Shao State Key Laboratory of Radio Frequency Heterogeneous Integration Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong ProvinceCollege of Physics and Optoelectronics EngineeringShenzhen UniversityShenzhen518060China Department of Biomedical Engineering The Chinese University of Hong KongShatinHong Kong Department of Bioengineering and COMSET Clemson UniversityClemsonSC29634USA

Optical tweezers system has emerged as an efficient tool to manipulate tiny particles in a non-invasive *** stiffness,as an essential parameter of an optical potential well,represents the trapping ***,trapping inorganic nanoparticles such as metallic nanoparticles or other functionalized inorganic nanoparticles is important due to their properties of good stability,high conductivity,tolerable toxicity,etc.,which makes it an ideal detection strategy for bio-sensing,force calculation,and determination of particle and environmental ***,the trapping stiffness measurement(TSM)methods of inorganic nanoparticles have rarely been analyzed and ***,in this review,the principle and methods of TSM are *** also systematically summarize the progress in acquiring inorganic particles trapping stiffness and its promising *** addition,we provide prospects of the energy and environment applications of optical tweezering technique and ***,the challenges and future directions of achieving the nanoparticles trapping stiffness are discussed.

关键词： Optical tweezers Optothermal tweezers Trapping stiffness measurement Inorganic nanoparticles Energy and environment applications

Improvement in Resolution of Multiphoton Scanning Structured Illumination Microscopy via Harmonics

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Engineering 2022年第9期16卷 65-72页

作者： Lei Wang Xiaomin Zheng Jie Zhou Meiting Wang Jiajie Chen Youjun Zeng Gaixia Xu Ying Wang Haixia Qiu Yonghong Shao junle qu Bruce Zhi Gao Ying Gu College of Physics and Optoelectronic Engineering Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong ProvinceShenzhen UniversityShenzhen 518060China Department of Laser Medicine First Medical Center of PLA General HospitalBeijing 100853China Department of Bioengineering and COMSET Clemson UniversityClemsonSC 29634USA

We describe a multiphoton(mP)-structured illumination microscopy(SIM)technique,which demonstrates substantial improvement in image resolution compared with linear SIM due to the nonlinear response of *** nonlinear response is caused by the effect of nonsinusoidal structured illumination created by scanning a sinusoidally modulated illumination to excite an mP fluorescence *** harmonics of the structured fluorescence illumination are utilised to improve *** present an mP-SIM theory for reconstructing the super-resolution image of the ***,the resolution of our m P-SIM is unlimited if all the high-order harmonics of the nonlinear response of fluorescence are ***,we demonstrate an 86 nm lateral resolution for two-photon(2P)-SIM and a 72 nm lateral resolution for second-harmonic-generation(SHG)-*** further demonstrate their application by imaging cells stained with F-actin and collagen fibres in mouse-tail *** method can be directly used in commercial mP microscopes and requires no specific fluorophores or high-intensity laser.

关键词： Super-resolution microscopy Structured illumination microscopy Multiphoton-structured illumination microscopy(SIM) SIM Second-harmonic-generation(SHG)-SIM