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Chinese Science Bulletin 1992年第7期37卷 602-606页

作者：马润娣于立坚王永清 HOYOKU NISHINO junko TAKAYASU Department of Biochemistry Shaanxi Provincial Academy of Traditional Chinese Medicine and Pharmacology Xi'an 710003 PRC Department of Pharmacy Shaanxi Provincial Health School Xi'an 710000 PRC Department of Biochemistry Kyoto Prefectural University of Medicine Kyoto Japan

Numerous attempts have been made to select compounds that might reduce the incidence of cancer. Previously we have found out that several kinds of natural and

关键词： tubeimoside 1 anti-inflammatory activity antitumor promoting action.

Gender differences in recognising depression in a case vignette in a university student population: Interaction of participant and vignette subject gender with depressive symptomatology

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Open Journal of Psychiatry 2013年第4期3卷 384-392页

作者： junko Andou Toshinori Kitamura Asahi Clinic Kawagoe Japan Kitamura Institute of Mental Health Tokyo Tokyo Japan

Objective: Gender difference in depression prevalence may be explained by variation in the recognition of depression due to differences in gender identity. Method: We distributed one of four questionnaires describing fictional cases of Major Depressive Episode (MDE) (2 predominant symptom types × 2 case vignette subject genders) to 72 students. Participants were asked whether and how much they thought the subject in the case was emotionally as well as somatically ill. They were also administered the Center for Epidemiologic Studies-Depression Scale and the Ito Sex Role Scale. Results: Participants scoring high in gender identity communion and ideal gender roles communion and delicacy were more likely to identify the vignette subject as ill. The severity of somatic illness was rated more highly for the case of predominantly somatic symptomatology. The recognition of severity of psychological illness was influenced by two interactive terms: the gender of the vignette subjects x gender of the participants and predominant symptoms x gender of the vignette subjects. Recognition of MDE case vignettes as indicating illness, particularly psychological illness, was more likely when the participant was female, scored highly in femininity, or was of the gender as the case subject. Conclusion: These findings may be concordant with the self-schema theory.

关键词： Depression Gender Difference Gender Identity Gender Role

Concept Development and Implementation of Family Care/Caring Theory in Concentric Sphere Family Environment Theory

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Open Journal of Nursing 2015年第9期5卷 749-757页

作者： Naohiro Hohashi junko Honda Division of Family Health Care Nursing Department of Nursing Graduate School of Health Sciences Kobe University Kobe Japan

Caring is directed toward a variety of things. One of them is thought to be the concept of “family caring” aimed at families. This study attempts to clarify family caring and develop Family Care/ Caring Theory (FCCT), with the aim of implementing it in conjunction with an existing family nursing theory, the Concentric Sphere Family Environment Theory (CSFET). In Japan and in Hong Kong, family ethnography (including formal interviews) was conducted. As a result, the item “family health care nurses and their colleagues” was added to the family external environment of the CSFET. In the family environment, evidence was obtained to the effect that the family system unit is cared for by the nursing professional, and conversely the family system unit cares for the nursing professional, in a circular transaction. Observing the two-dimensional plane formed by the structural distance and functional distance, family caring assumes a structure of concentric circles, and according to transactions, the structural distance and functional distance between the nursing professional and family system unit are gradually approached, and through deepening of mutual trust maintain an appropriate distance. Moreover observing the three-dimensional space-time continuum which is created through addition of the temporal distance, family caring forms a helical structure. As transactions are repeated along the temporal axis, the family system unit’s self-actualization of other individuals and the self-actualization of the nursing professional are realized. Through these processes, a family care/caring relationship is reinforced and established. This is the concept of FCCT. Through future utilization in clinical settings this will be empirically substantiated, and it will be necessary to continue making creative corrections and revisions.

关键词： Family Caring Family Care/Caring Theory (FCCT) Concentric Sphere Family Environment Theory (CSFET) Family Health Care Nurses and Their Colleagues

Impact Values : 30 Discussion topics to help you explore your own values / Richard ***, junko Yamanaka, Joseph Shaules.

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Glycosylation and secretion of human α-amylases

2003年

作者： Richard R.Day junko Yamanaka Joseph Shaules.

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Advances in Biological Chemistry 2012年第1期2卷 10-19页

作者： Shou Takashima junko Amano Laboratory of Glycobiology The Noguchi Institute Tokyo Japan New Industry Creation Hatchery Center Tohoku University Sendai Japan

Three human α-amylases exist: Amy1 (salivary amylase), Amy2A (pancreatic amylase), and Amy2B (expressed in various tissues). These amylases share a 97% - 99% amino acid sequence identity, and two potential N-glycosylation sites (N427 and N476) are commonly found in the C-terminal region. In general, salivary amylase is more frequently glycosylated than pancreatic amylase, and it is still uncertain why differences in the glycosylation pattern among human amylase iso-zymes occur. In this study, we found that there was no significant change of ratio of glycosylated molecules among isozymes produced by the same cultured cells, indicating that glycosylation of amylase is influenced by the type of cell producing the enzyme rather than being an inherent property of the amylase isozymes. We analyzed the glycosylation efficiency of N-glycosylation sites in recombinant Amy2A mutants produced by HEK293 cells and found that glycosylation efficiencies of N427 and N476 were 3% - 18% and 40% - 52%, respectively, indicating that the major N-glycosylation site of glycosylated Amy2A produced by HEK293 cells is N476. The difference in the glycosylation efficiency of each N-glycosylation site also seemed to contribute in part to generate different glycosylation patterns of human amylases. We also confirmed that the C-terminal region of human amylase plays a critical role in secretion, although glycosylation does not play a part in this effect.

关键词： Amylase Gycosylation Efficiency N-Glycan Secretion

Case of clear-cell hepatocellular carcinoma that developed in the normal liver of a middle-aged woman

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World Journal of Gastroenterology 2008年第1期14卷 129-131页

作者： Atsushi Takahashi Hironobu Saito Yukiko Kanno Kazumichi Abe junko Yokokawa Atsushi Irisawa Akira Kenjo Takuro Saito Mitsukazu Gotoh Hiromasa Ohira Department of Internal Medicine Ⅱ Fukushima Medical University School of Medicine 1 Hikarigaoka Fukushima 960-1295 Japan Department of Surgery Ⅰ Fukushima Medical University School of Medicine 1 Hikarigaoka Fukushima 960-1295 Japan

A 36-year-old woman was admitted to our department for close examination of a liver tumor that was found during a medical checkup. Abdominal US, CT and MRI showed a tumor in segment 7 (S7) of the liver. Although imaging suggested hepatocellular carcinoma, laboratory tests showed no abnormality in liver function, hepatitis virus markers were negative, and tumor markers including protein induced by vitamin K absence or antagonist Ⅱ (PIVKA-Ⅱ), α-fetoprotein (AFP), carbohydrate antigen 19-9 (CA19-9), and carcinoembryonic antigen (CEA) were all within normal ranges. Upon aspiration biopsy of the liver, the histopathological diagnosis was moderately differentiated hepatocellular carcinoma. Therefore, right hepatectomy was performed. Although a part of the tumor was necrotic, about 60% of the viable part showed a clear-cell variant. Consequently, it was diagnosed as clear-cell hepatocellular carcinoma. It was noted that the background liver tissue was normal. This case is worthy of reporting because development of clear-cell hepatocellular carcinoma in the normal liver of a middle-aged woman is rarely seen.

关键词： Clear-cell hepatocellular carcinoma Liver Middle-aged

A case of primary biliary cirrhosis complicated by Behcet's disease and palmoplantar pustulosis

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World Journal of Gastroenterology 2006年第13期12卷 2136-2138页

作者： Haruyo Iwadate Hiromasa Ohira Hironobu Saito Atsushi Takahashi Tsuyoshi Rai junko Takiguchi Tomomi Sasajima Hiroko Kobayashi Hiroshi Watanabe Yukio Sato Department of Internal Medicine Ⅱ Fukushima Medical University School of Medicine Fukushima Japan

A 46-year-old woman was diagnosed with palmoplantar pustulosis （PPP） at the Department of Dermatology, Fukushima Medical University Hospital in 2000, and was treated with ointment. However, because liver dysfunction developed in 2003, she was referred to our department, where primary biliary cirrhosis （PBC） was also diagnosed on the basis of clinical findings. One year later, at the age of 49, she developed manifestations of Behcet＇s disease （BD）, including erythema nodosum in the lower extremities. Because she had a history of uveitis, recurrent oral ulceration was present, and the HLA typing was positive for B51, BD was additionally diagnosed. Liver function normalized within three months of the start of treatment with ursodesoxycholic acid （UDCA）. This is the first case of PBC associated with BD and PPP.

关键词： Primary biliary cirrhosis Behcet's disease Palmoplantar pustulosis

Development of autoimmune hepatitis type 1 after pulsed methylprednisolone therapy for multiple sclerosis: A case report

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World Journal of Gastroenterology 2008年第35期14卷 5474-5477页

作者： Atsushi Takahashi Yukiko Kanno Yuta Takahashi Natsumi Sakamoto Kyoko Monoe Hironobu Saito Kazumichi Abe junko Yokokawa Atsushi Irisawa Hiromasa Ohira Department of Internal Medicine Ⅱ Fukushima Medical University School of MedicineFukushimaJapan

A 43-year-old woman with multiple sclerosis （MS） was treated with pulsed methylprednisolone and interferon 13 at a hospital. Four weeks after initiating treatment, liver dysfunction occurred and she was referred and admitted to our hospital. Clinical and laboratory findings were consistent with and fulfilled the criteria for drug-induced hepatitis, but not for autoimmune hepatitis （AIH）. She was successfully treated with corticosteroids. As ataxia developed after i year, she was treated with pulsed methylprednisolone for 3 days, then readmitted to our hospital when liver dysfunction occurred. Clinical and laboratory findings led to the diagnosis of AIH. To the best of our knowledge, this is the second case of AIH developed after pulsed methylprednisolone for MS.

关键词： Multiple sclerosis Autoimmune hepatitis Pulsed methylprednisolone

Historical Sources on the Hakka in Thai An Introductory Note

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客家研究辑刊 2005年第2期 38-42页

作者： junko KOIZUMI 小泉顺子

日本学者小泉顺子在泰国国家档案馆发现了20世纪早期关于客家的一些重要资料。在本文中，小泉顺子通过对这些资料的介绍和分析，向读者说明了客家在泰国和东亚、东南亚社会中比起其它族群（如潮州、广府），虽然人数相对较少，却扮演着... 详细信息

日本学者小泉顺子在泰国国家档案馆发现了20世纪早期关于客家的一些重要资料。在本文中，小泉顺子通过对这些资料的介绍和分析，向读者说明了客家在泰国和东亚、东南亚社会中比起其它族群（如潮州、广府），虽然人数相对较少，却扮演着十分重要的角色。

关键词：泰国国家档案馆客家历史资料角色扮演地方志

Challenges of Bioethics Education in Pediatric Basic Nursing Education: A Faculty Perspective

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Health 2024年第2期16卷 105-117页

作者： junko Nemoto Chikage Kubota Yukiko Yoshikawa Faculty of Nursing Hyogo University Kakogawa Japan Department of Emergency Medical Science Suzuka University of Medical Science Suzuka Japan

In the field of pediatric nursing, in the perinatal period, numerous ethical issues arise alongside the advancement of medical technology. However, sufficient education on bioethics is not provided in the pediatric nursing domain of basic nursing education. The purpose of this research is to examine the current status of bioethics education in the pediatric nursing domain of basic nursing education and explore the challenges perceived by the pediatric nursing faculty regarding bioethics education. The research method was a questionnaire survey on 100 randomly selected pediatric nursing faculty members from nursing universities across Japan. The results revealed that although bioethics issues were considered important, the emphasis remained primarily on addressing bioethics as part of nursing that respects children’s rights. Furthermore, respondents expressed difficulties regarding teaching methods and content related to bioethics.

关键词： Basic Nursing Education Bioethics Education Pediatric Nursing