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Differences of Plasma Levels of Tryptophan, Serotonin, 5-Hydroxyindole Acetic Acid, and Kynurenine between Healthy People and Patients of Major Monopolar Depression at Various Age and Gender

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Food and Nutrition Sciences 2020年第6期11卷 431-441页

作者： Hiroi Tomioka junichi masuda Akikazu Takada Akira Iwanami Department of Psychiatry School of Medicine Showa University Tokyo Japan Department of Psychiatry Showa University Northern Yokohama Hospital Yokohama Japan Global Application Development Center Shimadzu Corporation Tokyo Japan International Projects on Food and Health (NPO) Tokyo Japan

Background: It is not well analyzed whether there are differences in plasma levels of tryptophan (TRP) metabolites between healthy control people (HC) and patients of major monopolar depression (MMD). Methods: Ultra high-speed liquid chromatography/mass spectrometry has been used for the simultaneous determination of plasma levels of tryptophan metabolites in depressive patients. Results: There are no significant differences between plasma levels of TRP between HC and MMD. Plasma levels of TRP of HC are higher in young men, young women, old men, and old women in this order. Serotonin (5-HT) levels are higher in MMD than HC. Plasma levels of 5-HIAA of HC are also higher than those of patients of MMD. Plasma levels of kynurenine (KYN) of healthy old men and old women are higher than those of young men and old women. Plasma levels of KYN are higher in old women and young men of MMD than those of HC. Conclusion: Plasma levels of 5-HT are higher in patients of MMD than those of HC, which may suggest that use of drugs inhibiting the 5-HT transportation may increase plasma levels of 5-HT in MMD.

关键词： Depression Monopolar Depression Bipolar Depression Tryptophan Serotonin 5-Hydroxyindole Acetic Acid Kynurenine 3-Hydroxykynurenine Kynurenic Acid Anthranilic Acid Xanthurenic Acid Indole-3-Acetic Acid SSRI (Selective Serotonin Reuptake Inhibitor) SNRI (Serotonin Norepinephrine Reuptake Inhibitor)

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Comparison of Plasma Levels of Tryptophan Metabolites between Healthy People and Patients of Bipolar Depression at Various Age and Gender

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Journal of Biomedical Science and Engineering 2020年第6期13卷 120-129页

作者： Hiroi Tomioka junichi masuda Akikazu Takada Akira Iwanami Department of Psychiatry Showa University School of Medicine Tokyo Japan Department of Psychiatry Showa University Northern Yokohama Hospital Yokohama Japan Global Application Development Center Shimadzu Corporation Kanagawa-ken Japan International Projects on Food and Health (NPO) Tokyo Japan

Background: It is not well analyzed whether there are differences in plasma levels of tryptophan (TRP) metabolites between healthy control people (HC) and patients of type II bipolar depression (BDII). Methods: Ultra high-speed liquid chromatography/mass spectrometry has been used for the simultaneous determination of plasma levels of tryptophan metabolites in depressive patients. Results: Plasma levels of TRP are not different between HC and patients of BDII. Serotonin (5-HT) levels are higher in BDII than HC. Plasma levels of 5-HIAA of HC are higher than those of old women of BDII, but lower in young women of BDII. Plasma levels of kynurenine (KYN) of HC are not different from those of patients of BDII. Conclusion: Plasma levels of 5-HT are higher in patients of BDII than those of HC, which may suggest that use of drugs inhibiting the 5-HT transportation and lower transporter biding may increase plasma levels of 5-HT in patients of BD.

关键词： Depression Monopolar Depression Bipolar Depression Tryptophan Serotonin 5-Hydroxyindole Acetic Acid Kynurenine SSRI (Selective Serotonin Reuptake Inhibitor) SNRI (Serotonin Norepinephrine Reuptake Inhibitor) Anxiolytic Antipsychotic

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Measurement of Tryptophan Metabolites in Healthy Old Men and Patients of Type 2 Diabetes Mellitus (T2DM)

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Food and Nutrition Sciences 2018年第10期9卷 1206-1220页

作者： Akikazu Takada Fumiko Shimizu Tetsuya Takao junichi masuda International Projects on Food and Health (NPO) Tokyo Japan Faculty of Life and Environmental Sciences Showa Women’s University Tokyo Japan Global Application Development Center Shimadzu Corporation Kyoto Japan

Background: Plasma levels of tryptophan (TRP) metabolites have not been measured extensively in patients of type 2 diabetes mellitus (T2DM). Methods: Metabolites analysis was performed by a liquid chromatograph tandem mass spectrometer, the LCMS-8060 quadrupole mass spectrometer combined with Nexera X2 liquid chromatograph system (Shimadzu Corporation, Kyoto, Japan). Body mass index (BMI) and TRP metabolites have been measured in healthy old men (n = 20) and patients of T2DM (n = 20). TRP metabolites were measured by using the ultrahigh speed liquid chromatography-mass spectros-copy (Shimadzu Corporation). Results: The plasma levels of 5-hydroxytryptophan (5-HTRP), 5-hydroxyindoleacetic acid (5-HIAA), kynurenic acid (KNA), 3-hydroxykynurenine (3-HKN), and 3-hydroxyanthranilic acid (3-HAA) were higher in patients of T2DM than healthy old men. Since 5HTRP and 5-HIAA belong to the serotonin pathway, and KNA, 3-HKN, and 3-HAA belong to the KN pathway of TRP metabolism, these pathways were activated more in the patients of T2DM. Since plasma levels of Indole-3-acetic acid were not elevated in T2DM, that pathway was not activated more in T2DM. Serotonin levels were not increased but 5-HIAA levels were increased in the plasma of T2DM patients, which may mean that serotonin was quickly metabolized to 5-HIAA in the patients of T2DM. Conclusion: Plasma levels of tryptophan metabolites in serotonin and kynurenine pathways increased in T2DM patients. Obesity expressed by BMI may not influence tryptophan metabolism in healthy old men and T2DM patients. These results indicate that our new method of the simultaneous measurements of all the tryptophan metabolites is the powerful measure to identify factor related to endogenous stresses seen in DM.

关键词： Tryptophan Serotonin 5-Hydroxyindole Acetic Acid Kynurenine 3-Hydroxykynurenine Kynurenic Acid

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Comparison of Age and Gender Differences of Tryptophan Metabolites in Patients of Major Monopolar and Bipolar Depression

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Food and Nutrition Sciences 2020年第3期11卷 172-185页

作者： Hiroi Tomioka junichi masuda Akikazu Takada Akira Iwanami Department of Psychiatry Showa University School of Medicine Showa Japan Department of Psychiatry Showa University Northern Yokohama Hospital Showa Japan Global Application Development Center Shimadzu Corporation Kanagawa-ken Japan International Projects on Food and Health (NPO) Tokyo Japan

Background: No research has been done for the determination of plasma levels of tryptophan metabolites in patients of monopolar and bipolar depression. Methods: Ultra high-speed liquid chromatography/mass spectrometry has been used for the simultaneous determination of plasma levels of tryptophan metabolites in depressive patients. Results: No significant age and gender differences were shown in monopolar depressive patients and some differences were shown in bipolar patients. The administration of drugs such as antidepressants, antipsychotics, mood stabilizers do not seem to have affected the results. Conclusion: In patients of major monopolar depression age and gender differences of plasma levels of tryptophan metabolites disappear although significant differences are observed in healthy volunteers. Some differences of age and gender differences were shown between monopolar and bipolar depressive patients.

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Effects of Gender, Age, and Clot Formation on the Measurements of Tryptophan Metabolites in Blood

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Food and Nutrition Sciences 2019年第7期10卷 761-775页

作者： junichi masuda Masato Karayama Takafumi Suda Masato Maekawa Fumiko Shimizu Akikazu Takada Global Application Development Center Shimadzu Corporation Kanagawa-ken Japan Second Department of Internal Medicine Hamamatsu University School of Medicine Hamamatsu Japan Department of Laboratory Medicine Hamamatsu University School of Medicine Hamamatsu Japan Faculty of Life and Environmental Sciences Showa Women’s University Tokyo Japan International Projects on Food and Health (NPO) Tokyo Japan

Background: Tryptophan metabolism plays important roles in health and diseases. Although simultaneous measurements of tryptophan metabolites are successfully measured, influences of age, gender, and clot formation on the measurements have not been reported. Methods: We took blood from young and old Japanese men and women and compared plasma levels of tryptophan metabolites. We also took plasma and serum from the blood of middle-aged men (n = 10). Metabolites analysis was performed by a liquid chromatograph tandem mass spectrometer, the LCMS-8060 quadrupole mass spectrometer combined with Nexera X2 liquid chromatograph system (Shimadzu Corporation, Kyoto, Japan). Body mass index (BMI) and TRP metabolites have been measured in healthy young men (n = 48), young women (n = 47), old men (n = 44), and old women (n = 39). TRP metabolites were measured by using the ultrahigh speed liquid chromatography-mass spectroscopy (Shimadzu Corporation). Results: Tryptophan and its metabolites such as serotonin, 5-hydroxyindole acetic acid, indole-3-acetic acid, kynurenine, anthranilic acid, were higher in young women and old men than young men and old women. Plasma levels of 3-hydroxykynurenine and xanthurenic acid were lower in young women and old men. Comparison of plasma and serum indicates that most of metabolites were higher in serum than plasma except for 3-hydroxy-kynurenine and quinolinic acid. Conclusion: Metabolites of the upper stream of degradation of tryptophan were higher in young women and old men than young men and old women, which suggests that the degradation of tryptophan was accelerated in young men and old women than young women and old men. Serum preparation may activate tryptophan degradation resulting in higher levels of metabolites in serum than in plasma.

关键词： Plasma Serum Platelet Tryptophan Serotonin 5-Hydroxyindole Acetic Acid Kynurenine 3-Hydroxykynurenine Kynurenic Acid Anthranilic Acid Xanthurenic Acid Indole-3-Acetic Acid

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Selection of treatment modality for hepatocellular carcinoma according to the modified Japan Integrated Staging score

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World Journal of Gastroenterology 2008年第1期14卷 58-63页

作者： Atsushi Nanashima junichi masuda Satoshi Miuma Yorihisa Sumida Takashi Nonaka Kenji Tanaka Shigekazu Hidaka Terumitsu Sawai Takeshi Nagayasu Division of Surgical Oncology Department of Translational Medical Sciences Nagasaki University Graduate School of Biomedical Sciences 1-7-1 Sakamoto Nagasaki 852-8501 Japan Second Department of Internal Medicine Department of Translational Medical Sciences Nagasaki University Graduate School of Biomedical Sciences 1-7-1 Sakamoto Nagasaki 852-8501 Japan First Department of Internal Medicine Department of Translational Medical Sciences Nagasaki University Graduate School of Biomedical Sciences 1-7-1 Sakamoto Nagasaki 852-8501 Japan

AIM： To compare the prognosis of patients who underwent hepatectomy and ablation using the modified Japan Integrated Staging score （mJIS）. METHODS： We examined the clinicopathologic records and patient outcomes in 278 HCC patients including 226 undergoing hepatectomy and 52 undergoing ablation therapy. RESULTS： Cirrhosis was more frequent in the ablation group. Tumor size, number and presence of vascular invasion were significantly higher in the operation group compared to the ablation group. The local recurrence rate adjacent to treated lesions was significantly higher in the ablation group compared to the operation group （P 〈 0.05）. The 3- and 5-year survival rates in the ablation and the operation group were 66% and 78%, and 50% and 63%, respectively, but not significantly different. Over 50% survival rates were observed in patients with a *** score of 0-2 in both groups. However, survival rates with a score of 3-5 in both groups were significantly lower. CONCLUSION： According to the mJIS system, both local treatments could be selected for patients with a score of 0-2. However, for patients with a score more than 3, liver transplantation might be a better option in patients with HCC.

关键词： Hepatocellular carcinoma Hepatectomy,Ablation Modified Japan integrated staging score Liver transplantation

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Best mix of primary energy resources by renewable energy and fossil fuel with CCS in view of security,stability and sustainability——A vision on hydrogen supply chain by organic chemical hydride method

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Science China(Technological Sciences) 2010年第1期53卷 62-68页

作者： junichi SAKAGUCHI Research Institute of Technology Innovation & Strategy of Chiyoda Corporation 2-12-1TsurumichuoTsurumi-kuYokohama230-8601Japan

The best mix scenario by renewable energy and fossil fuel with or without CCS(Carbon Dioxide Capture and Storage) would be a solution to compromise Greenhouse Gases emission issue caused by carbon dioxide(CO2),and depletion of crude oil and natural gas *** fossil fuel with pre-combustion CCS means hydrogen manufacturing and also hydrogen can be produced via electrolysis with renewable energy,it is desirable to establish transportation and storage systems of hydrogen as a clean *** this paper a vision on Hydrogen Supply Chain by Organic Chemical Hydride(OCH) Method as well as comparison of CCS configuration are discussed.

关键词： pre-combustion CCS compressors and pumps for CCS Hydrogen Supply Chain Organic Chemical Hydride Method

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SICE benchmark problem:starting speed control of SI engines

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Control Theory and Technology 2019年第2期17卷 138-147页

作者： junichi KAKO Advanced Powertrain Planning&Management Div.Toyota Motor Corporation ShizuokaJapan

Starting the engine and quickly adjusting the engine speed to the target value after that will always be a challenge for vehicles with an internal combustion engines at development sites in the automotive *** SICE Research Committee on Advanced Powertrain Control Theory provided this task as a benchmark problem with the engine *** as control developers in the industry are provided actual engines,many of the academic experts have acquired engine models,analyzed behavior and constructed controls,and solved control *** summarize this activity by explaining the methods by many challengers that achieved the target performance.

关键词： Engine start control benchmark problem engine model

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IT APPLICATIONS PORTFOLIO MANAGEMENT UNDER BUSINESS AND IMPLEMENTATION UNCERTAINTY

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Journal of Systems Science and Systems Engineering 2008年第1期17卷 109-124页

作者： Masafumi KOTANI junichi IIJIMA IBM Japan Industrial Sector Marketing Executive Graduate School of Decision Science and Technology Tokyo Institute of Technology

Corporations need to improve business processes in order to enhance velocity and service levels while reducing their processing costs and differentiating themselves in the face of competition. The levitation of importance beyond support roles has raised IT investment decisions to high priority in chief executive officers＇ agendas. Corporate planning groups as well as lines of business are increasingly applying techniques of IT applications portfolio management in a more systematic fashion to improve decision-making and resource-allocation processes. Recent advances in software engineering and IT service delivery methodologies have achieved the logical separation of business functions from implementation. This separation has made a new breed of innovative IT project possible with a new project risk structure; the adjustment of portfolio management techniques is appropriate. We present an integrated portfolio management model so that the corporation can focus on organic growth through sources at both the department and top management levels. The research gives clear advice as to how top management can seek economic growth by selecting an entrepreneurial strategic posture, implying a strong risk-taking propensity. By integrating a risk-return model and risk-tolerance paradigm to cope with today＇s risk structure, overall capabilities can improve the decision process and the corporation＇s performance as well. The application of the integrated technique to a Japanese manufacturing firm is described.

关键词： IT-investment management application portfolio management real options analysis risk-return model risk-tolerance paradigm timing decision

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Earthquake simulation test of circular reinforced concrete bridge column under multidirectional seismic excitation

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Earthquake Engineering and Engineering Vibration 2006年第1期5卷 103-110页

作者： junichi Sakai Shigeki Unjoh Earthquake Engineering Research Team Earthquake Disaster Prevention Research Group Public Works Research InstituteTsukuba Ibaraki 305-8516 Japan

Structures behave multi-directionally when subjected to earthquake excitation. Thus, it is essential to evaluate the effect of multidirectional loading on the dynamic response and seismic performance of reinforced concrete bridge columns in order to develop more advanced and reliable design procedures. To investigate such effects, a 1/4 scaled circular reinforced concrete bridge column specimen was tested under two horizontal and one vertical components of a strong motion that has long duration with several strong pulses. Damage progress of reinforced concrete columns subjected to strong excitation was evaluated from the test. The test results demonstrate that the lateral force response in the principal directions become smaller than computed flexural capacity due to the bilateral flexural loading effects, and that the lateral response is not significantly affected by the fluctuation of the axial force because the horizontal response and axial force barely reached the maximum simultaneously due to difference of the predominant natural periods between the vertical and the horizontal directions. Accuracy of fiber analyses is discussed using the test results.

关键词： multidirectional seismic excitation reinforced concrete bridge columns shake table test nonlinear dynamic analyses fiber analysis

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