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Ectopic peritoneal paragonimiasis mimicking tuberculous peritonitis:A care report

World Journal of Clinical Cases 2022年第16期10卷 5359-5364页

作者： jung Woo choi Chang Min Lee Seong Je Kim Se In Hah Ji Yoon Kwak Hyun Chin cho Chang Yoon Ha Woon Tae jung Ok Jae Lee Department of Internal Medicine Gyeongsang National University College of Medicine and Gyeongsang National University HospitalJinju 52727South Korea Institute of Health Sciences Gyeongsang National UniversityJinju 52828South Korea

BACKGROUND The most common site of paragonimiasis is in the *** migratory route passes through the duodenal wall,peritoneum,and diaphragm to the lungs;thus,the thoracic cavity and central nervous system,as well as the liver,intestine,and abdominal cavity may be ***,we present a case of intraperitoneal paragonimiasis without other organ involvement,mimicking tuberculous *** SUMMARY A 57-year-old man presented with recurrent abdominal pain for 4 *** examination revealed tenderness in the right lower *** findings showed complete blood counts within the normal range without *** reactive lymph nodes and diffuse peritoneal infiltration were noted on abdominal computed tomography(CT).There were no abnormalities on chest CT or *** findings of diagnostic laparoscopy for the differential diagnosis of tuberculous peritonitis and peritoneal carcinomatosis included multiple small whitish nodules and an abscess in the *** reports confirmed the presence of numerous eggs of Paragonimus westermani(***).A postoperative serum enzyme-linked immunosorbent assay revealed *** *** and repetitive history-taking led him to retrospectively recall the consumption of freshwater *** 3 d of treatment with praziquantel(1800 mg;25 mg/kg),he recovered from all *** In patients who require diagnostic laparoscopy for the differential diagnosis of tuberculous peritonitis and peritoneal carcinomatosis,repetitive history-taking and preoperative serologic antibody tests against Paragonimus may be helpful in diagnosing intraperitoneal paragonimiasis without other organ involvement.

关键词： Differential diagnoses Intraperitoneal abscess Paragonimiasis Paragonimus westermani Peritonitis Tuberculosis Case report

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A thorough analysis of the effect of surfactant/s on the solubility and pharmacokinetics of (S)-zaltoprofen

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Asian Journal of Pharmaceutical Sciences 2019年第4期14卷 435-444页

作者： Cuong Viet Pham Jong-Suep Baek Jong-Hun Park Sang-Hun jung Jong-Seong Kang Cheong-Weon cho College of Pharmacy and Institute of Drug Research and Development Chungnam National UniversityDaejeon 34134Republic of Korea Department of Herbology College of Korean MedicineDongguk UniversityGyeongju 38066Republic of Korea

Until now, there are no publications about the preformulation studies on(S)-zaltoprofen((S)-ZPF). Hence, we first investigated the solubility of(S)-ZPF, screened solubilizers and performed the pharmacokinetic study of(S)-ZPF in the presence of the solubilizers. The measurement of the solubility of(S)-ZPF in 26 different solvents was carried out, including d-alpha tocopheryl polyethylene glycol 1000 succinate(TPGS), 2-hydroxypropyl-β-cyclodextrin(HPCD), and mixtures of individual solvent. The plasma concentration of(S)-ZPF and the amount of(S)-ZPF retained in stomach were determined after oral(35.0 mg/kg) and intravenous(5.0 mg/kg) administration. The solubility of(S)-ZPF showed an increase of 484-fold in TPGS compared to its aqueous solubility. There was a significant increase of AUC 0-24 h for pure(S)-ZPF in the TPGS group(813.59 ± 64.17 μg h/ml) in comparison with AUC 0-24 h in the HPCD group(595.57 ± 71.76 μg h/ml) and water group(465.57 ± 90.89 μg h/ml). In addition, the T max of(S)-ZPF in the TPGS group was 2 h, much faster than that in the HPCD or water groups(5.50 or 5.67 h, respectively). This suggested that TPGS played a significant role in the increase of solubility and bioavailability of(S)-ZPF.

关键词： (S)-zaltoprofen Solubility Bioavailability D-alpha tocopheryl polyethylene glycol 1000 succinate 2-hydroxypropyl-β-cyclodextrin

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Segmented tomographic evaluation of structural degradation of carbon support in proton exchange membrane fuel cells

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Journal of Energy Chemistry 2022年第11期31卷 359-367,I0010页

作者： jung A.Hong Min-Hyoung jung Sung Yong cho Eun-Byeol Park Daehee Yang Young-Hoon Kim Sang-Hyeok Yang Woo-Sung Jang Jae Hyuck Jang Hyo June Lee Sungchul Lee Hu Young Jeong Young-Min Kim Department of Energy Science Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Fuel Cell Core Parts Development Cell Hyundai Mobis Co.Ltd.Uiwang 16082Republic of Korea Electron Microscopy&Spectroscopy Team Korea Basic Science Institute(KBSI)Daejeon 34133Republic of Korea Graduate School of Semiconductor Materials and Devices Engineering Ulsan National Institute of Science and Technology(UNIST)Ulsan 44919Republic of Korea

The variation of the three-dimensional(3D)structure of the membrane electrode of a fuel cell during proton exchange cycling involves the corrosion/compaction of the carbon *** increasing degradation of the carbon structure continuously reduces the electrocatalytic performance of proton exchange membrane fuel cells(PEM-FCs).This phenomenon can be explained by performing 3D tomographic analysis at the ***,conventional tomographic approaches which present limited experimental feasibility,cannot perform such evaluation and have not provided sufficient structural information with statistical significance thus ***,a reliable methodology is required for the 3D geometrical evaluation of the carbon ***,we propose a segmented tomographic approach which employs pore network analysis that enables the visualization of the geometrical parameters corresponding to the porous carbon structure at a high *** approach can be utilized to evaluate the 3D structural degradation of the porous carbon structure after cycling in terms of local surface area,pore size distribution,and their 3D *** geometrical parameters of the carbon body were demonstrated to be substantially reduced owing to the cycling-induced *** information enables a deeper understanding of the degradation phenomenon of carbon supports and can contribute to the development of stable PEM-FC electrodes.

关键词： Electron tomography Fuel cell Proton exchange membrane Membrane electrode assembly Carbon corrosion

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Does proximal femoral nail antirotation achieve better outcome than previous-generation proximal femoral nail?

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World Journal of Orthopedics 2020年第11期11卷 483-491页

作者： Seung-Hoon Baek Seunggil Baek Heejae Won Jee-wook Yoon Chul-Hee jung Shin-Yoon Kim Department of Orthopedic Surgery Kyungpook National University HospitalDaegu 41944South Korea Department of Orthopedic Surgery School of MedicineKyungpook National UniversityDaegu 41944South Korea Department of Orthopedic Surgery Goodssen HospitalDaegu 42010South Korea

BACKGROUND There are few studies in the literature comparing the clinical outcomes and radiographic results of proximal femoral nail(PFN)and proximal femoral nail antirotation(PFNA)for pertrochanteric femoral fracture(PFF)in elderly *** To evaluate both clinical and radiographic outcomes after fixation with PFN and PFNA in an elderly patient *** One hundred fifty-eight patients older than 65 years with PFF who underwent fixation with either PFN or PFNA were ***-three patients underwent fixation with PFN,whereas 85 were fixed with *** mean follow-up was 2.4 years(range,1-7 years).Clinical outcome was measured in terms of operation time,postoperative function at each follow-up visit,and mortality within one *** evaluation included reduction quality after surgery,Cleveland Index,tip-apex distance(TAD),union rate,time to union,and sliding distance of the screw or *** including nonunion,screw cutout,infection,osteonecrosis of the femoral head,and implant breakage were also *** Postoperative function was more satisfactory in patients who underwent PFNA than in those who underwent PFN(P=0.033).Radiologically,the sliding difference was greater in PFN than in PFNA patients(6.1 and 3.2 mm,respectively,P=0.036).The rate of screw cutout was higher in the PFN group;eight for PFN(11.0%)and two for PFNA patients(2.4%,P=0.027).There were no differences between the two groups in terms of operation time,mortality rate at one year after the operation,adequacy of reduction,Cleveland Index,TAD,union rate,time to union,nonunion,infection,osteonecrosis,or implant *** Elderly patients with PFF who underwent PFNA using a helical blade demonstrated better clinical and radiographic outcomes as measured by clinical score and sliding distance compared with patients who underwent PFN.

关键词： Pertrochanteric fracture Proximal femoral nail Proximal femoral nail antirotation Sliding distance Cutout Outcome

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Serum 25-hydroxyvitamin deficiency in middle-aged a cross-sectional study D levels and testosterone Korean men：

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Asian Journal of Andrology 2015年第2期17卷 324-328,I0012页

作者： Young Jin Tak Jeong Gyu Lee Yun Jin Kim Nam Cheol Park Sang Soo Kim Sangyeoup Lee Byung Mann cho Eun Hee Kong Dong wook jung Yu Hyeon Yi Department of Family Medicine Pusan National University School of Medicine Busan Korea Biomedical Research Institute Pusan National University Hospital Busan Korea Department of Urology Pusan National University School of Medicine Busan Korea Department of Internal Medicine Pusan National University School of Medicine Busan Korea Medical Education Unit Pusan National University School of Medicine Yangsan Korea Department of Preventive Medicine and Occupational Medicine Pusan National University School of Medicine Yangsan Korea Department of Family Medicine College of Medicine Kosin University Busan Korea.

Previous studies have demonstrated that male hypogonadism is associated with a low level of vitamin D. However, no reports have investigated the effects of vitamin D on testosterone levels in Korean men. Our aim was to investigate whether testosterone levels are associated with serum vitamin D levels and whether seasonal variation exists. This cross-sectional study analyzed serum 25-hydroxyvitamin D [25（OH）D], total testosterone （TT）, and free testosterone （FT） in 652 Korean men over 40 years of age who had undergone a comprehensive medical examination. The average age of the subjects was 56.7± 7.9 years, and the mean serum 25（OH）D, TT and FT levels were 21.23 ± 7.9 ng m1-1, 4.70 ±1.6 ng m1-1, and 8.12± 3.3 pg m1-1, respectively. In the multiple linear regression model, 25（OH）D showed positive association with TT （β =0.137, P〈 0.001） and FT （p =0.103, P= 0.008）. 25（OH） D and FT showed similar seasonal or monthly variation after adjustment for age. A vitamin D deficiency [25（OH）D 〈 20 ng m1-1] was associated with an increased risk of deficiencies of TT （〈2.30 ng ml-1）（odds ratio [OR]： 2.65; 95% confidence interval [CI]. 1.21-5.78, P = 0.014） and FT （〈6.50 pg ml-1）（OR： 1.44; 95% Ch 1.01-2.06 P = 0.048） after adjusting for age, season, body mass index, body composition, chronic disease, smoking, and alcohol use. In conclusion, we demonstrated a positive correlation between 25（OH）D and testosterone, which showed similar seasonal variation in Korean men.

关键词： 25-hydroxyvitamin D hypogonadism seasons testosterone vitamin D

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Nanowire-assisted freestanding liquid metal thin-film patterns for highly stretchable electrodes on 3D surfaces

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npj Flexible Electronics 2022年第1期6卷 956-963页

作者： Minwoo Kim Chulmin cho Wooseop Shin jung Jae Park Jaewon Kim Phillip Won Carmel Majidi Seung Hwan Ko Applied Nano and Thermal Science Lab Department of Mechanical EngineeringSeoul National UniversitySeoulGwanak-guKorea Mechatronics Research Samsung ElectronicsHwaseong-siGyeonggi-doKorea Soft Machines Lab Department of Mechanical EngineeringCarnegie Mellon UniversityPittsburghPAUSA Institute of Advanced Machines and Design/Institute of Engineering Research Seoul National UniversitySeoulKorea

Stretchable electronics is playing an integral role in fields such as wearable electronics and soft *** soft conductive materials,liquid metal is drawing intense attention as an electrode material due to its liquid nature at room ***,the merits of liquid metal conductor are limited by the presence of substrates or enclosed microchannels from physical disturbances by the underlying substrate when applying it to 3D surface and modifying complex *** overcome this limitation,we develop freestanding patterned liquid metal thin-film conductor(FS-GaIn).FS-GaIn was achieved by introducing metal nanowires to liquid metal and subsequent sequential selective laser processing and etching of directly patterned *** can be applied directly to nonflat surface without *** incorporated into electrical circuits,FS-GaIn shows high electrical conductivity,stretchability,and *** concept of freestanding liquid metal can open a functionality to the conventional liquid metal electronics.

关键词： liquid film free

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Simultaneous intrahepatic and subgaleal hemorrhage in antiphospholipid syndrome following anticoagulation therapy

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World Journal of Gastroenterology 2013年第38期19卷 6494-6499页

作者： In-Chul Park Yang-Hyun Baek Sang-Young Han Sung-wook Lee Won-Tae Chung Sung-Won Lee Sang-Hyeon Kang Duk-Song cho Division of Gastroenterology and Hepatology Department of Internal MedicineCollege of MedicineDong-A University

Warfarin is a widely used *** differences in drug response,a narrow therapeutic range and the risk of bleeding render warfarin difficult to use *** 18-year-old woman with antiphospholipid syndrome received long-term warfarin therapy for a recurrent deep vein *** years later,she developed right flank *** diagnosed intrahepatic and subgaleal hemorrhages secondary to anticoagulation *** stopping oral anticoagulation,a follow-up computed tomography showed improvement in the *** restarting warfarin because of a recurrent thrombosis,the intrahepatic hemorrhage *** decided to start clopidogrel and hydroxychloroquine instead of *** patient has not developed further recurrent thrombotic or bleeding *** hemorrhage is a very rare complication of warfarin,and our patient experienced intrahepatic and subgaleal hemorrhage although she did not have any risk factors for bleeding or instability of the international normalized ratio control.

关键词： Warfarin Liver Subgaleal Hemorrhage Antiphospholipid syndrome

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Differential diagnoses of magnetic resonance imaging for suspected acute appendicitis in pregnant patients

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World Journal of Emergency Medicine 2018年第1期9卷 26-32页

作者： Ji Yong jung Ji Ung Na Sang Kuk Han Pil cho choi Jang Hee LEE Dong Hyuk Shin Department of Emergency Medicine Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine

BACKGROUND: Accurate and timely diagnosis of acute surgical disease in pregnant patient is chal enging. Although magnetic resonance imaging(MRI) is the most accurate modality to diagnose acute appendicitis in pregnant patients, it is often used as a last resort because of high cost and long scan time. We performed this study to analyze differential diagnoses of appendix MRI and to investigate if there are any blood tests that can predict surgical condition in pregnant ***: A retrospective, cross-sectional study was conducted on 46 pregnant patients who underwent non-enhanced appendix MRI in suspicion of acute appendicitis from 2010 to 2016. Differential diagnoses of appendix MRI were analyzed and blood tests were compared between those who had surgical and non-surgical ***: Appendix MRI differentiated two surgical disease; acute appendicitis and ovarian torsion; and various non-surgical conditions such as uterine myoma, hydronephrosis, ureterolithiasis and diverticulitis among clinically suspected acute appendicitis in pregnancy. The diagnostic accuracy of MRI for acute appendicitis in this study was 93.5%. Patients who had surgical disease showed significantly higher WBC count(≥11,000/mm^3), proportion of neutrophils in the WBC(≥79.9%), neutrophil-to-lymphocyte ratio(NLR≥6.4), levels of C-reactive protein(CRP≥1.82 mg/dL) and bilirubin(≥0.66 mg/dL) than those who had non-surgical ***: MRI can reliably differentiate surgical conditions and several blood tests(WBC, proportion of neutrophils in the WBC, NLR, CRP, bilirubin) can help anticipate acute surgical condition among pregnant patients suspected to have acute appendicitis.

关键词： Appendicitis Magnetic resonance imaging Pregnancy Neutrophils

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Contemporary trends in radical prostatectomy and predictors of recovery of urinary continence in men aged over 70 years:comparisons between cohorts aged over 70 and less than 70 years

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Asian Journal of Andrology 2020年第3期22卷 280-286页

作者： Young Ju Lee Jin-Woo jung Sangchul Lee Sang wook Lee Jeong Hyun Kim Sung Kyu Hong Seok-Soo Byun Sang Eun Lee Seong Jin Jeong Departme nt of Urology Seoul National University Bundang HospitalSeongnam 13620Korea Department of Urology Catholic Kwan dong Univerisity International St.Mary's HospitalIncheon 22711Korea Department of Urology Kangwon National University School of MedicineChuncheon 24341Korea.

We evaluated contemporary trends in radical prostatectomy(RP)in men aged>70 years and investigated associations of selected variables with recovery of urinary continence(UC)in two age groups:>70 and70 years[n=610]vs70 years gradually increased up to 30.0%,and the rate of robot-assisted RP and neurovascular bundle(NVB)saving increased continually to 80.0%and 67.4%of older patients,*** the rate of recovery of UC within 12 months(3 months)in patients aged>70 years was lower than that in those aged S70 years(81.5%[52.6%]vs 88.6%[60.9%],respectively;both P70 ***,unlike younger patients,only variables(age and MUL),possibly associated with the inhere nt fun ction of the urinary sphi ncter,were predictors of recovery of UC in patients aged>70 years.

关键词： elderly predictor prostate cancer radical prostatectomy urinary incontinence

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Annexin A10 expression in colorectal cancers with emphasis on the serrated neoplasia pathway

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World Journal of Gastroenterology 2015年第33期21卷 9749-9757页

作者： Jeong Mo Bae jung Ho Kim Ye-Young Rhee Nam-Yun cho Tae-You Kim Gyeong Hoon Kang Laboratory of Epigenetics Cancer Research InstituteSeoul National University College of Medicine Department of Pathology Seoul National University College of Medicine Department of Internal Medicine Seoul National University College of Medicine

AIM: To validate the utility of Annexin A10 as a surrogate marker of the serrated neoplasia pathway in invasive colorectal cancers(CRCs).METHODS: A total of 1133 primary CRC patients who underwent surgical resection at Seoul National University Hospital between January 2004 and December 2007 were *** of Annexin A10 was evaluated by immunohistochemistry using tissue microarray and paired to our findings on clinicopathologic and molecular characteristics of each *** G island methylator phenotype was determined by Methy Light assay and microsatellite instability was determined by high performance liquid *** and BRAF mutation status was evaluated by direct sequencing and allele-specific *** and stage-specific survival analyses were performed to reveal the prognostic value of Annexin A10 ***: Annexin A10 expression was observed in 66(5.8%) of the 1133 *** A10 expression was more commonly found in females and was associated with proximal location,ulcerative gross type,advanced T category,N category and TNM *** with Annexin A10 expression showed an absence of luminal necrosis,luminal serration and mucin *** with Annexin A10 expression were associated with Cp G island methylator phenotype,microsatellite instability and BRAF *** survival analysis,Annexin A10 expression was associated with poor overall survival and progression-free survival,especially in stage Ⅳ ***: Annexin A10 expression is associated with poor clinical behavior and can be used a supportive surrogate marker of the serrated neoplasia pathway in invasive CRCs.

关键词： Annexin A10 Serrated neoplasia pathway CpG island

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