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α- Carbonyl Radical Cyclization for the Total Synthesis of Natural Products

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α- Carbonyl Radical Cyclization for the Total Synthesis of ...

Aberrant activation of nuclear factor of activated T cell 2 in lamina propria mononuclear cells in ulcerative colitis

第三届全国有机化学学术会议

作者： SHA, Chin-Kang CHIU, Rei-Torng LIH, Shinn-Horng SANTHOSH, K. C. chang, Ching-jung TSENG, Wei-Hong HO, Wen-Yueh ( Department of Chemistry, National Tsing HIM University , Hsinchu. 300, Taiwan)

＜正＞ Intramolecular radical cyclization reactions are now used routinely to synthesize carbocyclic and heterocyclic structures. We have reported that a -carbonyl radicals 1, generated from the corresponding iodo ket...

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来源： cnki会议评论

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World Journal of Gastroenterology 2008年第11期14卷 1759-1767页

作者： Tsung-Chieh Shih Sen-Yung Hsieh Yi-Yueh Hsieh Tse-Chin Chen Chien-Yu Yeh Chun-jung Lin Deng-Yn Lin Cheng-Tang Chiu Clinical Proteomics Center Chang Gung Memorial HospitalTaoyuan 333Taiwan Clinical Proteomics Center Chang Gung Memorial HospitalTaoyuan 333Taiwan Department of Hepato-GastroenterologyChang Gung Memorial HospitalChang Gung University School of Medicine Taoyuan 333Taiwan Department of Anatomic Pathology Chang Gung Memorial HospitalTaoyuan 333Taiwan Department of Colorecto-Surgery Chang Gung Memorial HospitalTaoyuan 333Taiwan Department of Hepato-Gastroenterology Chang Gung Memorial HospitalChang Gung University School of Medicine Taoyuan 333Taiwan

AIM:To investigate the role of nuclear factor of activated T cell 2(NFAT2),the major NFAT protein in peripheral T cells,in sustained T cell activation and intractable inflammation in human ulcerative colitis(UC). METHODS:We used two-dimensional gel-electrophoresis, immunohistochemistry,double immunohistochemical staining,and confocal microscopy to inspect the expression of NFAT2 in 107,15,48 and 5 cases of UC, Crohn's disease(CD),non-specific colitis,and 5 healthy individuals,respectively. RESULTS:Up-regulation with profound nucleo- translocation/activation of NFAT2 of lamina propria mononuclear cells(LPMC)of colonic mucosa was found specifically in the affected colonic mucosa from patients with UC,as compared to CD or NC(P<0.001,Kruskal- Wallis test).Nucleo-translocation/activation of NFAT2 primarily occurred in CD8+T,but was less prominent in CD4+T cells or CD20+B *** was strongly associated with the disease activity,including endoscopic stage (τ=0.2145,P=0.0281)and histologic grade(τ=0.4167, P<0.001). CONCLUSION:We disclose for the first time the nucleo-translocation/activatin of NFAT2 in lamina propria mononuclear cells in ulcerative *** of NFAT2 was specific for ulcerative colitis and highly associated with disease *** activation of NFAT2is implicated in an auto-regulatory positive feedback loop of sustained T-cell activation and NFAT proteins play key roles in the calcium/calcineurin signaling pathways,our results not only provide new insights into the mechanism for sustained intractable inflammation,but also suggest the calcium-calcineurin/NFAT pathway as a new therapeutic target for ulcerative colitis.

关键词： T细胞大肠炎核因子蛋白质

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世界胃肠病学杂志：英文版 2008年第27期14卷 4359-4364页

作者： Young Hye Byun Jun Haeng Lee Moon Kyung Park Ji Hyun Song Byung-Hoon Min Dong Kyung chang Young- Ho Kim Hee jung Son Poong-Lyul Rhee Jae J Kim Jong Chul Rhee Ji Hye Hwang Dong Il Park Sang Goon Shim In Kyung Sung Department of Medicine Sungkyunkwan University School of Medicine Samsung Medical Center Department of Physical Medicine and Rehabilitation Sungkyunkwan University School of Medicine Samsung Medical Center Department of Medicine Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Department of Medicine Sungkyunkwan University School of Medicine Masan Samsung Hospital Department of Internal Medicine Konkuk University College of Medicine

AIM: To determine the prevalence and risk factors of work-related musculoskeletal disorders in gastrointestinal endoscopists in Korea. METHODS: A survey of musculoskeletal symptoms, using a self-administered questionnaire, was conducted on 55 endoscopists practicing in general hospitals or health promotion centers. RESULTS: Forty-nine (89.1%) endoscopists reported musculoskeletal pain on at least one anatomic location and 37 (67.3%) endoscopists complained of pain at rest. Twenty-six (47.3%) endoscopists had severe musculoskeletal pain defined as a visual analogue score greater than 5.5. Factors related to the development of severe pain were (1) standing position during upper endoscopy, (2) specific posture/ habit during endoscopic procedures, and (3) multiple symptomatic areas. Finger pain was more common in beginners, whereas shoulder pain was more common in experienced endoscopists. Sixteen percent of symptomatic endoscopists have modified their practice or reduced the number of endoscopic examinations. Only a few symptomatic endoscopists had sought professional consultation with related specialists. CONCLUSION: The prevalence of musculoskeletal pain in endoscopists is very high. The location of pain was different between beginners and experienced endoscopists. Measures for the prevention and adequate management of endoscopy-related musculoskeletal symptoms are necessary.

关键词：内窥镜检查法肌与骨骼症状胃肠检查韩国

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论中国手语的分类词谓语

中文信息学报 2018年第3期32卷 1-8页

作者：姚登峰江铭虎张荣兴阿布都克力木.阿布力孜北京联合大学北京市信息服务工程重点实验室北京100101 清华大学人文学院计算语言学实验室北京100084 清华大学心理学与认知科学研究中心北京100084 台湾中正大学语言学研究所

分类词谓语是手语中一种独特的语言现象。中国大陆学者对分类词谓语的研究刚开始涉足,尚未见到系统的研究报道。该文试图从语言学的角度对中国手语分类词谓语做了语义认知分析,首先结合Talmy的动态事件和代形词的分析,解释中国手语的分... 详细信息

分类词谓语是手语中一种独特的语言现象。中国大陆学者对分类词谓语的研究刚开始涉足,尚未见到系统的研究报道。该文试图从语言学的角度对中国手语分类词谓语做了语义认知分析,首先结合Talmy的动态事件和代形词的分析,解释中国手语的分类词谓语现象,分析主体和背景的代形词如何形成以达到手语同时性和序列性要求,并由此确定主体代形词和背景代形词通常是由非运动的手形组成;另一方面也说明中国手语与汉语的相互影响,对"动作"和"位于"这两类的手语代形词做了较为详细的描述及分类。

关键词：中国手语分类词谓语代名词

利用稻杆衍生吸附剂去除液相中呋喃丹(英文)

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新型炭材料 2014年第1期29卷 47-54页

作者：张耿岐陈志成林俊宏谢荣攀汪印赵峰施怡碹邢贞娇陈水田中国科学院城市环境研究所福建厦门361021 台北科技大学环境工程与管理研究所中国台湾台北南华大学科技学院自然医学研究所中国台湾嘉义天主教辅仁大学食品科学系中国台湾新北中央研究院生物化学所中国台湾台北

以KOH为活化剂进行两段式活化程序,将废弃生物质材料转化为活性炭,并评估此活性炭吸对液相中农药(呋喃丹)的去除能力。结果表明,此活性炭具有大比表面积与高吸附能力可快速有效地去除液相中的呋喃丹。吸附前后的活性炭用扫描电子显微镜... 详细信息

以KOH为活化剂进行两段式活化程序,将废弃生物质材料转化为活性炭,并评估此活性炭吸对液相中农药(呋喃丹)的去除能力。结果表明,此活性炭具有大比表面积与高吸附能力可快速有效地去除液相中的呋喃丹。吸附前后的活性炭用扫描电子显微镜、元素分析仪与傅里叶变换红外光谱仪进行特征分析。活性炭的比表面积与平均孔径分别为1304.8 m2/g与2.39 nm。同时对不同的吸附参数进行批次分析,包括呋喃丹初始浓度,吸附时间、温度与酸碱度。最大吸附量(296.52mg/g)的吸附参数为90min、30℃、吸附剂剂量100mg/L、180 r/min、呋喃丹初始浓度200mg/L。根据三种平衡吸附等温线(Langmuir,Freundlich and Temkin)与动力学分析,Langmuir模式最符合此活性炭的吸附结果,伪二级动力学方程可预测此活性炭的吸附动力学。

关键词：稻杆呋喃丹活性炭吸附等温线动力学

THE INFLUENCE OF CHLORIDE ION ON THE CATALYTIC POLAROGRAPHIC CURRENT OF URANIUM(Ⅵ)

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Chinese Science Bulletin 1966年第2期24卷 76-79页

作者：章健民张继先胡惠容何锺林 Department of Chemistry Nankai University Tientsin. Medical College of Inner Mongolia Shenyang College of Light Industry

There are known two catalytic waves of uranium（Ⅵ）, one from the catalytic effect of vanadium （Ⅳ） on the first reduction wave of the UO2++ ion and the other from that of the NO3- ion on the second reduction wave ... 详细信息

关键词： uranium vanadium reagent maintained straight explained standardized satisfactory purification anion

Absolute monocyte and lymphocyte count prognostic score for patients with gastric cancer

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World Journal of Gastroenterology 2015年第9期21卷 2668-2676页

作者： Wan Kyu Eo Da Wun Jeong Hye jung chang Kyu Yeoun Won Sung Il Choi Se Hyun Kim Sung Wook Chun Young Lim Oh Tae Hwa Lee Young Ok Kim Ki Hyung Kim Yong Il Ji Ari Kim Heung Yeol Kim Department of Hematology/Medical Oncology Kyung Hee University Hospital at GangdongSeoul 134727South Korea Department of Pathology Kyung Hee University Hospital at GangdongSeoul 134727South Korea Department of Surgery Kyung Hee University Hospital at GangdongSeoul 134727South Korea Graduate School Dankuk UniversityYongin 448701South Korea Department of Obstetrics and Gynecology Inje University College of MedicineBusan 612896South Korea Department of Obstetrics and Gynecology Kosin University College of MedicineBusan 602702South Korea Department of Pathology Kosin University College of MedicineBusan 602702South Korea Department of Obstetrics and Gynecology Pusan National University HospitalPusan National University School of Medicineand Biomedical Research Institute and Pusan Cancer CenterBusan 602739South Korea Department of Obstetrics and Gynecology Institute of Wonkwang Medical ScienceCollege of MedicineWonkwang UniversityIksan 570749South Korea

AIM:To measure the prognostic significance of absolute monocyte count/absolute lymphocyte count prognostic score(AMLPS) in patients with gastric ***:We retrospectively examined the combination of absolute monocyte count(AMC) and absolute lymphocyte count(ALC) as prognostic variables in a cohort of 299 gastric cancer patients who underwent surgical resection between 2006 and 2013 and were followed at a single *** AMC and ALC were dichotomized into two groups using cut-off points determined by receiving operator characteristic curve *** AMLPS was generated,which stratified patients into three risk groups:low risk(both low AMC and high ALC),intermediate risk(either high AMC or low ALC),and high risk(both high AMC and low ALC).The primary objective of the study was to validate the impact of AMLPS on both disease-free survival(DFS) and overall survival(OS),and the second objective was to assess the AMLPS as an independent prognostic factor for survival in comparison with known prognostic ***:Using data from the entire cohort,the most discriminative cut-off values of AMC and ALC selected on the receiver operating characteristic curve were 672.4/μL and 1734/μL for DFS and *** risk groups included 158(52.8%) patients in the lowrisk,128(42.8%) in the intermediate-risk,and 13(4.3%) in the high-risk *** a median followup of 37.2 mo(range:1.7-91.4 mo),five-year DFS rates in the low-,intermediate-,and high-risk groups were 83.4%,78.7%,and 19.8%,*** fiveyear OS rates in the low-,intermediate-,and high-risk groups were 89.3%,81.1%,and 14.4%,*** multivariate analysis performed with patient- and tumor-related factors,we identified AMLPS,age,and pathologic tumor-node-metastasis stage as the most valuable prognostic factors impacting DFS and ***:AMLPS identified patients with a poor DFS and OS,and it was independent of age,pathologic stage,and various inflammatory markers.

关键词： Monocytes Absolute lymphocyte count Stomach neopla

Development of a Lightning Warning System

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Journal of Energy and Power Engineering 2012年第2期6卷 287-292页

作者： Gyung-Suk Kil Dae-Won Park Kwang-Seok jung chang-Hwan Ahn Division of Electrical and Electronics Engineering National Korea Maritime University Busan 606-791 Korea Department of Digital Electronics ＆ Information Inha Technical College Incheon 402-752 Korea

A lightning warning system (LWS) which can predict the possibility of lightning strike and the position of lightning discharge was developed. The LWS uses the electric field intensity at the ground as a parameter to warn the possibility of lightning strikes. A planar shutter type electric field mill (EFM) with a rotating vane is studied to measure the electric field. From a calibration experiment, the sensitivity of the EFM was adjusted to 0.15 V/kV/m, and this covers the ranges from 200 V/m to 20 kV/m. Magnetic field waveform is detected by a crossed loop coil and an integral amplifier. Frequency bandwidth of the circuit ranges from 5 kHz to 1.2 MHz. The polarity of lightning discharges is discriminated by electric field component. After fixing the polarity, we can calculate the direction and distance of lightning discharge by the peak and the zero cross time of the detected magnetic field waveform.

关键词：雷电放电预警系统电场强度波形检测固定极性积分放大器零交叉检测放电位置

COUPLING BETWEEN THE LEFT VENTRICLE AND ARTERIAL SYSTEM IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION

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COUPLING BETWEEN THE LEFT VENTRICLE AND ARTERIAL SYSTEM IN P...