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Phosphorylated p70S6K in urothelial carcinoma of the tumor recurrence noninvasive low-grade bladder： correlation with

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Asian Journal of Andrology 2014年第4期16卷 611-617页

作者： Soon-Ja Kim jung hoon Kim Hui Seok jung Tae-Jin Lee Kyung Mee Lee In Ho Chang Department of Convergence Medicine and Pharmaceutical Biosciences Chung-Ang University Graduate School Seoul Department of Urology Department of Pathology Chung-Ang University College of Medicine Seoul Korea.

We investigated whether inhibiting phosphorylated p70S6K （p-p70S6K） suppresses the proliferation and growth of noninvasive low-grade urothelial carcinoma （LG-URCa） in vitro and whether p-p70S6K can serve as a predictive biomarker for the recurrence of noninvasive LG-URCa of the bladder in patients. We constructed a tissue microarray （TMA） for 95 LG-URCa and 35 benign urothelium samples and performed immunohistochemical staining for p-p70S6K and p-4E-BP1. A Cox regression model was used to investigate the predictive factors for recurrence of LG-URCa. We investigated the dose-dependent antiproliferative effect of rapamycin, its antiproliferative effect and the growth-inhibition effect of p70S6K siRNA transfection in RT4 and 253J cell lines. The pT1 staged group （P 〈 0.05; hazard ratio （HR）, 2.415） and the high p-p70S6K staining group （P 〈 0.05; HR, 2.249） were independent factors for predicting recurrence. Rapamycin inhibited RT4 and 253J cell proliferation in a dose-dependent manner （r = -0.850, P 〈 0.001 in RT4 cells; r = -0.835, P 〈 0.001 in 253J cells）. RT4 and 253J cell proliferation and growth were inhibited by the transfection of p70S6K siRNA and rapamycin, respectively （P 〈 0.05）. Transfection of p70S6K siRNA resulted in inhibitory effects on cell proliferation and growth that were similar to those of rapamycin. Our results suggest that inhibiting p70S6K phosphorylation is important to prevent recurrence and that p70S6K phosphorylation can be used as a molecular biomarker to predict recurrence of certain LG-URCa of the bladder.

关键词： bladder cancer p7OS6K

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The Arabidopsis Floral Repressor BFT DelaysFlowering by Competing with FT for FD Bindingunder High Salinity

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Molecular Plant 2014年第2期7卷 377-387页

作者： Jae Yong Ryu Hyo-Jun Lee Pil Joon Seo Jae-hoon jung Ji hoon Ahn Chung-Mo Park Department of Chemistry Seoul National University Seoul 151-742 Korea Present address: Department of Chemistry Chonbuk National University Jeonju 561-756 Korea The Sainsbury Laboratory University of Cambridge Cambridge UK Creative Research Initiatives Division of Life Sciences Korea University Seoul 136-701 Korea PGBI Seoul National University Seoul 151-742 Korea

Soil salinity is one of the most serious agricultural problems that significantly reduce crop yields in the aridand semi-arid regions. It influences various phases of plant growth and developmental processes, such as seed germina-tion, leaf and stem growth, and reproductive propagation. Salt stress delays the onset of flowering in many plant spe-cies. We have previously reported that the Arabidopsis BROTHER OF FT AND TFL1 （BFT） acts as a floral repressor undersalt stress. However, the molecular mechanisms underlying the BFT function in the salt regulation of flowering inductionis unknown. In this work, we found that BFT delays flowering under high salinity by competing with FLOWERING LOCUST （FT） for binding to the FD transcription factor. The flowering time of FD-deficient fd-2 mutant was insensitive to highsalinity. BFT interacts with FD in the nucleus via the C-terminal domain of FD, which is also required for the interactionof FD with FT, and interferes with the FT-FD interaction. These observations indicate that BFT constitutes a distinct saltstress signaling pathway that modulates the function of the FT-FD module and possibly provides an adaptation strategythat fine-tunes photoperiodic flowering under high salinity.

关键词： Arabidopsis BFT FD flowering time FT salt stress

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Adaptive Model Predictive Control for Yaw System of Variable-speed Wind Turbines

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Journal of Modern Power Systems and Clean Energy 2021年第1期9卷 219-224页

作者： Dongran song Qing Chang songyue Zheng Sheng Yang Jian Yang Young hoon Joo the School of Automation Central South Universityand Hunan Provincial Key Laboratory of Power Electronics Equipment and GridChangsha 410083China the School of Energy Science and Engineering Central South UniversityChangsha 410083China the School of IT Information and Control Engineering Kunsan National UniversityKunsan 54150Korea

Due to varying characteristics of the wind condition, the performance of the wind turbines can be optimized by adapting the parameters of the control system. In this letter, an adaptive technique is proposed for the novel model predictive control(MPC) for the yaw system of the wind turbines. The control horizon is adapted to the one with the best predictive performance among multiple control horizons. The adaptive MPC is demonstrated by simulations using real wind data, and its performance is compared with the baseline MPC at fixed control horizon. Results show that the adaptive MPC provides better comprehensive performance than the baseline ones at different preview time of wind directions. Therefore, the proposed adaptive technique is potentially useful for the wind turbines in the future.

关键词： Wind turbine yaw system wind direction adaptive model predictive control

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Intramedullary spinal cord metastasis from pancreatic neuroendocrine tumor

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World Journal of Gastroenterology 2014年第38期20卷 14063-14067页

作者： jung Ho Kim Chang Lim Hyun Sang hoon Han Department of Internal Medicine Gachon University Gil Medical Center Department of Pathology Jeju National University School of Medicine Department of Internal Medicine Jeju National University School of Medicine

Intramedullary spinal cord metastasis(ISCM) is very rare and its optimal treatment remains controversial. Pancreatic neuroendocrine tumor(pNET) is a rare tumor that usually presents with hepatic metastasis. Hepatic failure due to tumor progression is the major cause of death in cases of pNET. To date,no report has described a case of ISCM from pNET. Although spinal cord metastasis of a solid tumor is uncommon,it is a critical condition that can cause a potentially irreversible loss of neurologic function. Here,we report the case of a 45-year-old man who presented with leg weakness and voiding difficulty,and was found to have ISCM from pNET. Surgical treatment prevented further neurological deterioration. This is the first case report of ISCM from pNET.

关键词： Intramedullary Spinal cord neoplasm Metastasis Neuroendocrine tumor Pancreas

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Materials and devices for flexible and stretchable photodetectors and light-emitting diodes

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Nano Research 2021年第9期14卷 2919-2937页

作者： Jun-Kyul song Min Sung Kim Seungwon Yoo Ja hoon Koo Dae-Hyeong Kim Center for Nanoparticle Research Institute for Basic Science(IBS)Seoul 08826Republic of Korea School of Chemical and Biological Engineering and Institute of Chemical Processes Seoul National UniversitySeoul 08826Republic of Korea Interdisciplinary Program for Bioengineering Seoul National UniversitySeoul 08826Republic of Korea Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea

Recently,significant efforts have been directed at overcoming the limitations of conventional rigid optoelectronic devices,particularly their poor mechanical stability under bending,folding,and stretching *** of major approaches for rendering optoelectronic devices mechanically deformable is to replace the conventional electronic/optoelectronic materials with functional nanomaterials or organic materials that are intrinsically flexible/***,advanced device designs and unconventional fabrication methods have also contributed to the development of soft optoelectronic ***,new devices such as bio-inspired curved image sensors,wearable light emitting devices,and deformable bio-integrated optoelectronic devices have been *** this review,recent progress in the development of soft optoelectronic materials and devices is ***,various materials such as nanomaterials,organic materials,and their hybrids that are suitable for developing deformable photodetectors,are ***,the nanomaterials and organic/polymeric materials that are applicable in deformable light-emitting diodes are ***,representative system-level applications of flexible and stretchable photodetectors and light-emitting diodes are reviewed,and future prospects are discussed.

关键词： nanomaterial organic material photodetector light-emitting diode flexible optoelectronics stretchable optoelectronics

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SPL3/4/5 Integrate Developmental Aging and Photoperiodic Signals into the FT-FD Module in Arabidopsis Flowering

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Molecular Plant 2016年第12期9卷 1647-1659页

作者： Jae-hoon jung Hyo-Jun Lee Jae Yong Ryu Chung-Mo Park Sainsbury Laboratory University of Cambridge Cambridge CB2 1LR UK Department of Chemistry plant Genomics and Breeding Institute Seoul National University Seou1151-742 Korea These authors contributed equally to this article

Environmental sensitivity varies across developmental phases in flowering plants. In the juvenile phase, mi- croRNA156 （miR156）-mediated repression of SQUAMOSA PROMOTER-BINDING PROTEIN-LIKE （SPL） transcription factors renders Arabidopsis plants incompetent to floral inductive signals, including long- day （LD） photoperiod. During the vegetative phase transition, which accompanies a reduction of miR156 and a concomitant elevation of its targets, plants acquire reproductive competence such that LD signals promote flowering. However, it remains largely unknown how developmental signals are associated with photoperiodic flowering. Here, we show that SPL3, SPL4, and SPL5 （SPL3/4/5） potentiate the FLOWERING LOCUS T （FT）-FD module in photoperiodic flowering. SPL3/4/5 function as transcriptional activators through the interaction with FD, a basic leucine zipper transcription factor which plays a critical role in photoperiodic flowering. SPL3/4/5 can directly bind to the promoters of APETALA1, LEAFY, and FRUITFULL, thus mediating their activation by the FT-FD complex. Our findings demonstrate that SPL3/ 4/5 act synergistically with the FT-FD module to induce flowering under LDs, providing a long-sought mo- lecular knob that links developmental aging and photoperiodic flowering.

关键词： photoperiodic flowering developmental aging SPL transcription factors FT-FD complex

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Arabidopsis ABF3 and ABF4 Transcription Factors Act with the NF-YC Complex to Regulate SOC1 Expression and Mediate Drought-Accelerated Flowering

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Molecular Plant 2019年第4期12卷 489-505页

作者： Keumbi Hwang Hendry Susila Zeeshan Nasim Ji-Yul jung Ji hoon Ahn Department of Life Sciences Korea University Anamro 145 Seongbuk-Gu Seoul 02841 South Korea

The drought-escape response accelerates flowering in response to drought stress, allowing plants to adaptively shorten their life cycles. Abscisic acid (ABA) mediates plant responses to drought, but the role of ABA-responsive element (ABRE)-binding factors (ABFs) in the drought-escape response is poorly understood. Here, we show that Arabidopsis thaliana ABF3 and ABF4 regulate flowering in response to drought through transcriptional regulation of the floral integrator SUPPRESSOR OF OVEREXPRESSION OF CONSTANS1 (SOC1). The abf3 abf4 mutant displayed ABA-insensitive late flowering under long-day conditions. Ectopic expression of ABF3 or ABF4 in the vasculature, but not in the shoot apex, induced early flowering, whereas expression of ABF3 fused with the SRDX transcript!onal repressor domain delayed flowering. We identified SOC1 as a direct downstream target of ABF3/4, and found that SOC1 mRNA levels were lower in abf3 abf4 than in wild-type plants. Moreover, induction of SOC1 by ABA was hampered in abf3 abf4 mutants. ABF3 and ABF4 were enriched at the -1028- to -657-bp region of the SOC1 promoter, which does not contain canonical ABF-ABRE-binding motifs but has the NF-Y binding element. We found that ABF3 and ABF4 interact with nuclear factor Y subunit C (NF-YC) 3/4/9 in vitro and in planta, and induction of SOC1 by ABA was hampered in nf-yc3 yc4 yc9 mutants. Interestingly, the abf3 abf4, nf-yc3 yc4 yc9, and sod mutants displayed a reduced drought-escape response. Taken together, these results suggest that ABF3 and ABF4 act with NF-YCs to promote flowering by inducing SOC1 transcription under drought conditions . This mechanism might contribute to adaptation by enabling plants to complete their life cycles under drought stress.

关键词： drought escape abscisic acid ABF3 ABF4 NF-YC SOC1

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Comparison of magnetic properties of DNA-cetyltrimethyl ammonium complex with those of natural DNA

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Science China Chemistry 2012年第5期55卷 814-821页

作者： KWON Young-Wan CHOI Dong hoon JIN jung-Il LEE Chang hoon KOH Eui Kwan GROTE James G. Department of Chemistry Korea University Seoul 136-701 Korea Department of Polymer Science & Engineering Chosun University Gwangju 501-759 Korea Korea Basic Science Institute-Seoul Branch Korea University Seoul 136-701 Korea US Air Force Research Laboratory Materials and Manufacturing Directorate AFRL/MLPS Wright-Patterson Air Force Base Ohio USA

We prepared the DNA-cetyltrimethyl ammonium complex, as well as the same complex intercalated with stable organic free radicals, and studied their magnetic properties by electron magnetic resonance (EMR) spectroscopy and by measuring the magnetization on a superconducting quantum interference device (SQUID). The UV-vis and CD spectra of DNA-quaternary alkyl ammonium complex (DNA--Q+) in organic solvent clearly demonstrated that it retained the double helical B-form conformation. The interhelical spacing of double strand DNA (dsDNA) increased when the counter ions (Na+) of phosphate groups of the natural DNA were replaced with the long alkyl quaternary ammonium groups. The inter-helical distance of DNA-cetyltrimethyl ammonium (CTMA) was 39.1  as confirmed by X-ray diffractometry. In general, the magnetization of the DNA-CTMA complex solid was found to be significantly lower than that of natural DNA. Moreover, intercalation of the complex with stable organic free radicals did not improve magnetization, which again was in marked contrast to natural DNA. EMR spectroscopic behavior of the complex in the solid state also was quite different from that of natural DNA: The unique broad EMR signal of natural DNA in the low field region with g-value greater than 10 disappeared in the DNA-CTMA complex.

关键词： natural DNA DNA-CTMA DNA-CTMA-PTMI magnetic property electron magnetic resonance (EMR) superconducting quantum interference device (SQUID)

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Extracorporeal shock wave therapy treatment of painful hematoma in the calf:A case report

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World Journal of Clinical Cases 2020年第24期8卷 6511-6516页

作者： Ji Won jung Hyeon Seong Kim jung Ho Yang Kyu hoon Lee Si-Bog Park Department of Rehabilitation Medicine Hanyang University HospitalSeoul 04763South Korea

BACKGROUND Extracorporeal shock wave therapy (ESWT) can be applied to variousmusculoskeletal conditions including calcific tendinitis. Muscle injuries can leadto hematomas, and unabsorbed hematomas sometimes cause pain. We report acase of painful hematoma successfully treated with ESWT. To our knowledge, thisis the first reported case of painful intramuscular hematoma treated with *** SUMMARY A 65-year-old man visited the outpatient department for left calf pain withswelling that had persisted since he slipped two weeks prior. The calf pain hadpersisted and was rated visual analog scale 7. On physical examination, there wasa localized, stiff, ovoid mass on his left upper posterior calf. The pain wasaggravated by dorsiflexion of the left ankle or weight-bearing on the left *** diagnostic ultrasonography showed a hematoma in the left gastrocnemiusmuscle;its texture was firm with low heterogeneity. We applied ESWT to thehematoma. His pain decreased immediately to a visual analog scale 3, and themass was softened. The texture of the hematoma became more heterogeneous onultrasonography. Due to planned overseas travel, he returned three months afterthe initial visit to report that the pain and swelling were dramatically relievedafter *** We propose that painful hematomas could be a new indication for ESWT. Furtherinvestigation on the effects of ESWT for hematomas is needed.

关键词： Extracorporeal shock wave therapy Hematoma Ultrasonography Indication Pain Case report

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Acute idiopathic pancreatitis in pregnancy:A case study

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World Journal of Gastroenterology 2014年第43期20卷 16364-16367页

作者： Ji Yeon Kim Sung hoon jung Hyung Wook Choi Dong Jin song Cheol Yoon Jeong Dong Hyun Lee Il Soon Whang Department of Internal Medicine Cheil General Hospital and Women’s Healthcare CenterKwandong University College of MedicineSeoul KS013South Korea

Acute pancreatitis during pregnancy is a rare event,and can be associated with high maternal mortality and fetal *** disease is thought to be the most common causative factor of acute pancreatitis,but,in many cases,the cause remains *** report a case of a 36-year-old woman at 35 wk of gestation,who presented with severe pain confined to the upper abdomen and radiating to the *** patient was diagnosed with acute idiopathic pancreatitis,which was managed conservatively;she recovered within several days and then delivered a healthy *** it is important to consider acute pancreatitis when a pregnant woman presents with upper abdominal pain,nausea and vomiting in order to improve fetal and maternal outcomes for patients with acute pancreatitis.

关键词： Acute pancreatitis Pregnancy Pancreatitis in pregnancy Idiopathic Idiopathic acute pancreatitis

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