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Bruch's membrane opening-minimum rim width and visual field loss in glaucoma:a broken stick analysis

International Journal of Ophthalmology(English edition) 2018年第5期11卷 828-834页

作者： Keun-Heung Park Ji-Woong lee Jin-Mi Kim Kouros Nouri-Mahdavi Joseph Caprioli Department of Ophthalmology Pusan National University College of Medicine Biomedical Research Institute Pusan National University Hospital Department of Biostatistics Clinical Trial CenterBiomedical Research InstitutePusan National University Hospital Stein Eye Institute David Geffen School of Medicine at UCLA

AIM：To determine the Bruch＇s membrane opening-minimum rim width（BMO-MRW） tipping point where corresponding visual field（VF） damages become ***：A total of 85 normal subjects and 83 glaucoma patients（one eye per participant） were recruited for the *** of the patients had VF examinations and spectral-domain optical coherence tomography to measure the *** deviation values for 52 VF points were allocated to the corresponding sector according to the Garway-Heath distribution *** evaluate the relationship between VF loss and BMOMRW measurements,a ＂broken-stick＂ statistical model was *** tipping point where the VF values started to sharply decrease as a function of BMO-MRW measurements was estimated and the slopes above and below this tipping point were ***：A 25.9% global BMO-MRW loss from normative value was required for the VF loss to be ***,substantial BMO-MRW thinning in inferotemporal sector（33.1%） and relatively less BMO-MRW thinning in the superotemporal sector（8.9%） were necessary for the detection of the VF *** the tipping point,the slopes were close to zero throughout all of the sectors and the VF loss was unrelated to the BMO-MRW *** VF loss was related to the BMO-MRW loss below the tipping *** difference between the two slopes was statistically significant（P≤0.002）.CONCLUSION：Substantial BMO-MRW loss appears to be necessary for VF loss to be detectable in patients with open angle glaucoma with standard achromatic perimetry.

关键词： Bruch's membrane opening-minimum rim width visual field loss structure function relationship broken stick model optical coherence tomography

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Modified embedded-atom interatomic potential for Co-W and Al-W systems

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Transactions of Nonferrous Metals Society of China 2015年第3期25卷 907-914页

作者：董卫平陈铮 Byeong-Joo lee 浙江师范大学工学院金华321004 西北工业大学材料学院凝固国家重点实验室西安710072 Department of Materials Science and Engineering Division of Advanced Nuclear EngineeringPohang University of Science and Technology(POSTECH)Pohang 790-784Korea

A semi-empirical interatomic potential formalism,the second-nearest-neighbor modified embedded-atom method(2NN MEAM),has been applied to obtaining interatomic potentials for the Co-W and Al-W binary system using previously developed MEAM potentials of Co,Al and *** potential parameters were determined by fitting the experimental data on the enthalpy of formation,lattice parameter,melting point and elastic *** present potentials generally reproduce the fundamental physical properties of the Co-W and Al-W systems *** lattice parameters,the enthalpy of formation,the thermal stability and the elastic constants match well with experiment and the first-principles *** enthalpy of mixing and the enthalpy of formation and mixing of liquid are in good agreement with CALPHAD *** potentials can be easily combined with already-developed MEAM potentials for binary cobalt systems and can be used to describe Co-Al-W-based multicomponent alloys,especially for interfacial properties.

关键词： modified embedded-atom method Co-W system Al-W system atomistic simulation

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Taxonomic revisionofthegenus Lactarius(Russulales,Basidiomycota)in Korea

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Fungal Diversity 2019年第2期95卷 275-335页

作者： Hyun lee Komsit Wissitrassameewong Myung Soo Park Annemieke Verbeken John Eimes Young Woon Lim School of Biological Sciences and Institute of Microbiology Seoul National University1 Gwanak-roGwanak-guSeoul 08826Korea Department of Biology Research Group MycologyGhent UniversityK.L.Ledeganckstraat 359000 GhentBelgium University College Sungkyunkwan University2066 SeoburoJangan-guSuwon 16419Korea

The genus Lactarius Pers.(Russulales)is a cosmopolitan group of Basidiomycota that forms ectomycorrhizal relationships primarily with both deciduous and coniferous *** the genus has been well-studied in Europe and North America,only fragmentary researches have been carried out on Asian *** particular,the distribution of Lactarius species in South Korea is poorly understood due to insufficient morphological descriptions and a lack of DNA sequence *** addition,the misuse of European and North American names has added to confusion regarding the taxonomy of Asian Lactarius *** this study,the diversity of Lactarius in South Korea was evaluated by employing both morphological and phylogenetic approaches.A multi-locus phylogenetic analysis of 729 Lactarius specimens collected between 1960 and 2017 was performed using the internal transcribed spacer(ITS)region,partial nuclear ribosomal large subunit(nrLSU),partial second largest subunit of RNA polymerase II(rpb2),and minichromosome maintenance complex component 7(mcm7).49 Lactarius species were identified in three Lactarius subgenera:***(17 spp.),***(22 spp.),and ***(10 spp.).Among them,28 Lactarius species were identified as new to science,while just 17 were previously described Lactarius *** of the taxa remain un-named due to paucity of materials.A key to Korean Lactarius species,molecular phylogenies,a summary of diversity,and detailed description are provided.

关键词： Intercontinental conspecificity mcm7 Milkcaps Multi-locus phylogeny Species delimitation

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VETA:Visual eye-tracking analytics for the exploration of gaze patterns and behaviours

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Visual Informatics 2022年第2期6卷 1-13页

作者： Sarah Goodwin Arnaud Prouzeau Ryan Whitelock-Jones Christophe Hurter lee Lawrence Umair Afzal Tim Dwyer Monash University ClaytonAustralia Inria&LaBRI(University of Bordeaux CNRSBordeaux-INP)BordeauxFrance ENAC UniversitédeToulouseToulouseFrance Swinburne University of Technology MelbourneAustralia

Eye tracking is growing in popularity for multiple application areas,yet analysing and exploring the large volume of complex data remains difficult for most *** present a comprehensive eye tracking visual analytics system to enable the exploration and presentation of eye-tracking data across time and space in an efficient *** application allows the user to gain an overview of general patterns and perform deep visual analysis of local gaze *** ability to link directly to the video of the underlying scene allows the visualisation insights to be verified on the *** system was motivated by the need to analyse eye-tracking data collected from an‘in the wild’study with energy network operators and has been further evaluated via interviews with 14 eye-tracking experts in multiple *** suggest that,thanks to state-of-the-art visualisation techniques and by providing context with videos,our system could enable an improved analysis of eye-tracking data through interactive exploration,facilitating comparison between different participants or conditions,thus enhancing the presentation of complex data analysis to *** research paper provides four contributions:(1)analysis of a motivational use case demonstrating the need for rich visual-analytics workflow tools for eye-tracking data;(2)a highly dynamic system to visually explore and present complex eye-tracking data;(3)insights from our applied use case evaluation and interviews with experienced users demonstrating the potential for the system and visual analytics for the wider eye-tracking community.

关键词： Eye tracking Visual analytics Spatial-temporal visualisation

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Review of vortex methods for rotor aerodynamics and wake dynamics

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Advances in Aerodynamics 2022年第1期4卷 413-448页

作者： H.lee B.Sengupta M.S.Araghizadeh R.S.Myong School of Mechanical and Aerospace Engineering Gyeongsang National UniversityJinjuGyeongnam52828South Korea

Electric vertical take-off and landing(eVTOL)aircraft with multiple lifting rotors or prop-rotors have received significant attention in recent years due to their great potential for next-generation urban air mobility(UAM).Numerical models have been developed and validated as predictive tools to analyze rotor aerodynamics and wake *** various numerical approaches,the vortex method is one of the most suitable because it can provide accurate solutions with an affordable computational cost and can represent vorticity fields downstream without numerical dissipation *** paper presents a brief review of the progress of vortex methods,along with their principles,advantages,and *** of the vortex methods for modeling the rotor aerodynamics and wake dynamics are also ***,the vortex methods suffer from the problem that it cannot deal with the nonlinear aerodynamic characteristics associated with the viscous effects and the flow behaviors in the post-stall *** overcome the intrinsic drawbacks of the vortex methods,recent progress in a numerical method proposed by the authors is introduced,and model validation against experimental data is discussed in *** validation works show that nonlinear vortex lattice method(NVLM)coupled with vortex particle method(VPM)can predict the unsteady aerodynamic forces and complex evolution of the rotor wake.

关键词： Vortex methods Nonlinear vortex lattice method Viscous vortex particle method Rotor aerodynamics Wake dynamics

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Photodeposited metal-semiconductor nanocomposites and their applications

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Journal of Materiomics 2018年第2期4卷 83-94页

作者： Yoonkyung lee Eunpa Kim Yunjeong Park Jangho Kim WonHyoung Ryu Junsuk Rho Kyunghoon Kim School of Mechanical Engineering Sungkyunkwan UniversitySuwon 16419Republic of Korea Semiconductor R&D Center Samsung ElectronicsHwaseong 18448Republic of Korea Department of Rural and Biosystems Engineering Chonnam National UniversityGwangju 61186Republic of Korea Department of Mechanical Engineering Yonsei UniversitySeoul 03722Republic of Korea Department of Mechanical Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea Department of Chemical Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea

While two-dimensional layered nanomaterials including transition metal oxides and transition metal dichalcogenides have been widely researched because of their unique electronic and optical properties,they still have some *** overcome these limitations,transition metal oxides and transition metal dichalcogenides based nanocomposites have been developed using various methods and have exhibited superior *** this paper,we introduce the photodeposition method and review the photodeposition of metal nanoparticles on the surface of transition metal oxide and transition metal *** current applications are also explained,such as photocatalysis,hydrogen evolution reaction,surface enhanced Ramanscattering,*** approach for nanocomposites has potential for future research areas such as photocatalysis,hydrogen evolution reaction,surface enhanced Raman scattering,and other *** approach for nanocomposite has the potential for future research areas.

关键词： Photodeposition Nanocomposite Transition metal oxide Transition metal dichalcogenide

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Subwavelength on-chip light focusing with bigradient all-dielectric metamaterials for dense photonic integration

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InfoMat 2022年第2期4卷 139-151页

作者： Zhihao Ren Bowei Dong Qifeng Qiao Xinmiao Liu Jinyuan Liu Guangya Zhou Chengkuo lee Department of Electrical and Computer Engineering National University of SingaporeSingaporeSingapore Center for Intelligent Sensors and MEMS(CISM) National University of SingaporeSingaporeSingapore NUS Suzhou Research Institute(NUSRI) SuzhouChina Department of Mechanical Engineering National University of SingaporeSingaporeSingapore NUS Graduate School-Integrative Sciences and Engineering Programme(ISEP) National University of SingaporeSingaporeSingapore

Photonic integrated circuits(PICs)provide a promising platform for miniaturized on-chip optical systems for communication,computation,and sensing *** dense integration of photonic components is one of the keys to exploit the advantages of *** light focusing is a fundamental and indispensable function in PICs,focusing light at the micro/nanometer-scale is ***,a bigradient on-chip metalens(BOML)is proposed to achieve ultrasmall focal lengths and spot sizes at the subwavelength scale for dense *** design of BOML combines gradient geometry and gradient refractive index into one metalens by simultaneously engineering the length and width of subwavelength silicon *** a small device footprint of only 168μm,the BOML achieves efficient on-chip focusing with the recordbreaking figure-of-merits,which are the ratio of wavelength to focal length/spot size(0.268 and 2.83)and numerical aperture(1.78).Leveraging on the Fresnel design,the footprint of BOML is further reduced by 55.1%,and the numerical aperture is enhanced to *** demonstration of mode conversion and beam steering with efficiency over 80%and a tilting range of 7.2°holds the potential for highly dense on-chip photonic systems for optical communication,optical sensing,nonlinear optics,and neural networks for deep learning.

关键词： all-dielectric metamaterials beam steering mid-infrared on-chip focusing photonic integrated circuits

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Incipient sediment motion based on turbulent fluctuations

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International Journal of Sediment Research 2020年第2期35卷 125-133页

作者： Wan Hanna Melini Wan Mohtar Ji Wang lee Najwa Izzaty Mohammad Azha Nian-Sheng Cheng Department of Civil & Structural Engineering Faculty of Engineering and Built EnvironmentUniversiti Kebangsaan Malaysia School of Civil and Environmental Engineering College of EngineeringNanyang Technical University

The current study modifies the representation of the Shields parameter using turbulent strength,*** root-mean-square(rms) fluid *** were done under a steady,uniform flow using eight sediment sizes with particle Reynolds numbers(Rep) ranging between 1.0(fine sediment) and 183.4(coarse sediment).Utilising the peak rms horizontal(u) values,the critical Shields parameter,θ,was calculated and a trend similar to the well-established Shields curve was *** analysis was extended to the Shields curve obtained based on the critical shear velocity,Reynolds shear stress,and data extracted fro m the oscillating grid-turbulence *** show that turbulent fluctuations are crucial for the incipient sediment motion and are essentially better predictors than the commonly used critical shear velocity.A quadrant analysis to identify the role of turbulent bursting events in incipient sediment motion also was done where sweeps and ejections are dominant for finer and coarser sediment sizes,respectively.

关键词： Incipient sediment motion Root-mean-square fluid velocity Grid-turbulence Quadrant analysis Turbulent fluctuations

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T4 cervical esophageal cancer cured with modern chemoradiotherapy: A case report

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World Journal of Clinical Cases 2020年第10期8卷 1950-1957页

作者： Chia Ching lee Chong Ming Yeo Wee Khoon Ng Akash Verma Jeremy CS Tey Department of Radiation Oncology National University Cancer InstituteNational University HospitalTan Tock Seng HospitalSingapore 119228Singapore Department of Medical Oncology Tan Tock Seng HospitalSingapore 308433Singapore Department of Gastroenterology and Hepatology Tan Tock Seng HospitalSingapore 308433Singapore Department of Respiratory and Critical Care Medicine Tan Tock Seng HospitalSingapore 308433Singapore

BACKGROUND T4 esophageal cancer portends a poor prognosis,particularly when it is complicated by a tracheoesophageal fistula(TEF)either resulting from disease or occurring as a complication of *** with TEF that occurs during treatment are commonly treated with palliative intent because fistula-associated treatment complications such as aspiration pneumonia and mediastinitis are associated with high morbidity and *** date,there is no clear evidence on the optimal treatment of T4 esophageal cancer,particularly when a TEF formation *** SUMMARY A 67-year-old gentleman who presented with dysphagia and weight *** and imaging revealed a T4N1M0 cervical esophageal squamous cell *** received image-guided intensity-modulated radiation therapy,with concurrent weekly carboplatin(area under curve 2 mg/mL per minute)and paclitaxel(50 mg/m2 of body surface area).One week after treatment initiation(16.2 Gy thus far),he developed cough on swallowing.A TEF was detected on image-guided radiation therapy using cone-beam computed tomography during the treatment course,for which a tracheal stent was *** discussing the risks and morbidity of continuing treatment,he resumed chemoradiotherapy with an additional radiation dose of 45 Gy in 25 *** months after completion of chemoradiotherapy,he developed an esophageal stricture that required esophageal stenting and *** patient remains cancer-free at two year on *** response of esophageal cancer was evident on post-treatment endoscopy and computed tomography imaging,with successful closure of *** This case highlights that successful curative treatment for esophageal cancer complicated by a TEF is possible using novel chemotherapeutic regimens and modern radiation technologies.

关键词： Esophageal cancer Chemoradiotherapy Fistula Stenting T4 Case report

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Drug Usage Safety from Drug Reviews with Hybrid Machine Learning Approach

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Computer Systems Science & Engineering 2023年第6期45卷 3053-3077页

作者： Ernesto lee Furqan Rustam Hina Fatima Shahzad Patrick Bernard Washington Abid Ishaq Imran Ashraf Department of Computer Science Broward CollegeBroward CountFloridaUSA Department of Computer Science Khwaja Fareed University of Engineering and Information TechnologyRahim Yar Khan64200Pakistan Division of Business Administration and Economics Morehouse CollegeAtlantaGAUSA Department of Information and Communication Engineering Yeungnam UniversityGyeongsan-si38541Korea

With the increasing usage of drugs to remedy different diseases,drug safety has become crucial over the past few *** medicine from several companies is offered for a single disease that involves the same/similar substances with slightly different *** diversification is both helpful and danger-ous as such medicine proves to be more effective or shows side effects to different *** clinical trials,side effects are reported when the medicine is used by the mass public,of which several such experiences are shared on social media platforms.A system capable of analyzing such reviews could be very helpful to assist healthcare professionals and companies for evaluating the safety of drugs after it has been *** analysis of drug reviews has a large poten-tial for providing valuable insights into these ***,this study proposes an approach to perform analysis on the drug safety reviews using lexicon-based and deep learning techniques.A dataset acquired from the‘***’contain-ing reviews of drug-related side effects and reactions,is used for experiments.A lexicon-based approach,Textblob is used to extract the positive,negative or neu-tral sentiment from the review *** classification is achieved using a novel hybrid deep learning model of convolutional neural networks and long short-term memory(CNN-LSTM)*** CNN is used at thefirst level to extract the appropriate features while LSTM is used at the second *** well-known machine learning models including logistic regression,random for-est,decision tree,and AdaBoost are evaluated using term frequency-inverse docu-ment frequency(TF-IDF),a bag of words(BoW),feature union of(TF-IDF+BoW),and lexicon-based *** analysis with machine learning models,long short term memory and convolutional neural network models,and state-of-the-art approaches indicate that the proposed CNN-LSTM model shows superior performance with an 0.96 *** also

关键词： Drug safety analysis lexicon-based techniques drug reviews sentiment analysis machine learning CNN-LSTM

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