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Therapeutic potential of neuromodulation for demyelinating diseases

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Neural Regeneration Research 2021年第2期16卷 214-217页

作者： Elliot H.Choi Chioma Nwakalor Nolan J.Brown Joonho lee Michael Y.Oh In Hong Yang Department of Pharmacology School of MedicineCase Western Reserve UniversityClevelandOHUSA Department of Ophthalmology Gavin Herbert Eye InstituteSchool of MedicineUniversity of CaliforniaIrvineCAUSA Department of Neurological Surgery University of CaliforniaIrvineCAUSA Department of Mechanical Engineering and Engineering Science Center for Biomedical Engineering and ScienceUniversity of North Carolina at CharlotteCharlotteNCUSA University of Rochester School of Medicine and Dentistry RochesterNYUSA

Neuromodulation represents a cutting edge class of both invasive and non-invasive therapeutic methods which alter the activity of ***,several different techniques have been developed-or are currently being investigated–to treat a wide variety of neurological and neuropsychiatric ***,in vivo and in vitro studies have revealed that neuromodulation can also induce myelination,meaning that it could hold potential as a therapy for various demyelinating diseases including multiple sclerosis and progressive multifocal *** findings come on the heels of a paradigm shift in the view of myelin's role within the nervous system from a static structure to an active co-regulator of central nervous system plasticity and participant in neuron-mediated *** the present review,we highlight several of the recent findings regarding the role of neural activity in altering myelination including several soluble and contact-dependent factors that seem to mediate neural activitydependent *** also highlight several considerations for neuromodulatory techniques,including the need for further research into spatiotemporal precision,dosage,and the safety and efficacy of transcranial focused ultrasound stimulation,an emerging neuromodulation *** the field of neuromodulation continues to evolve,it could potentially bring forth methods for the treatment of demyelinating diseases,and as such,further investigation into the mechanisms of neuron-dependent myelination as well as neuro-imaging modalities that can monitor myelination activity is warranted.

关键词： central nervous system deep brain stimulation myelination neural activity oligodendrocyte optogenetic stimulation transcranial electrical stimulation transcranial focused ultrasound stimulation transcranial magnetic stimulation

水中痕量有机污染物质富集技术的发展──聚氨酯类泡沫富集回收水中的多环芳烃

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高等学校化学学报 1997年第7期18卷 1022-1026页

作者：王翊如王小如 FrankSC.lee 厦门大学化学系国家教育委员会材料和生命过程分析科学开放实验室厦门361005 香港浸会大学化学系

用聚氨酯类泡沫（PUF）富集回收蒸馏水、自来水与河水中的多环芳烃，方法简便，回收率高，适于现场采集各种不同类型的水样．GC／MS分析中，氘化芘在IL蒸馏水中的检出限为26ng／L；而在HPLC／FLD分析中，苯并（k）荧蒽、苯并（a）芘、... 详细信息

用聚氨酯类泡沫（PUF）富集回收蒸馏水、自来水与河水中的多环芳烃，方法简便，回收率高，适于现场采集各种不同类型的水样．GC／MS分析中，氘化芘在IL蒸馏水中的检出限为26ng／L；而在HPLC／FLD分析中，苯并（k）荧蒽、苯并（a）芘、二苯并（a，h）蒽、苯并（ghi）在IL蒸馏水中的检出限分别为0.86、0.51、2.1和3.0ng／L.

关键词： PUF 固相萃取 PAHs 聚氨酯泡沫水处理

Matrix metalloproteinase-9 in patients with acute coronary syndrome

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Chinese Medical Journal 2012年第4期125卷 720-720页

作者： Regent lee Department of Cardiovascular Medicine University of Oxford UK Royal Australasian College of Surgeons Australia

To the Editor： I congratulate Wang et al1 in reporting further evidence for the role of matrix metalloproteinase-9 （MMP9）as a biomarker in acute coronary syndrome （ACS）. In this study, the Authors examined the levels of MMP9 and C-reactive protein （CRP） in patients with a clinical diagnosis of unstable angina pectoris who subsequently underwent coronary angiography to evaluate the presence of coronary artery disease.

关键词： Matrix metalloproteinase-9 acute coronary syndrome CRP unstable angina pectoris plaque disease

Interfacial reaction between the oxidized SiC particles and Al-Mg alloys

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Chinese Science Bulletin 2001年第23期46卷 1948-1952页

作者： SHI Zhongliang GU Mingyuan LIU Junyou LIU Guoquan lee Jae-chul ZHANG Di WU Renjie State Key Lab of Metal Matrix Composites Shanghai Jiao Tong UniversityShanghai 200030China School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China Division of Materials Science and Engineering Korea Institute of Sciecne and TechnologyP.O.Box 131CheongryangSeoulKorea

The interfacial reactions of oxidized SiC particles reinforced Al-Mg matrix composites were investigated by the field emission-scanning electron microscopy (FE-SEM), TEM and X-ray diffraction. It was found that the nanoscale MgO forms initially due to the interfacial reaction, then whether it reacts with molten Al continuously or not depends on the content of Mg in the matrix and its covering densification at the surface of particles. When there is not enough Mg in the matrix for the formation of dense MgO layer, MgO will transform into MgAl2O4 crystal owing to the continuous reaction with SiO2 and molten Al. When dense MgO layer forms at the surface of the particles due to the affluence of Mg for the initial reaction, it will protect the inner SiC from the attack of molten Al. However, the reaction products of both MgO and MgAl2O4 are thermo-stable phases at the surface of the particles under high temperature. The results clarify the interfacial reaction route and they are of great value to the

关键词： oxidized SiC particle Al-Mg matrix composite interfa- cial reaction FE-SEM nanoscale MgO MgAl2O4.

Electromagnetic emanation exploration in FPGA-based digital design

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Journal of Central South University 2019年第1期26卷 158-167页

作者： Van Toan NGUYEN Minh Tung DAM Jeong-Gun lee E-SoC Laboratory/Smart Computing Laboratory Department of Computer Engineering Hallym University

As semiconductor technologies have been shrinking,the speed of circuits,integration density,and the number of I/O interfaces have been significantly *** a consequence,electromagnetic emanation(EME)becomes a critical issue in digital system *** devices must meet electromagnetic compatibility(EMC)requirements to ensure that they operate properly,and safely without interference.I/O buffers consume high currents when they *** bonding wires,and lead frames are long enough to play as efficient antennas to radiate electromagnetic interference(EMI).Therefore,I/O switching activities significantly contribute to the *** this paper,we evaluate and analyze the impact of I/O switching activities on the *** will change the circuit configurations such as the supply voltage for I/O banks,their switching frequency,driving current,and slew ***,a trade-off between the switching frequencies and the number of simultaneous switching outputs(SSOs)is also considered in terms of ***,we evaluate the electromagnetic emissions that are associated with the different I/O switching *** results show that the electromagnetic emissions associated I/O switching activities depend strongly on their operating parameters and *** the circuit implementations and measurements are carried out on a Xilinx Spartan-3 FPGA.

关键词： electromagnetic interference electromagnetic emanation near field emissions field programmable gate array slew rate

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The Trend of Beauty

Women of China 1995年第12期 38-40页

作者： LINDA lee

EVER since ancient times Shanghai people have pursued beauty. The Shanghai History Museum, mounted an exhibition entitled "Spectacular Garments, Cultural Relics and Documents of Modern Shanghai" which certainly proved this point. This exhibit showed that throughout Shanghai’s long history, dress and personal adomment have been important to the residents. During the

关键词： The Trend of Beauty

Dialogue Across the Pacific

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Women of China 2000年第2期 32-35页

作者： MICHELLE lee

WERE the blondes dancing the Macarena in U.S. discos? No, they were in Beijing to mark the end of the Second China-U.S. Conference on Women's Issues. Even Gu Xiulian, First Vice President of the All-China Women's Federation, joined her American sisters to celebrate its happy ending. As the American convener Jerrie Ueberle, President of Global Interactions Inc, said, the four-day conference, "not only feasts our ears but also our eyes." At the opening ceremony in the

关键词： Pr Dialogue Across the Pacific

THE RENMINBI ASGAME CHANGER

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Beijing Review 2014年第7期57卷 10-11页

作者： Ann lee New York University

The announcement of the Shanghai Free Trade Zone, which heralds China＇s plans to liberalize the financial economy, has been seen as a welcome indication by most Western financial firms who have been pressuring China for years to allow unrestricted convertibility of its currency, the renminbi. This announcement follows a historical pattern of U.S. policy pressure on other countries＇ monetary management such as when the United States pressured Japan to float its currency in 1973 after the U.S. unilaterally abandoned the gold standard in 1971.

关键词：人民币游戏规则保税区金融货币中国施压美国

兔耳动脉的交感性血管收缩对α肾上腺素能受体拮抗剂的部分阻抗(英文)

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中国药理学与毒理学杂志 1992年第1期6卷 14-18页

作者： Tony J-F lee Department of Pharmacology Southern Illinois University School of Medicine Springfield Illinois 62794-9230 USA

本文利用离体组织灌流技术,对刺激家兔颈上神经节内壁交感神经引起兔耳中央动脉收缩的本质进行探讨,α受体拮抗剂仅部分阻断跨壁神经刺激(TNS)引起的收缩,若预先使用利血平耗竭离体血管内源性儿茶酚胺,由TNS引起的此种家兔耳中央动脉收... 详细信息

本文利用离体组织灌流技术,对刺激家兔颈上神经节内壁交感神经引起兔耳中央动脉收缩的本质进行探讨,α受体拮抗剂仅部分阻断跨壁神经刺激(TNS)引起的收缩,若预先使用利血平耗竭离体血管内源性儿茶酚胺,由TNS引起的此种家兔耳中央动脉收缩则明显减弱,与此同时,α受体拮抗剂却增强了后期(residual)收缩反应,这种增强作用可能是因突触前膜α受体同时被阻断而引起,由此可见,交感神经冲动引起的家兔耳中央动脉收缩绝大部分是由去甲肾上腺素(NE)介导的,但后期收缩反应则可能是由另一种不明递质所介导,而这种属于外周循环系统的耳动脉交感神经与血管之间冲动传递方式又有别于大脑动脉的传递方式。

关键词：耳动脉 α肾上腺素能受体拮抗剂