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电力系统自动化 2004年第11期28卷 28-32页

作者：闵亮余贻鑫 Stephen T lee Pei Zhang 天津大学电气与自动化工程学院天津市300072 美国电力科学研究院

提出了一种快速识别初始运行点附近失稳模态的方法,该方法基于大量计算观察到的初始运行点附近不同运行点注入下模型的可达性格纳姆矩阵元素近乎不变的性质,将基于K-中心点算法的同调识别和初加速度法相结合,快速识别初始运行点附近的... 详细信息

提出了一种快速识别初始运行点附近失稳模态的方法,该方法基于大量计算观察到的初始运行点附近不同运行点注入下模型的可达性格纳姆矩阵元素近乎不变的性质,将基于K-中心点算法的同调识别和初加速度法相结合,快速识别初始运行点附近的失稳模态,为实用动态安全域(PDSR)直接法提供了临界点搜索建议,改善了PDSR法。该方法的有效性在New England 10机39节点系统得到了验证。

关键词：实用动态安全域可达性格纳姆矩阵 K-中心点算法同调识别失稳模态

On the Relations of Graph Parameters and Its Total Parameters

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Acta Mathematicae Applicatae Sinica 2010年第3期26卷 525-528页

作者： Jing-wen Li Zhi-wen Wang Jaeun lee Moo Young Sohn Zhong-fu Zhang En-qiang Zhu Institute of Applied Mathematics Lanzhou Jiaotong University Lanzhou 730070 China School of Mathematics and Computer Science Ningxia University Yinchuan 750021 China Department of Mathematics Yeungnam University Kyongsan 712-749 Korea Department of Applied Mathematics Changwon University Changwon 641 773 Korea

In this paper we get some relations between α（G）, α＇（G）, β（G）, β＇（G） and αT（G）, βT（G）. And all bounds in these relations are best possible, where α（G）, α＇（G）,/3（G）, β（G）, αT（G） and βT（G） are the covering number, edge-covering number, independent number, edge-independent number （or matching number）, total covering number and total independent number, respectively.

关键词： Graph covering number edge covering number independent number edge independent number,total covering number total independent number

Thrombolytic activity of cheonggukjang kinase in recovery from brain damage in a rat cerebral embolic stroke model

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Neural Regeneration Research 2010年第24期5卷 1875-1882页

作者： Angella M Anthony Jalin Chae Kwan lee Chae Yeon lee A Reum Kang Chung Mu Park Jae Ho Cha Jeong Hwan Kim Soo Woong lee Young Sun Song Jong Tae lee Sung Goo Kang School of Biological Sciences First Research GroupInje University Institute of Environmental and Occupational Medicine & Department of Occupational and Environmental Medicine Pusan Paik HospitalInje University Department of Smart Foods & Drugs Inje University Department of Microbiology Pusan National University Division of Applied Life Science Gyeongsang National University Advanced Research Center for Multiple Myeloma Department of MicrobiologyBio-Marker Research Center for Personalized TherapyCollege of MedicineInje University

Cheonggukjang is a soybean paste made by fermenting whole cooked soybeans with Bacillus subtilis. Cheonggukjang contains a fibrinolytic enzyme that could provide clinical applications for removing blood clots. In the present study, the term ＂cheonggukjang kinase＂（CGK） was used to refer to this fibrinolytic enzyme. The thrombolytic effects of CGK were analyzed in a rat model of cerebral embolic stroke produced by middle cerebral artery occlusion （MCAO）. Results from fibrin and platelet-rich clot lysis assays demonstrated that thrombolytic activity was greatest in CGKs, which were cultured for 40 hours. In addition, T50, the time needed to decompose 50% of the clot, did not change with plasminogen treatment, indicating that CGK was not a plasminogen activator, but was rather presumed to act as a plasmin-like protein. An intravenous infusion of CGK （1 U plasmin-like activity/100 μg CGK/kg） at 1 hour after MCAO resulted in removal of clots in a rat model of cerebral embolic stroke. CGK-treated groups exhibited a significant dose-dependent reduction in infarct volume. CGK treatment also improved functional recovery, as assessed by neurological deficit scores. Decreased infarct volume and improved functional recovery following CGK treatment was greater compared with recombinant tissue plasminogen activator （10 mg/kg）. These results suggested that CGK effectively reduced infarct volume and improved functional recovery following ischemic brain injury. CGK exhibits a number of potential clinical applications ir the treatment of cerebral embolic stroke.

关键词： brain damage cheonggukjang kinase fibrin clot lysis assay middle cerebral artery occlusion platelet rich clot lysis assay thrombolytic activity

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自发电式轨道车辆轴箱温度预测方法研究

计算机与数字工程 2024年第5期52卷 1541-1545页

作者：关博陈威彭乐乐丁亚琦郑树彬上海工程技术大学城市轨道交通学院上海201620 上海航天设备制造总厂有限公司上海200245 上海地铁维护保障有限公司车辆分公司上海200031

针对上海地铁所采用的自发电式轴温监测系统中的轴箱温度预测问题,通过长短时记忆网络(LSTM)、BP神经网络以及支持向量回归机(SVR)三种预测方法进行轴箱温度预测并将结果进行对比分析。最后,利用实测数据,对各方法的预测结果进行对比,... 详细信息

针对上海地铁所采用的自发电式轴温监测系统中的轴箱温度预测问题,通过长短时记忆网络(LSTM)、BP神经网络以及支持向量回归机(SVR)三种预测方法进行轴箱温度预测并将结果进行对比分析。最后,利用实测数据,对各方法的预测结果进行对比,结果表明,SVR的预测结果均优于其他预测方法,且预测精度可达到98.59%。

关键词：轴箱温度预测长短时记忆网络 BP神经网络支持向量回归机

Role of extracellular vesicles in lung diseases

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Chinese Medical Journal 2022年第15期135卷 1765-1780页

作者： Li Zhou Hong Luo Jae Woo lee Department of Pulmonary and Critical Care Medicine The Second Xiangya Hospital of Central South UniversityChangshaHunan 410011China Department of Anesthesiology University of CaliforniaSan FranciscoSan FranciscoCalifornia 94143USA

Extracellular vesicles(EVs)are anuclear particles composed of lipid bilayers that contain nucleic acids,proteins,lipids,and *** act as an important mediator of cell-to-cell communication by transmitting biological signals or components,including lipids,proteins,messenger RNAs,DNA,microRNAs,organelles,etc,to nearby or distant target cells to activate and regulate the function and phenotype of target *** physiological conditions,EVs play an essential role in maintaining the homeostasis of the pulmonary milieu but they can also be involved in promoting the pathogenesis and progression of various respiratory diseases including chronic obstructive pulmonary disease,asthma,acute lung injury/acute respiratory distress syndrome,idiopathic pulmonary fibrosis(IPF),and pulmonary artery *** addition,in multiple preclinical studies,EVs derived from mesenchymal stem cells(EVs)have shown promising therapeutic effects on reducing and repairing lung ***,in recent years,researchers have explored different methods for modifying EVs or enhancing EVs-mediated drug delivery to produce more targeted and beneficial *** article will review the characteristics and biogenesis of EVs and their role in lung homeostasis and various acute and chronic lung diseases and the potential therapeutic application of EVs in the field of clinical medicine.

关键词： Lung diseases Biomarker Lung disease pathogenesis Extracellular vesicles Clinical application

Feasibility and short-term outcomes of transcatheter valve-in-valve implantation for failed aortic and mitral bioprosthesis-a single-center experience

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Journal of Geriatric Cardiology 2018年第7期15卷 486-495页

作者： Wei-Hsian YIN Yung-Tsai lee Tien-Ping TSAO Kuo-Chen lee Ho-Ping YU Ming-Chon HSIUNG Jeng WEI Heart Center Cheng Hsin General Hospital Taipei Taiwan China Faculty of Medicine Cheng Hsin General Hospital Taipei Taiwan China Institute of Microbiology and Immunology.School of Medicine National Yang Ming University Taipei Taiwan China Faculty of Medicine National Defense Medical Center Taipei Taiwan China

Objectives Transcatheter valve-in-valve （VIV） implantation for failed bioprostheses has become an alternative to open surgery in those deemed high risk. The purpose of this study was to evaluate the effectiveness and outcomes of this emerging procedure. Methods Fourty VIV procedures were performed in 38 consecutive patients （mean age 70 ± 14 years and mean Logistic EuroScore 23.6 ± 15.5%） with severe aortic （n = 19） or mitral （n = 21） bioprosthetic valve dysfunction between 2014 and 2017. Bioprosthetic failure was secondary to stenosis in 11 （27.5%）, regurgitation in 19 （47.5%）, and combined in 10 （25.0%） bioprostheses. Clinical, echocardiographic, and procedural profiles were characterized, and the short-term results of the study patients were reported. Results Successful transfemoral （n = 15）, trans-subclavian （n = 1）, or transapical （n = 3） aortic VIV using either balloon-expandable valves （Edwards Sapien XT, n = 7） or self-expandable valves （Medtronic CoreValve, n = 12）; and transapical （n = 21） mitral VIV using either Edwards Sapien XT （n = 15） or me-chanically expandable valves （Boston Scientific Lotus, n = 6） were accomplished in all 40 VIV procedures. Implantation was successful with immediate restoration of satisfactory valve function in all patients. Five patients （13.2%） died at a median follow up of 9.3 months. Most of the 33 patients alive were in good functional status with good prosthetic valve performance. Conclusions Transcatheter VIV implantation is a feasible and safe option for the management of bioprosthetic valve failure. It may offer a less invasive alternative for those high-risk patients needing repeat valve replacement.

关键词： Aortic valve Bioprosthesis Mitral valve Transcatheter Valve-in-valve

Value of CT pulmonary arteriography and venography in the evaluation of venous thromboembolism in a multiracial Asian population

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Chinese Medical Journal 2013年第11期126卷 2049-2053页

作者： Yeong Ji lee Rozman Zakaria Zaleha Abdul Manaf Zahiah Mohamed Yeong Yeh lee Department of Radiology Hospital Sultan Ismail Mount Austin81100 Johor Bahru Johor Malaysia Department of Radiology Universiti Kebangsaan Malaysia MedicalCenter 56000 Cheras Kuala Lumpur Malaysia Department of Radiology Hospital Kuala Lumpur 50586 KualaLumpur Malaysia Department of Medicine School of Medical Sciences Universiti Sains Malaysia 16150 Kubang Kerian Kelantan Malaysia

Background There is increasing evidence that CT pulmonary arteriography and venography allow a better diagnostic yield for deep vein thrombosis （DVT） in suspected acute pulmonary embolism （PE）. The aim was to investigate the value for using such an approach in a multiracial Asian population. Methods A total of 135 consecutive subjects with clinically suspected PE in various clinical settings （postoperative in 23 subjects） were referred and evaluated for venous thromboemboUsm using CT pulmonary arteriography and venography in a tertiary hospital, Malaysia. The distribution of DVT was assessed based on the frequency rate of thrombosis in a particular anatomical region （inferior vena cava, pelvic, femoral and popliteal）. Results In 130 subjects, excluding 5 subjects having poor images, both DVT and PE were detected in 11.5% （15/130） subjects and DVT alone was detected in 6.9% （9/130） subjects giving a combined rate of venous thromboembolism of 18.4%. A history of malignancy was significantly associated with positive scans, P=0.02. It was found that left pelvic veins （18.2%） and left femoral veins （19.5%） were more commonly thrombosed in this population. Conclusion CT pulmonary arteriography and venography is a useful technique in the evaluation of venous thromboembolism in a multi-racial Asian population.

关键词： CT pulmonary arteriography and venography deep venous thrombosis pulmonary embolism multi-racial Asians

Trends in characteristics of neurologists who provide stroke consultations in the USA,2008-2021

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Stroke & Vascular Neurology 2023年第1期8卷 86-88页

作者： Carter H Nakamoto Andrew D Wilcock lee H Schwamm Jennifer J Majersik Kori S Zachrison Ateev Mehrotra Department of Health Care Policy Harvard Medical SchoolBostonMassachusettsUSA Department of Family Medicine University of Vermont Larner College of MedicineBurlingtonVermontUSA Department of Neurology Massachusetts General HospitalBostonMassachusettsUSA Department of Neurology University of UtahSalt Lake CityUtahUSA Department of Emergency Medicine Massachusetts General HospitalBostonMassachusettsUSA Division of General Medicine and Primary Care Beth Israel Deaconess Medical CenterBostonMassachusettsUSA

Introduction Patients with acute ischaemic strokes(AIS),on average,fare better with timely neurologist consultation,and a growing proportion of them receive ***,little is known about trends in the characteristics of neurologists who treat *** We identified AIS and transient ischaemic attack(TIA)episodes with neurologist consults in fee-for service Medicare from January 2008 to September *** each episode,we determined whether the neurologist was a vascular neurologist,was a high-volume provider,whether the patient was transferred between hospitals and the distance between the patient’s home and physician’s *** From 2008 to 2021,the share of AIS/TIA episodes(n=5073294)with neurologist consults increased(52.9%to 61.7%).Among episodes with consults,the fraction conducted by a vascular neurologist(5.2%to 13.7%)or by a high-volume neurologist(13.2%to 14.9%)also *** fraction with the patient’s home and neurologist greater than 100 miles apart(4.8%to 9.6%)or in different states(5.1%to 8.1%)increased,as did the fraction with transfers(4.2%to 8.5%).Discussion Over the study period,the proportion of AIS/TIA episodes with consultations from neurologists with either vascular neurology certifications or high volumes increased substantially.

关键词： acute characteristics consultation

Motivations for Loan Herding by Chinese Banks and Its Impact on Bank Performance

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China & World Economy 2019年第4期27卷 29-52页

作者： Hao Fang Yen-Hsien lee Chung-Hua Shen Chien-Ping Chung School of Economics Qu Fu Normal University China Department of Finance Chung Yuan Christian University Taiwan China College of Management National Taiwan University of Science and Technology Taiwan China

This study uses a dynamic herding model that considers intertemporal and crosssectional correlation to confirm that loan herding occurs among joint-stock commercial banks (JSCBs) and city commercial banks (CCBs). We clarify the motivations for bank loan herding. We find that loan herding by both JSCBs and CCBs results more from following the behavior of other same-type banks than different-type banks because of characteristic herding or reputational concerns. Loan herding by JSCBs is motivated by investigative herding, whereas loan herding by CCBs results from informational cascades. Moreover, loan herding has a significantly harmful impact on the operating performance of CCBs but not JSCBs, which may be explained by the irrational behavior of CCBs. Our results will help Chinese bank supervisors develop appropriate policies for handling loan herding.

关键词： financial crisis irrational herding loan herding