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Pemetrexed in Previously Treated Non-small Cell Lung Cancer Patients with Poor Performance Status

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中国肺癌杂志 2011年第1期14卷 33-38页

作者： sun Young jung Su Jin YOO Ji Young SHIN Ji Won park Jeong Eun LEE Hee sun park Ju Ock KIM sun Young KIM Department of Internal Medicine Chungnam National University Hospital

Background and objective Pemetrexed have been approved for the treatment of patients affected by advanced non-small cell lung cancner(NSCLC) in progression after first-line *** evaluated the activity and feasibility of pemetrexed in previously treated *** Patients with histologically or cytologically confirmed NSCLC were evaluated from April 2007 to March *** patients had relapsed or progressed after prior chemotherapy ***(500 mg/m2) was administered intravenously once every 3 weeks after progression to prior *** tumor response was evaluated according to RECIST criteria by chest CT at every 2 cycles of *** A total 61 patients were eligible for *** status of them(100%) was over *** response rate and disease control rate were 14.7% and 37.7% ***-squamous cell carcinoma histology was significantly associated with a superior response rate(P=0.045) and disease control rate(P=0.008).The median survival time and the median progression free survival(PFS) time were 6.11 months and 2.17 months,*** the efficacy of pemetrexed in these two settings [second-line versus(12/61) more than third(49/61)],there was no significant difference in regard to median survival(11.18 months vs 11.46 months,P=0.922,5),but PFS was more longer in third-or further-line groups than second-line group(1.39 months vs 2.25 months,P=0.015,3).Conclusion Pemetrexed is a feasible regimen in previously treated NSCLC with poor performance status.

关键词：肺癌症状化学疗法临床治疗

Solar-harvesting lead halide perovskite for artificial photosynthesis

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Journal of Energy Chemistry 2021年第11期30卷 11-26,I0001页

作者： sunje Lee Gyu Yong Jang jung Kyu Kim Jong Hyeok park Department of Chemical and Biomolecular Engineering Yonsei University50 Yonsei-roSeodaemun-guSeoul 03722Republic of Korea School of Chemical Engineering Sungkyunkwan University(SKKU)2066 Seobu‐roJangan‐guSuwon 16419Republic of Korea

Facing the upcoming energy and environmental crisis, artificial photosynthesis for producing various solar fuels (e.g., hydrogen or carbon products) via a solar-to-chemical energy conversion is receiving increasing attention;however, its low conversion efficiency is a challenge for commercialization. To resolve low-efficiency issues, lead halide perovskite (LHP) with outstanding optoelectronic properties compared to conventional semiconductors can be a promising approach to improve the solar-to-fuel conversion reactions and solar fuel production efficiency. The tunable energy band structure and charge transport properties of LHP have promoted their extensive use in the production of solar fuels. This study summarizes the recent advancements of LHP-mediated solar-to-fuel conversions, classified by their redox reactions, namely solar water splitting, hydrohalic acid splitting, and CO_(2) reduction. Advanced approaches for achieving high conversion efficiency and long-term durability are discussed, including the configuration of devices, the composition of LHP, and the protection strategy of LHP. Moreover, the reaction mechanisms of LHP-mediated solar-to-chemical energy conversions and obstacles for enhancing the conversion efficiency are discussed. Finally, we present the perspectives on the development of LHP-incorporated solar-to-fuel conversion systems, which might open a new era of energy harvesting and storage.

关键词： Perovskite Photocatalytic reaction Photoelectrochemistry Photovoltaic Water splitting HI splitting CO_(2)reduction

Anti-carcinogenic properties of curcumin on colorectal cancer

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World Journal of Gastrointestinal Oncology 2010年第4期2卷 169-176页

作者： jung park Chris N Conteas Department of Internal Medicine Kaiser Permanente Los Angeles Medical Center1526 Edgemont AveLos AngelesCA 90027United States Department of Gastroenterology Kaiser Permanente Los Angeles Medical Center1526 Edgemont AveLos AngelesCA 90027United States

Curcumin has been used in traditional Indian medicine for many centuries for its anti-inflammatory and anticarcinogenic *** has been some promising research concerning curcumin as a safe therapeutic agent for many cancers,colorectal cancer being among *** has been shown through research in cell cultures,animal models,and *** this time,it appears that curcumin’s anti-carcinogenic properties are most likely due to its effects on multiple molecular targets,such as nuclear factorκ-light-chain-enhancer of activated B cells(NF-κB)and activator protein 1(AP-1).NF-κB and AP-1 are both major transcription factors that regulate inflammation and thus affect cell proliferation,differentiation and even *** has also been shown to affect a variety of other key players involved in carcinogenesis,such as cyclooxygenase-2,matrix metallopeptidases 2 and 9 and tumor necrosis factorαinduced vascular cell adhesion molecule,just to name a *** many molecular targets are involved,curcumin has been well tolerated in many studies:doses up to 8 g a day have been confirmed to be safe for *** this brief review,we will examine the current studies and literature and touch upon many molecular pathways affected by curcumin,and demonstrate the exciting possibility of curcumin as a chemopreventive agent for colorectal cancer.

关键词： Chemopreventive Anti-inflammatory Anticarcinogenic Curcumin Turmeric Cancer Colorectal cancer

Room-temperature synthesis of ZrSnO4 nanoparticles for electron transport layer in efficient planar hetrojunction perovskite solar cells

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Journal of Materials Science & Technology 2020年第7期42卷 38-45页

作者： Young Wook Noh In Su Jin Sang Hyun park Jae Woong jung Department of Advanced Materials Engineering for Information&Electronics Kyung Hee University1732 Deogyeong-daeroGiheung-guYongin-siGyeonggi-do 446-701Republic of Korea

The interface engineering plays a key role in controlled optoelectronic properties of perovskite photovoltaic devices,and thus the electron transport layer(ETL)material with tailored optoelectronic properties remains a challenge for achieving high photovoltaic performance of planar perovskite solar cells(PSCs).Here,the fine and crystalline zirconium stanate(ZrSnO4)nanoparticles(NPs)was synthesized at low temperature,and its optoelectronic properties are systematically *** from the favorable electronic structure of ZrSnO4 NPs for applications in ETL,efficient electron transport and extraction with suppre s sed charge recombination are achieved at the interface of perovskite *** a result,the optimized ZrSnO4 NPs synthesized at room-temperature deliver the optimized power conversion efficiency up to 16.76%with acceptable *** work opens up a new class of ternary metal oxide for the use in ETL of the planar PSCs and should pave the way toward designing new interfacial materials for practical optoelectronic devices.

关键词： ZrSnO4 Electron transport layer Nanoparticles Perovskite solar cells

Complete remission of advanced hepatocellular carcinoma by radiofrequency ablation after sorafenib therapy

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World Journal of Gastroenterology 2015年第8期21卷 2568-2572页

作者： jung Gil park Soo Young park Hye Won Lee Division of Gastroenterology and Hepatology Department of Internal Medicine CHA University Gumi CHA Medical Center Division of Gastroenterology and Hepatology Department of Internal Medicine School of Medicine Kyungpook National University Department of Pathology School of Medicine Kyungpook National University

Sorafenib,a potent multikinase inhibitor,lead to a significant improvement in progression free survival and overall survival in patients with advanced hepatocellular carcinoma(HCC).Though sorafenib has proven its efficacy in advanced stage HCC,there are limitedreports on the role of sorafenib allowing for curative treatment by *** herein report a case of advanced HCC with vascular invasion,which showed treatment response by sorafenib therapy as to allow for radiofrequency ablation as curative *** patient was followed-up for 6 mo without recurrence with continued sorafenib therapy.

关键词： Hepatocellular carcinoma Radiofrequency ablation S

Detection and treatment of synchronous lesions in colorectal cancer: The clinical implication of perioperative colonoscopy

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World Journal of Gastroenterology 2007年第30期13卷 4108-4111页

作者： Min sun Kim Young Jin park Department of Surgery Dongguk University International Hospital Dongguk University School of Medicine Goyang Korea Department of Surgery Ilsanpaik Hospital Inje University School of Medicine Goyang Korea

AIM： To evaluate the clinical significance of preand intra-operative colonoscopy for the detection of synchronous lesions in colon cancer.METHODS： Two hundred and sixty-five pre-operative and 51 intra-operative colonoscopic evaluations were performed in 316 colorectal cancer patients who underwent curative resection from January 2001 to June 2006. The incidence and characteristics of synchronous lesions and their influence on surgery were evaluated.RESULTS： Two hundred and eighty-two synchronous lesions were detected in 124 （39.2%） of 316 patients including all lesions regardless of their histologic type. True adenomatous polyps were found in 91 （28.8%） of 326 patients, and 27 （5.4% of all patients） patients had synchronous colon cancers. The preoperative identification of synchronous lesions altered the planned surgery in 37 （14.0%） of 265 patients. In 18 patients among the surgically removed cases, the lesions were removed by extending the resection range. Further segmental resection or polypectomy through enterotomy was necessary in 29 patients. Nineteen （37.2%） of 52 intraoperative colonoscopy cases had synchronous lesions. Additional surgical procedures including segmental bowel resection and polypectomy with enterotomy were necessary in 7 （23.7%） of 52 intraoperative colonoscopy cases to remove the lesions.CONCLUSION： Synchronous colorectal polyps or cancer are frequent and their preoperative detection is important for optimal surgical planning and treatment. Intraoperative colonoscopy is a useful option in cases where a preoperative colonoscopy is not feasible.

关键词： Colon cancer Synchronous colon polyp Intraoperative colonoscopy

Mitochondria-targeting self-assembled nanoparticles derived from triphenylphosphonium-conjugated cyanostilbene enable site-specific imaging and anticancer drug delivery

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Nano Research 2018年第2期11卷 1082-1098页

作者： Ka Young Kim Hanyong Jin Jaehyeon park sung Ho jung Ji Ha Lee Hyesong park sung Kuk Kim Jeehyeon Bae Jong Hwa jung Department of Chemistry and Research Institute of Natural Sciences Gyeongsang National University Jinju Republic of Korea School of Pharmacy Chung-Ang University Seoul Republic of Korea

Subcellular organelle-specific nanoparticles for simultaneous tumor targeting, imaging, and drug delivery are of enormous interest in cancer therapy. Herein, we report a selective mitochondria-targeting probe 1, which was synthesized by incorporating a triphenyl phosphine with a cyanostilbene and a long alkyl chain moiety. Probe 1 was found to display fluorescence via aggregation-induced emission （AIE）. The low molecular-weight cyanostilbene-based probe 1, with and without an anticancer drug, formed a narrow homogeneous nanorod with ca. 110 nm of length or nanopartides with ca. 20 nm diameter in aqueous media. The self-assembled cyanostilbene nanoparticles （N1） selectively accumulated in the mitochondria of cancer cells and emitted fluorescence. N1 was also able to deliver an anticancer drug, doxorubicin （DOX）, to the mitochondria with high efficiency. More importantl~ N1 exhibited highly selective cytotoxicity for cancer cells over normal cells. The great potential applications of this self-assembled nanoparticle to biological systems result from its ability to aggregate in the mitochondria. This aggregation led to a significant increase in the generation of intraceUular reactive oxygen species and to a decrease in the mitochondrial membrane potential in cancer cells. Furthermore, tumor tissue uptake experiments in mice proposed that the self-assembled N1 had the ability to internalize and deliver the anticancer drug into tumor tissues effectively. Moreover, both N1 and Nl-encapsulated doxorubicin （N1-DOX） effectively suppressed tumor growth in a xenograft model in vivo. Taken together, our findings indicate that applications of N1 as a mitochondrial targeting probe, drug delivery platform, and chemotherapeutic agent provide a unique strategy for potential image-guided therapy as well as a site-specific delivery system to cancer cells.

关键词： aggregation-inducedemission,chemotherap3 drug deliver3 mitochondria-targeting,fluorescence imaging

Optimal operation of microgrid using hybrid differential evolution and harmony search algorithm

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Frontiers in Energy 2016年第3期10卷 355-362页

作者： S. SURENDER REDDY Jae Young park Chan Mook jung Department of Railroad and Electrical Engineering Woosong University Republic of Korea Department of Railroad and Civil Engineering Woosong UniversityRepublic of Korea

This paper proposes the generation scheduling approach for a microgrid comprised of conventional generators, wind energy generators, solar photovoltaie （PV） systems, battery storage, and electric vehicles. The electrical vehicles （EVs） play two different roles： as load demands during charging, and as storage units to supply energy to remaining load demands in the MG when they are plugged into the microgrid （MG）. Wind and solar PV powers are intermittent in nature; hence by including the battery storage and EVs, the MG becomes more stable. Here, the total cost objective is minimized considering the cost of conventional generators, wind generators, solar PV systems and EVs. The proposed optimal scheduling problem is solved using the hybrid differential evolution and harmony search （hybrid DE-HS） algorithm including the wind energy generators and solar PV system along with the battery storage and EVs. Moreover, it requires the least investment.

关键词： battery storage electric vehicles (EVs),microgrid (MG) optimal scheduling solar photovoltaic(PV) system wind energy conversion system

Recent advances in electronic devices for monitoring and modulation of brain

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Nano Research 2021年第9期14卷 3070-3095页

作者： Yong Won Kwon Yoon sun Jun Young-Geun park Jiuk Jang Jang-Ung park Nano Science Technology Institute Department of Materials Science and EngineeringYonsei UniversitySeoul 03722Republic of Korea Center for Nanomedicine Institute for Basic Science(IBS)Seoul 03722Republic of Korea Graduate Program of Nano Biomedical Engineering(NanoBME) Advanced Science InstituteYonsei UniversitySeoul 03722Republic of Korea

The brain is actuated by billions of neurons with trillions of interconnections that regulate human *** the mechanisms of these systems that induce sensory reactions and respond to disease remains one of the greatest challenges in science,engineering,and *** advances in nanomaterials and nanotechnologies have led to the extensive research of electronic devices for brain interfaces to better understand the neural activities of the brains complex nervous *** development of sensor devices for monitoring the physiological signals of the brain related to traumatic injury status has accompanied by the progress of electronic neural probes in *** addition,these neurological and stereotactic surgical revolutions hold immense potential for clinical analysis of pharmacological systems within cerebral ***,we review the progress of electronic devices interfacing with brain in terms of the materials,fabrication technologies,and device *** activity can be measured and modulated by brain probes based on newly developed nanofabrication ***,in vivo pathological monitoring of the brain and pharmacological assessment has been developed in miniaturized and wireless *** also consider the key challenges and prospects for further development,and explore the future directions emerging in the latest research.

关键词： neural interfaces neural recording neuromodulation intracranial pressure monitoring microfluidic drug delivery