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Inhibitory Effect of the Extract of Phellodendron amurense Ruprecht Root on Collagen-Induced Arthritis in Mice

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Chinese Journal of Integrative Medicine 2017年第10期23卷 755-762页

作者： Hyo Won jung Kyung-Ho Kim Yong-Ki park Department of Herbology College of Korean Medicine Dongguk University Gyeongju (740-814) Republic of Korea Korean Medicine Research and Development Center Dongguk University Gyeongju (740-814) Republic of Korea Department of Acupuncture College of Korean Medicine Dongguk University Gyeongju (740-814) Republic of Korea

Objective： To investigate whether the dried root of Phellodendron amurense Ruprecht（Phellodendri cortex; PC） extract improves arthritic symptoms through anti-inflammatory and immune-modulatory effects in collagen-induced arthritis in mice. Methods： Rheumatoid arthritis（RA） was induced in male DBA/1 mice by immunization with type Ⅱ collagen（ColⅡ）. CIA mice were divided into 5 groups（n=10 per a group） with normal, CIA control, PC extract（50 mg/kg and 100 mg/kg）-treated, and meloxicam（50 mg/kg）-treated as the reference drug. The PC extract or meloxicam were administered orally in CIA mice once a day for 14 days after arthritis induction. Arthritic score, levels of anti-ColⅡ IgG2a antibody, prostaglandin E2（PGE2）, tumor necrosis factor（TNF）-α, and interleukin（IL）-17 in the sera of CIA mice were measured. Histopathological changes in the ankle joints of CIA mice were also analyzed by staining with hematoxylin and eosin（H and E）, safranin-O and immunohistochemistry using anti-TNF-α and anti-IL-17 antibodies. Results： The arthritic score was increased in CIA mice in a time-dependent manner, as were the serum levels of anti-ColⅡ IgG2a antibody, PGE2, TNF-α, and IL-17. However, the oral administration of PC extract at 50 and 100 mg/kg in CIA mice significantly decreased the arthritic scores, and the serum levels of anti-ColⅡ IgG2a, PGE2, TNF-α, and IL-17 compared with those in the CIA group（P〈0.05 or P〈0.01）. Furthermore, histopathological improvement of the joint architecture in CIA mice was observed after administration of PC extract. PC extract also significantly inhibited the expression of TNF-α and IL-17 in the joints of CIA mice by suppressing the expression of their m RNA and proteins. Conclusion： PC extract may improve the pathological progression of RA through the inhibition of joint destruction by synovial inflammation and immune-stimulation, therefore, it would be a potential anti-arthritic agent in RA.

关键词： Phellodendron amurense Phellodendri cortex collagen-induced arthritis anti-arthritic effect

Electrochemically Deposited CZTSSe Thin Films for Monolithic Perovskite Tandem Solar Cells with Efficiencies Over 17%

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Energy & Environmental Materials 2024年第1期7卷 147-152页

作者： sun Kyung Hwang Ik Jae park Se Won Seo Jae Hyun park So Jeong park Jin Young Kim Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Korea Department of Applied Physics Sookmyung Women's UniversitySeoul 04310Korea Research Institute of Advanced Materials and Systems Sookmyung Women's UniversitySeoul 04310Korea Research Institute of Advanced Materials(RIAM) Seoul National UniversitySeoul 08826Korea

In spite of the high potential economic feasibility of the tandem solar cells consisting of the halide perovskite and the kesterite Cu2ZnSn(S,Se)4(CZTSSe),they have rarely been demonstrated due to the difficulty in implementing solution-processed perovskite top cell on the rough surface of the bottom ***,we firstly demonstrate an efficient monolithic two-terminal perovskite/CZTSSe tandem solar cell by significantly reducing the surface roughness of the electrochemically deposited CZTSSe bottom *** surface roughness(R_(rms))of the CZTSSe thin film could be reduced from 424 to 86 nm by using the potentiostatic mode rather than using the conventional galvanostatic mode,which can be further reduced to 22 nm after the subsequent ion-milling *** perovskite top cell with a bandgap of 1.65 eV could be prepared using a solution process on the flattened CZTSSe bottom cell,resulting in the efficient perovskite/CZTSSe tandem solar *** the current matching between two subcells involving the thickness control of the perovskite layer,the best performing tandem device exhibited a high conversion efficiency of 17.5%without the hysteresis effect.

关键词： CZTSSe monolithic tandem solar cells perovskite solution process surface roughness control

Fragile histidine triad gene alterations are not essential for hepatocellular carcinoma development in South Korea

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World Journal of Gastroenterology 2008年第22期14卷 3526-3533页

作者： Chang Woo Nam jung Woo Shin Neung Hwa park Department of Surgery University of Ulsan College of Medicine Biomedical Research Center Ulsan University Hospital Ulsan 682-714 South Korea Internal Medicine University of Ulsan College of Medicine Biomedical Research Center Ulsan University Hospital Ulsan 682-714 South Korea

AIM: To establish the role of FHIT in the pathogenesis hepatocellular carcinoma (HCC). METHODS: We examined genomic alterations, as well as, mRNA and protein expression patterns from the FHIT gene, in 48 surgically resected hepatocellular carcinoma (HCC) tissues. Additionally, p53 mutations were analyzed. RESULTS: Aberrant FHIT transcripts were detected in 11 of 48 surrounding non-tumor liver tissues and 27 of 48 HCC samples (22.9% vs 56.3%, P = 0.002). No point mutations were identified within the open reading frame region of FHIT. Loss of heterozygosity (LOH) of the FHIT locus was detected in 4 of 42 informative cases for D3S1300, and 3 of 29 informative cases for D3S1313. Reduced expression of FHIT protein (Fhit) was observed in 8 (16.7%) of 48 HCC samples, with complete loss of Fhit in only 1 case. There were no associations with abnormal transcripts, LOH, and Fhit expression. p53 mutations were identified in 9 of the 48 HCC cases. However, none of the cases displayed a G to T transversion at p53 codon 249. CONCLUSION: Aberrant FHIT transcripts were more common in HCC tissues as compared to non-cancerous liver tissues. However, Fhit expression was lost or reduced in a minor fraction of HCC tissues, while it was strongly expressed in non-cancerous liver ***, our study suggests that FHIT plays a role in relatively few HCC cases in South Korea.

关键词： Fragile histidine triad Aberrant transcripts Microsatellite instability Protein expression Hepatocellular carcinoma

Silver nanoislands on cellulose fibers for chromatographic separation and ultrasensitive detection of small molecules

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Light(Science & Applications) 2016年第1期5卷 796-802页

作者： Hyukjin jung Moonseong park Minhee Kang Ki-Hun Jeong Department of Bio and Brain Engineering KAIST Institute for Optical Science and TechnologyKorea Advanced Institute of Science and Technology291 Daehak-roYuseong-guDaejeon 305-701Korea

High-throughput small-molecule assays play essential roles in biomedical diagnosis,drug discovery,environmental analysis,and physiological function *** holds a great potential for the label-free detection of small molecules at extremely low ***,we report the development of nanoplasmonic paper(NP-paper)for the rapid separation and ultrasensitive detection of mixed small ***-paper employs nanogap-rich silver nanoislands on cellulose fibers,which were simply fabricated at the wafer level by using low-temperature solid-state dewetting of a thin silver *** nanoplasmonic detection allows for the scalable quantification and identification of small molecules over broad concentration ***,the combination of chromatographic separation and nanoplasmonic detection allows both the highly sensitive fluorescence detection of mixed small molecules at the attogram level and the label-free detection at the sub-nanogram level based on surface-enhanced Raman *** novel material provides a new diagnostic platform for the high-throughput,low-cost,and label-free screening of mixed small molecules as an alternative to conventional paper chromatography.

关键词： nanoplasmonics paper chromatography plasmon-enhanced spectroscopy silver nanoislands small-molecule assay

Dual-frequency piezoelectric micromachined ultrasound transducer based on polarization switching in ferroelectric thin films

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Microsystems & Nanoengineering 2023年第5期9卷 233-243页

作者： Jin Soo park Soo Young jung Dong Hun Kim jung Ho park Ho Won Jang Tae Geun Kim Seung-Hyub Baek Byung Chul Lee Bionics Research Center Korea Institute of Science and TechnologySeoul 02792Republic of Korea Department of Electrical Engineering Korea UniversitySeoul 02841Republic of Korea Center for Electronic Materials Korea Institute of Science and TechnologySeoul 02792Republic of Korea Department of Material Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Division of Bio-Medical Science and Technology KIST SchoolUniversity of Science and Technology(UST)Seoul 02792Republic of Korea KHU-KIST Department of Converging Science and Technology Kyung Hee UniversitySeoul 02447Republic of Korea

Due to its additional frequency response,dual-frequency ultrasound has advantages over conventional ultrasound,which operates at a specific frequency ***,a tunable frequency from a single transducer enables sonographers to achieve ultrasound images with a large detection area and high *** facilitates the availability of more advanced techniques that simultaneously require low-and high-frequency ultrasounds,such as harmonic imaging and image-guided *** this study,we present a novel method for dual-frequency ultrasound generation from a ferroelectric piezoelectric micromachined ultrasound transducer(PMUT).Uniformly designed transducer arrays can be used for both deep low-resolution imaging and shallow high-resolution *** switch the ultrasound frequency,the only requirement is to tune a DC bias to control the polarization state of the ferroelectric *** vibration of the PMUT membrane strongly depends on the polarization state,producing low-and high-frequency ultrasounds from a single excitation *** strategy for dual-frequency ultrasounds meets the requirement for either multielectrode configurations or heterodesigned elements,which are integrated into an ***,this technique significantly reduces the design complexity of transducer arrays and their associated driving circuits.

关键词： piezoelectric ferroelectric enable

Regular moderate aerobic exercise improves high-fat diet-induced nonalcoholic fatty liver disease via monoacylglycerol O-acyltransferase 1 pathway suppression

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Journal of Sport and Health Science 2020年第5期9卷 472-478页

作者： Kyung-Wan Baek Jeong-An Gim jung-Jun park Division of Sport Science Pusan National UniversityBusan 46241Korea Department of Biological Sciences College of Natural SciencesPusan National UniversityBusan 46241Korea

Purpose:Monoacylglycerol O-acyltransferase 1(MGAT1)is reported to play a key role in the development of diet-induced nonalcoholic fatty liver disease(NAFLD).Thus,this study investigated the effect of exercise on suppression of the MGAT1 pathway in NAFLD tissue of high-fat diet(HFD)-induced obese ***:Male Sprague-Dawley rats were fed an HFD containing 45%fat for 6 *** confirmation that NAFLD had been induced in the obese animals,they were divided into HFD-fed groups provided with exercise(HFD+EXE)or without exercise(HFD)and a group given dietary adjustment(DA)only,for a further 6 weeks of intervention *** 6-week regular moderate aerobic exercise consisted of an accommodation phase with increasing *** accumulation in the liver tissue was determined by Oil Red O *** MGAT1 and liver lipogenic gene mRNA levels were measured by qPCR,and their protein levels by western blot ***:Oil Red O staining showed that NAFLD was successfully induced by *** gene expression of MGAT1 was significantly lower in HFD+EXE than ***,there was no significant difference between HFD+EXE and *** protein expression of MGAT1 was significantly lower in HFD+EXE than both HFD and *** RNA and protein expression of other lipogenic genes were not different among *** data indicate that exercise suppresses MGAT1 pathway regardless of HFD feeding;in part,this effect could be greater than ***:Our data suggest that exercise can improve NAFLD,which is probably due to suppression of MGAT1 pathway.

关键词： Exercise High-fat diet Monoacylglycerol O-acyltransferase 1 Nonalcoholic fatty liver disease Obesity

Stiefel–Whitney classes and topological phases in band theory

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Chinese Physics B 2019年第11期28卷 1-17页

作者： Junyeong Ahn sungjoon park Dongwook Kim Youngkuk Kim Bohm-jung Yang Department of Physics and Astronomy Seoul National UniversitySeoul 08826Korea Center for Correlated Electron Systems Institute for Basic Science(IBS)Seoul 08826Korea Center for Theoretical Physics(CTP) Seoul National UniversitySeoul 08826Korea

We review the recent progress in the study of topological phases in systems with space–time inversion symmetry *** an anti-unitary symmetry which is local in momentum space and satisfies I2 ST= 1 such as PT in two dimensions(2 D)and three dimensions(3 D) without spin–orbit coupling and C2 T in 2 D with or without spin–orbit coupling, where P, T, C2 indicate the inversion, time-reversal, and two-fold rotation symmetries, respectively. Under IST, the Hamiltonian and the periodic part of the Bloch wave function can be constrained to be real-valued, which makes the Berry curvature and the Chern number vanish. In this class of systems, gapped band structures of real wave functions can be topologically distinguished by the Stiefel–Whitney numbers instead. The first and second Stiefel–Whitney numbers w1 and w2, respectively,are the corresponding invariants in 1 D and 2 D, which are equivalent to the quantized Berry phase and the Z2 monopole charge, respectively. We first describe the topological phases characterized by the first Stiefel–Whitney number, including1 D topological insulators with quantized charge polarization, 2 D Dirac semimetals, and 3 D nodal line semimetals. Next we review how the second Stiefel–Whitney class characterizes the 3 D nodal line semimetals carrying a Z2 monopole *** particular, we explain how the second Stiefel–Whitney number w2, the Z2 monopole charge, and the linking number between nodal lines are related. Finally, we review the properties of 2 D and 3 D topological insulators characterized by the nontrivial second Stiefel Whitney class.

关键词： topological semimetal

Sex-dependent difference in the effect of metformin on colorectal cancer-specific mortality of diabetic colorectal cancer patients

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World Journal of Gastroenterology 2017年第28期23卷 5196-5205页

作者： jung Won park Jin Ha Lee Ye Hyun park Soo jung park Jae Hee Cheon Won Ho Kim Tae Il Kim Department of Internal Medicine and Institute of Gastroenterology Yonsei University College of Medicine Cancer Prevention Center Yonsei University College of Medicine

To assess factors associated with the higher effect of metformin on mortality in diabetic colorectal cancer (CRC) patients, since the factors related to the effectiveness of metformin have not been identified *** January 2000 and December 2010, 413 patients diagnosed with both stage 3/4 CRC and diabetes mellitus were identified. Patients’ demographics and clinical characteristics were analyzed. The effect of metformin on CRC-specific mortality and the interactions between metformin and each adjusted factor were *** follow-up duration was median 50 mo (range: 1-218 mo). There were 85 deaths (45.9%) and 72 CRC-specific deaths (38.9%) among 185 patients who used metformin, compared to 130 total deaths (57.0%) and 107 CRC-specific deaths (46.9%) among 228 patients who did not use metformin. In multivariate analysis, survival benefit associated with metformin administration was identified (HR = 0.985, 95%CI: 0.974-0.997, P = 0.012). Interaction test between metformin and sex after adjustment for relevant factors revealed that female CRC patients taking metformin exhibited a significantly lower CRC-specific mortality rate than male CRC patients taking metformin (HR = 0.369, 95%CI: 0.155-0.881, P = 0.025). Furthermore, subgroup analysis revealed significant differences in CRC-specific mortality between the metformin and non-metformin groups in female patients (HR = 0.501, 95%CI: 0.286-0.879, P = 0.013) but not male patients (HR = 0.848, 95%CI: 0.594-1.211, P = 0.365). There were no significant interactions between metformin and other adjusted factors on CRC-specific *** showed a strong sex-dependent difference in the effect of metformin on CRC-specific mortality in advanced stage CRC patients with diabetes.

关键词： Colorectal cancer Metformin Survival Sex

Interfacial modulation of bifunctional electrolyte additive engineering for dendrite-free and robust lithium metal anode

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Journal of Energy Chemistry 2024年第10期97卷 120-127,I0003页

作者： Mahammad Rafi Shaik Yongmin park Young-Kwang jung Won Bin Im Division of Materials Science and Engineering Hanyang University222Wangsimni-roSeongdongguSeoul 0473Republic of Kor Department of Chemical Engineering and Biotechnology University of CambridgeCambridge CB3 OASUK

Anode materials for rechargeable electric car batteries are obtained from Li-metal owing to their extremely high specific capacity and low redox ***,safety concerns related to dendrite formation on the anode surface caused by the uneven distribution of Li-ions during the discharge process interfere with the use of Li-metal in industrial *** this study,methyl vinyl sulfone(MVS),a sulfone-based functional electrolyte additive,is used in an additive engineering strategy to control Lielectrolyte interactions and address the aforementioned *** dendrite growth may be restricted,and transition metal degradation on the surface of the cathode can be reduced by the MVS-derived functional electrolyte additive interfacial *** electrochemical performance of an ethylene carbonate/dimethyl carbonate(EC/DMC)+1 wt% MVS Li-metal anode of a Li||Li symmetric cell exhibits remarkable cycle stability,maintaining a low overvoltage for over 750 h at 1 mA cm^(-2),and capacity of 1 mA h cm^(-2).Additionally,LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(NCM811) full cells with the MVS additive exhibit enhanced electrochemical stability for 250 cycles at a current density of 100 mA g^(-1).This study provides an innovative approach for stabilizing the metal-electrolyte interfacial layer that may be used for practical applications in metal-based rechargeable batteries.

关键词： Lithium rechargeable battery Dendrite-free Electrolyte additive Bifunctional electrolyte Interfacial layer