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World Journal of AIDS 2011年第4期1卷 155-164页

作者： Hee jung Choi Kyoung Ae Kong jung won min Hun-Jae Lee Hae-Sook Park 不详

Purpose: This study was conducted to develop a guideline for HIV testing in South Korea where the HIV prevalence is very low. It is necessary to make the recommendations presented here based on the epidemiology of opportunistic infection and cancer in the community. Methods: The development of a guideline for HIV testing was conducted using literature reviews and the agreement of Korean experts for HIV patients using a two-round Delphi consensus technique. Each expert was asked to independently answer to each item related to HIV risk. Ten experts participated in the two-round survey. Results: The individual items were determined based on the following categories: high risk behavior, symptom and diseases, colo-rectal diseases, uro-genital diseases and gynecology, skin and oral diseases. The final guideline consisted of 4-scale agreement rating (strongly recommended, recommended, not routinely recommended, no recommendation for routine provision). Discussion: We have developed the guideline for HIV testing in a country where the HIV prevalence is low based on a systematic investigation and expert consensus.

关键词： HIV Testing Guideline Consensus Delphi Studies

Tolerating Permanent State Transition Faults in Asynchronous Sequential Machines

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Journal of Computer Science & Technology 2016年第5期31卷 1028-1037页

作者： jung-min Yang School of Electronics Engineering Kyungpook National University Daegu 41566 Korea

Corrective control theory lays a novel foundation for the fault-tolerant control of asynchronous sequential machines. In this paper, we present a corrective control scheme for tolerating permanent state transition faults in the dynamics of asynchronous sequential machines. By a fault occurrence, the asynchronous machine may be stuck at a faulty state, not responding to the external input. We analyze the detectability of the considered faults and present the necessary and sufficient condition for the existence of a controller that overcomes any permanent transition faults. Fault tolerance is realized by using potential reachability and asynchronous mechanisms in the machine. A case study on an asynchronous counter is provided to illustrate the proposed fault detection and tolerance scheme.

关键词： asynchronous sequential machine corrective control permanent fault fault tolerance

Effects of irradiation on superconducting properties of small-grained MgB_(2) thin films

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Chinese Physics B 2023年第12期32卷 534-540页

作者：刘丽 jung min Lee Yoonseok Han Jaegu Song Chorong Kim Jaekwon Suk won Nam Kang 刘杰 Soon-Gil jung Tuson Park Center for Quantum Materials and Superconductivity(CQMS) Sungkyunkwan UniversitySuwon 16419Republic of Korea Department of Physics Sungkyunkwan UniversitySuwon 16419Republic of Korea Institute of Modern Physics Chinese Academy of Sciences(CAS)Lanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of Sciences(UCAS)Beijing 100049China Korea Multi-purpose Accelerator Complex Korea Atomic Energy Research InstituteGyeongjuGyeongbuk 38180Republic of Korea Department of Physics Education Sunchon National UniversitySuncheon 57922Republic of Korea

We investigate the effect of ion irradiation on MgB_(2) thin films with small grains of approximately 122 nm and 140 *** flux pinning by grain boundaries is insignificant in the pristine MgB_(2) films due to good inter-grain connectivity,but is significantly improved after 120-keV Mn-ion *** scaling behavior of the flux pinning force density for the ion-irradiated MgB_(2) thin films with nanoscale grains demonstrates the predominance of pinning by grain boundaries,in contrast to the single-crystalline MgB_(2) films where normal point pinning was dominant after low-energy ion *** results suggest that irradiation-induced defects can accumulate near the grain boundaries in metallic MgB_(2) superconductors.

关键词： MgB_(2)films grain boundaries flux pinning low-energy ion irradiation

Assessment of risk of complications in cirrhosis using portal thallium scans

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World Journal of Gastroenterology 2014年第1期20卷 228-234页

作者： Hye-Jin Tae Dae-won Jun Yun-Young Choi min-jung Kwak min-Ho Lee Department of Internal Medicine Hanyang University School of MedicineSeoul 133-792South Korea Department of Nuclear Medicine Hanyang University College of MedicineSeoul 133-792South Korea Department of Computer Science and Statistics Pyongtaek UniversityPyongtaek 450-701South Korea

AIM:To investigate the usefulness of a novel thallium scan shunt index for assessing portosystemic shuntrelated cirrhotic ***:We enrolled 209 chronic hepatitis B-related cirrhosis *** rectal thallium instillation,radioactive isotope activity in the heart and liver was *** ratio of radiation uptake between the heart and the liver was calculated(the shunt index).This value indicates the degree of portosystemic circulation *** tests,serum biochemistry tests,abdominal ultrasonography,gastroscopy and examination of clinical features such as the occurrence of varices,bleeding and hepatic encephalopathy were *** analysis was used to identify independent risk factors for *** compared the cumulative incidence rates of complications during the follow-up ***:The thallium scan shunt index was significantly higher in the decompensated liver cirrhosis group than in the compensated liver cirrhosis group(0.91±0.39 vs 0.39±0.32,P<0.001).It was also higher in the varices group,the hepatic encephalopathy group,and the variceal bleeding group than in the control group(P<0.001).Multivariate analysis showed that the index was an independent risk factor for predicting decompensated liver *** the cut-off value was 0.75,the shunt index had a sensitivity of 82.6%,a specificity of 84%,a positive predictive value of 61.5%,and a negative predictive value of 94.4%in diagnosing decompensated *** the shunt index was greater than 0.75,there was a significant increase in the number of decompensated ***:The thallium shunt index is a good predictor of cirrhosis-related complications.

关键词： Liver cirrhosis Portosystemic shunt Decompensation

Winter distribution of diatom assemblages along the coastline of *** in 2010

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Acta Oceanologica Sinica 2022年第6期41卷 68-77页

作者： Joon Sang Park Kyun-Woo Lee Seung won jung Taek-Kyun Lee Hyoung min Joo Library of Marine Samples Korea Institute of Ocean Science&TechnologyGeoje 53201R.O.Korea Marine Biotechnology Research Center Korea Institute of Ocean Science&TechnologyBusan 49111R.O.Korea Risk Assessment Research Center Korea Institute of Ocean Science&TechnologyGeoje 53201R.O.Korea Unit of Next Generation IBRV Building Program Korea Polar Research InstituteIncheon 21990R.O.Korea

Diatoms are a globally successful and eukaryotic photosynthetic organism with an ornamented silica external *** relationship between their valve morphology and habitat means that diatoms can be used as bioindicators to characterize the aquatic *** estimate the differential distribution and diversity of diatom assemblages along the coastal line,we collected phytoplankton samples from 114 coastal sites of waters of *** applied the unweighted pair-group technique using the arithmetic averages clustering method to cluster the sampling sites,apart from those where the biota consisted of other groups,such as dinoflagellates,into four regions:the Yellow Sea,South Sea,southern East Sea,and northern East *** species analysis in each region led to the selection of tychoplanktonic,chain-forming,attached species to substrates and psychrophilic indicator diatoms,respectively,each of which represented a planktonic lifestyle associated with one of the four *** study shows the diatom assemblages to serve as bioindicators of Korean coastal water in winter,and the subsequent seasonal survey will provide a starting point for the improved understanding of Korean diatom-based ecoregions,in both time and space.

关键词： diatom assemblage indicator species life-form Korean coastal waters species diversity

Selexipag as Add-on Therapy for Patients with Pulmonary Arterial Hypertension Associated with Congenital Heart Disease:A Single-Center Retrospective Study

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Congenital Heart Disease 2021年第3期16卷 233-244页

作者： Se Yong jung Doyoung jung Ah Young Kim Jae Hee Seol jung min Park Jo won jung Jae Young Choi Division of Pediatric Cardiology Congenital Heart Disease CenterSeverance Cardiovascular HospitalDepartment of PediatricsYonsei University College of MedicineSeoulKorea

Purpose:This study examined the efficacy and safety of selexipag in treating pulmonary arterial hypertension(PAH)associated with congenital heart disease(CHD).Materials and Methods:We conducted a retrospective study of patients with CHD-associated PAH,treated with selexipag since December *** adult patients(mean age,45.4 years;women,77%)were treated with selexipag as add-on *** characteristics,World Health Organization functional class,6-minute walking distance(6MWD)test results,N-terminal pro-B-type natriuretic peptide levels,echocardiographic data,and incidence of side effects were ***:The majority of patients(12/13,92.3%)experienced more than one treatment-associated complication;one patient dropped out of the study due to intolerable *** results of 6MWD test(from 299.2±56.2 m to 363.8±86.5 m,p=0.039)and tricuspid regurgitation(TR)pressure gradient(from 84.7±20.5 mmHg to 61.6±24.0 mmHg,p=0.018)improved and remained improved after selexipag treatment in 12 *** on the results of a non-invasive risk assessment,8(66.7%)patients showed improvement,3(25.0%)showed no interval change,and the status of one patient(8.3%)***,compared to patients treated with a low dosage,patients treated with a medium-to-high dosage showed a greater increase in 6MWD results(88.3±26.4 m vs.55.3±27.6 m,p=0.043)and a greater reduction in the TR pressure gradient(-33.7±10.9 mmHg vs.-12.5±12.0 mmHg,p=0.015).Conclusion:Selexipag is an efficient pulmonary vasodilator as add-on therapy in treating CHD-associated PAH.

关键词： Selexipag congenital heart disease pulmonary arterial hypertension

Effects of Salvia miltiorrhiza Bunge extract and its single components on monosodium urate-induced pain in vivo and lipopolysaccharide-induced inflammation in vitro

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Journal of Traditional Chinese Medicine 2021年第2期41卷 219-226页

作者： FENG Jinghui Set Byeol Kim Hee jung Lee Su min Sim Soon Sung Lim Hong won Suh Department of Pharmacology College of MedicineHallym UniversityChuncheon 200-702South Korea Department of Food Sciences and Nutrition College of NaturalHealthand Life SciencesHallym UniversityChuncheon 200-702Republic of

OBJECTIVE:To investigate the possible antinociceptive effects of Salvia(S.)miltiorrhiza Bunge and its single components in monosodium urate(MSU)-induced pain model in mice and lipopolysaccharide(LPS)-induced inflammation model in RAW264.7 ***:Pretreatment of *** Bunge extract(from 1 to 50μg/mL)concentration-dependently attenuated LPS-induced nitric oxide(NO)*** extract of *** Bunge(50 or 100 mg/kg)also caused reversals of decreased threshold for pain in the MSU-treated group as measured by Von-Frey ***,we assessed the antinociceptive and anti-inflammatory properties of the active single components from *** Bunge such as 15,16-dihydrotanshinoneⅠ,tanshinoneⅠ,cryptotanshinone,miltirone,tanshinoneⅡA,and salvianolic acid *** of them showed an anti-inflammatory effect in LPS-induced NO release model and an antinociceptive effect in MSU-treated pain ***:Our results suggest that *** Bunge extract may exert anti-inflammatory effect by reducing LPS-induced NO release and an antinociceptive property in MSU-treated pain ***,tanshinoneⅡA,miltirone,cryptotanshinone,and 15,16-dihydrotanshinoneⅠ,not only appear to be responsible for LPS-induced NO release induced by *** Bunge,but also in the production of *** Bunge extract-induced antinociception in MSU-treated pain ***:Therefore,the analgesic and anti-inflammatory property of *** Bunge indicate it as a therapeutic potential candidate for the treatment of pain and inflammation.

关键词： Salvia miltiorrhiza lipopolysaccharides nitric oxide inflammation analgesics

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Facile synthesis of fully ordered L10-FePt nanoparticles with controlled Pt-shell thicknesses for electrocatalysis

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Nano Research 2017年第8期10卷 2866-2880页

作者： Yonghoon Hong Hee Jin Kim Daehee Yang Gaehang Lee Ki min Nam Myung-Hwa jung Young-min Kim Sang-II Choi won Seok Seo Department of Chemistry Sogang University Seou104107 Republic of Korea Department of Chemistry and Green-Nano Materials Research Center Kyungpook National University Daegu 41566 Repubfic of Korea Korea Basic Science Institute and University of Science and Technology Daejeon 34133 Republic of Korea Department of Chemistry Mokpo National University Jeonnam 58554 Republic of Korea Department of Physics Sogang University Seoul 04107 Republic of Korea Center for Integrated Nanostructure Physics Institute for Basic Science (IBS) Suwon 16419 Repubfic of Korea Department of Energy Science Sungkyunkwan University (SKKU) Suwon 16419 Republic of Korea

We report a simple one-step approach for the synthesis of -4 nm uniform and fully L10-ordered face-centered tetragonal （fct） FePt nanoparticles （NPs） embedded in -60 nm MCM-41 （fct-FePt NPs@MCM-41）. We controlled the Pt-shell thickness of the fct-FePt NPs by treating the fct-FePt NPs@MCM-41 with acetic acid （HOAc） or hydrochloric acid （HC1） under sonicafion, thereby etching the surface Fe atoms of the NPs. The fct-FePt NPs deposited onto the carbon support （fct-FePt NP/C） were prepared by mixing the fct-FePt NPs@MCM-41 with carbon and subsequently removing the MCM-41 using NaOH. We also developed a facile method to synthesize acid-treated fct-FePt NP/C by using a HF solution for simultaneous surface-Fe etching and MCM-41 removal. We studied the effects of both surface-Fe etching and Pt-shell thickness on the electrocatalytic properties of fct-FePt NPs for the methanol oxidation reaction （MOR）. Compared with the non-treated fct-FePt NP/C catalyst, the HOAc-treated and HCl-treated catalysts exhibit up to 34% larger electrochemically active surface areas （ECASAs）; in addition, the HCl-treated fct-FePt NP （with -1.0 nm Pt shell）/C catalyst exhibits the highest specific activity. The HF-treated fct-FePt NP/C exhibits an ECASA almost 2 times larger than those of the other acid-treated fct-FePt NP/C catalysts and shows the highest mass activity （1,435 mA·mgPt^-1, 2.3 times higher than that of the commercial Pt/C catalyst） and stability among the catalysts tested. Our findings demonstrate that the surface-Fe etching for the generation of the Pt shell on fct-FePt NPs and the Pt-shell thickness can be factors for optimizing the electrocatalysis of the MOR.

关键词： FePt face centered tetragonal bimetallic methanol oxidation reaction electrocatalysts

Densification simulation of compacted Al powders using multi-particle finite element method

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中国有色金属学会会刊：英文版 2009年第B09期19卷 68-75页

作者： Kyung-Hun LEE jung-min LEE Byung-min KIM School of Mechanical Engineering Pu san National University

The powder compaction simulations were performed to demonstrate deformation behavior of particles and estimate the effect of different punch speeds and particle diameters on the relative density of powder by a multi-particle finite element model(MPFEM). Individual particle discretized with a finite element mesh allows for a full description of the contact mechanics. In order to verify the reliability of compaction simulation by MPFEM, the compaction tests of porous aluminum with average particle size of 20 μm and 3 μm were performed at different ram speeds of 5, 15, 30 and 60 mm/min by MTS servo-hydraulic tester. The results show that the slow ram speed is of great advantage for powder densification in low compaction force due to sufficient particle rearrangement and compaction force increases with decrease in average particle size of aluminum.

关键词：粉末压实粉末粒子多孔铝有限元法模拟致密化平均粒径有限元模型

Gram-negative bacteria and their lipopolysaccharides in Alzheimer’s disease:pathologic roles and therapeutic implications

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Translational Neurodegeneration 2021年第4期10卷 643-665页

作者： Hyeon soo Kim Sujin Kim Soo jung Shin Yong Ho Park Yunkwon Nam Chae won Kim Kang won Lee Sung-min Kim In Duk jung Hyun Duk Yang Yeong-min Park minho Moon Department of Biochemistry College of MedicineKonyang UniversityDaejeon 35365Republic of Korea Research Institute for Dementia Science Konyang UniversityDaejeon 35365Republic of Korea Dandi Bioscience Inc 6th Floor of Real Company Building66Achasan-roSungdong-guSeoulRepublic of Korea Harvard Neurology Clinic 294 Gwanggyojungang-roSuji-guYongin 16943Republic of Korea Department of Immunology School of MedicineKonkuk University268ChungwondaeroChungju-siChungcheongbuk-doRepublic of Korea

Alzheimer's disease(AD)is the most serious age-related neurodegenerative disease and causes destructive and irreversible cognitive *** in the development of therapeutics targeting amyloid-β(Aβ)and tau;principal proteins inducing pathology in AD,suggest a paradigm shift towards the development of new therapeutic *** gram-negative bacteria and lipopolysaccharides(LPS)are attractive new targets for AD ***,an altered distribution of gram-negative bacteria and their LPS has been reported in AD ***,gram-negative bacteria and their LPS have been shown to affect a variety of AD-related pathologies,such as Aβ homeostasis,tau pathology,neuroinflammation,and ***,therapeutic approaches targeting gram-negative bacteria or gram-negative bacterial molecules have significantly alleviated AD-related pathology and cognitive *** multiple evidence showing that the gram-negative bacteria and their LPS play a crucial role in AD pathogenesis,the pathogenic mechanisms of gram-negative bacteria and their LPS have not been ***,we summarize the roles and pathomechanisms of gram-negative bacteria and LPS in ***,we discuss the possibility of using gram-negative bacteria and gram-negative bacterial molecules as novel therapeutic targets and new pathological characteristics for AD.

关键词： Alzheimer's disease Gram-negative bacteria Lipopolysaccharide Exotoxin Amyloid beta Tau