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Neutrophil-to-lymphocyte ratio and carbohydrate antigen 19-9 as prognostic markers for advanced pancreatic cancer patients receiving first-line chemotherapy

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World Journal of Gastrointestinal Oncology 2021年第8期13卷 915-928页

作者： Kabsoo shin Eun-Kyo jung Se Jun Park Sangwoon Jeong In-Ho Kim Myung-ah Lee Division of Medical Oncology Department of Internal MedicineSeoul St.Mary's HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea Catholic Cancer Research Institute College of MedicineThe Catholic University of KoreaSeoul 06591South Korea

BACKGROUND A decline in serum carbohydrate antigen 19-9(CA19-9)levels during systemic chemotherapy is considered as a prognostic marker for patients with advanced pancreatic ***-to-lymphocyte ratio(NLR)has been extensively studied as a simple and useful indicator of prognosis in various cancers including pancreatic *** To assess the prognostic significance of NLR and CA19-9 in patients with advanced pancreatic adenocarcinoma received first-line chemotherapy according to CA19-9 *** We retrospectively analyzed patients diagnosed with advanced pancreatic cancer who received first-line chemotherapy between January 2010 and July 2017 at the Catholic University of Seoul ***’s *** were divided according to CA19-9 positivity(CA19-9-positive vs-negative groups)and pre-and posttreatment NLR *** determine cut-off value of NLR and CA19-9 reduction,time-dependent receiver operating characteristic curve was *** evaluated overall survival(OS)and progression-free survival(PFS)for each group using Kaplan-Meier method,and we performed multivariate analyses on the entire *** We included 271 patients in this ***-off value of NLR and CA19-9 reduction was determined as 2.62 and 18%.Multivariate analysis showed that post-treatment NLR<2.62 and reduction of≥18%of baseline CA19-9 were significantly associated with OS and ***-treatment NLR≥2.62 showed hazard ratio(HR)of 2.47[95%confidence interval(CI):1.84-3.32,P<0.001]and CA19-9 decline(≥18%)showed HR of 0.51(95%CI:0.39-0.67,P<0.001)for *** CA19-9-positive patients were divided into groups according to CA19-9 response(responder vs non-responder)and post-treatment NLR(<2.62 vs≥2.62),CA19-9 responder and post-treatment NLR<2.62 group showed better survival than CA19-9 non-responder and post-treatment NLR≥2.62 group(OS 11.0 mo vs 3.9 mo,P<0.001;PFS 6.3 mo vs 2.0 mo,P<0.001).The combination of CA19-9 decline and post-treatment NLR showed a significant c

关键词： Pancreatic adenocarcinoma Serum carbohydrate antigen 19-9 Neutrophil-tolymphocyte ratio Multivariate analysis Prognosis Chemotherapy

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Solitary Peutz-Jeghers-type appendiceal hamartomatous polyp growing into the terminal ileum

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World Journal of Gastroenterology 2014年第16期20卷 4822-4826页

作者： Chang In Choi Dae hwan Kim Tae Yong Jeon Dong Heon Kim Na Ri shin Do Youn Park Department of Surgery Medical Research InstitutePusan National University HospitalSeo-GuBusan 602-739South Korea Department of Pathology Medical Research InstitutePusan National University HospitalSeo-GuBusan 602-739South Korea

Solitary Peutz-Jeghers type hamartomatous polyp is *** is considered to be related to a variant PeutzJeghers syndrome(PJS)and may be a separate disease entity.A 50-year-old man was referred to our hospital with a diagnosis of intussusception in the terminal ileum and underwent segmental ileal resection with *** identified a 3.5-cm diameter polyp arising from the appendix with ingrowth into the terminal *** polyp was confirmed to be a hamartomatous polyp of Peutz-Jeghers-type,***,the patient had no characteristic manifestations of PJS such as mucocutaneous pigmentation and family *** are few reports of appendiceal hamartomatous polyp in PJS patients and solitary appendiceal hamartomatous polyp is even ***,rather than telescoping,ours is the first reported intussuscepted lesion,to the best of our knowledge.

关键词： Peutz-Jeghers syndrome Hamartomatous intestinal polyposis Neoplasms Intussusception Intestinal obstruction

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Therapeutic effect of DA-9601 on chronic reflux gastritis induced by sodium taurocholate in rats

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World Journal of Gastroenterology 2005年第47期11卷 7430-7435页

作者： Tae Young Oh Chang Yell shin Yong Sung Sohn Dong hwan Kim Byoung Ok Ahn Eun Bang Lee Cho Hyun Park Dong-A Pharmaceutical Research Institute YonginKorea Department of General Surgery Catholic University of MedicineSeoulKorea

AIM: To investigate the therapeutic effects of DA-9601 on sodium taurocholate (TCA)-induced chronic reflux gastritis in SD ***: In this study, we have investigated the therapeutic effects of DA-9601 on chronic erosive and atrophic gastritis induced by 6 mo of TCA administration (5 mmol/L in drinking water) in SD rats. RESULTS: Four weeks of DA-9601 administration (0.065%, 0.216% in rat chow), following the withdrawal of TCA treatment, resulted in a significant decrease in total length of erosions in rats in a dose-dependent manner. Furthermore, the indicators of atrophic gastritis, such as reduced mucosal thickness and reduction in the number of parietal cells, were improved by the administration of DA-9601 in a dose-related manner. DA-9601 also attenuated inflammatory cell infiltration and the proliferation of collagenous fiber in the gastric mucosa. The improvement in the reduction of the gastric mucus was observed in the rats receiving a high dose of DA-9601 (0.216%). The therapeutic effect of DA-9601 on experimental chronic erosive gastritis was superior to that of rebamipide (1.08% in rat chow). Biochemical analyses showed increased mucosal prostaglandin E2 and reduced glutathione levels by DA-9601 treatment. CONCLUSION: We suggest that DA-9601 is apromising agent for the treatment of chronic erosive and atrophic gastritis with an etiological factor of bile reflux. Increasedmucosal prostaglandin E2 and reduced glutathione by DA-9601 treatment may be therapeutic mechanisms for chronic erosive and atrophic gastritis.

关键词： DA-9601 Reflux gastritis Erosive gastritis Atrophic gastritis Sodium taurocholate

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Occipital artery bypass importance in unsuitable superficial temporal artery:Two case reports

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World Journal of Clinical Cases 2023年第9期11卷 2091-2097页

作者： Jong-hwan Hong Sung-Chan jung Han-Seung Ryu Tae-Sun Kim Sung-Pil Joo Department of Neurosurgery Chonnam National University Hospital and Medical SchoolGwangju 61469South Korea

BACKGROUND Superficial temporal artery-middle cerebral artery(STA-MCA)bypass helps treat cerebral ***,the STA is not available for bypass in some ***,with some technical tips,the authors introduced a bypass technique using the occipital artery(OA).CASE SUMMARY Two female patients complained of *** magnetic resonance imaging(MRI)indicated contralateral infarction from the MCA *** Diamox single photon emission computed tomography or perfusion MRI,the contralateral front parietotemporal reserve was *** transfemoral cerebral angiography,the STA was thin with a weak flow;however,the OA was *** OA-MCA end-to-side extracranial-intracranial bypass surgery was implemented instead of STA because the caliber was too *** postoperative course was uneventful in both cases,with well-maintained bypass patency and neurological stability during *** OA might be an acceptable alternative for MCA cerebral ischemic cases with an unsuitable STA.

关键词： Bypass Occipital artery Superficial temporal artery Cerebral ischemia Case report

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Transanal excision of a malignant fibrous histiocytoma of anal canal:A case report and literature review

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World Journal of Gastroenterology 2008年第9期14卷 1459-1462页

作者： Beom Gyu Kim In Taik Chang Jun Seok Park Yoo shin Choi Gi Hyeon Kim Eon Sub Park Chang hwan Choi Department of Surgery College of MedicineChung-Ang University Seoul 156-755Korea Department of Radiology College of MedicineChung-Ang University Seoul 156-755Korea Department of Pathology College of MedicineChung-Ang University Seoul 156-755 Korea Department of Internal Medicine College of Medicine Chung-Ang UniversitySeoul 156-755Korea

Malignant fibrous histiocytoma, which is composed of spindle-shaped cells arranged in a pleomorphic and storiform pattern, is rarely found in the colorectum. Although complete surgical excision remains the main stem of therapy, an optimal treatment strategy according to the stage has not been elucidated. We report a case of a 63-year-old woman with an ulcerative lesion in the anorectal junction and a final diagnosis of malignant fibrous histiocytoma. We introduced an access for transanal local excision and adjuvant radiotherapy because the patient refused abdominoperineal resection. No local recurrences or distant metastases were observed 15 mo after the operation. To our knowledge, this is the first case reported in the English literature of a malignant fibrous histiocytoma treated with the transana local excision and adjuvant radiotherapy. This report showed that this approach is selectively reserved for early-stage malignant fibrous histiocytoma and for those patients who refuse radical surgery because of the risk in a permanent colostomy.

关键词： Malignant fibrous histiocytoma Anorectal junction Transanal local excision

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Eosinophilic gastroenteritis presenting as small bowel obstruction: A case report and review of the literature

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World Journal of Gastroenterology 2007年第11期13卷 1758-1760页

作者： Min Young Yun Young Up Cho In Suh Park Sun Keun Choi Sei Joong Kim Seok hwan shin Kyung Rae Kim Department of Surgery College of Medicine Inha University Incheon Korea Department of Pathology College of Medicine Inha University Incheon Korea

Eosinophilic gastroenteritis is a rare disease of unknown etiology. It is characterized by eosinophilic infiltration of the bowel wall to a variable depth and symptoms associated with gastrointestinal tract. Recently, the authors experienced a case of eosinophilic gastroenteritis presenting as small bowel obstruction. A 51-year old woman was admitted to our hospital complaining of abdominal pain and vomiting. Physical examination revealed a distended abdomen with diffuse tenderness. Complete blood count showed mild leukocytosis without eosinophilia. Computed tomography confirmed a dilatation of the small intestine with ascites. An emergency laparotomy was performed for a diagnosis of peritonitis due to intestinal obstruction. Segmental resection of the ileum and end to end anastomosis were performed. Histologically, there was a dense infiltration of eosinophils throughout the entire thickness of ileal wall and eosinophilic enteritis was diagnosed. The patient recovered well, and was free from gastrointestinal symptoms at the time when we reported her disease.

关键词： Eosinophilic gastroenteritis Small bowel obstruction Eosinophilic infiltration

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Clinical significance of hepatitis B e antigen level measurement during long-term lamivudine therapy in chronic hepatitis B patients with e antigen positive

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World Journal of Gastroenterology 2006年第41期12卷 6693-6698页

作者： jung Woo shin Neung Hwa Park Seok Won jung Byung Chul Kim Sung Ho Kwon Jae Serk Park In Du Jeong Sung-Jo Bang Do Ha Kim Division of Gastroenterology Department of Internal MedicineUniversity of Ulsan College of Medicine Ulsan University HospitalUlsanKorea

AIM： To determine the changes of quantitative hepatitis B e antigen （HBeAg） that predicts early detection of non-response or breakthrough to long-term lamivudine （LAM） therapy. METHODS： Among HBeAg positive chronic hepatitis B patients who failed to achieve HBeAg seroconversion within 12 too, we retrospectively analyzed 220 patients who had received LAM more than 24 too. RESULTS： The mean duration of LAM therapy was 36 （range, 24-72） mo. HBeAg seroconversion after the first 12 mo of LAM therapy was achieved in 53 （24.1%） patients. Viral breakthrough was observed in 105 （47.7%） patients. To find out whether the changing patterns of HBeAg levels can predict the outcome of LAM therapy, we analyzed the reduction rates of HBeAg levels during LAM therapy. Using the decrease more than 90% of pretreatment HBeAg levels, the sensitivity and specificity of response were 96.2% and 70.1%, respectively. Patients were divided into 3 groups according to the reduction patterns of the decrease of quantitative HBeAg： decrescendo, decrescendo-crescendo, no change or fluctuating groups. The optimal time to predict non-response or breakthrough was the first 9 mo of therapy. At 9 mo of therapy, 49 （92.5%） of 53 patients who had achieved HBeAg seroconversion were included in the decrescendo group. On the contrary, in the no change or fluctuating group, only four （7.5%） had achieved HBeAg seroconversion. Among patients who did not show the continuous decrease of HBeAg levels at 9 too, 95.2% （negative predictive value） failed to achieve HBeAg seroconversion. CONCLUSION： Almost all patients who failed to show a continuous decrease of HBeAg levels at 9 mo of LAM therapy were non-response or breakthrough. Therefore, monitoring changes of HBeAg levels during LAM therapy in HBeAg positive chronic hepatitis B may be valuable for identifying patients who are at high risk of non-response or breakthrough.

关键词： Hepatitis B e antigen positive chronic hepatitis B lamivudine Quantitative HBeAg levels Non- response Breakthrough

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Change in renal function after sodium phosphate preparation for screening colonoscopy

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World Journal of Gastroenterology 2010年第16期16卷 2010-2016页

作者： Dong Choon Seol Sung Noh Hong Jeong hwan Kim In Kyung Sung Hyung Seok Park jung Hyun Lee Chan Sup Shim Department of Internal Medicine Konkuk University School of Medicine Department of Health Promotion Healthcare CenterKonkuk University Medical Center Healthcare Center Konkuk University Medical CenterDepartment of Internal MedicineKonkuk University School of MedicineMedical Immunology CenterInstitute of Biomedical Science and Technology Department of Internal Medicine Konkuk University School of MedicineMedical Immunology CenterInstitute of Biomedical Science and Technology

AIM:To investigate the changes in renal function at 12-24 mo in patients following sodium phosphate(NaP) preparation for screening ***:We carried out a retrospective study on the results from patients who received health check-up services as part of an employer-provided wellness program performed between August 2006 and May 2008 and who were followed up for 12-24 *** to screening colonoscopy,224 patients underwent bowel cleansing with NaP(NaP group) and 113 patients with polyethylene glycol(PEG group).The control group comprised 672 age-matched *** compared the changes in the creatinine levels and the glomerular filtration rates(GFRs) from baseline to 12-24 mo between the NaP,PEG,and control groups using two-way repeated measured analysis of *** addition,multivariate linear regression analysis was performed to assess the risk factors for a decreased ***:The baseline mean serum creatinine level in the NaP,PEG,and control groups was 1.12 ± 0.15,1.12 ± 0.16,and 1.12 ± 0.15 mg/dL,which increased to 1.15 ± 0.15,1.15 ± 0.18,and 1.15 ± 0.15 mg/dL,respectively,after 12-24 *** baseline mean GFR in the NaP,PEG,and control groups was 69.0 ± 7.7,68.9 ± 8.0,and 69.6 ± 6.7 mL/min per 1.73 m2,which decreased to 66.5 ± 7.8,66.5 ± 8.3,and 67.4 ± 6.4 mL/min per 1.73 m2,respectively,after 12-24 *** changes in serum creatinine levels and GFRs were not significantly between the NaP,PEG,and control groups(P = 0.992 and P = 0.233,respectively).Using multivariate linear regression analysis,only the baseline GFR was associated with the change in GFR(P < 0.001).Indeed,the bowel preparations were not associated with the change in GFR(P = 0.297).CONCLUSION:NaP bowel preparation in subjects with normal renal function was not associated with renal injury,and NaP can thus be used safely for screening colonoscopy.

关键词： Sodium phosphate Polyethylene glycol Purgatives Colonoscopy Creatinine Glomerular filtration rate

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Synthesis of Co/SiO2 hybrid nanocatalyst via twisted Co3Si2O5（OH）4 nanosheets for high-temperature Fischer- Tropsch reaction

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Nano Research 2017年第3期10卷 1044-1055页

作者： Ji Chan Park shin Wook Kang Jeong-Chul Kim Jae In Kwon Sanha Jang Geun Bae Rhim Mijong Kim Dong Hyun Chun Ho-Tae Lee Heon jung Hyunjoon Song jung-li Yang Clean Fuel Laboratory Korea Institute of Energy Research Daejeon 34129 Republic of Korea Advanced Energy Technology University of Science and Technology Daejeon 34713 Republic of Korea Center for Nanomaterials & Chemical Reactions Institute for Basic Science Daejeon 34141 Republic of Korea Department of Chemistry Korea Advanced Institute of Science and Technology Daejeon 34141 Republic of Korea

A cobalt-silica hybrid nanocatalyst bearing small cobalt particles of diameter -5 nm was prepared through a hydrothermal reaction and hydrogen reduction. The resulting material showed very high CO conversion （〉82%） and high hydrocarbon productivity （-1.0gHC·gcat^-1·h^-1 ） with high activity （-8.5 × 10^-5 ***^-1.s-1） in the Fischer-Tropsch synthesis reaction.

关键词： hybrid nanostructure Fischer-Tropsch synthesis thermal stability metal silicate hydroxide cobalt catalyst

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Adult intussusception caused by cystic lymphangioma of the colon:A rare case report

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World Journal of Gastroenterology 2006年第13期12卷 2130-2132页

作者： Tae Oh Kim jung Hyun Lee Gwang Ha Kim Jeong Heo Dae hwan Kang Geun Am Song Mong Cho Division of Gastroenterology Department of Internal Medicine College of MedicinePusan National University College of MedicineBusanKorea

We experienced a case of intussusception caused by cystic lymphangioma of the colon in a 32 years old female who was admitted to our hospital for the chief complaint of bloody stool. In the colonoscopic examination, cystic mass with stalk which had smooth mucosal surface was noted at the descending colon. Abdominal ultrasonography and computed tomography revealed left colon intussusception with a multilocular cystic tumor as a leading point. Emergent operation was performed. On the histopathologic examination, the cystically dilated spaces lined by endothelium and septated by fibrous septa were present. The pathological diagnosis was cystic lymphangioma of the colon. Although intussusception due to lymphangioma in an adult are rare, it should be taken into consideration that it is possible diagnosis.

关键词： Cystic lymphangioma of the colon Adult intussusception

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