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Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan choi Soo-Ho choi Keun-young Kim Yury I.Miller Won-Kyu Ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

机器人甲状腺切除术在韩国将成为一种新的规范术式？

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中国微创外科杂志 2012年第7期12卷 590-593页

作者： M.Rahman Selamat june young choi Do Hoon Koo Kyu Eun Lee Yeo-Kyu Youn 潘笑露嵇武 Department of Surgery Seoul National University College of Medicine Cancer Research Institute Seoul National University College of Medicine Department of Surgery Seoul National University Boramae Medical Center 南京军区南京总医院解放军普通外科研究所南京210002

近年来,日新月异的医学技术新发明为外科技术带来了巨大发展。当今,甲状腺手术技术的趋势在韩国也正逐渐发生着改变。因为机器人手术较腔镜手术具有更好的术后美容效果及在人体工程学上的巨大优势,机器人在甲状腺手术中的应用日益增加... 详细信息

近年来,日新月异的医学技术新发明为外科技术带来了巨大发展。当今,甲状腺手术技术的趋势在韩国也正逐渐发生着改变。因为机器人手术较腔镜手术具有更好的术后美容效果及在人体工程学上的巨大优势,机器人在甲状腺手术中的应用日益增加。此外,机器人甲状腺手术可能成为治疗甲状腺疾病的新规范术式,尤其是在青少年患者的甲状腺恶性肿瘤中。常规机器人及机器人辅助甲状腺手术有多种方法。本文对经双侧腋窝和乳晕入路法(bilateral axillo-breast approach,BABA)在首尔国立大学医学院的运用进行介绍,并讨论其优势。

关键词：机器人甲状腺切除术 BABA法机器人甲状腺手术肿瘤整形甲状腺术甲状腺微创手术韩国

High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki Kim Bum Jun Kim Seungyon Koh Hyo Jin Cho Xuelian Jin Byung Gon Kim Jun young choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

Materials property mapping from atomic scale imaging via machine learning based sub-pixel processing

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npj Computational Materials 2022年第1期8卷 1868-1876页

作者： Junghun Han Kyoung-june Go Jinhyuk Jang Sejung Yang Si-young choi Department of Biomedical Engineering Yonsei UniversityWonju26493Republic of Korea Department of Materials Science and Engineering Pohang University of Science and TechnologyPohang37673Republic of Korea

Direct visualization of the atomic structure in scanning transmission electron microscopy has led to a comprehensive understanding of the structure-property ***,a reliable characterization of the structural transition on a picometric scale is still challenging because of the limited spatial resolution and ***,we demonstrate that the primary segmentation of atomic signals from background,succeeded by a denoising process,enables structural analysis in a sub-pixel *** noise is eliminated using the block matching and three-dimensional filtering with Anscombe transformation,and remnant noise is removed via morphological filtering,which results in an increase of peak signal-to-noise ratio from 7 to 11 *** the centroids of atomic columns segmented via K-means clustering,an unsupervised method for robust thresholding,achieves an average error of less than 0.7 pixel,which corresponds to 4.6 *** study will contribute to a profound understanding of the local structural dynamics in crystal structures.

关键词： property filtering removed

Optical coherence tomography imaging of cranial meninges post brain injury in vivo

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Chinese Optics Letters 2017年第9期15卷 16-19页

作者： Woo june choi Ruikang K.Wang Department of Bioengineering University of WashingtonSeattleWA 98195USA

We report a new application of optical coherence tomography（OCT） to investigate the cranial meninges in an animal model of brain injury in vivo. The injury is induced in a mouse due to skull thinning, in which the repeated and excessive drilling exerts mechanical stress on the mouse brain through the skull, resulting in acute and mild brain injury. Transcranial OCT imaging reveals an interesting virtual space between the cranial meningeal layers post skull thinning, which is gradually closed within hours. The finding suggests a promise of OCT as an effective tool to monitor the mechanical trauma in the small animal model of brain injury.

关键词： Optical coherence tomography imaging of cranial meninges post brain injury in vivo

Probing temperature-dependent interlayer coupling in a MoS2/h-BN heterostructure

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Nano Research 2020年第2期13卷 576-582页

作者： Hamin Park Gwang Hyuk Shin Khang june Lee Sung-Yool choi School of Electrical Engineering Centerfor Advanced Materials Discovery towards 3D Display KAISTDaejeon 34141Republic of Korea

Stacking of atomically thin layers of two-dimensional materials has revealed extraordinary physical phenomena owing to van der Waals(vdW)interaction at the ***,most of the studies focused on the transition metal dichalcogenide(TMD)/TMD heterostructure,while the interlayer coupling of the TMD/hexagonal boron nitride(h-BN)heterostructure has not been extensively explored despite its *** this study,the temperature-dependent interlayer coupling is demonstrated in a heterostructure of molybdenum disulfide(MoS2)and *** interface between MoS2 and the insulating substrate exerts a significant spectroscopic impact on MoS2 through substrate-induced local strain,charged impurity,and vdW *** non-resonant conditions,temperature-dependent peak shifts in Raman and photoluminescence(PL)spectra of MoS2 reveal the evolution of interlayer *** frequencies and PL peak energies at different temperatures demonstrate how substrate-induced strain,impurity,and vdW interactions at the interface influence phonon vibration and excitonic transition of *** resonant conditions at low temperature,anomalous Raman modes appear in the MoS2/h-BN heterostructure because of the enhanced electron-phonon coupling and vdW *** anomalous Raman modes are quantitatively investigated by the deconvolution of the resonance Raman spectra and described by interlayer coupling at low temperature,in agreement with complementary indications from the temperature-dependent evolution of non-resonant Raman and PL spectra.

关键词： van der Waals heterostructures interlayer coupling Raman spectroscopy excitonic resonance photoluminescence

Landscapes of SARS-CoV-2-reactive CD8^(+)T cells:heterogeneity of host immune responses against SARS-CoV-2

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Signal Transduction and Targeted Therapy 2021年第5期6卷 1399-1401页

作者： june-young Koh Eui-Cheol Shin Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)DaejeonRepublic of Korea The Center for Epidemic Preparedness KAISTDaejeonRepublic of Korea

In a recent study published in Science Immunology,^Kusnadi et *** single-cell RNA sequencing(scRNA-seq)of SARS-CoV-2-reactive CD8^(+)T cells and reported ***-CoV-2 infection causes COVID-19,which is an ongoing pandemic disease threatening public *** virology of SARS-CoV-2 and immune responses against the virus have been urgently investigated to develop effective measures against *** viral infection,CD84 T cells contribute to elimination of the virus by exerting cytotoxicity against virus-infected cells and producing effector cytokines,whereas neutralizing antibodies interfere with viral entry of host cells.

关键词： al. infection Immunology

Assessment of the clear-sky bias issue using continuous PM10 data from two AERONET sites in Korea

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Journal of Environmental Sciences 2017年第3期29卷 151-160页

作者： Yongjoo choi young Sung Ghim Department of Environmental Science Hankuk University of Foreign StudiesYongin 449-791Korea

A bias in clear-sky conditions that will be involved in estimating particulate matter （PM） concentration from aerosol optical depth （AOD） was examined using PM10 from two Aerosol Robotic Network sites in Korea. The study periods were between 2004 and 2007 at Anmyon and between 2003 and 2011 at Gosan, when both PM10 and AOD were available. Mean PM10 when AOD was available （PMAOD） was higher than that from all PM10 data （PMall） by 5.1 and 9.9 μg/m3 at Anmyon and Gosan, which accounted for 11% and 26% of PMall, respectively. Because of a difference between mean PM10 under daytime clear-sky conditions （PMclear） and PMAoD, the variations in APM10, the difference of PMan from PMdear rather than from PMAoD, were investigated. Although monthly variations in APMlo at the two sites were different, they were positively correlated to those in AT, similarly defined as APM10 except for temperature, at both sites. APM10 at Anmyon decreased to a negative value in January due to an influence of the Siberian continental high-pressure system while APM10 at Gosan was high in winter due to an effect of photochemical production at higher temperatures than at Anmyon.

关键词： AERONETData recovery rateCloud amountWind speedPhotochemical productionSiberian high

Ex situ aging effect on sulfonated poly(ether ether ketone) membrane:Hydration-dehydration cycling and hydrothermal treatment

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Journal of Energy Chemistry 2022年第7期31卷 583-592,I0014页

作者： Seung-young choi Kyeong Sik Jin Polymer&Materials Chemistry Department of ChemistryLund UniversitySE-22100Sweden Center for Hydrogen·Fuel Cell Research Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Pohang Accelerator Laboratory Pohang University of Science and Technology(POSTECH)PohangKyungbuk 37673Republic of Korea

Prolonged hydrothermal treatment for sulfonated poly(ether ether ketone) membranes induces mechanical degradation and developing hydrophilic-hydrophobic phase separation, simultaneously. The enhanced phase separation provides incremental proton conductivity to the membranes, whereas mechanical degradation drastically reduces device stability. On this basis, we describe here the effects of two different ex situ aging processes on sulfonated poly(ether ether ketone) membranes: hydrationdehydration cycling and prolonged hydrothermal treatment. Both aged membranes exhibited enhanced phase separation under the hydrated conditions, as characterized by small angle X-ray ***, when the aged membranes were dried again, the nanostructure of the membranes aged via the hydration-dehydration cycling was recoverable, whereas that of the membranes aged via prolonged hydrothermal treatment was irreversible. Furthermore, the two differently aged membranes showed clear differences in thermal, mechanical, and electrochemical properties. Finally, we implemented both aged membranes in fuel cell application. The sample aged via hydration-dehydration cycling maintained its improved cell performance, whereas the sample aged via hydrothermal treatment showed drastically reduced cell performance after durability test for 50 h.

关键词： Sulfonated poly(ether ether ketone) Humidity cycle test Ex situ aging Proton exchange membrane Fuel cell