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Plasmid DNA-loaded asymmetrically porous membrane for guided bone regeneration

2000年

作者： Olsen june Looby

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Journal of Materials Science & Technology 2021年第4期63卷 161-171页

作者： Se Heang Oh june-Ho Byun So Young Chun Young-Joo Jang Jin Ho Lee Department of Nanobiomedical Science Dankook UniversityCheonan 31116Republic of Korea Department of Oral and Maxillofacial Surgery Gyeongsang National University School of MedicineGyeongsang National University HospitalInstitute of Health SciencesGyeongsang National UniversityJinju 52727Republic of Korea BioMedical Research institute Kyungpook National University HospitalDaegu 41404Republic of Korea Department of Advanced Materials Hannam UniversityDaejeon 34054Republic of Korea

Although bone defects can be restored spontaneously,bone reconstruction with sufficient strength and volume continues to be a challenge in clinical *** recent years,the use of a variety of biomaterials with bioactivity has been attempted to compensate for this ***,we fabricated a pDNA(encoding for BMP-2)-loaded asymmetrically porous polycaprolactone(PCL)/Pluronic F127 membrane as a bioactive guided bone regeneration(GBR)membrane,using a modified immersion-precipitation *** was observed that the GBR membrane allows continuous release of pDNA for more than20 *** pDNA was sufficiently transfected into human bone marrow stem cells(h BMSCs)without significant cytotoxicity and the gene-transfected cells showed prolonged synthesis of *** in vitro osteogenic differentiation and in vivo animal studies,the effective induction of osteogenic differentiation of h BMSCs and enhanced bone regeneration by the pDNA-loaded asymmetrically porous PCL/Pluronic F127 membrane was observed,suggesting that the pDNA-loaded membrane as a bioactive GBR membrane can be an alternative therapeutic technique for effective bone regeneration.

关键词： loaded porous attempted

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热潮之下企业要不要做数据中台?

数字经济 2022年第1期 93-97页

作者： june 智领云科技

2020的开端,一场疫情按下了企业数字化转型的加速键,数字化、智能化的需求更为迫切,在企业数字化浪潮下,云计算、大数据、人工智能、5G等“确定性”技术,成为企业追赶浪潮的必要手段,而“数据中台”的不确定性,却令众多企业欲迎还拒。... 详细信息

2020的开端,一场疫情按下了企业数字化转型的加速键,数字化、智能化的需求更为迫切,在企业数字化浪潮下,云计算、大数据、人工智能、5G等“确定性”技术,成为企业追赶浪潮的必要手段,而“数据中台”的不确定性,却令众多企业欲迎还拒。如何扫除“不确定”带给大家的疑惑,放心地成为先行者而抢占先机?希望本文能够带给您一些启发。

关键词：数字化转型人工智能大数据云计算数字化浪潮中台不确定性加速键

An Objective Penalty Method for Optimistic Bilevel Programming Problems

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Journal of the Operations Research Society of China 2020年第1期8卷 177-187页

作者： june Liu Tao Zhang Yu-Xin Fan Bing Han Yue Zheng School of Management Huaibei Normal UniversityHuaibei 235000AnhuiChina School of information and Mathematics Yangtze UniversityJingzhou 434023HubeiChina Huazhong University of Science and Technology Wuhan 430074China

in this paper,we consider an optimistic nonlinear bilevel programming *** some conditions,we first show that the sequence of solutions to penalty problems converges to the optimal solution of the original bilevel programming *** then present an objective penalty method to solve such a ***,some numerical experiments are performed to illustrate its feasibility.

关键词： Bilevel programming Optimistic formulation Penalty method Objective penalty method

BRi1-Associated Receptor Kinase 1 Regulates Guard Cell ABA Signaling Mediated by Open Stomata 1 in Arabidopsis

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Molecular Plant 2016年第3期9卷 447-460页

作者： Yun Shang Changbo Dai Myeong Min Lee june M. Kwak Kyoung Hee Nam Department of Biological Sciences Sookmyung Women's University Seou1140-742 Republic of Korea Department of Systems Biology Yonsei University Seou1120-749 Republic of Korea Department of New Biology Center for Plant Aging Research Institute for Basic Science Daegu Gyeongbuk Institute of Science and Technology Daegu 711-873 Republic of Korea

Stomatal movements are critical in regulating gas exchange for photosynthesis and water balance between plant tissues and the atmosphere. The plant hormone abscisic acid （ABA） plays key roles in regulating stomatal closure under various abiotic stresses. in this study, we revealed a novel role of BAKi in guard cell ABA signaling. We found that the brassinosteroid （BR） signaling mutant bakl lost more water than wild- type plants and showed ABA insensitivity in stomatal closure. ABA-induced OST1 expression and reactive oxygen species （ROS） production were also impaired in bakl. Unlike direct treatment with H202, overex-pression of OST1 did not completely rescue the insensitivity of bakl to ABA. We demonstrated that BAK1 forms a complex with OST1 near the plasma membrane and that the BAKi/OST1 complex is increased in response to ABA in planta. Brassinolide, the most active BR, exerted a negative effect on ABA-induced formation of the BAK1/OST1 complex and OST1 expression. Moreover, we found that BAK1 and ABi1 oppositely regulate OST1 phosphorylation in vitro, and that ABi1 interacts with BAK1 and inhibits the interaction of BAK1 and OST1. Taken together, our results suggest that BAK1 regulates ABA-induced stomatal closure in guard cells.

关键词： BAK1 OST1 ABA-induced stomatal closure Arabidopsis thaliana

Theoretical solution for wave diffraction by wedge or corner with arbitrary reflection characteristics

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Acta Oceanologica Sinica 1992年第2期11卷 287-303页

作者： Hong Guangwen(Received December 20 1990 acepted june 15, 1991)

An exact analytic solution for wave diffraction by wedge or corner with arbitrary angle (rπ) and reflection coefficients (R0 and Rr) is presented in this paper. it is expressed in two forms-series and integral representations, corresponding recurrence relation and asymptotic expressions are also derived. The solution is simplified for some special cases of rπ. For Rr= R0,r= 1/N and Rr≠R0,r = 1/2N, the solution can be reduced to linear superpositions of incident and partially reflected waves, hence a nonlinear solution of forth order for this problem can be obtained by using the author's theory of nonlinear interaction among gravity surface waves. The given solution is related to inhomogeneous Robin boundary conditions, which include the Neumann boundary conditions usually accepted in wave diffraction theory.

关键词： wave Theoretical solution for wave diffraction by wedge or corner with arbitrary reflection characteristics

New perspectives on computer concepts : comprehensive 8th ed.

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Non-recovery of renal function was correlated with increased mortality in the cancer cohort with septic shock

丛书名：经典原版书库

2006年

作者： Parsons june Jamrich.

本书介绍了计算机领域的相关知识, 包括: 计算机的基本概念、计算机系统基础、文档、工作表、数据库、计算机文件和数据库存储等内容。

ISBN: (数字)7111173260

ISBN: (纸本)7111173260

本书介绍了计算机领域的相关知识, 包括: 计算机的基本概念、计算机系统基础、文档、工作表、数据库、计算机文件和数据库存储等内容。

关键词： Electronic data processing.

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Cancer Communications 2021年第12期41卷 1420-1422页

作者： june-sung Kim Youn-Jung Kim Won Young Kim Department of Emergency Medicine University of Ulsan College of MedicineAsan Medical CenterSeoul 05505Korea

Dear Editor,As the overall survival rate of cancer patients has been increasing,an increasing number of patients are experiencing septic shock,and the corresponding mortality rate is becoming unacceptably high[1].Among cases of organ failure caused by septic shock,the development of acute kidney injury(AKi)is known to be common and correlated with poor outcomes[2].Moreover,a large Danish cohort study revealed that critically ill patients with cancer had a greater risk of AKi and requirement of renal replacement therapy(RRT)compared to patients without cancer[3].Adverse outcomes dramatically increase in patients with severe AKi who received RRT,and a recent survey in China reported that the hospital mortality rate for this population was up to 80%[4].

关键词： mortality cancer acute

New perspectives on computer concepts Tenth ed.

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Collapse behavior evaluation of hybrid thin-walled member by stacking condition

丛书名：经典原版书库9jing dian yuan ban shu ku

2008年

作者： Parsons june Jamrich.

本书采用最先进的方法和技术讲述了计算机基础知识，涉及面之广、内容之丰富、方法之独特，令人叹为观止，堪称计算机基础知识的百科全书。

ISBN: (纸本)9787111232506

本书采用最先进的方法和技术讲述了计算机基础知识，涉及面之广、内容之丰富、方法之独特，令人叹为观止，堪称计算机基础知识的百科全书。

关键词： Computers.

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Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 135-140页

作者： Kil-Sung LEE Hyeon-Kyeong SEO Yong-june YANG Woo-Chae HWANG Kwang-Hee iM in-Young YANG R&D Center Dacc LTD. 948-13 Dunsan-ri Bongdong-eup Wanju-gun Jeonbuk 565-902 Korea Departments of Advanced Parts and Materials Engineering Graduate School Chosun University Department of Automotive Engineering Woosuk University Departments of Mechanical Design Engineering Chosun University

The recent trend of vehicle design aims at crash safety and environmentally-friendly aspect. For the crash safety aspect, the energy absorbing members should absorb collision energy sufficiently but for the environmentally-friendly aspect, the vehicle structure must be light weight in order to improve the fuel efficiency and reduce the tail gas emission. Therefore, the light weight of vehicle must be achieved in a securing safety status of crash. An aluminum or carbon fiber reinforced plastics (CFRP) is representative one of the light-weight materials. Based on the respective collapse behavior of aluminum and CFRP member, the collapse behavior of hybrid thin-walled member was evaluated. The hybrid members were manufactured by wrapping CFRP prepreg sheets outside the aluminum hollow members in the autoclave. Because the CFRP is an anisotropic material whose mechanical properties, such as strength and elasticity, change with its stacking condition, the effects of the stacking condition on the collapse behavior evaluation of the hybrid thin-walled member were tested. The collapse mode and energy absorption capability of the hybrid thin-walled member were analyzed with the change of the fiber orientation angle and interface number.

关键词：行为评价薄壁混合堆放碳纤维复合材料能量吸收能力碰撞安全性碳纤维增强塑料