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Relationship between Acute Organophosphorus Pesticide Poisoning and Damages Induced by Free Radicals

Biomedical and Environmental Sciences 2002年第2期15卷 177-186页

作者： zhou jun-fu XU GEN-BO FANG WEI-jun SecondAffiliatedHospitalofCollegeofMedicine ZhejiangUniversity88JiefangRoadHangzhou310009ZhejiangProvinceChina

OBJECTIVE: To study the relationship between abnormal reactions of free radicals in bodies of patients with acute organophosphorus pesticide poisoning (AOPP) and damages induced by free radicals. METHODS: 58 AOPP patients and 58 healthy adult volunteers (HAV) were enrolled in an independent samples control design, in which spectrophotometric methods were used to determine the concentrations of nitric oxide (NO) and lipoperoxides (LPO) in plasma, and LPO in erythrocytes, vitamin C (VC), vitamin E (VE) and beta-carotene (beta-CAR) in plasma as well as activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and acetylcholinesterase (AChE) in erythrocytes. RESULTS: Compared with the average values of every biochemical parameter in the HAV group, the average values of LPO in plasma and in erythrocytes, and NO in plasma in the AOPP group were significantly increased (P = 0.000001), while the average values of VC, VE, beta-CAR in plasma as well as SOD, CAT, GSH-Px and AChE in erythrocytes in the AOPP group were significantly decreased (P = 0.000001). The findings of Pearson product-moment correlation analysis between the value of AChE in erythrocytes and the values of above biochemical parameters for 58 AOPP patients showed that there was a significant linear negative correlation between AChE in erythrocytes and LPO, NO in plasma, and LPO in erythrocytes (P = 0.000001-0.001319), while there was a significant linear positive correlation between AChE in erythrocytes and VC, VE, beta-CAR in plasma as well as SOD, CAT, GSH-Px in erythrocytes (P = 0.000013-0.000824). The results of discriminant analysis of above chemical parameters for 58 AOPP patients and 58 HAV suggested that the correct rates of discriminant analysis were increased to 100% when the values of AChE and LPO in plasma and in erythrocytes, or AChE and others, were jointly used for the discriminant analysis. CONCLUSION: The findings of the present study suggest that a series of fr

关键词： Organophosphorus pesticide poisoning Free radicals Lipoperoxides Nitric oxide Antioxidants Antioxidases

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Imbalanced free radicals and antioxidant defense systems in schizophrenia:A comparative study

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2006年第12期7卷 981-986页

作者： LI Hui-chun CHEN Qiao-zhen MA Ying zhou jun-fu Department of Psychiatry the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China

Objective: To examine changes of blood oxidative-antiovidative level in schizophrenic patients and its relationship with clinical symptoms. Methods: Forty-six Chinese patients met DSM-IV (Diagnostic and Statistical Manual of Mental Disor- ders-IV) criteria for schizophrenia and fifty age- and sex-matched healthy controls were enrolled in the present study. Baseline psychiatric symptom severity was assessed with brief psychiatric rating scale, positive and negative syndrome scale on the blood draw day. Fresh blood samples were collected to measure levels of nitric oxide and lipid peroxide in plasma as well as activities of superoxide dismutase, catalase and glutathione peroxidase in red blood cells by spectrophotometric assays simultaneously. Results: Comparison of the biochemical parameters indicated that the level of nitric oxide and lipid peroxide increased in patient group, which represented a positive correlation with positive scale scores; while the activities of three critical enzymes decreased and showed a negative linear correlation. Conclusion: This study showed that there are dysregulation of free radical metabolism and poor activities of the antioxidant defense systems in schizophrenic patients. Excess free radicals formation may play a critical role in the etiology of schizophrenia. Using antioxidants might be an effective therapeutic approach to partially alleviate or prevent the symptoms of schizophrenia.

关键词： Schizophrenia Nitric oxide (NO) Lipid peroxide (LPO) Glutathione peroxidase (GSH-Px) Catalase (CAT) Superoxide dismutase (SOD) Symptom

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A study on relationship of nitric oxide,oxidation,peroxidation,lipoperoxidation with chronic cholecystitis

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World Journal of Gastroenterology 2000年第4期6卷 501-507页

作者： jun fu zhou Dong Cai You Gen Zhu Jin Lu Yang Cheng Hong Peng Yang Hai Yu The Second Affiliated Hospital of Medical College of Zhejiang University Hangzhou 310009ZhejiangChina The People’s Hospital of Jinhua City Jinhua 321000ZhejiangChina

AIM:To study relationship of injury induced by nitric oxide, oxidation, peroxidation,lipoperoxidation with chronic ***:The values of plasma nitric oxide (P-NO), plasma vitamin C (P-VC), plasma vitamin E (P-VE), plasma beta-carotene (P-beta-CAR), plasma lipoperoxides (P-LPO), erythrocyte superoxide dismutase (E-SOD), erythrocyte catalase (E-CAT), erythrocyte glutathione peroxidase (E-GSH-Px) activities and erythrocyte lipoperoxides (E-LPO) level in 77 patients with chronic cholecystitis and 80 healthy control subjects were determined, differences of the above average values between the patient group and the control group and differences of the average values between preoperative and postoperative patients were analyzed and compared, linear regression and correlation of the disease course with the above determination values as well as the stepwise regression and correlation of the course with the values were ***:Compared with the control group, the average values of P-NO, P-LPO, E-LPO were significantly increased (P<0.01), and of P-VC, P-VE, P-beta-CAR, E-SOD, E-CAT and E-GSH-Px decreased (P <0.01) in the patient group. The analysis of the linear regression and correlation showed that with prolonging of the course, the values of P-NO, P-LPO and E-LPO in the patients were gradually ascended and the values of P-VC,P-VE, P-beta-CAR, E-SOD, E-CAT and E-GSH-Px descended (P<0.01). The analysis of the stepwise regression and correlation indicated that the correlation of the course with P-NO, P-VE and P-beta-CAR values was the closest. Compared with the preoperative patients, the average values of P-NO, P-LPO and E-LPO were significantly decreased (P <0.01) and the average values of P-VC, E-SOD, E-CAT and E-GSH-Px in postoperative patients increased (P <0.01) in postoperative patients. But there was no significant difference in the average values of P-VE, P-beta-CAR preoperative and postoperative ***:Chronic cholec

关键词： nitric oxide oxidation peroxidation lipoperoxidation chronic cholecystitis

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Increased oxidative stress and oxidative damage associated with chronic bacterial prostatitis

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Asian Journal of Andrology 2006年第A03期8卷 317-323页

作者： jun-fu zhou Wei-Qiang Xiao Yi-Chun Zheng Jie Dong Shu-Mei Zhang Laboratory for Free Radical Medicine Second Affiliated Hospital College of Medicine Zhejiang University Hangzhou 310009 China Department of Urology Second Affiliated Hospital College of Medicine Zhejiang University Hangzhou 310009 China

Aim： To investigate whether chronic bacterial prostatitis might increase oxidative stress and oxidative damage in chronic bacterial prostatitis patients （CBPP）, and to explore its possible mechanism. Methods： Enrolled in a casecontrol study were 70 randomly sampled CBPP and 70 randomly sampled healthy adult volunteers （HAV）, on whom plasma nitric oxide （NO）, vitamin C （VC）, vitamin E （VE） and β-carotene （β-CAR） level, erythrocyte malondialdehyde （MDA） level, as well as erythrocyte superoxide dismutase （SOD）, catalase （CAT） and glutathione peroxidase （GPX） activities were determined by spectrophotometry. Results： Compared with the HAV group, values of plasma NO and erythrocyte MDA in the CBPP group were significantly increased （P 〈 0.001）; those of plasma VC, VE and β-CAR as well as erythrocyte SOD, CAT and GPX activities in the CBPP group were significantly decreased （P 〈 0.001）. Findings from partial correlation for the 70 CBPP showed that with prolonged course of disease, values of NO and MDA were gradually increased （P 〈 0.001）, and those of VC, VE, β-CAR, SOD, CAT and GPX were gradually decreased （P 〈 0.05- 0.001）. The findings from stepwise regression for the 70 CBPP suggested that the model was Y= -13.2077 ＋ 0.1894MDA ＋ 0.0415NO - 0.1999GPX, F = 18.2047, P 〈 0.001, r = 0.6729, P 〈 0.001. Conclusion： The findings suggest that there exist increased oxidative stress and oxidative damage induced by chronic bacterial prostatitis in the patients, and such phenomenon was closely related to the course of disease.

关键词： chronic bacterial prostatitis oxidative stress oxidative damage free radicals oxidation lipid peroxidation antioxidant antioxidative enzyme nitric oxide malondialdehyde

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Increased Oxidative Stress in Women With Pregnancy-induced Hypertension

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Biomedical and Environmental Sciences 2005年第6期18卷 419-426页

作者： jun-fu zhou XIN-Yu WANG XUE-jun SHANGGUAN Zu-MING GAO SHU-MEI ZHANG WEI-QIANG XIAO CHANG-GUI CHEN Second Affiliated Hospital College of Medicine Zhejiang University 88 Jiefang RoadHangzhou 310009 Zhejiang China Affiliated Obstetrical and Gynecological Hospital College of Medicine Zhejiang University 2 Xueshi Road Hangzhou 310006 Zhejiang China

Objective To investigate whether pregnancy-induced hypertension （PIH） may increase oxidative stress in women with PIH, and to explore the mechanisms by which PIH may increase oxidative stress and potential free radical damage. Methods Seventy women with PIH and seventy women with uncomplicated normotensive pregnancy （UNP） whose age, nutritional conditions, levels of hemoglobin and albumin were all matched, were enrolled in a randomized controlled trial. Their plasma concentrations of nitric oxide （NO）, vitamin C （VC）, vitamin E （VE）, and β-carotene （β-CAR） as well as their erythrocyte malondialdehyde （MDA）, and activities of superoxide dismutase （SOD）, catalase （CAT） and glutathione peroxidase （GPX） were determined by spcctrophotometry. Results Compared with average values of the above experimental parameters in the women with UNP, the average value of erythrocyte MDA in the women with PIH significantly increased （P〈0.0001）, while the average values of plasma NO, VC, VE, and β-CAR as well as those of erythrocyte SOD, CAT, and GPX in the women with PIH significantly decreased （P〈0.0005-0.0001）. The findings from partial correlation analysis （controlling for age） for 70 women with PIH showed that with elevated systolic blood pressure （SBP） and diastolic blood pressure （DBP）, MDA value gradually increased （P〈0.001）, and NO, VC, VE, β-CAR, SOD, CAT, and GPX values gradually decreased （P〈0.02-0.001）. The findings from reliability analysis for NO, VC, VE, β-CAR, SOD, CAT, GPX, and MDA values used to reflect increased oxidative stress and potential free radical damage in women with PIH showed that the reliability coefficients （alpha, 8 items） = 0.7062, P〈 0.0001, and the standardized item alpha = 0.9116, P〈 0.0001. Conclusion The findings in the present research suggest that pregnancy-induced hypertension can increase oxidative stress and potential free radical damage in women with pregnancy-induced hypertension.

关键词： Pregnancy-induced hypertension Oxidative stress Free radicals Free radical damage Oxidation Lipoperoxidation Antioxidant Antioxidase Malondialdehyde

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Oxidative Stress before and after Operation in Patients with Chronic Cholecystitis Containing Gallstone

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Biomedical and Environmental Sciences 2000年第4期13卷 254-262页

作者： zhou jun fu , CHEN PENG , YANG JIN LU +, ZHU YOU GEN + PENG CHENG HONG , AND WU YU LIAN  The 2nd Affiliated Hospital, Medical College of Zhejiang University, 88 Jiefang Road, Hangzhou, 310009, Zhejian 2nd Affiliated Hospital Medical College of Zhejiang University 88 Jiefang Road Hangzhou 310009 Zhejiang Province China.

To study the relationship of oxidative, antioxidative constituents and antioxidases in blood with chronic cholecystitis containing gallstone, levels of lipoperoxides (LPO), nitric oxide (NO), vitamin C(VC), vitamin E (VE) and β carotene (β CAR) in plasma as well as level of LPO, activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH Px) in erythrocytes were investigated by spectrophotometric assay in 107 patients with this condition (PCg) and 100 healthy volunteers (HVs). Compared with HVs group, the average value of LPO and NO in plasma and that of LPO in erythrocytes of PCg group were significantly increased ( P furthermore, the average value of VC in plasma and that of SOD, CAT and GSH Px in erythrocytes of the postoperative PCg group were significantly increased ( P <0.0001), whereas no significant difference was found between their average value of VE and β CAR in pla

关键词： Wang with Chronic Cholecystitis Containing Gallstone Oxidative Stress before and after Operation in Patients

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Increased Oxidative Stress and Damage in Patients With Chronic Bacterial Prostatitis

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Biomedical and Environmental Sciences 2006年第6期19卷 481-486页

作者： JIAN-GUO LOU JIE DONG Yt-CHUN ZHENG SHU-MEI ZHANG WEJ-QIANG XIAO AND jun-fu zhou Laboratory for Free Radical Medicine Medical College Second Hospital Zhejiang University Hangzhou 310009 Zhejiang China Department of Traditional Chinese Medicine Medical College Second Hospital Zhejiang University Hangzhou 310009 Zhejiang China Department of Urology Medical College Second Hospital Zhejiang University Hangzhou 310009 Zhejiang China

Objective To investigate whether chronic bacterial prostatitis （CBP） increases oxidative stress and damage in patients with CBP, and to explore its possible mechanism. Methods Eighty patients with CBP and 80 healthy adults as controls were enrolled in a case-control study, in which levels of nitric oxide （NO）, vitamin C （VC）, and vitamin E （VE） in plasma, as well as malondialdehyde （MDA）, activities of superoxide dismutase （SOD）, and eatalase （CAT） in erythrocytes were determined by spectrophotometry. Results Compared with the average values of NO, VC, VE, MDA, SOD, and CAT in the healthy control group, those of plasma N O and erythrocyte MDA in the CBP group were significantly increased （P〈0.00 1）, and those of plasma VC and VE as well as erythrocyte SOD and CAT in the CBP group were significantly decreased （P〈0.001）. Findings from partial correlation analysis for course of the disease and NO, VC, VE, MDA, SOD, and CAT in 80 patients with CBP, adjusted for age, suggested that with prolonged course of the disease, values of NO and MDA were gradually increased （P〈0.001）, and those of VC, VE, SOD, and CAT were gradually decreased （P〈0.05-0.001）. The findings from stepwise regression analysis for course of the disease and NO, VC, VE, MDA, SOD, and CAT in CBP group suggested that the model of stepwise regression was Y = -19.1160 ＋0.3112MDA ＋ 0.0337NO, F = 22.1734, P〈0.001, r = 0.6045, P〈0.001. The findings from the reliability analysis for VC, VE, SOD, CAT, NO, and MDA in the CBP group showed that the reliability coefficients＇ alpha （6 items） was 0.7195, P〈0.0001, and the standardized item alpha was 0.9307, P〈0.0001. Conclusion There exist increased oxidative stress and damage induced by chronic bacterial prostatitis in patients, and such a phenomenon is closely related to the course of disease.

关键词： Chronic bacterial prostatitis Oxidative stress Oxidative damage Free radicals Oxidation Lipid peroxidation Antioxidant Antioxidative enzyme Nitric oxide Malondialdehyde

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Overweight and Obesity-Induced Oxidative Stress in Children

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Biomedical and Environmental Sciences 2006年第5期19卷 353-359页

作者： YOU-GEN ZHU SHU-MEI ZHANG JI-YUE WANG WEI-QIANG XIAO XIN-YU WANG jun-fu zhou Jinhua Medical College Jinhua 321007 Zhejiang China Second Affiliated Hospital College of Medicine Zhejiang University Hangzhou 310009 Zhejiang China Affiliated Children＇s Hospital College of Medicine Zhejiang University Hangzhou 310003 Zhefiang China Affiliated Obstetrical and Gynecological Hospital College of Medicine Zhefiang University Hangzhou 310006 Zhefiang China

Objective To investigate whether overweight and obesity might cause oxidative stress and potential oxidative damage in overweight and obese children, and to explore its possible mechanism. Methods Eighty-five overweight and obese children （OOC）, and eighty-five age-matched healthy children （HC） were recruited in this case-control study. The present study analyzed spectrophotometrically vitamin C （VC）, vitamin E （VE）, and β-carotene （β-CAR） in plasma, as well as the activities of superoxide dismutase （SOD）, catalase （CAT）, and the level of malondialdehyde （MDA） in erythrocytes. Results Compared with those of VC, VE, β-CAR, SOD, CAT and MDA in the HC group, the average values of VC, VE, β-CAR, SOD, and CAT in the OOC group were significantly decreased （P〈0.001）, while the average value of MDA in the OOC group was significantly increased （P〈0.001）. The regression analysis demonstrated that VC, VE, β-CAR, SOD, and CAT were negatively correlated （P〈0.05-0.01）, and MDA was positively correlated with BMI （P〈0.05）. Fitting to the model of multiple stepwise regression of BMI on VC, VE, β-CAR, SOD, CAT, and MDA in 85 OOC was Y = 27.0041 ＋ 0,2541MDA - 2.1448β-CAR -- 0.0090CAr, where F = 43.8088, P〈0.001, r = 0.7866, r^2= 0.6187, adjusted r^2= 0.6046. The findings from the reliability analysis for VC, VE, β-CAR, SOD, CAT, and MDA used to reflect increased oxidative stress and potential oxidative damage in the OOC showed that the reliability coefficients （alpha, 6 items） = 0.7231, P〈0.0001, and that the standardized item alpha = 0.9207, P〈0.0001, Conclusion The present study suggests that there exists an increased oxidative stress in overweight and obese children.

关键词： Antioxidant Antioxidative enzyme Free radicals Lipid Oxidation Malondialdehyde Obesity Overweight Oxidative stress

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糖尿病肾病血液透析患者发生卒中的危险因素研究

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中国现代医学杂志 2016年第23期26卷 72-76页

作者：王新宇何凤傅君舟广州医科大学附属广州市第一人民医院肾内科广东广州510180

目的探讨糖尿病肾病(DN)血液透析患者发生卒中的危险因素。方法选取2007年1月-2012年1月广州市第一人民医院、广州军区广州总医院及南昌大学第二附属医院的肾内科血液净化中心收治的血液透析患者,根据患者有无合并DN病史,分为DN组及非D... 详细信息

目的探讨糖尿病肾病(DN)血液透析患者发生卒中的危险因素。方法选取2007年1月-2012年1月广州市第一人民医院、广州军区广州总医院及南昌大学第二附属医院的肾内科血液净化中心收治的血液透析患者,根据患者有无合并DN病史,分为DN组及非DN组。主要终点事件是卒中,通过Cox回归模型探讨DN血液透析患者发生卒中的独立危险因素。两组间累积卒中事件采用Kaplan–Meier曲线分析。结果 1 148例血液透析患者纳入研究,平均随访时间23.8个月,最长随访时间72.0个月;DN组卒中发病率为63.5/1000人年,显著高于非DN组的29.6/1 000人年。多因素分析发现,低血清白蛋白[HR=0.86(95%CI:0.76,0.97),P=0.011]是DN血液透析患者发生卒中的独立危险因素。结论较低的血清白蛋白是DN血液透析患者发生卒中事件的独立危险因素,该类患者应避免营养不良。

关键词：卒中流行病学糖尿病肾病危险因素

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The Coupling Effect of Spatial Reticulated Shell Structure with Cables

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Journal of Shanghai Jiaotong university(Science) 2005年第1期10卷 52-56页

作者：马骏周岱符旭晨 Research Center of Spatial Structures Shanghai Jiaotong Univ. Shanghai 200030China

The spatial reticulated shell structure with cables (RSC) is a kind of coupling working system, which consists of flexible cables, reticulated shell structure (RS) and tower columns. The dynamic analysis of RSC based on the coupling model was carried out. Three kinds of elements such as the spatial bar element, cable element and beam element were introduced to analyze the reticulated shell, cable and tower column respectively. furthermore, such parameter influences as structural boundary conditions, grid configuration, the span-to-depth ratio and the arrangement of cable system upon structural dynamics were analyzed. The structural vibration modes can be divided into four groups based on some numerical examples. And the frequencies in the same group are very close while the frequencies in different groups are different from each other obviously. It is clear that the sequence of the appearance of the each mode group heavily depends on the comparative stiffness of the tower column system, RS and cables.

关键词： reticulated shell structure cable tower column coupling effect vibration mode

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