检索结果-南通市图书馆

Involvement of Rho-associated coiled-coil kinase signaling inhibition in TGF-β1/Smad2,3 signal transduction in vitro

引用

International Journal of Ophthalmology(English edition) 2017年第12期10卷 1805-1811页

作者： Zhao-Hui Feng Xiao-Hui Zhang Jia-Qi Zhao jun-ze ma Department of Ophthalmology the Second Affiliated Hospital of Xi’an Jiaotong University Medical CollegeXi’an 710004Shaanxi ProvinceChina

AIM：To research the effect of Y-27632,a selective Rhoassociated coiled-coil kinase（ROCK） inhibitor,on TGF-β1/Smad2,3 signal transduction in ocular Tenon＇s capsule fi broblasts（OTFs）.METHODS：Primary ocular Tenon＇s capsule fibroblasts had been cultured in *** effect of Y27632 on proliferation of OTF stimulated by lysophosphatidic acid（LPA） was evaluated by MTT colorimetric assay so as to sift out the proper concentrations range of Y-27632 for the next *** time-polymerase chain reactor（RT-PCR） was to analyze the changes of Smad2 and Smad3 genes of cells affected by Y-27632,though unaffected by transforming growth factorbeta1（TGF-β1）.Proteins of Smad2,Smad3,phosphorylated Smad2（Ser245/250/255）,and phosphorylated Smad3（Ser423/425/203） were respectively quantifi ed by Western blot after OTFs were successively incubated by TGF-β1 and ***,α-smooth muscular actin（α-Sma） protein was also quantified after the small intervening gene fragments of human Smad2 and Smad3 were designed,synthesized,and then transfected to ***：Y-27632 signifi cantly inhibited OTFs proliferation stimulated by *** Y-27632 signifi cantly suppressed the expressions of Smad2 m RNA,Smad2,3 proteins expressions,Smad3 phosphorylation at the carboxylic terminals of Ser423/425/203 which had been radically promoted by TGF-β*** RNA-Smad2,3 suppressed α-Sma expressions,but less effectively than ***：The inhibition of ROCK signaling may be a potential therapeutic candidate for the treatment of the fi ltration channel fi brosis.

关键词： ROCK Y-27632 transforming growth factor-betal Smad human ocular Tenon's capsule fibroblasts

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of Nb Content on the Hot Deformation Behavior of S460ML Steel

引用

Acta Metallurgica Sinica(English Letters) 2019年第4期32卷 526-534页

作者： Yu-Cheng Zhang Zhen-Sheng Meng Yang Meng Xin-Hua Ju Zhong-Hang Jiang ze-jun ma Research Institute of Technology of Shougang Group Co.Ltd.

The hot deformation behavior of S460 ML steel with different Nb contents was investigated by single-pass compression experiment on the Gleeble-1500 thermo-machine simulator at deformation temperatures ranging from 900 to 1200 ℃ and strain rates from 0.1 to 5.0 s^(-1). The critical strain of dynamic recrystallization(DRC) under different conditions was determined by using working hardening rate-strain curves. The relationship between critical strain and peak strain of DRC was discussed. By means of regression analysis method, the hot deformation activation energy of steels and the mathematical model for predicting DRC critical strain were calculated and established, respectively. The results showed that DRC occurred during hot deformation. As the deformation temperature increased and strain rate decreased, the critical strain of DRC decreased. The critical strain(εc) showed linear relationship with peak strain(εp). As Nb content increased,the needed deformation temperature for occurring DRC increased, while the needed strain rate for it decreased. The activation energy for hot deformation of S460 ML steel increased with increasing Nb content.

关键词： Dynamic recrystallization Critical strain Nb content Deformation temperature Strain rate Hot deformation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Establishment and industrial practice of high-temperature process evaluation system in sintering

引用

Journal of Iron and Steel Research International 2018年第9期25卷 910-922页

作者： Yuan-dong Pei Sheng-li Wu Xiao-jing Shao Zhi-xing Zhao Gang An ze-jun ma Wei-dong Zhang School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083 China Shougang Research Institute of Technology Beijing 100043China Beijing Key Laboratory of Green Recyclable Process for Iron and Steel Production Technology Beijing 100043 China Shougang Jingtang Integrated Iron and Steel Co. Ltd.Tangshan 063200 Hebei China

The behaviors of typical iron ores at high temperature were observed by confocal scanning laser microscopy. Four critical temperature points and liquid flow velocity at high temperatures of iron ores were obtained and the temperature points contain temperature at which sample starts to shrink, temperature at which the initial liquid phase forms, temperature at which a lot of liquid forms and temperature at which liquid consolidation ends. Under the same CaO to Fe203 ratio, the liquid phase fluidity of iron ore fines of Carajas （IOC） is good. However, under the same basicity, as the content of SiO2 in IOC is low, the liquid phase fluidity of IOC is much smaller than that of Yandi fine. After analysis of the initial formation and development of the liquid phase and the final consolidation process, the high-temperature process evaluation system （HTPES for short） of iron ore was established. The idea of ＂dense ore matching fusible ore＂ instead of ＂relatively fusible ore＂ was proposed based on the results of HTPES and applied in ore matching of a sinter plant from Shougang Jingtang. The use of IOC （13-18%） instead of standard sintering fines （SSF） improved liquid phase fluidity and ensured the sinter quality. Furthermore, the use of IOC fine （18-23%） with Hainan fine （0-2%） instead of SSF, a mixture of hematite and marra mamba ore and concentrates guaranteed the quality of sinter ore through improving fluidity, in the meantime reducing ore matching costs. With the establishment and application of HTPES, the sinter plant has achieved good economic benefits under the premise of ensuring the quality of sinter ore.

关键词： Sinter Iron ore In situ observation Fluidity Evaluation Industrial practice

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Analysis of retained austenite in TRIP590 steel by electron backscattered diffraction method

引用

Journal of Iron and Steel Research International 2020年第3期27卷 355-365页

作者： Yu-cheng Zhang Yang Meng Gui-bin Cui Hui-ping Jia Xin-hua Ju Zhong-hang Jiang ze-jun ma Bruker(Beijing)Scientific Technology Co. Ltd.Beijing 100192.China Research Institute of Technology Shougang Group Co.Ltd.Beijing 100043China

The retained austenite content in TRIP590 steel was first measured by X-ray diffraction(XRD)***,the effect of different test parameters(indexing rate,step size,field number,etc.)on the measured results of retained austenite content in TRIP590 steel by electron backscattered diffraction(EBSD)method was *** comparing the measured results between XRD and EBSD method,the optimal test parameters for the analysis of retained austenite content using EBSD were ***,the total content of retained austenite and the retained austenite contents with different aspect ratios in TRIP590 steel were analyzed,*** results showed that the test parameters have a great influence on the measured results of retained austenite content in TRIP590 *** order to improve the test accuracy,high indexing rates,small step sizes and more field number are necessary for the analysis of retained austenite content in TRIP590 steel by EBSD method.

关键词： TRIP590 steel Retained austenite Electron backscattered diffraction Indexing rate Step size

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

玻璃体内注射酮咯酸治疗白内障术后慢性黄斑囊样水肿

引用

国际眼科杂志 2016年第12期16卷 2332-2334页

作者：马君择西安交通大学第二附属医院眼科中国陕西省西安市710004

目的:探讨玻璃体内注射酮咯酸治疗白内障术后慢性黄斑囊样水肿的临床疗效。方法:选取2014-03/2016-02我院收治的白内障手术后并发黄斑囊样水肿患者38例,行玻璃体内注射酮咯酸治疗。治疗后,采用荧光素血管造影术(FFA)和光学相干断层扫描(... 详细信息

目的:探讨玻璃体内注射酮咯酸治疗白内障术后慢性黄斑囊样水肿的临床疗效。方法:选取2014-03/2016-02我院收治的白内障手术后并发黄斑囊样水肿患者38例,行玻璃体内注射酮咯酸治疗。治疗后,采用荧光素血管造影术(FFA)和光学相干断层扫描(OCT)进行临床检查,观察临床疗效,对比分析治疗前及治疗后2、4wk,3、6mo患者的矫正视力变化、眼压、黄斑区中心视网膜厚度。结果:与治疗前相比,玻璃体内注射酮咯酸治疗后FFA显示患者渗漏显著地减低,患者黄斑区水肿消退,同时,矫正视力显著提高,差异有统计学意义(P<0.05),眼压显著改善,差异有统计学意义(P<0.05),黄斑区平均厚度显著减少,差异有统计学意义(P<0.05)。结论:玻璃体内注射酮咯酸治疗白内障术后慢性黄斑囊样水肿有良好的治疗效果。

关键词：酮咯酸白内障术后慢性黄斑囊样水肿玻璃体内

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

脉络膜厚度与特发性黄斑前膜的关系研究

引用

国际眼科杂志 2018年第4期18卷 734-736页

作者：马君择权彦龙杨格强西安交通大学第二附属医院眼科中国陕西省西安市710004 中国陕西省西安市中心医院眼科 710004

目的:探讨脉络膜厚度和特发性黄斑前膜(idiopathic macular epiretinal membrane,IMEM)发生发展的关系。方法:回顾性分析2014-01/2016-12期间我院就诊的IMEM患者48例48眼,并选取同期体检健康者50例的右眼进行对照,比较IMEM组患眼、健眼... 详细信息

目的:探讨脉络膜厚度和特发性黄斑前膜(idiopathic macular epiretinal membrane,IMEM)发生发展的关系。方法:回顾性分析2014-01/2016-12期间我院就诊的IMEM患者48例48眼,并选取同期体检健康者50例的右眼进行对照,比较IMEM组患眼、健眼及对照组黄斑中心凹脉络膜厚度(subfoveal choroidal thickness,SFCT)水平,随访观察术后IMEM患者患眼及健眼SFCT水平变化,并分析术后脉络膜厚度和最佳矫正视力的相关性。结果:术前IMEM组患眼SFCT(362.22±40.75μm)明显较对侧健眼(410.56±38.45μm)及对照组右眼(420.73±39.63μm)低,且对侧健眼较对照组右眼低,差异均有统计学意义(均P0.05),而术后1mo患眼和健眼SFCT均显著升高,和术前相比差异有统计学意义(P0.05);术前不同SFCT值患者术后BCVA≥0.5患者构成比差异有统计学意义(P380μm组术后BCVA≥0.5患者构成比明显较<320μm组和320～380μm组高,经Fisher确切概率法分析,差异有统计学意义。经Pearson分析,IMEM患者术后脉络膜厚度和术后最佳矫正视力存在正相关性(r=0.629,P<0.05)。结论:脉络膜变薄可能是IMEM的重要诱因。

关键词：特发性黄斑前膜脉络膜厚度关系

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of cholesterol metabolism on hepatolithiasis

引用

World Journal of Gastroenterology 2025年第1期31卷 157-162页

作者： Lin Zheng Zi-Yu Ye jun-Ji ma Department of Gastroenterology The Second Hospital of Hebei Medical UniversityHebei Key Laboratory of GastroenterologyHebei Institute of GastroenterologyHebei Clinical Research Center for Digestive DiseasesNo.215 Heping West RoadShijiazhuang 050000Hebei ProvinceChina

Surgical intervention is currently the primary treatment for hepatolithiasis;how-ever,some patients still experience residual stones and high recurrence rates after *** metabolism seems to play an important role in hepatoli-thiasis pathogenesis.A high cholesterol diet is one of the significant reasons for the increasing incidence of ***,regular diet and appropriate medical intervention are crucial measures to prevent hepatolithiasis and reduce recurrence rate after *** dietary cholesterol and drugs that increase cholesterol stone solubility are key therapeutic approaches in treating *** article discusses the cholesterol metabolic pathways related to the pathogenesis of hepatolithiasis,as well as food intake and targeted therapeutic drugs.

关键词： Hepatolithiasis Cholesterol metabolism High-fat diet 3-hydroxy-3-methylglutaryl-coenzyme A reductase Interlobular bile duct

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Structural and microwave absorption properties of CoFe_(2)O_(4)/residual carbon composites

引用

International Journal of Minerals,Metallurgy and materials 2025年第1期32卷 221-232页

作者： Yuanchun Zhang Shengtao Gao Xingzhao Zhang Dacheng ma Chuanlei Zhu jun He Joint National-Local Engineering Research Centre for Safe and Precise Coal Mining Anhui University of Science and TechnologyHuainan 232001China School of Chemical and Blasting Engineering Anhui University of Science and TechnologyHuainan 232001China

Electromagnetic interference,which necessitates the rapid advancement of substances with exceptional capabilities for bsorbing electromagnetic waves,is of urgent concern in contemporary *** this work,CoFe_(2)O_(4)/residual carbon from coal gasification fine slag(CFO/RC)composites were created using a novel hydrothermal *** mechanisms for microwave absorption,including conductive loss,natural resonance,interfacial dipole polarization,and magnetic flux loss,are involved in these ***,compared with pure residual carbon materials,this composite offers superior capabilities in microwave *** 7.76GHz,the CFO/RC-2 composite achieves an impressive minimum reflection loss(RL_(min))of-43.99 dB with a thickness of 2.44 ***,CFO/RC-3 demonstrates an effective absorption bandwidth(EAB)of up to 4.16 GHz,accompanied by a thickness of *** study revealed the remarkable capability of the composite to diminish electromagnetic waves,providing a new generation method for microwave absorbing materials of superior quality.

关键词： coal gasification slag residual carbon hydrothermal method microwave absorption CoFe_(2)O_(4)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of Bifidobacterium lactis BLa80 on fecal and mucosal flora and stem cell factor/c-kit signaling pathway in simulated microgravity rats

引用

World Journal of Gastroenterology 2025年第1期31卷 93-109页

作者： Ping Zhang Ying Zhu Pu Chen Tong Zhou Zhe-Yi Han jun Xiao Jian-Feng ma Wen ma Peng Zang Ying Chen Graduate School Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Key Laboratory of Aerospace Nutrition and Food Engineering China Astronaut Research and Training CenterBeijing 100094China Department of Gastroenterology The Air Force Medical CenterBeijing 100142China Department of Blood Transfusion Air Force Medical CenterBeijing 100142China

BACKGROUND Simulated microgravity environment can lead to gastrointestinal motility *** pathogenesis of gastrointestinal motility disorders is closely related to the stem cell factor(SCF)/c-kit signaling pathway associated with intestinal flora and Cajal stromal ***,intestinal flora can also affect the regulation of SCF/c-kit signaling pathway,thus affecting the expression of Cajal stromal *** cells are the pacemakers of gastrointestinal *** To investigate the effects of Bifidobacterium lactis(***)BLa80 on the intestinal flora of rats in simulated microgravity and on the gastrointestinal motility-related SCF/c-kit *** The internationally recognized tail suspension animal model was used to simulate the microgravity environment,and 30 rats were randomly divided into control group,tail suspension group and drug administration tail suspension group with 10 rats in each group for a total of 28 *** tail group was given *** BLa80 by intragastric administration,and the other two groups were given water intragastric administration,the concentration of intragastric administration was 0.1 g/mL,and each rat was 1 mL/***&eosin staining was used to observe the histopathological changes in each segment of the intestine of each group,and the expression levels of SCF,c-kit,extracellular signal-regulated kinase(ERK)and p-ERK in the gastric antrum of each group were detected by Western blotting and *** fecal flora and mucosal flora of rats in each group were detected by 16S *** Simulated microgravity resulted in severe exfoliation of villi of duodenum,jejunum and ileum in rats,marked damage,increased space between villi,loose arrangement,shortened columnar epithelium of colon,less folds,narrower mucosal thickness,reduced goblet cell number and crypts,and significant improvement after probiotic *** microgravity reduced the expressions of SCF and c-kit,and increased the express

关键词： Simulated microgravity Rat Intestinal flora Gastrointestinal motility Stem cell factor/c-kit signaling pathway

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Staged dendrite suppression for high safe and stable lithium-sulfur batteries

引用

Journal of Energy Chemistry 2025年第1期100卷 674-683页

作者： jun Jiang Zhenjie Lu Yanwen Ding Shujun Liu Zhijie Qi Tian Tang Yunfan Zhang Zhiyuan ma Jingwen Sun Liang Xue Wenyao Zhang Pan Xiong Xin Wang junwu Zhu Yongsheng Fu Key Laboratory for Soft Chemistry and Functional materials of Ministry of Education Nanjing University of Science and Technology Jiangsu Pylon Battery Co.Ltd

The unavoidable dendrite growth and shuttle effect have long been stranglehold challenges limiting the safety and practicality of lithium-sulfur ***,we propose a dual-action strategy to address the lithium dendrite issue in stages by constructing a multifunctional surface-negatively-charged nanodiamond layer with high ductility and robust puncture resistance on polypropylene （PP） *** uniformly loaded compact negative layer can not only significantly enhance electron transmission efficiency and promote uniform lithium deposition,but also reduce the formation of dendrite during early deposition *** importantly,under the strong puncture stress encountered during the deterioration of lithium dendrite growth under limiting current,the high ductility and robust puncture resistance（145.88 MPa） of as-obtained nanodiamond layer can effectively prevent short circuits caused by unavoidable lithium *** Li||Li symmetrical cells assembled with nanodiamond layer modified PP demonstrated a stable cycle of over 1000 h at 2 ma cm-2with a polarization voltage of only 29.3 ***,the negative charged layer serves as a physical barrier blocking lithium polysulfide ions,effectively mitigating capacity *** improved cells achieved a capacity decay of only 0.042%per cycle after 700 cycles at 3 C,demonstrating effective suppression of dendrite growth and capacity attenuation,showing promising prospect.

关键词： Lithium-sulfur batteries Staged dendrite suppression Shuttle effect Surface-negatively-charged nanodiamond

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：