Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance. T...
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Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance. The precise coordination of the gene networks controlling neurogenesis in naive and mature tanycytes is essential for maintaining homeostasis in adulthood. However, our understanding of the molecular mechanisms and signaling pathways that govern the proliferation and differentiation of tanycytes into neurons remains limited. This article aims to review the recent advancements in research into the mechanisms and functions of tanycyte-derived neurogenesis. Studies employing lineage-tracing techniques have revealed that the neurogenesis specifically originating from tanycytes in the hypothalamus has a compensatory role in neuronal loss and helps maintain energy homeostasis during metabolic diseases. Intriguingly,metabolic disorders are considered early biomarkers of Alzheimer's disease. Furthermore,the neurogenic potential of tanycytes and the state of newborn neurons derived from tanycytes heavily depend on the maintenance of mild microenvironments, which may be disrupted in Alzheimer's disease due to the impaired blood–brain barrier ***, the specific alterations and regulatory mechanisms governing tanycyte-derived neurogenesis in Alzheimer's disease remain unclear. Accumulating evidence suggests that tanycyte-derived neurogenesis might be impaired in Alzheimer's disease, exacerbating neurodegeneration. Confirming this hypothesis, however, poses a challenge because of the lack of long-term tracing and nucleus-specific analyses of newborn neurons in the hypothalamus of patients with Alzheimer's disease. Further research into the molecular mechanisms underlying tanycyte-derived neurogenesis holds promise for identifying small molecules capable of restoring tanycyte proliferation in neurodegenerative diseases. This line of investigation could pro
Personal care products(PCPs)are a class of emerging pollutants that have attracted public concern owing to their harmful effects on humans and the *** data is valuable for insight the levels of PCPs in the human body ...
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Personal care products(PCPs)are a class of emerging pollutants that have attracted public concern owing to their harmful effects on humans and the *** data is valuable for insight the levels of PCPs in the human body and can be crucial for identifying potential health *** gain a better understanding of timely exposure profiles and health risk of reproductive-age population to PCPs,we determined six parabens,six benzophenone-type ultraviolet filters,and three disinfectants in 256 urine samples collected from young adults aged 18-44 years in Beijing,*** urinary levels of benzophenone-3(BP-3)and 4-hydroxybenzophenone(4-OHBP)were significantly higher in summer compared to winter,suggesting these compounds have different seasonal usage ***,the total concentration of 15 PCPs in female was 430 ng/mL,approximately two times higher than that in male.P-chloro-m-xylenol(PCMX),as a new type of antibacterial agent,has the greatest level among all target analytes,indicating the increasingly use of this antibacterial alternative *** potential influencing factors that lead to the elevated exposure level of PCPs were *** 19%of the target population had a high hazard index value(greater than 1)which was attributed to exposure to propyl paraben(PrP),benzophenone-1(BP-1),BP-3 and PCMX,indicating that PCPs may pose a relatively high exposure risk at environmental levels that should be a cause for concern.
After the ultralow emission transformation of coal-fired power plants,cement production became China’s leading industrial emission source of nitrogen *** gas dust contents at the outlet of cement kiln preheaters were...
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After the ultralow emission transformation of coal-fired power plants,cement production became China’s leading industrial emission source of nitrogen *** gas dust contents at the outlet of cement kiln preheaters were as high as 80-100 g/m^(3),and the calcium oxide content in the dust exceeded 60%.Commercial V_(2)O_(5)(-WO3)/TiO_(2) catalysts suitable for coal-fired flue gas suffer from alkaline earth metal Ca poisoning of cement kiln flue *** studies have also identified the poisoning of cement kiln selective catalytic reaction(SCR)catalysts by the heavy metals lead and *** of the poisoning process is the primary basis for analyzing the catalytic *** review summarizes and analyzes the SCR catalytic mechanism and chronicles the research progress concerning this poisoning *** on the catalytic and toxification mechanisms,it can be inferred that improving the anti-poisoning performance of a catalyst enhances its acidity,surface redox performance-active catalytic sites,and shell layer *** data provide support in guiding engineering practice and reducing operating costs of SCR ***,future research directions for SCR denitrification catalysts in the cement industry are *** study provides critical support for the development and optimization of poisoning-resistant SCR denitrification catalysts.
Recently, we introduced the twist polynomials of delta-matroids and gave a characterization of even normal binary delta-matroids whose twist polynomials have only one term and posed a problem:what would happen for odd...
Recently, we introduced the twist polynomials of delta-matroids and gave a characterization of even normal binary delta-matroids whose twist polynomials have only one term and posed a problem:what would happen for odd binary delta-matroids? In this paper, we show that a normal binary deltamatroid whose twist polynomials have only one term if and only if each connected component of the intersection graph of the delta-matroid is either a complete graph of odd order or a single vertex with a loop.
Taurine， a multifunctional sulfur-containing amino acid and conditionally essential nutrient for humans， plays a key role in various biological processes and has attracted significant attention for its therapeutic p...
Taurine， a multifunctional sulfur-containing amino acid and conditionally essential nutrient for humans， plays a key role in various biological processes and has attracted significant attention for its therapeutic potential. Originally isolated from ox bile， taurine has broad applications， but a comprehensive understanding of its pharmacological properties， health benefits， and safety profile remains incomplete. In this review， we critically evaluate the existing evidence on taurine’s effects based on an extensive literature search of multiple databases， including PubMed， Web of Science， Scopus， ScienceDirect， Google Scholar， CNKI， and Baidu Scholar， up to May 2024. Taurine demonstrates a range of beneficial effects， including antioxidant and anti-inflammatory activities， modulation of lipid metabolism， neuroprotection， and cardiovascular protection. It has shown substantial impacts on anti-tumor activity， immune system modulation， blood pressure and lipid regulation， glycemic control， hepatobiliary protection， and potential anti-aging effects. However， the precise regulatory pathways underlying these benefits are not yet fully understood. Epidemiological studies indicate a correlation between high taurine dosage and a reduced risk of diseases. However， direct evidence from interventional studies remains insufficient， and existing clinical trials require further in-depth investigation. Concerns about improper use and potential health risks also highlight the need for thorough safety assessments. To address these gaps， we recommend conducting well-designed， long-term randomized controlled trials to establish effective doses for disease prevention and assess taurine’s potential as a primary or adjunct therapy. This review aims to guide future research and support public health efforts， ultimately improving health outcomes.
In this article,we comment on the article published by Yu et *** employing LASSO regression and Cox proportional hazard models,the article identified nine significant variables affecting survival,including body mass i...
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In this article,we comment on the article published by Yu et *** employing LASSO regression and Cox proportional hazard models,the article identified nine significant variables affecting survival,including body mass index,Karnofsky performance status,and tumor-node-metastasis *** firmly concur with Yu et al regarding the vital significance of clinical prediction models(CPMs),including logistic regression and Cox regression for assessment in esophageal carcinoma(EC).However,the nomogram's limitations and the complexities of integrating genetic factors pose *** integration of immunological data with advanced statistics offers new research ***-throughput sequencing and big data,facilitated by machine learning,have revolutionized cancer research but require substantial computational *** future of CPMs in EC depends on leveraging these technologies to improve predictive accuracy and clinical application,addressing the need for larger datasets,patientreported outcomes,and regular updates for clinical relevance.
In this article,we discuss Ye et al's recent article on the association between age at diabetes diagnosis and subsequent risk of age-related ocular *** study,which utilized United Kingdom Biobank data,highlighted a st...
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In this article,we discuss Ye et al's recent article on the association between age at diabetes diagnosis and subsequent risk of age-related ocular *** study,which utilized United Kingdom Biobank data,highlighted a strong link between early diabetes onset and major eye conditions,such as cataracts,glaucoma,agerelated macular degeneration,and vision loss,independent of glycemic control and disease *** finding challenges the previous belief that diabetic eye disease primarily correlates with *** lifestyles evolve and the age of diabetes diagnosis decreases,understanding this relationship may reveal the complex pathogenesis underlying diabetes-related *** editorial summarizes potential mechanisms connecting the age of diabetes onset with four types of ocular diseases,emphasizing the significance of early diagnosis.
Electronic-state modulation strategy offers great potential in designing RuO2-based bifunctionalelectrocatalysts for rechargeable Zn-air batteries（ZABs）.Various three-dimensional（3D） transition metal oxides are at...
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Electronic-state modulation strategy offers great potential in designing RuO2-based bifunctionalelectrocatalysts for rechargeable Zn-air batteries（ZABs）.Various three-dimensional（3D） transition metal oxides are attempted to couple with RuO2for constructing an appropriate Ru—O—M *** work aims to construct Co3O4-RuO2heterostructures on carbon sheets（Co3O4/RuO2/NCNS） for boosting electronic transfer and *** and theoretical calculations identify the electronic transfer from Co3O4to RuO2that modulates the electronic structure of metal surfaces/***,it leads to the increase in Co3+content,electron-rich state at RuO2surface and electronic accumulation at ***,this electronic-state modulation optimizes the d-band center in Co3O4/RuO2that lowers the reaction barriers and endows interfaces as the biggest contributor to oxygen reduction reaction（ORR） and oxygen evolution reaction（OER） performance,The Co3O4/RuO2/NCNS shows a quite low potential difference of 0.62 V and remarkable durability for ORR/***3O4/RuO2/NCNS-assembled ZABs exhibit an excellent specific capacity of 818.3 mA h g-1and a superior lifespan over 750 h.
Water use efficiency(WUE),as a pivotal indicator of the coupling degree within the carbon–water cycle of ecosystems,holds considerable importance in assessment of the carbon–water balance within terrestrial ***,in t...
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Water use efficiency(WUE),as a pivotal indicator of the coupling degree within the carbon–water cycle of ecosystems,holds considerable importance in assessment of the carbon–water balance within terrestrial ***,in the context of global warming,WUE evolution and its primary drivers on the Tibetan Plateau remain *** study employed the ensemble empirical mode decomposition method and the random forest algorithm to decipher the nonlinear trends and drivers of WUE on the Tibetan Plateau in 2001–*** indicated an annual mean WUE of 0.8088 gC/mm·m^(2)across the plateau,with a spatial gradient reflecting decrease from the southeast toward the *** manifesting monotonous trends of increase or decrease in WUE accounted for 23.64%and 9.69%of the total,***,66.67%of the region exhibited trend reversals,i.e.,39.94%of the area of the Tibetan Plateau showed transition from a trend of increase to a trend of decrease,and 26.73%of the area demonstrated a shift from a trend of decrease to a trend of *** factors accounted for 70.79%of the variability in *** leaf area index and temperature served as the major driving forces of WUE variation.
Immune cells are essential components of the human immune system,playing a critical role in maintaining human health and defending against *** in nutritional metabolism influence the activation,proliferation,apoptosis...
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Immune cells are essential components of the human immune system,playing a critical role in maintaining human health and defending against *** in nutritional metabolism influence the activation,proliferation,apoptosis,differentiation direction,and other behaviors of immune cells,affecting immune *** acids,fundamental nutrients in all living organisms,are crucial for maintaining redox balance,regulating energy,supporting biosynthesis,and preserving *** availability of amino acids influences the behaviors and functions of immune cells ***,understanding the intricate relationship between amino acid metabolism and immune cell behavior leads to identifying unique therapeutic targets and improving clinical *** review summarizes the impact of different types of amino acid metabolism on the behaviors of dendritic cells and T cells,hoping to provide a valuable reference for researchers and clinicians in related fields.
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