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Combination of serum gamma-glutamyltransferase and alkaline phosphatase in predicting the diagnosis of asymptomatic choledocholithiasis secondary to cholecystolithiasis

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World Journal of Clinical Cases 2019年第2期7卷 137-144页

作者： Yong Mei Li Chen Peng-Fei Zeng Ci-jun Peng jun Wang Wen-Ping Li Chao Du Kun Xiong Kai Leng Chun-Lin feng Ji-Hu Jia Department of Hepatopancreatobiliary Surgery the Third Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina Diagnostics Laboratory Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina Department of Hepatopancreatobiliary Surgery Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina

BACKGROUND Gamma-glutamyltransferase(GGT) is one of the most important laboratory tests for the evaluation of liver damage. Through a long-term clinical observation of patients with secondary asymptomatic choledocholithiasis, we found that most patients had abnormal GGT serum *** To investigate the combination of serum GGT and alkaline phosphatase(ALP) in predicting the diagnosis of asymptomatic choledocholithiasis secondary to *** In this retrospective cohort study, the clinical data of 829 patients with cholecystolithiasis admitted to the Third Affiliated Hospital of Zunyi Medical College from August 2014 to August 2017 were collected. Among these patients,151 patients had secondary asymptomatic choledocholithiasis and served as the observation group, and the remaining 678 cholecystolithiasis patients served as the control group. Serum liver function indexes were detected in both groups,and the receiver operating characteristic(commonly known as ROC) curves were constructed for markers showing statistical significances. The cutoff value,sensitivity, and specificity of each marker were calculated according to the ROC *** The overall incidence of asymptomatic choledocholithiasis secondary to cholecystolithiasis was 18.2%. The results of liver function indexes including serum aspartate aminotransferase, alanine aminotransferase, direct bilirubin and total bilirubin levels showed no significant differences between the two groups(P> 0.05). However, the serum GGT and ALP levels were significantly higher in the observation group than in the control group(P < 0.05). The ROC curve analysis showed that the area under the curve was 0.881(95%CI: 0.830-0.932), 0.647(95%CI: 0.583-0.711) and 0.923(0.892-0.953) for GGT, ALP, and GGT + ALP,respectively. The corresponding cut-off values of GGT and ALP were 95.5 U/L and 151.5 U/L, sensitivity were 90.8% and 65.1%, and specificity were 83.6% and59.8%, respectively. The sensitivity and specifi

关键词： Asymptomatic choledocholithiasis Gamma-glutamyltransferase Cholecystolithiasis Alkaline phosphatase Diagnosis Screening

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Effect of decompression range on decompression limit of cervical laminoplasty

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Chinese Medical Journal 2020年第8期133卷 909-918页

作者： Yin-Ze Diao Miao Yu feng-Shan Zhang Yu Sun Shao-Bo Wang Li Zhang sheng-Fa Pan Zhong-jun Liu Wei-Shi Li Department of Orthopedics Institute of Spinal SurgeryPeking University Third HospitalBeijing Key Laboratory of Spinal DiseaseBeijing 100191China

Backgrounds:Cervical posterior decompression surgery is used to relieve ventral compression indirectly by incorporating a backward shift of the spinal cord, and this indirect decompression is bound to be limited. This study aimed to determine the decompression limit of posterior surgery and the effect of the decompression ***:We retrospectively reviewed the data of 129 patients who underwent cervical open-door laminoplasty through 2008 to 2012 and were grouped as follows: C4-C7 ( n = 11), C3-C6 ( n = 61), C3-C7 ( n = 32), and C2-C7 ( n = 25). According to the relative location of spinal levels within a decompression range, the type of decompression at a given level was categorized as external decompression (ED;achieved at the levels located immediately external to the decompression range margin), internal decompression (ID;achieved at the levels located immediately internal to the decompression range margin), and central decompression (CD;achieved at the levels located in the center, far from the decompression range margin). The vertebral-cord distance (VCD) was used to evaluate the decompression limit. The C2-C7 angle and VCD on post-operative magnetic resonance images were analyzed and compared between groups. The relationship between VCD and decompression type was analyzed. Moreover, the relationship between the magnitude of the ventral compressive factor and the probability of post-operative residual compression at each level for different decompression ranges was studied. Results:There was no significant kyphosis in cervical curvature (>-5°), and there was no significant difference among the groups ( F = 2.091, P = 0.105). The VCD of a specific level depended on the decompression type of the level and followed this pattern: ED < ID < CD ( P < 0.05). The decompression type of a level was sometimes affected by the decompression range. For a given magnitude of the ventral compressive factor, the probability of residual compression was lower for the group

关键词： Cervical spondylosis Ossification of posterior longitudinal ligament Magnetic resonance imaging Laminoplasty

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A review on WO_(3)-based composite photocatalysts:synthesis,catalytic mechanism and diversified applications

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Rare Metals 2024年第8期43卷 3441-3459页

作者： Xue Zhang Zi-Qi Zhang Yan-Dong Sun Xiao-Jia Ma feng-Xian Jin Fang-Yuan Zhang Wei-Guang Han Bo-Xiong Shen sheng-Qi Guo College of Energy and Environmental Engineering Hebei University of TechnologyTianjin 300401China Department of Food and Chemical Engineering Liuzhou Institute of TechnologyLiuzhou 545616China

Photocatalysis as an emerging "green" energy conversion technology has attracted domestic and international *** technology uses semiconductor photocatalysts to convert solar energy into directly usable chemical energy,showing great potential for application in environmental pollutant purification and clean energy production,with broad development *** many semiconductor materials,tungsten trioxide(WO_(3)) is favored by researchers in the field of photocatalysis because of its good visible light response and excellent valence band hole oxidation ***,a large number of photocatalysts based on WO_(3),in particular W03-based composite photocatalysts,have been reported,and their applications cover a wide range of *** order to promote the development of WO_(3)-based photocatalysts and provide a reference for colleagues,we present a systematic summary of the applications and research progress of W03-based composites in the field of photocatalysis in recent *** from the structural properties of WO_(3)itself,this article summarizes the preparation methods and structure-activity relationships of WO_(3)-based composite ***,it introduces the current application status of existing WO_(3)-based composite photocatalysts in CO_(2) reduction,hydrogen production,nitrogen fixation,and pollutant ***,the development prospects were analyzed.

关键词： WO_(3)-based composite photocatalysts Intrinsic characteristic Preparation method Reaction mechanism Applications

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Diastereoselective and Enantioselective Nickel-Catalyzed Reductive Coupling of Imines and Unactivated Alkenes

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CCS Chemistry 2023年第4期5卷 814-822页

作者： Biao Wang Xian-Ming Liu Kai-Xiang Zhang Wei-Min feng Li-jun Xiao Qi-Lin Zhou State Key Laboratory and Institute of Elemento-Organic Chemistry College of ChemistryNankai UniversityTianjin 300071

Herein we report a method for highly diastereoselective and enantioselective nickel-catalyzed reductive coupling of imines and unactivated alkenes.A monodentate chiral spiro phosphoramidite ligand is the key to controlling the *** efficient,straightforward method allows for the construction of chiral benzocyclic and indole-fused cyclic amines with two contiguous stereogenic centers in good yields from readily accessible starting materials.

关键词： nickel catalysis enantioselective alkenes imines reductive coupling

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膨胀阻燃聚丙烯材料燃烧的模拟研究

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高校化学工程学报 2007年第5期21卷 797-802页

作者：张峰张军青岛科技大学橡塑材料与工程教育部重点实验室山东青岛266042

通过对膨胀阻燃聚丙烯材料在锥形量热仪实验条件下燃烧的分析和研究,建立了能够描述膨胀阻燃材料升温、燃烧过程的物理模型。同时考虑传质传热过程并结合膨胀速度的经验公式,建立了膨胀阻燃聚合物燃烧的数学模型。实验中测量了样品在膨... 详细信息

通过对膨胀阻燃聚丙烯材料在锥形量热仪实验条件下燃烧的分析和研究,建立了能够描述膨胀阻燃材料升温、燃烧过程的物理模型。同时考虑传质传热过程并结合膨胀速度的经验公式,建立了膨胀阻燃聚合物燃烧的数学模型。实验中测量了样品在膨胀燃烧过程中的样品厚度随时间变化规律。通过比较发现,模拟的样品厚度随时间变化曲线与实验结果吻合较好,模型比较可靠。模型还可模拟样品在火灾燃烧过程中的温度分布。

关键词：膨胀聚合物燃烧锥形量热仪模拟

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The long non-coding RNA expression profile of Coxsackievirus A16 infected RD cells identified by RNA-seq

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Virologica Sinica 2016年第2期31卷 131-141页

作者： Yingying Shi Huilin Tu Xiong Chen Yingying Zhang Liujun Chen Zhongchun Liu Jiqun sheng Song Han jun Yin Biwen Peng Xiaohua He Wanhong Liu Pathogenic Organism and Infectious Diseases Research Institute School of Basic Medical SciencesWuhan University Wuhan 430071 China Hubei Province Key Laboratory of Allergy and Immunology Wuhan 430071 China Hubei Provincial Key Laboratory of Developmentally Originated Disease School of Basic Medical Sciences Wuhan University Wuhan 430071 China Institute of Neuropsychiatry Renmin Hospital Wuhan University Wuhan 430060 China College of Life Science and Technology Hubei Engineering University Xiaogan 432000 China

Coxsackievirus A16(CVA16) is one of major pathogens of hand, foot and mouth disease(HFMD) in children. Long non-coding RNAs(Inc RNAs) have been implicated in various biological processes,but they have not been associated with CVA16 infection. In this study, we comprehensively characterized the landscape of Inc RNAs of normal and CVA16 infected rhabdomyosarcoma(RD)cells using RNA-Seq to investigate the functional relevance of Inc RNAs. We showed that a total of 760 Inc RNAs were upregulated and 1210 Inc RNAs were downregulated. Out of these dysregulated Inc RNAs, 43.64% were intergenic, 22.31% were sense, 15.89% were intronic, 8.67% were bidirectional, 5.59% were antisense, 3.85% were s RNA host Inc RNAs and 0.05% were enhancer. Six dysregulated Inc RNAs were validated by quantitative PCR assays and the secondary structures of these Inc RNAs were projected. Moreover, we conducted a bioinformatics analysis of an Inc RNAs(ENST00000602478) to elucidate the diversity of modification and functions of Inc RNAs. In summary, the current study compared the dysregulated Inc RNAs profile upon CVA16 challenge and illustrated the intricate relationship between coding and Inc RNAs transcripts. These results may not only provide a complete picture of transcription in CVA16 infected cells but also provide novel molecular targets for treatments of HFMD.

关键词： RNA transcripts infected bidirectional bioinformatics illustrated enhancer picture landscape genomic

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Clinical and experimental study on regional administration of phosphorus32 glassmicrospheres in treating hepatic carcinoma

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World Journal of Gastroenterology 1999年第6期5卷 492-505页

作者： LIU Lu, JIANG Zao, TENG Gao jun, SONG Ji Zhi, ZHANG Dong sheng, GUO Qing Ming, FANG Wen, HE Shi Cheng and GUO Jin He 南京铁道医科大学江苏苏州

AIM To study the therapeutical effectiveness, dosage range and toxic adverse effects of domestic phosphorus 32 glass microsphere and evaluate its clinical significance. METHODS Ⅰ. Fifty two BALB/*!c tumor bearing male nude mice were allocated into treatment group( n =38) and control group( n =14). In the former group different doses of 32 P GMS were injected into the tumor mass, while in the latter 31 P GMS or no treatment was given. The experimental animals were sacrificed in batches, and then the tumors and their nearby tissues were examined by light and electron microscopy. Ⅱ. Through selective catheterization of hepatic artery, 32 P GMS was infused to 5 healthy domestic pigs in a dosage equivalent to the therapeutic dose for human being, and 31 P GMS was infused to another 5 healthy domestic pigs. Two pigs infused with contrast medium served as whole course blank controls. One pig from each group was surrendered to euthanasia at week 1, 4, 8 and 16 respectively. The ultrastructural histopath ological changes in liver tissues taken from different sites were evaluated semiquan titatively. Ⅲ. One hundred and twenty seven times of 32 P GMS intrahepatic artery interventional therapies were performed on 93 patients with hepatic carcinoma, including 79 cases of primary hepatic carcinoma and 14 cases of secondary hepatic carcinoma. 32 P GMS ( n =30), and group B, 32 P GMS and half dose of trans hepatic artery embolization (TAE) ( n =49) , and 18 patients with HCC by TAE only as control group C. Fourteen patients with secondary hepatic carcinoma were treated in the same way as group B or C. RESULTS Ⅰ. Comparing with the control group, the treatment group of tumor bearing nude mice attained the tumor inhibition rates of 59 7%-93 7% ( F =579 62, P <0 01) at 14*!d . At an absorbed dose of 7320Gy, the tumor cells were completely destroyed. When the absorbed doses ranged from 1830Gy to 3660Gy, most of the tumor cells showed the evidences of injury or necrosis, but there appea

关键词： liver neoplasms/therapy phosphorus 32 glass microspheres ( 32 P GMS) 31 P GMS interventional therapy

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Detection of prawn white spot baculovirusby polymerase chain reaction

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Acta Oceanologica Sinica 1999年第4期18卷 591-598页

作者： Wang Wei He jun Yang feng Wu Guikai and Xu Xun(Third Institute of Oceanography, Xiamen 361005, China) Third Institute of Oceanography Xiamen 361005 China

INTRODUCTIONAprawnbaculovirushas***,Pathogenesisandmorphologyofthevirusshowedthatitwasanon-occlUSiontheybaculoviruswhichcouldinfectPenaeusjaponicus,***,***... 详细信息

INTRODUCTIONAprawnbaculovirushas***,Pathogenesisandmorphologyofthevirusshowedthatitwasanon-occlUSiontheybaculoviruswhichcouldinfectPenaeusjaponicus,***,***...

关键词： Prawn baculovirus PCR PWSBV

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Prognostic factors and predictors of postoperative adjuvant transcatheter arterial chemoembolization benefit in patients with resected hepatocellular carcinoma

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World Journal of Gastroenterology 2020年第10期26卷 1042-1055页

作者： Ming-Yu Chen Sarun Juengpanich Jia-Hao Hu Win Topatana Jia-sheng Cao Chen-Hao Tong Jian Lin Xiu-jun Cai Department of General Surgery Sir Run-Run Shaw HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina School of Medicine Zhejiang UniversityHangzhou 310016Zhejiang ProvinceChina Engineering Research Center of Cognitive Healthcare of Zhejiang Province Hangzhou 310000Zhejiang ProvinceChina Department of General Surgery Shaoxing People’s HospitalZhejiang UniversityShaoxing 312000Zhejiang ProvinceChina Department of General Surgery Longyou People’s HospitalQuzhou 314400Zhejiang ProvinceChina

BACKGROUND Postoperative adjuvant transcatheter arterial chemoembolization (PA-TACE) has improved overall survival (OS) in patients with hepatocellular carcinoma (HCC).However,the prognostic and predictive factors remain *** To assess the prognostic factors and the predictors of PA-TACE benefit for OS in patients with resected *** Univariate and multivariate analyses were performed to identify the potential prognostic factors for *** order to assess the predictive factors of PA-TACE benefit,the interaction variables between treatments for each subgroup were evaluated using the Cox proportional hazards regression *** A total of 378 patients (PA-TACE vs surgery alone,189:189) from three centerswere included after a propensity-score 1:1 matching *** to the group receiving surgery alone,PA-TACE prolonged the OS rate in patients with resected HCC (P <0.001).The Barcelona Clinic Liver Cancer system and ferritinto-hemoglobin ratio (FHR) were used as the prognostic factors for OS in both *** (P=0.023) and microscopic vascular invasion (MVI)(P=0.002) were also identified in the PA-TACE group,while gender (P=0.027),hepatitis B virus(P=0.034) and albumin-bilirubin grade (P=0.027) were also selected in the surgery alone *** addition,PA-TACE resulted in longer OS than surgery alone across subgroups [all hazard ratios (PA-TACE-to-surgery alone)<1].Notably,a significantly prolonged OS following PA-TACE was observed in patients with high FHR (P=0.038) and without MVI (P=0.048).CONCLUSION FHR and Barcelona Clinic Liver Cancer stages were regarded as prognostic factors for ***,high FHR and the absence of MVI were important predictive factors,which can be used to assist clinicians in selecting which patients could achieve a better OS with PA-TACE.

关键词： Postoperative adjuvant transcatheter arterial chemoembolization Hepatocellular carcinoma Prognostic factors Predictive factors Overall survival

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金属螯合蛋白异源表达提高***对镉的生物吸附能力:修复潜力和潜在机制

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Journal of Central South University 2024年第4期31卷 1265-1275页

作者：武晨吴玉俊易盛炜李峰 College of Environment and Resources Xiangtan UniversityXiangtan 411105China Hunan Provincial University Key Laboratory for Environmental and Ecological Health Xiangtan UniversityXiangtan 411105China Hunan Provincial University Key Laboratory for Environmental Behavior and Control Principle of New Pollutants Xiangtan UniversityXiangtan 411105China

镉(Cd)作为一种生物非必需的有毒重金属,通过自然排放或人类活动进入环境,对人类健康构成威胁。在微生物中高效表达金属螯合蛋白(MCP)可以增强生物对Cd的吸附能力。本研究构建了mcp基因编码的MCP的异源表达体系(GEM01),探究了其对Cd的... 详细信息

镉(Cd)作为一种生物非必需的有毒重金属,通过自然排放或人类活动进入环境,对人类健康构成威胁。在微生物中高效表达金属螯合蛋白(MCP)可以增强生物对Cd的吸附能力。本研究构建了mcp基因编码的MCP的异源表达体系(GEM01),探究了其对Cd的吸附效果和潜在机制。结果表明,Cd^(2+)调控GEM01中mcp基因丰度,mcp基因的表达增加了Cd^(2+)的生物吸附能力(8.09 mg/g,比对照组高2.32倍)。在GEM01自溶过程中Cd^(2+)的保留率为87.87%。荧光光谱和分子动力学模拟表明了Cd^(2+)与MCP之间存在较强的相互作用且Cd^(2+)影响了MCP的二级结构。FT-IR证明了MCP中的官能团(如羧基、甲基和亚甲基)参与了MCP与Cd^(2+)的相互作用。分子对接进一步表明MCP蛋白表面的一些极性和亲水残基(如天冬酰胺、谷氨酰胺、丝氨酸和组氨酸)通过静电引力与Cd^(2+)结合。本研究为MCP介导的Cd^(2+)生物修复提供了新的见解,为微生物修复重金属污染提供了基因资源。

关键词：镉 mcp基因金属螯合蛋白相互作用微生物修复

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