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Muscle hypertrophy in transgenic mice due to over-expression of porcine myostatin mutated at its cleavage site

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Journal of Integrative Agriculture 2016年第11期15卷 2571-2577页

作者： QIAN Li-li MA De-zun GAO Peng-fei JIANG Sheng-wang WANG qing-qing cai Chun-bo XIAO Gao-jun AN Xiao-rong CUI Wen-tao State Key Laboratory of Agrobiotechnology China Agricultural University State Key Laboratory for Animal Nutrition Institute of Animal ScienceChinese Academy of Agricultural Sciences

Myostatin, a member of the transforming growth factor beta（TGF-β） superfamily, is a dominant inhibitor that acts to limit skeletal muscle growth and development. In this study, we generated transgenic mice that express porcine myostatin containg mutations at its cleavage site（RSRR） to evaluate its effect on muscle mass. Results showed that the weight of four skeletal muscles including gastrocnemius, rectus femoris, tibialis anterior, and pectoralis increased by 17.83 and 28.39%, 21.76 and 28.70%, 34.31 and 41.62%, 53.21 and 27.54% in transgenic male and female mice, respectively, compared to their corresponding non-transgenic control mice. Measurement of muscle fiber size and number indicated that the mean myofiber size increased by 50.73 and 61.30% in transgenic male and female mice respectively compared to the non-transgenic controls. However, there was no difference in the number of myofiber between transgenic and non-transgenic male mice. These results clearly demonstrated that the increase in skeletal muscle mass in transgenic mice is caused by hypertrophy instead of hyperplasia.

关键词： porcine myostatin muscle mass transgenic mice mutation hypertrophy hyperplasia

Effect of cold snare polypectomy for small colorectal polyps

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World Journal of Clinical Cases 2022年第19期10卷 6446-6455页

作者： qing-qing Meng Min Rao Pu-jun Gao Department of Hepatology and Gastroenterology The Second Part of First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Hepatology The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina

BACKGROUND Colorectal cancer remains a considerable challenge in healthcare *** 60%-80%of colorectal cancer is caused by intestinal polyps,and resection of intestinal polyps has been proved to reduce the incidence of colorectal *** vast majority of intestinal polyps can be found during colonoscopy and removed ***,more attention has been paid to the development of endoscopic resection of intestinal *** this study,we compared the efficacy and safety of cold snare polypectomy(CSP)and hot snare polypectomy(HSP).AIM To investigate the efficacy and safety of CSP and HSP for colorectal *** Between January and December 2020,301 patients with colorectal polyps 4-9 mm in diameter were treated with endoscopic therapy in our hospital,and were divided into the CSP group(n=154)and HSP group(n=147).The operating time,incidence of bleeding and perforation,use of titanium clips,and complete resection rate were compared between the two *** We included 249 patients(301 polyps).No differences in gender,age,and polyp size,location,shape and type were observed between the CSP and HSP groups,and the resection rates in these two groups were 93.4%and 94.5%,respectively,with no significant *** use of titanium clips was 15.6%and 95.9%,the operating time was 3.2±0.5 min and 5.6±0.8 min,the delayed bleeding rate was 0%and 2.0%,and delayed perforation was 0%and 0.7%,in the CSP and HSP groups,*** sessile colorectal polyps < 10 mm, CSP had the same resection rate of impaired tissue integrityas traditional HSP had. The rate of complications was lower in the CSP group. CSP is a safe andeffective method for polypectomy.

关键词： Colorectal polyps Cold snare polypectomy Hot snare polypectomy Complete polypectomy rate Immediate bleeding Delayed bleeding

Prenatal Hypoxia Altered Angiotensin Ⅱ-mediated Vasoconstrictions via PKC/ERK/ROCK Pathways and Potassium Channels in Rat Offsrping Middle Cerebral Artery

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Biomedical and Environmental Sciences 2021年第3期34卷 250-255页

作者： LI Da Wei BO Lel TU qing ZHOU An Wen SHI Lin Ling YANG Xiao jun MAO cai Ping Reproductive Medicine Center The First Affiliated Hospital of Soochow UniversitySuzhou 215000JiangsuChina Gynaecology and Obstetrics Suzhou Ninth People's HospitalSuzhou 215000JiangsuChina

Adverse environmental factors or prenatal insults may cause developmental and pathological changes in the brain[1].Previous studies showed that a number of unfavorable prenatal factors might trigger the pathological changes of adult diseases such as hypertension and diabetes mellitus[2].It is rational that inner-utero hypoxia could be a common problem of prenatal insults-induced development.

关键词： Potassium Angiotensin diseases

Numerical Simulation of Random Wave Overtopping of Rubble Mound Breakwater with Armor Units

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China Ocean Engineering 2021年第2期35卷 176-185页

作者： LI Jing-yuan ZHANG qing-he LU Yong-jun State Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin UniversityTianjin 300072China State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Nanjing Hydraulic Research InstituteNanjing 210029China

Based on the open source code OpenFOAM,a three-dimensional model is presented for simulation of the interaction between waves and rubble mound breakwater with armor *** armor units with their real geometries are depicted through computational *** volume-averaged RANS equation and the seepage equation containing nonlinear term are used to describe the percolation in the core and underlayer of the *** independence analysis are carried out,the horizontal and vertical grid size are recommended to take as one-fifteenth of the mean nominal diameter D_(50) of the armor units and one-fifteenth of the wave height *** wave overtopping of rubble mound breakwater with armor units is simulated through the proposed *** results show good agreement between the simulated and measured overtopping discharge rates for different types of armor *** developed numerical model can be used to evaluate the random wave overtopping in design of rubble mound breakwater with artificial armor blocs.

关键词： random wave armor units seepage equation overtopping discharges grid independence

Precipitation and stability of reversed austenite in 9Ni steel

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International Journal of Minerals,Metallurgy and Materials 2010年第5期17卷 587-595页

作者： Yue-hui Yang qing-wu cai Di Tang Hui-bin Wu Research Institute of Metallurgical Engineering University of Science and Technology Beijing Beijing 100083 China

A new method was used to analyze the factors affecting the precipitation of reversed austenite during tempering. The samples were kept at various tempering temperatures for 10 min and their length changes were recorded. Then, the precipitation of reversed austenite which led to the length reduction was shown by thermal expansion curves. The results show that the effects of process parameters on the precipitation of reversed austenite can be determined more accurately by this method than by X-ray diffraction. When the quenching and tempering process is adopted, both the lower quenching temperature and higher tempering temperature can promote the precipitation of reversed austenite during tempering; and when the quenching, lamellarizing, and tempering process is used, intercritical quenching is considered beneficial to the precipitation of reversed austenite in the subsequent tempering because of Ni segregation during holding at the intercritical temperature.

关键词： cryogenic equipment low carbon steel reversed austenite precipitation stability thermal expansion measurement

Simultaneous liver, pancreas-duodenum and kidney transplantation in a patient with hepatitis B cirrhosis, uremia and insulin dependent diabetes mellitus

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World Journal of Gastroenterology 2017年第45期23卷 8104-8108页

作者： Jiang Li qing-jun Guo Jin-Zhen cai Cheng Pan Zhong-Yang Shen Wen-Tao Jiang Department of Liver Transplant Tianjin First Central Hospital Department of Transplant Surgery Tianjin First Central Hospital

Simultaneous liver,pancreas-duodenum,and kidney transplantation has been rarely reported in the literature. Here we present a new and more efficient en bloc technique that combines classic orthotopic liver and pancreas-duodenum transplantation and heterotopic kidney transplantation for a male patient aged 44 years who had hepatitis B related cirrhosis,renal failure,and insulin dependent diabetes mellitus(IDDM). A quadruple immunosuppressive regimen including induction with basiliximab and maintenance therapy with tacrolimus,mycophenolate mofetil,and steroids was used in the early stage post-transplant. Postoperative recovery was uneventful and the patient was discharged on the 15 th postoperative day with normal liver and kidney function. The insulin treatment was completely withdrawn 3 wk after operation,and the blood glucose level remained normal. The case findings support that abdominal organ cluster and kidney transplantation is an effective method for the treatment of end-stage liver disease combined with uremia and IDDM.

关键词： Insulin dependent diabetes mellitus Cirrhosis Chronic renal failure Transplantation En bloc Liver-pancreas

A pyridoxal-based chemosensor for visual detection of copper ion and its application in bioimaging

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Chinese Chemical Letters 2014年第9期25卷 1230-1234页

作者： cai-Xia Yin Li-jun Qu Fang-jun Huo Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Institute of Molecular ScienceShanxi University Research Institute of Applied Chemistry Shanxi University

A pyridoxal-based chemosensor was synthesized by reacting hydrazine hydrate and pyridoxal hydrochloride in ethanol and characterized by NMR and ESI-MS. The optical properties of the compound were investigated in a methanol： HEPES solution. The compound displayed selectivity for Cu2＋, as evidenced by a colorless to yellow color change, which was characterized using UV-vis spectroscopy. The fluorescence of the compound can be quenched only by Cu2＋, accompanying by a color change from blue to colorless. Furthermore, it can be used in bioimaging.

关键词： Pyridoxal-based Copper ion Chemosensor Bioimaging

Myopia genetics in genome-wide association and postgenome-wide association study era

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International Journal of Ophthalmology(English edition) 2019年第9期12卷 1487-1492页

作者： Xuan Liao qing-qing Tan Chang-jun Lan Department of Ophthalmology Affiliated Hospital of North Sichuan Medical CollegeDepartment of Ophthalmology and Optometry North Sichuan Medical College

Genome-wide association studies(GWAS) of myopia and refractive error have generated exciting results and identified novel risk-associated loci. However, the interpretation of the findings of GWAS of complex diseases is not straightforward and has remained challenging. This review provides a brief summary of the main focus on the advantages and limitations of GWAS of myopia, with potential strategies that may contribute to further insight into the genetics of myopia in the post-GWAS or omics era.

关键词： myopia genetic variation genome-wide association studies omics

Large leiomyoma of lower esophagus diagnosed by endoscopic ultrasonography–fine needle aspiration:A case report

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World Journal of Clinical Cases 2020年第22期8卷 5809-5815页

作者： Min Rao qing-qing Meng Pu-jun Gao Department of Hepatology and Gastroenterology The Second Part of First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Hepatology The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina

BACKGROUND Benign esophageal tumors are rare accounting for5 cm are *** describe a case of a large esophageal leiomyoma involving the cardia and *** SUMMARY A 35-year-old woman presented to the doctor because of a choking sensation after *** examination showed no positive *** indicated an uplifted change in the *** computed tomography revealed spaceoccupying lesions in the lower part of the esophagus and cardia,which were likely to be *** emission tomography–computed tomography showed increased metabolism of soft tissue masses in the lower esophagus and near the *** lesions were considered,and mesenchymal tumors were not *** ultrasonography was performed to examine a hypoechoic mass in the lower esophagus,which was unclear from the esophageal *** evaluation suggested diagnosis of esophageal and cardiac stromal ***,histological specimens obtained by endoscopic ultrasonography–fine needle aspiration suggested *** patient underwent laparoscopic local resection of the *** postoperative pathological diagnosis was *** Endoscopic ultrasonography-fine needle aspiration is necessary for the diagnosis of gastrointestinal *** provides a strong basis for diagnosis of gastrointestinal tumors of unknown nature and origin.

关键词： Esophageal tumor Leiomyoma Endoscopic ultrasonography Fine needle aspiration Endoscopic ultrasonography-fine needle aspiration Case report