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Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng jun-Hong Wu Dan-Dan Xu Kang He Chang-Qing Liu Li-Fei Song Zheng-Zhi Wu qian-qian Jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

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竞争环境下双目标零售平台销售模式选择

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管理工程学报 2025年第1期39卷 227-242页

作者：张冲朱祎宋君南京邮电大学管理学院

电子商务行业发展迅速,具有“超越利润”战略导向以实现更广泛目标的组织正变得越来越普遍,兼顾消费者利益成为企业凸显竞争优势的方式。为此,本文构建由一个制造商和两个零售平台组成的两级供应链。其中,制造商和其中一个零售平台追求... 详细信息

电子商务行业发展迅速,具有“超越利润”战略导向以实现更广泛目标的组织正变得越来越普遍,兼顾消费者利益成为企业凸显竞争优势的方式。为此,本文构建由一个制造商和两个零售平台组成的两级供应链。其中,制造商和其中一个零售平台追求自身利润最大化,另外一个零售平台追求自身利润和消费者剩余的线性组合最大化,即考虑双目标最优。本文具体考虑两个零售平台分别选择转售模式或代理模式共四种情形,进而研究双目标零售平台销售模式选择问题,及其对供应链成员最优决策和供应链整体绩效的影响。结果表明:(1)在一定条件下,双目标零售平台能获得比竞争对手更高的利润;(2)当双目标零售平台选择转售模式时,无论其竞争对手选择哪种销售模式,其双目标策略都能使供应链总体利润得到优化;(3)当双目标零售平台的竞争对手选择代理模式时,其自身根据不同情况选择转售模式或者代理模式可以使两个零售平台的销售模式选择形成均衡。

关键词：双目标企业社会责任零售平台销售模式双渠道

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Discovery of a new family member of arsenic–vanadium polyoxometalates with high catalytic performance for one-pot coupling of CO2, epoxides and amines

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Tungsten 2025年第1期 80-87页

作者： Fang-qian Wang Yin zhang Wei-Wei Wang Mei-qian Fu Hong-Bing Mo Wei-Dong Yu Chao Liu jun Yan College of Chemistry and Chemical Engineering Central South University junior Education Department Changsha Normal University School of Science Hunan University of Technology and Business

Arsenic-vanadium polyoxometalates（POMs） represent a family of tremendous potential catalysts owing to their peculiar physical and chemical *** in CO2conversion,using POMs to catalyze the conversion of CO2and epoxide into chemical intermediates is the research ***,A new family number of arsenic-vanadium POMs,[N（CH3）4]4[As8V12O38（H2O）]·2H2O({As8V12O38}),was reported and characterized by single-crystal X-ray diffraction,fourier transform infrared spectroscopy,X-ray photoelectron spectroscopy,*** from other allotropicity,{As8V12O38}shows a different structure pattern with an I-43d *** obtained {As8V12O38} was employed as a catalyst for the *** initial catalytic reaction confirmed that {As8V12O38} can catalyze the formation of epoxy carbonate by using 1.01 kPa CO2and epoxide at 70℃.Furtherly,when added amine in the catalytic system,oxazolidinone could be obtained by high yields,which provides an efficient way to convert CO2into profitable ***,a possible catalytic reaction mechanism was proposed by using different characterization analyses.{As8V12O38} first catalyzes the epoxide and CO2to form an epoxy carbonate and then catalyzes epoxy carbonate and benzylamine into oxazolidinone.

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Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

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Science China Life Sciences 2025年第1期 300-302页

作者： Ze-Min Lin Mai Xiang Wen-Hui Wei Shu-Hui Fan Li Chen Jie Wang Xiao-qian Yang Chun-Hao Yang Shi-jun He Jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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Persistent alterations in gray matter in COVID-19 patients experiencing sleep disturbances:a 3-month longitudinal study

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Neural Regeneration Research 2025年第10期20卷 3013-3024页

作者： Kaixuan Zhou Gaoxiong Duan Ying Liu Bei Peng Xiaoyan Zhou Lixia Qin Lingyan Liang Yichen Wei Qingping zhang Xiaocheng Li Haixia Qin Yinqi Lai Yian Lu Yan zhang Jiazhu Huang Jinli Huang Yinfei Ouyang Bolin Bin Mingming Zhao jun Liu Jianrong Yang Demao Deng Guangxi Key Laboratory of Special Biomedicine School of MedicineGuangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology the People’s Hospital of Guangxi Zhuang Autonomous RegionGuangxi Academy of Medical SciencesNanningGuangxi Zhuang Autonomous RegionChina Department of Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Guangxi Clinical Research Center for Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina

Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 *** studies have demonstrated abnormal brain structures in patients with sleep disturbances who have recovered from coronavirus disease 2019(COVID-19).However,neuroimaging studies on sleep disturbances caused by COVID-19 are scarce,and existing studies have primarily focused on the long-term effects of the virus,with minimal acute phase *** a result,little is known about the pathophysiology of sleep disturbances in the acute phase of *** address this issue,we designed a longitudinal study to investigate whether alterations in brain structure occur during the acute phase of infection,and verified the results using 3-month follow-up data.A total of 26 COVID-19 patients with sleep disturbances(aged 51.5±13.57 years,8 women and 18 men),27 COVID-19 patients without sleep disturbances(aged 47.33±15.98 years,9 women and 18 men),and 31 age-and gender-matched healthy controls(aged 49.19±17.51 years,9 women and 22 men)were included in this *** COVID-19 patients with sleep disturbances were included in a longitudinal *** found that COVID-19 patients with sleep disturbances exhibited brain structural changes in almost all brain *** cortical thicknesses of the left pars opercularis and left precuneus were significantly negatively correlated with Pittsburgh Sleep Quality Index ***,we observed changes in the volume of the hippocampus and its subfield regions in COVID-19 patients compared with the healthy *** 3-month follow-up data revealed indices of altered cerebral structure(cortical thickness,cortical grey matter volume,and cortical surface area)in the frontal-parietal cortex compared with the baseline in COVID-19 patients with sleep *** findings indicate that the sleep disturbances patients had altered morphology in the cortical an

关键词： brain structure cortical gray matter volume cortical surface area cortical thickness hippocampus magnetic resonance imaging Pittsburgh Sleep Quality Index severe acute respiratory syndrome coronavirus 2 infections sleep disturbances sub-cortical volume

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中低温环境下太阳能蓄热系统传热特性研究

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节能技术 2016年第5期34卷 392-394,399页

作者：毛前军张丽娅方曦武汉科技大学城市建设学院湖北武汉430065 东北石油大学土木建筑学院黑龙江大庆163318

本文基于当前国内外能源结构和形势,结合工程热力学、传热学、流体力学、光学等学科知识,采用数值模拟方法,着重开展一种太阳能蓄热系统的传热特性研究。研究结果显示6种不同截面(坐标位置分别为:0 mm,100 mm,200 mm,300 mm,400 mm,500 ... 详细信息

本文基于当前国内外能源结构和形势,结合工程热力学、传热学、流体力学、光学等学科知识,采用数值模拟方法,着重开展一种太阳能蓄热系统的传热特性研究。研究结果显示6种不同截面(坐标位置分别为:0 mm,100 mm,200 mm,300 mm,400 mm,500 mm)工况下,温度分布呈现多种变化趋势,模拟结果也显示系统的总加载时间约为12 000 s。本文的研究结果将为太阳能高效利用及能源可持续发展提供技术参考和支持。

关键词：太阳能蓄热储罐数值模拟传热特性加载时间

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Accuracy and Consistency of the Explicit-Invariant Energy Quadratization Approach for the Cahn-Hilliard Equation

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Journal of Mathematical Research with Applications 2025年第1期 84-104页

作者： jun zhang Fangying SONG Yu zhang Computational Mathematics Research Center Guizhou University of Finance and Economics School of mathematics and statistics Guizhou University of Finance and Economics School of Mathematics and Stastistics Fuzhou University

It is well known that the explicit-invariant energy quadratization (EIEQ) approach can generate fully decoupled, linear and unconditionally energy-stable numerical schemes, so it is favored by many researchers. However, the undeniable fact is that the numerical method obtained by EIEQ approach preserves the “modified” energy law instead of the original *** is mainly due to the introduction of some auxiliary variables in EIEQ scheme, and the truncation error will make the auxiliary variables deviate from the original definition in the process of numerical calculation. The primary objective of this paper is to address this gap by providing the accuracy and consistency of the EIEQ method in the context of the CahnHilliard equation. We introduce a relaxation technique for auxiliary variables and construct two numerical schemes based on EIEQ. The analysis results show that the newly constructed schemes are not only unconditionally energy stable, linear and fully decoupled, but also can effectively correct the errors introduced by auxiliary variables and follow the original energy ***, several 2D and 3D numerical examples illustrate the accuracy and efficiency of the newly constructed numerical schemes.

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De novo synthesis of atropisomeric benzofurans via Cu/SPDO complex catalyzed asymmetric formal [3 + 2] annulation

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Science China Chemistry 2025年第1期 174-180页

作者： Fan-Xiao Meng Xing-Yu Wang Ka Lu Ju-Song Yang Fu-Min zhang Ai-jun Ma Bao Du Yong-qiang Tu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University School of Biotechnology and Health Sciences Wuyi University

Herein, the de novo synthesis of atropisomeric benzofurans through the Cu/spirocyclic-pyrrolidine-oxazoline(SPDO) complex catalyze asymmetric formal [3 + 2] cycloaddition between quinones and ynamides is explored, producing a range of structurally diverse axially chiral benzofurans in satisfactory yields with good to excellent enantioselectivities. Furthermore, density functional theory calculations were applied to explain the possible reaction mechanism.

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基于2018-2022年国家自然科学基金结题项目分析干细胞研究现状

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中国组织工程研究 2025年第19期29卷 4145-4150页

作者：蒋君张玢中国医学科学院医学信息研究所北京市100005

背景:目前大多数研究从国家自然科学基金资助论文和项目申请角度出发,对干细胞某一方面进行深入分析,或者验证某种评价方法,缺乏对干细胞领域国家自然科学基金已结题项目的全面分析。目的:了解2018-2022年干细胞领域国家自然科学基金结... 详细信息

背景:目前大多数研究从国家自然科学基金资助论文和项目申请角度出发,对干细胞某一方面进行深入分析,或者验证某种评价方法,缺乏对干细胞领域国家自然科学基金已结题项目的全面分析。目的:了解2018-2022年干细胞领域国家自然科学基金结题项目资助情况及研究热点,为后续研究提供参考。

关键词：干细胞国家自然科学基金聚类分析研究热点文献计量学

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Revolutionizing breast cancer detection:Advances in fluorescent probe technology

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Nano Research 2025年第1期18卷 653-674页

作者： qian Gao Lin Tang jun Zhan Yiyuan Xue Feng Luo State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases West China Hospital of StomatologySichuan UniversityChengdu 610041China Emergency Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China Department of Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China Department of Prosthodontics West China School of StomatologySichuan UniversityChengdu 610041China

With the increasing incidence of breast cancer globally,there is an urgent demand for enhanced diagnostic and therapeutic *** comprehensive review explores advancements in fluorescent probe technology for breast cancer imaging and early *** probes offer unparalleled sensitivity and specificity in detecting cancer biomarkers,enabling early diagnosis and delineation of tumor margins during *** categorize these probes into molecular,nano,ratiometric,the second near-infrared window(NIR-II),and multifunctional varieties,each with unique capabilities for targeting specific cancer *** review highlights recent innovations in probe design,emphasizing their applications in pathogenesis studies,drug development,precision medicine,and fluorescence-guided *** their promising clinical potential,challenges such as safety,biomarker targeting accuracy,system compatibility,and clinical translation *** these hurdles is crucial for the integration of fluorescent probes into standard cancer care,aiming to improve treatment outcomes and patient quality of life.

关键词： breast cancer fluorescent probes imaging early diagnosis biomarker

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