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Two missense STK11 gene variations impaired LKB1/adenosine monophosphate-activated protein kinase signaling in Peutz-Jeghers syndrome

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1532-1546页

作者： Jin Liu Si-Cong Zeng An Wang Hai-Ying Cheng qian-jun zhang Guang-Xiu Lu Hunan Guangxiu Hospital Hunan Normal UniversityChangsha 410000Hunan ProvinceChina Scientific Research Department Reproductive and Genetic Hospital of Citic-XiangyaChangsha 410000Hunan ProvinceChina

BACKGROUND Peutz-Jeghers syndrome(PJS)is a rare hereditary neoplastic disorder mainly associated with serine/threonine kinase 11(STK11/LKB1)gene *** genetic testing can protect a patient’s offspring from mutated genes;however,some variations in this gene have been interpreted as variants of uncertain significance(VUS),which complicate reproductive decision-making in genetic *** To identify the pathogenicity of two missense variants and provide clinical *** Whole exome gene sequencing and Sanger sequencing were performed on the peripheral blood of patients with PJS treated at the Reproductive and Genetic Hospital of *** was employed to predict the protein structure,conservation,and pathogenicity of the two missense variation sites in patients with ***,plasmids were constructed and transfected into HeLa cells to observe cell *** differences in signal pathway expression between the variant group and the wild-type group were compared using western blot and *** analysis was performed using one-way analysis of variance.PG(***297Gly)and c.733C>T(***245Phe)]in 9 unrelated PJS families who were seeking reproductive *** two missense VUS were located in the catalytic domain of serine/threonine kinase,which is a key structure of the liver kinase B1(LKB1)*** vitro experiments showed that the phosphorylation levels of adenosine monophosphate-activated protein kinase(AMPK)at Thr172 and LKB1 at Ser428 were significantly higher in transfected variation-type cells than in wild-type *** addition,the two missense STK11 variants promoted the proliferation of HeLa *** immunohistochemical analysis showed that phosphorylated-AMPK(Thr172)expression was significantly lower in gastric,colonic,and uterine polyps from PJS patients with misse

关键词： Missense STK11 Peutz-Jeghers syndrome Rare disease Genetic counseling Assisted reproductive technique

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Two-dimensional analysis of progressive delamination in thin film electrodes

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Acta Mechanica Sinica 2018年第2期34卷 359-370页

作者： Mei Liu Bo Lu Dong-Li Shi jun-qian zhang Shanghai Institute of Applied Mathematics and Mechanics Shanghai University Department of Mechanics Shanghai University Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai University Materials Genome Institute Shanghai University

By employing the two-dimensional analysis, i.e.,plane strain and plane stress, a semi-analytical method is developed to investigate the interfacial delamination in electrodes. The key parameters are obtained from the governing equations, and their effects on the evolution of the delamination are evaluated. The impact of constraint perpendicular to the plane is also investigated by comparing the plane strain and plane stress. It is found that the delamination in the plane strain condition occurs easier, indicating that the constraint is harmful to maintain the structure stability. According to the obtained governing equations, a formula of the dimensionless critical size for delamination is provided, which is a function of the maximum volumetric strain and the Poisson’s ratio of the active layer.

关键词： Lithium-ion battery Thin film electrode Delamination Critical size

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The Setting of Boundary Conditions for Boundary Value Problems of Hyperbolic-elliptic Coupled Systems

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Acta Mathematicae Applicatae Sinica 2008年第3期24卷 375-390页

作者： Shu-xing Chen Ze-jun Wang Yong-qian zhang School of Mathematical Sciences Fudan University Shanghai 200433 China

This paper is devoted to the study of the proper setting of the boundary conditions for the boundary value problems of the hyperbolic-elliptic coupled systems of first order. The wellposedness of the corresponding boundary value problems is also established. The Lopatinski conditions for the boundary value problems of the elliptic systems is then extended to the case for hyperbolic-elliptic coupled systems. The result in this paper can be applied to the Euler system in fluid dynamics, especially to give wellposed boundary value problems describing subsonic flow.

关键词： Boundary value problems hyperbolic-elliptic coupled systems pseudo-differential operators

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Analysis of delamination in thin film electrodes under galvanostatic and potentiostatic operations with Li-ion diffusion from edge

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Acta Mechanica Sinica 2013年第3期29卷 348-356页

作者： Bo Lu Yi-Cheng Song Zhan-Sheng Guo jun-qian zhang Shanghai Institute of Applied Mathematics and Mechanics Shanghai University Department of Mechanics Shanghai University Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai University

Progressive delamination driven by Li-ion diffusion in elastic disk-like thin film electrodes of Li-ion batteries is modeled based on the cohesive model. Axisymmetric diffusion model is considered under both galvanostatic and potentiostatic operations. The effect of edge diffusion on the delamination process is evaluated. It is found that the diffusion from edge leads to an earlier delamination initiation. The edge effect is significant for active disks with a small aspect ratio, but negligible for the case of large aspect ratio. The edge diffusion is weaker in the potentiostatic operation than in the galvanostatic operation.

关键词： Lithium-ion battery · Thin film electrode · De-lamination · Diffusion

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Effect of Coarse Aggregate Size on Relationship between Stress and Crack Opening in Normal and High Strength Concretes

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Journal of Materials Science & Technology 2005年第5期21卷 85-94页

作者： jun zhang qian LIU and Lin WANGDepaxtment of Civil Engineering, Tsinghua University, Beijing 100084, China Department of Civil Engineering Tsinghua University Beijing 100084 China

Fine and coarse aggregates play an important role in the fracture of concrete. However, quantitative informationavailable on the effect of the coarse aggregate size on the fracture properties of concrete is still limited. In the presentpaper, the effect of coarse aggregate size (single grade of 5~10, 10~16, 16~20 and 20~25 mm) on stress-crackopening (σ-ω) relation in normal and high strength concretes (compressive strength of 40 and 80 MPa, respectively)was studied. The investigation was based on three-point bending tests implemented by fictitious crack analysis. Theresult shows that coarse aggregate size and cement matrix strength significantly influence the shape of σ-ω *** a given total aggregate content, in normal strength concrete, smaller size of aggregate leads to a high tensilestrength and a sharp stress drop after the peak stress. The smaller the coarse aggregate, the steeper the σ-ω *** contrast, in high strength concrete, the effect of aggregate size on σ-ω relation almost vanishes. A similar σ-ωrelation is obtained for the concrete except for the case of 20~25 mm coarse aggregate size. The stress drop afterthe peak stress is more significant for high strength concrete than that for normal strength concrete. Meanwhile, thesmaller the coarse aggregate size, the higher the flexural strength. Fracture energy and characteristic length increasewith increasing coarse aggregate size in both normal and high strength concretes.

关键词： Aggregate size Stress-crack opening relation Fracture energy Bending test

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Diminishing the Perception Bias in the Working Environment Using a Network Generation-Based Framework

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Tsinghua Science and Technology 2024年第3期29卷 671-683页

作者： jun qian Tongda zhang Xiao Sun Yueting Chai Department of Automation Tsinghua UniversityBeijing 100084China Department of Mechanical and Energy Engineering Southern University of Science and TechnologyShenzhen 518055Chinaand with Systems Optimization LaboratoryStanford UniversityPalo AltoCA 94305USA

Income inequality is widespread in human society and has important implications for human ***’s perception of the environment bridges income inequality and individual behavioral *** research suggests that social income inequality is usually biased,either overestimated or ***,such phenomena have not been fully explored with quantitive prove,especially in the working environment based on performance data of actual *** fact,the correct perception of people is the basis of a fair environment for their production ***,the perception bias may weaken the adaptability and competitiveness of a company in the *** paper first confirms the prevalence of individual perception bias of income inequality within the working environment based on actual production *** results show that people tend to underestimate income inequity around them,and this underestimation grows with the real unfairness of the working ***,this paper proposes a network generation-based framework with a three-layer structure to correct perception bias using a cooperative network reengineering *** the framework,a homophily-based generative network model is proposed as the key *** simulation results show that our proposed framework effectively reduces individuals’perception bias of income inequality.

关键词： income inequality perception bias Gini coefficient factory production cooperative networkreengineering homophily-based generative network model

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Light(Science & Applications) 2024年第2期13卷 333-346页

作者： Yifan Sun qian Li Ling-jun Kong Xiangdong zhang Key Laboratory of advanced optoelectronic quantum architecture and measurements of Ministry of Education Beijing Key Laboratory of Nanophotonics&Ultrafine Optoelectronic SystemsSchool of PhysicsBeijing Institute of Technology100081BeijingChina

Compared with electrical neural networks,optical neural networks(ONNs)have the potentials to break the limit of the bandwidth and reduce the consumption of energy,and therefore draw much attention in recent *** far,several types of ONNs have been ***,the current ONNs cannot realize the acceleration as powerful as that indicated by the models like quantum neural *** to construct and realize an ONN with the quantum speedup is a huge ***,we propose theoretically and demonstrate experimentally a new type of optical convolutional neural network by introducing the optical *** is called the correlated optical convolutional neural network(COCNN).We show that the COCNN can exhibit“quantum speedup”in the training *** character is verified from the two *** is the direct illustration of the faster convergence by comparing the loss function curves of the COCNN with that of the traditional convolutional neural network(CNN).Such a result is compatible with the training performance of the recently proposed quantum convolutional neural network(QCNN).The other is the demonstration of the COCNN’s capability to perform the QCNN phase recognition circuit,validating the connection between the COCNN and the ***,we take the COCNN analog to the 3-qubit QCNN phase recognition circuit as an example and perform an experiment to show the soundness and the feasibility of *** results perfectly match the theoretical *** proposal opens up a new avenue for realizing the ONNs with the quantum speedup,which will benefit the information processing in the era of big data.

关键词： process quantum convolution

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Effect of Coarse Aggregate Size on and Crack Opening in Normal and Relationship between Stress High Strength Concretes

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Journal of Materials Science & Technology 2005年第5期21卷 691-700页

作者： jun zhang qian LIU Lin WANG Department of Civil Engineering Tsinghua University Beijing 100084 China

Fine and coarse aggregates play an important role in the fracture of concrete. However, quantitative information available on the effect of the coarse aggregate size on the fracture properties of concrete is still limited. In the present paper, the effect of coarse aggregate size （single grade of 5～10, 10～16, 16～20 and 20～25 mm） on stress-crack opening （σ-w） relation in normal and high strength concretes （compressive strength of 40 and 80 MPa, respectively） was studied. The investigation was based on three-point bending tests implemented by fictitious crack analysis. The result shows that coarse aggregate size and cement matrix strength significantly influence the shape of σ-w curve. For a given total aggregate content, in normal strength concrete, smaller size of aggregate leads to a high tensile strength and a sharp stress drop after the peak stress. The smaller the coarse aggregate, the steeper the σ-w curve. By contrast, in high strength concrete, the effect of aggregate size on σ-w relation almost vanishes. A similar σ-w relation is obtained for the concrete except for the case of 20～25 mm coarse aggregate size. The stress drop after the peak stress is more significant for high strength concrete than that for normal strength concrete. Meanwhile, the smaller the coarse aggregate size, the higher the flexural strength. Fracture energy and characteristic length increase with increasing coarse aggregate size in both normal and high strength concretes.

关键词： Aggregate size Stress-crack opening relation Fracture energy Bending test

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A Novel Sesquiterpenoid from Glechoma longituba

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Chinese Chemical Letters 2006年第3期17卷 355-357页

作者： qian jun zhang Xiao Sheng YANG Hal Yan ZHU Ye WANG Xiao Jiang HAO Bao An SONG The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences Guiyang 550002 Research and Development Center of Fine Chemicals Guizhou Univerisity Guiyang 550025

A novel sesquiterpenoid was isolated from the whole plant of Glechoma longituba. Its structure was elucidated as 1, 8-epoxy-7（11）-germacren-5-one-12, 8-olide 1 on the basis of spectral evidences.

关键词： Glechoma longituba sesquiterppenoid 1,8-epoxy-7(11)-germacren-5-one- 12,8-olide

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Evaluating the tumor stratification with a lysosomal pH sensitive-probe by fluorescence lifetime imaging

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Chinese Chemical Letters 2024年第3期35卷 262-267页

作者： jun Yan Xing Liang qian zhang Luolin Wang Weiying Lin Guangxi Key Laboratory of Electrochemical Energy Materials Institute of Optical Materials and Chemical BiologySchool of Chemistry and Chemical EngineeringGuangxi UniversityNanning 530004China

Owing to the anaerobic metabolism in the tumor,abundant acidic metabolites are produced and accumulated in the ***,the cells in different tumor layers are directly linked to the pH ***,due to the lack of robust tools,the high-efficient evaluation of the acidic micro-environment of tumor stratification faces the challenge of accurate *** designed a new pH sensitive fluorescent lifetime probe target to *** we expected,the fluorescence lifetime of PLN possesses a good linear fit to the pH value,which could detect the pH change at a single lysosome level in real time,and then evaluate the different acidity of tumor *** probe PLN is successfully used to evaluate the tumor stratification by fluorescence lifetime imaging microscopy(FLIM)for the first time,which is of great significance in the preoperative diagnosis of clinical tumor treatment or evaluation of drug delivery effect.

关键词： FLIM pH Fluorescence imaging Lysosome Tumor imaging

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