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Artificial intelligence in individualized retinal disease management

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1519-1530页

作者： Zi-Ran Zhang Jia-jun li Ke-Ran li The Affiliated Eye Hospital of Nanjing Medical University Nanjing 210029Jiangsu ProvinceChina Nanjing Medical University Nanjing 210029Jiangsu ProvinceChina

Owing to the rapid development of modern computer technologies,artificial intelligence(AI)has emerged as an essential instrument for intelligent analysis across a range of *** has been proven to be highly effective in ophthalmology,where it is frequently used for identifying,diagnosing,and typing retinal *** increasing number of researchers have begun to comprehensively map patients’retinal diseases using AI,which has made individualized clinical prediction and treatment *** include prognostic improvement,risk prediction,progression assessment,and interventional therapies for retinal *** have used a range of input data methods to increase the accuracy and dependability of the results,including the use of tabular,textual,or image-based input *** also combined the analyses of multiple types of input *** give ophthalmologists access to precise,individualized,and high-quality treatment strategies that will further optimize treatment outcomes,this review summarizes the latest findings in AI research related to the prediction and guidance of clinical diagnosis and treatment of retinal diseases.

关键词： artificial intelligence artificial intelligence in ophthalmology retinal disease

Cycloastragenol induces apoptosis and protective autophagy through AMPK/ULK1/mTOR axis in human non-small cell lung cancer cell lines

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Journal of Integrative Medicine 2024年第4期22卷 503-514页

作者： li-hua Zhu Yu-pei liang lian Yang Feng Zhu li-jun Jia He-gen li Department of Oncology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Cancer Institute of Traditional Chinese Medicine Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Department of Laboratory Medicine Huadong HospitalFudan UniversityShanghai 200237China

Objective:Studies have demonstrated that cycloastragenol induces antitumor effects in prostate,colorectal and gastric cancers;however,its efficacy for inhibiting the proliferation of lung cancer cells is largely *** study explores the efficacy of cycloastragenol for inhibiting non-small cell lung cancer(NSCLC)and elucidates the underlying molecular ***:The effects of cycloastragenol on lung cancer cell proliferation were assessed using an adenosine triphosphate monitoring system based on firefly luciferase and clonogenic formation ***-induced apoptosis in lung cancer cells was evaluated using dual staining flow cytometry with an annexin V-fluorescein isothiocyanate/propidium iodide *** elucidate the role of cycloastragenol in the induction of apoptosis,apoptosis-related proteins were examined using Western *** and Western blotting were used to determine whether cycloastragenol could induce autophagy in lung cancer *** techniques,including small interfering RNA technology,were used to investigate the underlying *** effects against lung cancer and biosafety of cycloastragenol were evaluated using a mouse subcutaneous tumor ***:Cycloastragenol triggered both autophagy and ***,cycloastragenol promoted apoptosis by facilitating the accumulation of phorbol-12-myristate-13-acetate-induced protein 1(NOXA),a critical apoptosis-related ***,cycloastragenol induced a protective autophagy response through modulation of the adenosine 5'-monophosphate-activated protein kinase(AMPK)/unc-51-like autophagy-activating kinase(ULK1)/mammalian target of rapamycin(mTOR)***:Our study sheds new light on the antitumor efficacy and mechanism of action of cycloastragenol in *** insight provides a scientific basis for exploring combination therapies that use cycloastragenol and inhibiting the AMPK/ULK1/mTOR pathway as a promising approach to

关键词： Non-small cell lung cancer Cycloastragenol Autophagy Apoptosis

Engineering phonon thermal transport in few-layer PdSe_(2)

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Frontiers of physics 2024年第3期19卷 135-141页

作者： Meilin li Huanhuan Sun jun Zhou Yunshan Zhao Phonon Engineering Research Center of Jiangsu Province Center for Quantum Transport and Thermal Energy ScienceInstitute of Physics Frontiers and Interdisciplinary SciencesSchool of Physics and TechnologyNanjing Normal UniversityNanjing 210023China

Engineering phonon transport in low-dimensional materials has great significance not only for fundamental research,but also for thermal management applications of electric ***,due to the difficulties of micro and nano processing and characterization techniques,the work on tuning phonon transport at nanoscale are *** this work,by introducing Ar+plasma,we probed the phonon transport in two-dimensional(2D)layered semiconductor PdSe_(2)under different defect *** using thermal bridge method,the thermal conductivity was measured to decrease by 50%after a certain Ar+irradiation,which implied a possible phase ***,Raman characterizations were performed to show that the Raman sensitive peaks of PdSe_(2)was red-shifted and finally became disappeared with the increase of defect concentration.“Defect engineering”proves be a practical strategy in tuning the phonon thermal transport in low-dimensional materials,thus providing guidance for potential application in designing thermoelectric devices with various emerging materials.

关键词： phonon transport PdSe_(2) defects thermal bridge method

Existence of Positive Solutions to a Fractional-Kirchhoff System

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Acta Mathematicae Applicatae Sinica 2024年第1期40卷 225-240页

作者： Peng-fei li jun-hui Xie Dan Mu School of Mathematics and Statistics Hubei Minzu UniversityEnshi445000China

LetΩbe a bounded smooth domain in RN(N≥3).Assuming that 00 are constants,we consider the existence results for positive solutions of a class of fractional elliptic system below,{(a+b[u]^(2)_(s))(-Δ)^(s)u=vp+h_(1)(x,u,v,▽u,▽v),x∈Ω,(-Δ)^(s)v=u^(q)+h_(2)(x,u,▽,▽u,▽v),x∈Q,u,v>0,x∈Ω,u=v=0,x∈RN\Ω.Under some assumptions of hi(x,u,v,▽u,▽v)(i=1,2),we get a priori bounds of the positive solutions to the problem(1.1)by the blow-up methods and rescali.g *** on these estimates and degree theory,we establish the existence of positive solutions to problem(1.1).

关键词： fractional-Kirchhoff system a priori bounds degree theory positive solution

Feedback of Efficient Shock Acceleration on Magnetic-field Structure Inside Young Type Ia Supernova Remnants

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Research in Astronomy and Astrophysics 2024年第6期24卷 234-244页

作者： jun-Yu Shen Bi-Wen Bao li Zhang Department of Astronomy Key Laboratory of Astroparticle Physics of Yunnan ProvinceYunnan UniversityKunming 650091China Key Laboratory of Statistical Modeli.g and Data Analysis of Yunnan Province Yunnan UniversityKunming 650091China

Using an effective adiabatic index γ_(eff) to mimic the feedback of efficient shock acceleration,we simulate the temporal evolution of a young type Ia supernova remnant (SNR) with two different background magnetic field(BMF) topologies:a uniform and a turbulent *** density distribution and magnetic-field characteristics of our benchmark SNR are studied with two-dimensional cylindrical magnetohydrodynamic *** γ_(eff)is considered,we find that:(1) the two-shock structure shrinks and the downstream magnetic-field orientation is dominated by the Rayleigh–Taylor instability structures;(2) there exists more quasi-radial magnetic fields inside the shocked region;and (3) inside the intershock region,both the quasi-radial magnetic energy density and the total magnetic energy density are enhanced:in the radial direction,with γ_(eff)=1.1,they are amplified about 10–26 times more than those with γ_(eff)=5/*** in the angular direction,the total magnetic energy densities could be amplified about 350 times more than those with γ_(eff)=5/3,and there are more grid cells within the intershock region where the magnetic energy density is amplified by a factor greater than 100.

关键词： methods:numerical ISM:magnetic fields ISM:supernova remnants magnetohydrodynamics(MHD)

Progress in the generation of spinal cord organoids over the past decade and future perspectives

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Neural Regeneration Research 2024年第5期19卷 1013-1019页

作者： gang Zhou Siyuan Pang Yongning li jun gao Department of Neurosurgery Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina Department of International Medical Service Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina

Spinal cord organoids are three-dimensional tissues derived from stem cells that recapitulate the primary morphological and functional characteristics of the spinal cord in *** emerging bioengineering methods have led to the optimization of cell culture protocols,spinal cord organoids technology has made remarkable advancements in the past *** literature search found that current spinal cord organoids do not only dynamically simulate neural tube formation but also exhibit diverse cytoarchitecture along the dorsal-ventral and rostral-caudal ***,fused organoids that integrate motor neurons and other regionally specific organoids exhibit intricate neural circuits that allows for functional *** qualities make spinal cord organoids valuable tools for disease modeli.g,drug screening,and tissue *** utilizing this emergent technology,researchers have made significant progress in investigating the pathogenesis and potential therapeutic targets of spinal cord ***,at present,spinal cord organoid technology remains in its infancy and has not been widely applied in translational *** of the next generation of spinal cord organoids will depend on good manufacturing practice standards and needs to focus on diverse cell phenotypes and electrophysiological functionality evaluation.

关键词： development organoid-on-a-chip pluripotent stem cells progress spinal cord diseases spinal cord organoids vascularization

The Q-index and Connectivity of graphs

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Journal of the Operations Research Society of China 2024年第2期12卷 505-519页

作者： Peng-li Zhang li-Hua Feng Wei-jun liu Xiao-Dong Zhang School of Mathematical Sciences MOE-LSCSHL-MACShanghai Jiao Tong UniversityShanghai 200240China School of Mathematics and Statistics Central South UniversityChangsha 410083HunanChina

A connected graph g is said to be k-connected if it has more than k vertices and remains connected whenever fewer than k vertices are *** this paper,for a connected graph g with sufficiently large order,we present a tight sufficient condition for g with fixed minimum degree to be k-connected based on the *** result can be viewed as a spectral counterpart of the corresponding Dirac-type condition.

关键词： Q-index Minimum degree k-connected

Discovery of the choristodere Hyphalosaurus baitaigouensis from the Lower Cretaceous Jiufotang Formation of western liaoning,China and its paleobiogeographic significance

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Journal of Palaeogeography 2024年第3期13卷 547-562页

作者： li-jun Zhang Shu-An Ji Hai-Chun Zhang South China Sea Culture Museum Hainan Tropical Ocean UniversitySanya 572022Hainan ProvinceChina Key Laboratory of Stratigraphy and Paleontology Ministry of Natural ResourcesInstitute of GeologyChinese Academy of Geological SciencesBeijing 100037China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and Palaeontology and Center for Excellence in Life and PaleoenvironmentChinese Academy of SciencesNanjing 210008Jiangsu ProvinceChina

The water-living reptile genus Hyphalosaurus was previously discovered in the Lower Cretaceous Yixian Formation bearing the middle Jehol Biota in western liaoning,*** complete skeletons of Hyphalosaurus are reported for the first time from the Jiufotang Formation bearing the late Jehol Biota at two sites in western *** show the typical characteristics of Hyphalosaurus baitaigouensis in terms of the contact between some cranial bones and the number of cervical and dorsal vertebrae,and therefore are assigned to *** discovery extends the stratigraphic range of this species from the Yixian Formation to the overlying Jiufotang *** paper further briefly compares the main characteristics of the two skeletons,summarizes the temporal and spatial distribution of Hyphalosaurus,and discusses the palaeogeographic evolution of western liaoning at the middle and late Jehol Biota stages based on the aquatic habits of Hyphalosaurus and the geological background of western *** analytical results show that the volcanic downwarped lakes,with distinct geographical divisions in western liaoning during the deposition of the Yixian Formation,had not completely disappeared till the deposition of the Jiufotang *** palaeo-lake in the Fuxin-Yixian Basin underwent the process of generation,expansion and shrinkage during the depositional period of the Yixian Formation and finally merged into a large *** palaeo-Dali.ghe River,which connected the main basins in western liaoning during the depositional period of the Jiufotang Formation,was formed simultaneously.

关键词： Western liaoning Jehol biota Jiufotang formation Hyphalosaurus baitaigouensis Palaeobiogeography

Interpretation of Chinese Expert Consensus on the Diagnosis and Management Strategy of Patients with Statin Intolerance: A guiding file for helping to lipid management for Chinese population

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Journal of geriatric Cardiology 2024年第7期21卷 713-715页

作者： Jian-jun li Cardiometabolic Center National Center for Cardiovascular DiseaseChinese Academy of Medical ScienceFuwai Hos-pitalBeijingChina

It is well-known that elevated low-density lipoprotein cholesterol(LDL-C)is a causal risk factor for atheroscler-otic cardiovascular disease(ASCVD),statins are cornerstone drugs for the cause-based treatment of ASCVD,which has created a new era for ASCVD ***,statin intolerance is not clinically uncommon,which there are several issues with confu-sion and ***,a file named Chinese Expert Consensus on the Diagnosis and Management Strategy of Pa-tients With Statin Intolerance,like a navigator,has recently been published written by a team of experts from the Cardiovascular Metabolic Medicine Professional Committee,Expert Committee of the National Center for Cardiovascular Diseases aiming to en-hance the standardized clinical application of statins and improve the prevention and clinical *** this article,author briefly summarized the key points of above consensus in order to helping to comprehending the content of the consensus sugges-tions.

关键词： Expert Strategy corners