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Anti-hemorrhoidal activity of Lian-Zhi-San,a traditional Chinese medicine,in an experimental hemorrhoidal model in rats

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Journal of Integrative Medicine 2021年第1期19卷 42-49页

作者： Hua Zhang Xiang-yang Yao Dan-feng Zhang Qi-le Guo jun-jun yang Bao-guo Zhu Dong-xiao Shen Ke-feng Ruan Yuan Wang jun-liang Peng Anorectal Department Shanghai Jinshan TCM-Integrated HospitalShanghai 201501China Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese MedicineShanghai 201203China Shanghai Zhangjiang Engineering Research Center of Modern Preparations of TCM Shanghai 201203China

Objective:Hemorrhoidal disease(HD)is the most common proctological disease,with an estimated prevalence rate of 4.4%,and a peak in individuals between 45 and 65 years of *** study was done to evaluate whether Lian-Zhi-San(LZS),a clinically used anti-hemorrhoidal ointment could alleviate the inflammatory injury,with its associated changes of inflammatory cytokines and morphology of anorectal tissues,in an experimental model of HD in ***:HD was induced by croton oil preparation(COP)applied to the anorectal *** were then treated with cotton swabs soaked in LZS ointment,water or white vaseline,twice a day for 7 *** the end of the experiment,HD was evaluated by measuring hemorrhoidal and biochemical parameters along with histopathological ***:In this study,COP induced a significant increase in the macroscopic severity score,anorectal coefficient and Evans blue extravasation,compared to normal ***,it greatly enhanced the expression and secretion levels of some important inflammation-related cytokines along with marked histological damage,compared to normal *** treated with LZS ointment experienced significantly ameliorated Evans blue extravasation(P<0.05),decreased macroscopic severity score(0.86±0.14 vs.1.65±0.16)and the anorectal coefficient(P<0.01);its use also attenuated tissue damage and inhibited the expression and secretion levels of inflammation-related cytokines(interleukin-1 b,interleukin-6 and tumor necrosis factor-a).Conclusion:This study validates a preliminary understanding of the use of LZS ointment to treat inflammatory factors and tissue damage in an experimental model of HD in rats.

关键词： Lian-Zhi-San Hemorrhoidal disease Anti-hemorrhoidal effect Croton oil preparation Berberine hydrochloride

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Facile synthesis of transition metal carbide nanoparticles embedded in mesoporous carbon nanosheets for hydrogen evolution reaction

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Rare Metals 2022年第7期41卷 2237-2242页

作者： Ying Yu Xuan-Li Wang Hong-Kun Zhang Zhi-Qin Cao Hao-yang Wu Bao-Rui Jia jun-jun yang Xuan-Hui Qu Ming-Li Qin Institute for Advanced Materials and Technology University of Science and Technology BeijingBeijing 100083China Inner Mongolia Key Laboratory of Advanced Ceramics and Device School of Materials and MetallurgyInner Mongolia University of Science and TechnologyBaotou 014010China China United Test&Certification Co. LtdBeijing 101407China GRINM Group Corporation Limited Beijing 100088China College of Vanadium and Titanium Panzhihua UniversityPanzhihua 617000China Beijing Advanced Innovation Center of Materials Genome Engineering University of Science and Technology BeijingBeijing 100083China

Transition metal carbides(TMC)modified by mesoporous carbon nanosheets(MCNSs)with high activity,fast elec-tron/ion transfer and long durability are considered as promising electrocatalysts for hydrogen evolution react... 详细信息

关键词： carbide hydrogen carbides

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Pulmonary deportation of hydatidiform mole:a 12-year,single tertiary center experience in China

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Chinese Medical Journal 2020年第16期133卷 1930-1934页

作者： Yu-Xin Dai yang Xiang Feng-Zhi Feng Tong Ren jun-jun yang jun Zhao Xi-Run Wan Department of Obstetrics and Gynecology Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

Background:Pulmonary deportation of hydatidiform mole is an exceedingly rare *** underlying mechanisms and proper management strategies remain unclear based on sporadic case reports over the past six *** study aimed to investigate the clinical features and rational treatment of patients with benign molar pregnancies with pulmonary deportation based on our ***:Medical records of 20 cases of hydatidiform mole with pulmonary deportation were retrospectively reviewed at Peking Union Medical College Hospital from November 2006 to May *** detailed information of all patients was recorded and *** were divided into different groups according to their characteristics and Mann-Whitney U test was used to compare the duration to achieve a normal b-human chorionic gonadotrophin(b-hCG)level after the first evacuation among ***:Initial pulmonary computed tomography scans showed suspected bilateral,left and right chest deportation of hydatidiform mole in 12,four,and four patients,respectively,with the maximum nodular diameter ranging from 0.6 to 1.2 *** patients achieved lesion resolution while the remaining ten patients achieved decreases in the size of their pulmonary *** median duration to achieve a normal b-hCG level after the first evacuation was 15.5(13.0,21.9)*** was no significant difference in the duration to achieve a normal b-hCG level after the first evacuation between two groups based on age(≥40 years vs.0.5 cm vs.0.5 cm:13.0[11.3,17.2]weeks vs.16.0[14.5,23.8]weeks,Z=1.815,P=0.070),and number of uterine evacuations(once *** or three time

关键词： Hydatidiform mole Pulmonary deportation Human chorionic gonadotrophin Computed tomography

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Unusual Ovarian Cancer Relapse Managed by Nivolumab in a Long-term Surviving Patient with PD-L1 Mutation

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Chinese Medical Journal 2017年第9期130卷 1125-1126页

作者： Jie yang jun-jun yang jun Zhao Tong Ren Feng-Zhi Feng Xi-Run Wan yang Xiang Department of Obstetrics and Gynecology Peking Union Medical College Hospital Beijing 100730 China

INTRODUCTION This report describes a case of ovarian cancer recurrent as sternal and costal metastasis long after initial treatment. The whole-exome sequencing suggested programmed death-ligand I （PD-L1） mutation. The patient responded well to nivolumab, an anti-PD-1 monoclonal antibody. We discuss the case and review the literature.

关键词： Extra Peritoneal Metastasis Long Survival Nivolumab Ovarian Cancer Programmed Death-ligand 1

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Study on the correlation between early three-dimensional gait analysis and clinical efficacy after robot-assisted total knee arthroplasty

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Chinese Journal of Traumatology 2023年第2期26卷 83-93页

作者： Rui He Ran Xiong Mao-Lin Sun jun-jun yang Hao Chen Peng-Fei yang Liu yang Center for Joint Surgery Southwest HospitalThird Military University(Amy Medical University)Chongqing400038China

Purpose:Robot-assisted technology is a forefront of surgical innovation that improves the accuracy of total knee arthroplasty (TKA).But whether the accuracy of surgery can improve the clinical efficacy still needs further *** purpose of this study is to perform three-dimensional (3D) analysis in the early postoperative period of patients who received robot-assisted total knee arthroplasty (RATKA),and to study the trend of changes in gait parameters after RATKA and the correlation with the early clinical ***:Patients who received RATKA in the Center of Joint Surgery,the First Hospital Affiliated to Army Military Medical University from October 2020 to January 2021 were *** imaging parameters,i.e.,hip-knee-ankle angle,lateral distal femoral angle,medial proximal tibial angle,posterior condylar angle were measured 3 months *** 3D gait analysis and clinical efficacy by Western Ontario Mac Master University Index (WOMAC) score were performed pre-TKA,3 and 6 months *** differences in spatiotemporal parameters of gait,kinetic parameters,and kinematic parameters of the operated limb and the contralateral limb were *** correlation between gait parameters and WOMAC scores was *** samplet-test and Wilcoxon rank-sum test were used to analyze the difference between groups,and Spearman correlation coefficient was used to analyze the ***:There were 31 patients included in this study,and the imaging indexes showed that all of them returned to normal *** WOMAC score at 3 months post-TKA was significantly lower than that pre-TKA,and there was no significant difference between at 3 and 6 *** 3D gait analysis results showed that the double support time of the operated limb reduced at 3 and 6 months (allp < 0.05),the maximum extension and maximum external rotation of the knee joint increased at stance phase,and the maximum flexion angle,the range of motion and the maximum external rotat

关键词： Total knee arthroplasty Robot Gait analysis Knee joint Osteoarthritis Correlation study

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A prospective study comparing endoscopic subcutaneous mastectomy plus immediate reconstruction with implants and breast conserving surgery for breast cancer

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Chinese Medical Journal 2009年第24期122卷 2945-2950页

作者： FAN Lin-jun JIANG jun yang Xin-hua ZHANG Yi LI Xing-gang CHEN Xian-chun ZHONG Ling Center of Breast Disease Southwest Hospital Third Military Medical University Chongqing 400038 China

Background Breast conserving surgery （BCS） has been the standard surgical procedure for the treatment of early breast cancer. Endoscopic subcutaneous mastectomy （ESM） plus immediate reconstruction with implants is an emerging procedure. The objective of this prospective study was to evaluate the clinical outcomes of these two surgical procedures in our clinical setting. Methods From March 2004 to October 2007, 43 patients with breast cancer underwent ESM plus axillary lymph node dissection and immediate reconstruction with implants, while 54 patients underwent BCS. The clinical and pathological characteristics, surgical safety, and therapeutic effects were compared between the two groups. Results There were no significant differences in the age, clinical stage, histopathologic type of tumor, operative blood loss, postoperative drainage time, and postoperative complications between the two groups （P 〉0.05）. The postoperative complications were partial necrosis of the nipple and superficial skin flap in the ESM patients, and hydrops in the axilla and residual cavity in the BCS patients. There was no significant difference in the rate of satisfactory postoperative cosmetic outcomes between the ESM （88.4%, 38/43） and BCS （92.6%, 50/54） patients （P 〉0.05）. During follow-up of 6 months to 4 years, all patients treated with ESM were disease-free, but 3 patients who underwent BCS had metastasis or recurrence -- one of these patients died of multiple organ metastasis. Conclusions After considering the wide indications for use, high surgical safety, and favorable cosmetic outcomes, we conclude that ESM plus axillary lymph node dissection and immediate reconstruction with implants -- the new surgery of choice for breast cancer -- warrants serious consideration as the prospective next standard surgical procedure.

关键词： breast neoplasm endoscope subcutaneous mastectomy segmental mastectomy," breast implant

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Anomalous quality factor evolution of induced transparency in a virtualized coupled-oscillator system

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 148-155页

作者： Yunhan yang Han Jia Tuo Liu Yuzhen yang jun yang Key Laboratory of Noise and Vibration Research Institute of Acoustics Chinese Academy of Sciences University of Chinese Academy of Sciences State Key Laboratory of Acoustics Institute of Acoustics Chinese Academy of Sciences

The phenomenon of induced transparency, characterized by a high quality(Q) factor, holds significant importance in the fields of high-precision sensing, energy storage and wave manipulation. Conventional transparency systems are often constrained by the limited experimentally accessible parameter space and the lack of independent control over intrinsic parameters, thereby hindering advanced research on high-Q effects. Here we propose a virtualized coupled-oscillator system that enables reconfigurable induced transparency in the reflection spectrum. By virtually incorporating a pair of coupled oscillators into an individual acoustic meta-atom, we achieve the manipulation of induced transparency in a decoupled, wide-ranging, and elaborate manner. Exploiting the diverse evolutions across the intrinsic parameter space, we show experimentally a counter-intuitive increase in the Q-factor of the transparency window, which is attributed to the enhanced dissipation of the bright ***, a constant group delay at the center frequency is observed accompanying this evolution. Our work demonstrates an intriguing platform as well as a novel strategy to engineer high-Q induced transparency phenomenon, and paves the way towards applications in programmable acoustic sensors, filters and slow-wave devices.

关键词： induced transparency acoustic meta-atom high quality-factor scattering programmable intrinsic parameter

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一种新的用于跨领域推荐的迁移学习模型

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计算机学报 2017年第10期40卷 2367-2380页

作者：王俊李石君杨莎金红余伟软件工程国家重点实验室武汉大学计算机学院武汉430072 汉口学院计算机科学与技术学院武汉430212

协同过滤是一种简单常用的推荐方法,但是当目标数据非常稀疏时,其性能会严重退化,借助与目标数据跨域关联的辅助数据进行跨领域推荐是解决此问题的一种有效途径.已有的跨领域推荐模型大多假设不同领域完全共享一个评分模式,忽略了领域... 详细信息

协同过滤是一种简单常用的推荐方法,但是当目标数据非常稀疏时,其性能会严重退化,借助与目标数据跨域关联的辅助数据进行跨领域推荐是解决此问题的一种有效途径.已有的跨领域推荐模型大多假设不同领域完全共享一个评分模式,忽略了领域特有评分模式,可能导致推荐性能退化.此外,许多模型基于单一桥梁迁移跨领域信息,正迁移不足.特别是在考虑领域特有被评分模式的前提下,据作者所知目前还没有模型利用项目的共享被评分模式进行跨领域推荐.因此,该文提出一种新的三元桥迁移学习模型,用于跨领域推荐.首先通过评分矩阵的集合分解提取用户的潜在因子和共享评分模式,以及项目的潜在因子和共享被评分模式,在此过程中考虑了领域特有模式,并对潜在因子施加相似性约束;然后利用潜在因子中的聚类信息构造邻接图;最后通过用户端和项目端的基于共享模式、潜在因子和邻接图的三元桥迁移学习联合预测缺失评分.在三个公开的真实数据集上进行的大量实验表明,该模型的推荐精度优于一些目前最先进的推荐模型.

关键词：迁移学习推荐协同过滤跨领域稀疏矩阵分解

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Effects of doping route on microstructure and mechanical properties of W−1.0wt.%La2O3 alloys

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Transactions of Nonferrous Metals Society of China 2020年第12期30卷 3296-3306页

作者： jun-jun yang Gang CHEN Zheng CHEN Xiao-dong MU Ying YU Lin ZHANG Xing-yu LI Xuan-hui QU Ming-li QIN Beijing Advanced Innovation Center for Materials Genome Engineering Institute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing 100083China Grinm Group Co. Ltd.Beijing 100088China

A comparative study was conducted by using solution combustion synthesis with three different doping routes(liquid-liquid(WL10), liquid-solid(WLNO) and solid-solid(WLO)) to produce nanoscale powders and further fabricate the ultrafine-grained W-1.0 wt.%La2O3 alloys by pressureless sintering. Compared with pure tungsten, W-1.0 wt.%La2O3 alloys exhibit ultrafine grains and excellent mechanical properties. After sintering, the average grain size of the WLO sample is larger than that of WL10 and WLNO samples;the microhardness values of WL10 and WLNO samples are similar but larger than the value of WLO sample. The optimized La2O3 particles are obtained in the WL10 sample after sintering at 1500 ℃ with the minimum mean size by comparing with WLNO and WLO samples, which are uniformly distributed either at grain boundaries or in the grain interior with the sizes of(57±29.7) and(27±13.1) nm, respectively. This study exhibits ultrafine microstructure and outperforming mechanical properties of the W-1.0 wt.%La2O3 alloy via the liquid-liquid doping route, as compared with conventionally-manufactured tungsten materials.

关键词： tungsten alloy solution combustion synthesis doping route ultrafine grain microhardness

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某大跨度混合结构屋盖独立设计与整体设计对比分析

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钢结构 2017年第6期32卷 66-68,72页

作者：狄军杨军新疆维吾尔自治区建筑设计研究院乌鲁木齐830002

应用3D3S及YJK建筑结构设计软件对一个上部为钢网架、下部支承结构为混凝土结构的游泳馆进行了设计,并对该结构整体分析设计结果与网架独立设计结果进行对比。同时,分析了采用不同阻尼比计算方式对该钢-混凝土结构的影响。结果表明:分... 详细信息

应用3D3S及YJK建筑结构设计软件对一个上部为钢网架、下部支承结构为混凝土结构的游泳馆进行了设计,并对该结构整体分析设计结果与网架独立设计结果进行对比。同时,分析了采用不同阻尼比计算方式对该钢-混凝土结构的影响。结果表明:分离的简化设计过程对于网架杆件、支座连接、下部结构来说,计算结果局部偏差很大,可能存在不合理、不安全的情况;统一的阻尼比计算方式与材料阻尼计算结果存在差异,建议设计时采用考虑不同材料的等效阻尼。通过该项目的设计分析,说明上、下部结构协同分析的可行性和必要性。

关键词：大跨度混合结构整体分析应用

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