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Identification of bis-benzylisoquinoline alkaloids as SARS-CoV-2 entry inhibitors from a library of natural products

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Signal Transduction and Targeted Therapy 2021年第4期6卷 1113-1115页

作者： Chang-Long He Lu-Yi Huang Kai Wang Chen-Jian gu jie Hu gui-Ji Zhang Wei Xu You-Hua Xie Ni Tang Ai-Long Huang Key Laboratory of Molecular Biology for Infectious Diseases(Ministry of Education) Institute for Viral HepatitisDepartment of Infectious DiseasesThe Second Affiliated HospitalChongqing Medical UniversityChongqingChina Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) Department of Medical Microbiology and ParasitologySchool of Basic Medical SciencesShanghai Medical CollegeFudan UniversityShanghaiChina Children's Hospital Fudan UniversityShanghaiChina

Dear Editor,Coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is a major public health *** spike(S)protein mutation D614G became dominant in SARS-CoV-2 during a global pandemic,which displayed increased infectivity.1 Entry of a virus into host cells is one of the most critical steps in the viral life *** blockade of the entry process is a promising therapeutic option for COVID-19,research attention has been focused on the discovery of viral entry *** SARS-CoV-2 entry inhibitor development is very attractive,no candidates have progressed into clinical trials yet.

关键词： acute respiratory attractive

Multiple soliton solutions and symmetry analysis of a nonlocal coupled KP system

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Communications in Theoretical Physics 2023年第8期75卷 69-77页

作者： Xi-zhong Liu jie-tong Li jun Yu Institute of Nonlinear Science Shaoxing UniversityShaoxing 312000China

A nonlocal coupled Kadomtsev–Petviashivili(ncKP) system with shifted parity(P_(s)^(x)) and delayed time reversal(T_(d)) symmetries is generated from the local coupled Kadomtsev–Petviashivili(cKP) system. By introducing new dependent variables which have determined parities under the action of P_(s)^(x)T_(d)^(d), the ncKP is transformed to a local system. Through this way, multiple even number of soliton solutions of the ncKPI system are generated from N-soliton solutions of the c KP system, which become breathers by choosing appropriate parameters. The standard Lie symmetry method is also applied on the ncKPII system to get its symmetry reduction solutions.

关键词： nonlocal coupled Kadomtsev-Petviashivili system N-soliton solutions symmetry reduction solutions

TopoisomeraseⅡalpha promotes gallbladder cancer proliferation and metastasis through activating phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin signaling pathway

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Chinese Medical Journal 2020年第19期133卷 2321-2329页

作者： Wen-jie Lyu Yi-jun Shu Ying-Bin Liu Ping Dong Department of General Surgery Xinhua HospitalAffiliated to Shanghai Jiao Tong UniversitySchool of MedicineShanghai 200092China.

Background:TopoisomeraseⅡalpha(TOP2A)has been reported to play a crucial role in the tumorigenesis of various cancer ***,the biological role of TOP2A in gallbladder cancer(GBC)remains *** current study aimed to explore the function and potential mechanism of TOP2A in ***:Based on Gene Expression Profiling Interactive Analysis data,we found TOP2A was significantly up-regulated in GBC tissues and resulting in shorter overall *** real-time polymerase chain reaction and immunohistochemistry were conducted to detect the expression of TOP2A in 45 pairs of GBC tissues and adjacent non-tumor *** vitro,cell proliferation,migration,and invasion ability were examined by cell counting kit-8 and transwell assay,***-mesenchymal transition(EMT)related and phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin(PI3K/Akt/mTOR)pathway-related markers were measured by Western *** model assay was performed to evaluate the effect of TOP2A in ***:TOP2A was found up-regulated in GBC(tumor ***,12.62 vs.0.34)and correlated with the late tumor node metastasis stage(P=0.0032),present of lymph node metastasis(P=0.0273),and poor prognosis in GBC patients(log-rank P=0.028).In vitro and in vivo assays showed that knockdown of TOP2A notably inhibited cell proliferation,migration,invasion,EMT process,and tumor growth in *** addition,TOP2A down-regulation significantly decreased the protein levels of phosphor(p)-PI3K,p-Akt,and ***:Our study demonstrates that TOP2A was overexpressed in GBC and associated with poor prognosis in GBC ***2A promotes GBC cell proliferation,migration,invasion,EMT process,and tumor growth through activating PI3K/Akt/mTOR signaling pathway,and may serve as a novel prognostic biomarker and therapeutic target for GBC.

关键词： TopoisomeraseⅡalpha Gallbladder cancer Proliferation Metastasis Epithelial-mesenchymal transition Phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin pathway

Multidisciplinary approaches for clavicle fracture with neurovascular injuries:A case report

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Chinese Medical Journal 2023年第18期136卷 2251-2253页

作者： Hongjiang Chen jiechen Chen Zhuo Chen Lei Xie Jiankun Xu Zhonglian Huang Yilin Zhu Jinghong Zheng jie Wu jun Hu Department of Orthopaedics The First Affiliated Hospital of Shantou University Medical CollegeShantouGuangdong 515041China

To the Editor:Neurovascular injury is an uncommon complication of clavicle fractures,and occurs in at most 1%of all clavicle *** injury is mostly caused by high-energy blunt injury to the clavicle.[1]Because its symptoms are less prominent,these vascular injuries are easily neglected and may result in severe ***,few studies have reported a standardized management for this rare ***,we present a case of a 30-year-old man who suffered an open clavicle fracture with acute subclavian artery and brachial plexus *** treating this case,we concluded that neurovascular examinations and multidisciplinary therapeutic strategies are urgently needed for clavicle fractures with associated neurovascular *** authors certify that they have obtained the patient’s consent to the publication of information about him in a journal or *** information will be published without the patient’s name attached and every attempt will be made to ensure anonymity.

关键词： injuries clavicle fracture

Dek219 encodes the DICER-LIKE1 protein that affects chromatin accessibility and kernel development in maize

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Journal of Integrative Agriculture 2023年第10期22卷 2961-2980页

作者： XIE Si-di TIAN Ran ZHANG jun-jie LIU Han-mei LI Yang-ping HU Yu-feng YU guo-wu HUANG Yu-bi LIU Ying-hong State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China Sichuan Agricultural UniversityChengdu 611130P.R.China College of Life Science Sichuan Agricultural UniversityYa’an 625014P.R.China College of Agronomy Sichuan Agricultural UniversityChengdu 611130P.R.China Maize Research Institute Sichuan Agricultural UniversityChengdu 611130P.R.China

Chromatin accessibility plays a vital role in gene transcriptional ***,the regulatory mechanism of chromatin accessibility,as well as its role in regulating crucial gene expression and kernel development in maize(Zea mays)are poorly *** this study,we isolated a maize kernel mutant designated as defective kernel219(dek219),which displays opaque endosperm and embryo ***219 encodes the DICER-LIKE1(DCL1)protein,an essential enzyme in mi RNA *** of function of Dek219 results in significant reductions in the expression levels of most mi RNAs and histone *** research showed that the Heat shock transcription factor17(Hsf17)-Zm00001d016571 module may be one of the factors affecting the expression of histone *** results for transposase-accessible chromatin sequencing(ATAC-seq)indicated that the chromatin accessibility of dek219 is altered compared with that of wild type(WT),which may regulate the expression of crucial genes in kernel *** analyzing differentially expressed genes(DEGs)and differentially accessible chromatin regions(ACRs)between WT and dek219,we identified 119 candidate genes that are regulated by chromatin accessibility,including some reported to be crucial genes for kernel *** together,these results suggest that Dek219 affects chromatin accessibility and the expression of crucial genes that are required for maize kernel development.

关键词： maize kernel development chromatin accessibility histone miRNA

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采场前方应力分布参数的分析与模拟计算

煤炭学报 2008年第7期33卷 743-747页

作者：刘俊杰大连大学建筑工程学院辽宁大连116622

从微观岩体力学模型入手,分析了采场前方应力集中峰位置分布计算公式中的煤体强度a0,应力集中系数k和摩擦因素fs等3个关键参数,指出它们是随着工作面推进而动态变化的参数;确定了公式中a0在不同区段的取值(如破坏区、塑性区和弹性区依... 详细信息

从微观岩体力学模型入手,分析了采场前方应力集中峰位置分布计算公式中的煤体强度a0,应力集中系数k和摩擦因素fs等3个关键参数,指出它们是随着工作面推进而动态变化的参数;确定了公式中a0在不同区段的取值(如破坏区、塑性区和弹性区依次取值为σc*,σ-c和σc)和计算公式,指出σc*,σ-c和σc等3个值之间存在过渡数值.在此基础上,进行了相关模拟计算和对比分析,结果显示,工作面推进过程中出现的破碎区宽度大于塑性区宽度.

关键词：采煤工作面动态变化参数煤体强度应力集中峰位置

Cerebrospinal fluid biomarkers in idiopathic normal pressure hydrocephalus

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Neuroimmunology and Neuroinflammation 2020年第2期7卷 109-119页

作者： Xin-jie Zhang Jian guo jun Yang Department of Neurosurgery Xiang'an Hospital of Xiamen University School of Medicine Xiamen University Xiamen 361102 Fujian China

Idiopathic normal pressure hydrocephalus (iNPH) is characterized by abnormal cerebrospinal fluid (CSF) flow and consequent cerebral ventricular enlargement due to imbalance of CSF production and absorption. The typical triad symptoms, namely cognitive decline, gait disturbance, and urinary incontinence, are thought to be caused by disruption of CSF circulation. However, some patients may still experience symptomatic progression after functional shunting, suggesting that iNPH is far more complicated than a simple disorder of CSF circulation. Moreover, the diagnostic workup of iNPH can be challenging due to symptomatic and neuroimaging overlaps with other neurological disorders, such as Alzheimer's disease. Furthermore, accumulating studies indicate that the pathogenesis of iNPH might relate to multiple mechanisms, including abnormalities of brain development, brain extracellular matrix, synaptic function, blood flow, and cerebral metabolism. Therefore, iNPH is not an isolated entity in occurrence and development. Nevertheless, different pathogeneses may result in protein content changes in CSF, and the biomarkers in CSF may reflect the possible mechanisms involving the etiology of iNPH and are potentially useful in assisting the diagnosis and treatment selection. In this review, we summarize the main findings of CSF biomarkers and aim to outline a possible synthetic profile in assisting iNPH diagnosis and therapeutic options.

关键词： Idiopathic normal pressure hydrocephalus cerebrospinal fluid biomarkers neurodegenerative diseases

高通量RNA测序技术分析结肠腺瘤转变为结肠癌的关键基因

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中国现代普通外科进展 2024年第4期27卷 286-291页

作者：边杰王涛叶长春高根旺麻春宏孙学军孙祺西安交通大学第一附属医院普通外科陕西西安710061

目的:通过RNA测序技术分析比较正常结肠组织、结肠腺瘤及癌组织中基因表达谱的差异,识别从结肠腺瘤发展为结肠癌过程中的关键基因,并探究其潜在机制。方法:对同一患者的正常结肠组织、腺瘤及癌组织进行RNA测序分析,识别在结肠癌中显著... 详细信息

目的:通过RNA测序技术分析比较正常结肠组织、结肠腺瘤及癌组织中基因表达谱的差异,识别从结肠腺瘤发展为结肠癌过程中的关键基因,并探究其潜在机制。方法:对同一患者的正常结肠组织、腺瘤及癌组织进行RNA测序分析,识别在结肠癌中显著表达、腺瘤组织中不显著表达的差异基因并进行GO和KEGG功能富集分析。结果:在结肠癌中显著表达、腺瘤组织中不显著表达的差异基因有4307个,其中5个差异最大的基因是EPYC、LINC01614、MCEMP1、NOX4、CLEC5A。对这些基因进行GO和KEGG功能富集分析发现,主要富集于生物过程调节、细胞过程调节、蛋白质结合等生物学过程和癌症通路、PI3K-Akt信号通路、MAPK信号通路等。结论:EPYC、LINC01614、MCEMP1、NOX4、CLEC5A等多个基因参与结肠腺瘤到结肠癌发展的过程,这些基因有望成为结直肠癌的治疗靶点。

关键词：结肠癌结肠腺瘤 RNA测序

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安立生坦治疗IgA肾病的疗效及安全性分析

中国血液净化 2024年第10期23卷 741-746页

作者：李秉哲师素芳朱厉周绪杰刘立军吕继成张宏北京大学第一医院肾内科北京大学肾脏疾病研究所卫生部肾脏疾病重点实验室教育部慢性肾脏病防治重点实验室北京100034

目的探讨安立生坦作为选择性内皮素受体拮抗剂(endothelin receptor antagonist,ERA)在IgA肾病(IgA nephropathy,IgAN)患者中的疗效和安全性。方法收集北京大学第一医院肾内科2022年11月─2023年12月接受安立生坦治疗的IgA肾病患者的病... 详细信息

目的探讨安立生坦作为选择性内皮素受体拮抗剂(endothelin receptor antagonist,ERA)在IgA肾病(IgA nephropathy,IgAN)患者中的疗效和安全性。方法收集北京大学第一医院肾内科2022年11月─2023年12月接受安立生坦治疗的IgA肾病患者的病历资料和随访数据,并在第4、8和12w时进行随访评估。研究的主要结果是随时间变化的24h尿蛋白、24h尿蛋白变化率、估算肾小球滤过率(estimate glomerular filtration rate,eGFR),同时监测药物的安全性。结果共纳入了147例IgA肾病患者。基线24h尿蛋白水平为1.16(0.74,1.99)g/d,安立生坦治疗后第4、第8、第12w的尿蛋白水平分别低于基线水平(Z=-8.157、-5.866、-5.238,均P0.05)。在12w随访期间,eGFR保持稳定。安立生坦在随访患者中耐受性良好,2例患者因水肿或肝功能损害停药。结论安立生坦可以降低IgA肾病患者尿蛋白且安全性良好。

关键词：内皮素受体拮抗剂 IgA肾病尿蛋白安立生坦