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Milk protein-shelled gold nanoparticles with gastrointestinally active absorption for aurotherapy to brain tumor

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Bioactive Materials 2022年第2期7卷 35-48页

作者： hyung Shik kim Seung Jae Lee Dong Yun Lee Department of Bioengineering College of Engineeringand BK FOUR Biopharmaceutical Innovation Leader for Education and Research GroupHanyang UniversitySeoul04763Republic of Korea Institute of Nano Science and Technology Hanyang UniversitySeoul04763Republic of Korea

Orally absorbable gold nanoparticles(AuNP)having cancer ablation therapy is strongly demanded to treat glioblastoma multiforme(GBM)for patients with its highest incidence ***,we develop a milk protein lactoferrin-conjugated AuNP for its oral absorption and targeting to the GBM through the interaction between lactoferrin(Lf)and lactoferrin receptor(LfR)that is highly expressed in the intestine,blood-brain barrier and *** stability and long circulation of AuNP,glutathione and polyethylene glycol(PEG)is introduced,which is called to *** Lf-PEG-AuNP are orally administered to orthotopic GBM-bearing mice,11-fold and 8-fold higher concentrations of AuNP are measured in bloodstreams and GBM in the brain,respectively,compared with ***,orally administered Lf-PEG-AuNP exhibit an outstanding temperature rise in GBM by irradiating laser and significantly reduce tumor ***,we suggest that the Lf-PEG-AuNP can fundamentally target GBM in the brain through oral absorption,and that its efficient photothermal therapy is possible.

关键词： intestine absorption gastrointestinal

Flow and mass balance analysis of eco-bio infiltration system

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Frontiers of Environmental Science & Engineering 2012年第5期6卷 612-619页

作者： Maria C. MANIQUIZ Lee-hyung kim Soyoung LEE Jiyeon CHOI Department of Civil and Environmental Engineering Kongju National University 275 Budaedong Seobuk-gu Cheonan City Chungnam-do 330-717 R. O. Korea

A structued stormwater infiltration system was developed and constructed at a university campus and monitoring of storm events was performed during a one- year operation period. The flow and pollutant mass balances were analyzed and the overall efficiency of the system was assessed. While significant positive correla- tions were observed among rainfall, runoff and discharge volume （R2= 0.93-0.99; p 〈 0.05）, there was no sig- nificant correlations existed between rainfall, runoff, discharge volume and pollutant load. The system was more effective in reducing the runoff volume by more than 50% for small storm events but the difference between the runoff and discharge volume was significant even with rainfall greater than 10ram. Results showed that the pollutant reduction rates were higher compared to the runoff volume reduction. Average pollutant reduction rates were in the range of 72% to 90% with coefficient of variation between 0.10 and 0.46. Comparable with runoff reduction, the system was more effective in reducing the pollutant load for small storm events, in the range of 80% to 100% for rainfall between 0 and 10mm; while 65% to 80% for rainfall between l0 and 20mm. Among the pollutant parameters, particulate matters was highly reduced by the system achieving only a maximum of 25% discharge load even after the entire runoff was completely discharged. The findings have proven the capability of the system as a tool in stormwater manage- ment achieving both flow reduction and water quality improvement.

关键词： best management practice flow balance lowimpact development mass balance nonpoint source,stormwater runoff

Preserving finger length in a patient with symmetric digital gangrene under local anesthesia:A case report

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World Journal of Clinical Cases 2023年第27期11卷 6640-6645页

作者： Keun hyung kim In Chang Ko Hoon kim Soo Yeon Lim Department of Plastic and Reconstructive Surgery Konyang University Medical CenterKonyang University of College of MedicineDaejeon 35365South Korea Department of Plastic and Reconstructive Surgery Konyang University HospitalKonyang University of College of MedicineMyunggok Medical Research CenterDaejeon 35365South Korea

BACKGROUND Case reports of symmetric digital gangrene resulting from high-dose vasopressors use in patients with alcoholic ketoacidosis,leading to cardiac arrest,are *** date,no specific treatment method for autolysis or surgical amputation or guidelines for determining the level of amputation have been *** SUMMARY In this case report,we describe a treatment method that effectively preserved the function of fingers by surgical treatment under local anesthesia with a minimum operative time,while also preserving finger length to the maximum possible *** Our approach may contribute to improved postoperative quality of life by preserving finger length.

关键词： Acidosis Disseminated intravascular coagulation Ketosis Purpura fulminans Surgical amputation Case report

Parameter selection of pocket extraction algorithm using interaction interface

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第9期7卷 1492-1499页

作者： kim Chong-Min WON Chung-In RYU Joonghyun CHO Cheol-hyung BHAK Jonghwa kim Deok-Soo Department of Industrial Engineering Hanyang University Seoul 133-791 Korea Voronoi Diagram Research Center Hanyang University Seoul 133-791 Korea Samsung Electronics Suwon Gyeonggi-do 443-742 Korea Korean Bioinformation Center Korea Research Institute of Bioscience and Biotechnology Daejeon 305-806 Korea Department of Industrial Engineering Hanyang University Seoul 133-791 Korea)

Pockets in proteins have been known to be very important for the life process. There have been several studies in the past to automatically extract the pockets from the structure information of known proteins. However, it is difficult to find a study comparing the precision of the extracted pockets from known pockets on the protein. In this paper, we propose an algorithm for extracting pockets from structure data of proteins and analyze the quality of the algorithm by comparing the extracted pockets with some known pockets. These results in this paper can be used to set the parameter values of the pocket extraction algorithm for getting better results.

关键词： Pocket Protein Interaction interface Protein interaction Voronoi diagram

Relative-Position Estimation Based on Loosely Coupled UWB–IMU Fusion for Wearable IoT Devices

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Computers, Materials & Continua 2023年第4期75卷 1941-1961页

作者： A.S.M.Sharifuzzaman Sagar Taein kim Soyoung Park Hee Seh Lee hyung Seok kim Sejong University Seoul05006Korea Samsung Advanced Institute of Technology Suwon16678Korea

Relative positioning is one of the important techniques in collaborativerobotics, autonomous vehicles, and virtual/augmented reality (VR/AR)applications. Recently, ultra-wideband (UWB) has been utilized to calculaterelative position as it does not require a line of sight compared to a camerato calculate the range between two objects with centimeter-level ***, the single UWB range measurement cannot provide the relativeposition and attitude of any device in three dimensions (3D) because oflacking bearing information. In this paper, we have proposed a UWB-IMUfusion-based relative position system to provide accurate relative positionand attitude between wearable Internet of Things (IoT) devices in 3D. Weintroduce a distributed Euler angle antenna orientationwhich can be equippedwith the mobile structure to enable relative positioning. Moving average andmin-max removing preprocessing filters are introduced to reduce the standarddeviation. The standard multilateration method is modified to calculate therelative position between mobile structures. We combine UWB and IMUmeasurements in a probabilistic framework that enables users to calculatethe relative position between two nodes with less error. We have carried outdifferent experiments to illustrate the advantages of fusing IMU and UWBranges for relative positioning systems. We have achieved a mean accuracy of0.31m for 3D relative positioning in indoor line of sight conditions.

关键词： Relative position UWB IMU trilateration IoT bayesian filter

Real-Time Tunable Gas Sensing Platform Based on SnO_(2) Nanoparticles Activated by Blue Micro-Light-Emitting Diodes

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Nano-Micro Letters 2024年第12期16卷 103-119页

作者： Gi Baek Nam jung-El Ryu Tae Hoon Eom Seung Ju kim jun Min Suh Seungmin Lee Sungkyun Choi Cheon Woo Moon Seon Ju Park Soo Min Lee Byungsoo kim Sung Hyuk Park Jin Wook Yang Sangjin Min Sohyeon Park Sung Hwan Cho Hyuk Jin kim Sang Eon jun Tae hyung Lee Yeong Jae kim Jae Young kim Young Joon Hong Jong-In Shim hyung-Gi Byun Yongjo Park Inkyu Park Sang-Wan Ryu Ho Won Jang Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Research Laboratory of Electronics Department of Mechanical EngineeringMassachusetts Institute of TechnologyCambridgeMA 02139USA Ming Hsieh Department of Electrical and Computer Engineering University of Southern CaliforniaLos AngelesCA 90089USA Department of Display Materials Engineering Soonchunhyang UniversityAsan 31538Republic of Korea Department of Photonics and Nanoelectronics BK21 FOUR ERICA-ACE CenterHanyang University ERICAAnsan 15588Republic of Korea Department of Nanotechnology and Advanced Materials Engineering Sejong UniversitySeoul 05006Republic of Korea Department of Electronics Information and Communication EngineeringKangwon National UniversitySamcheok 25913Republic of Korea Advance Institute of Convergence Technology Seoul National UniversitySuwon 16229Republic of Korea Department of Mechanical Engineering Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea Department of Physics Chonnam National UniversityGwangju 500-757Republic of Korea

Micro-light-emitting diodes(μLEDs)have gained significant interest as an activation source for gas sensors owing to their advantages,including room temperature operation and low power ***,despite these benefits,challenges still exist such as a limited range of detectable gases and slow *** this study,we present a blueμLED-integrated light-activated gas sensor array based on SnO_(2)nanoparticles(NPs)that exhibit excellent sensitivity,tunable selectivity,and rapid detection with micro-watt level power *** optimal power forμLED is observed at the highest gas response,supported by finite-difference time-domain ***,we first report the visible light-activated selective detection of reducing gases using noble metal-decorated SnO_(2)*** noble metals induce catalytic interaction with reducing gases,clearly distinguishing NH3,H2,and ***-time gas monitoring based on a fully hardwareimplemented light-activated sensing array was demonstrated,opening up new avenues for advancements in light-activated electronic nose technologies.

关键词： Micro-LED Gas sensor array Low power consumption Metal decoration Real-time detection

Design of BPS digital frontend for software defined radio receiver

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Journal of Central South University 2015年第12期22卷 4709-4716页

作者：王洪梅 kim Jae-hyung 王法广 LEE Sang-hyuk 王雪松 School of Information and Electrical Engineering China University of Mining and Technology School of Mechatronics Changwon National University Collaborative Innovation Center of Intelligent Mining Equipment China University of Mining and Technology Electrical and Electronic Engineering Xi'an Jiaotong-Liverpool University

In radio receivers,complete implementation of the software defined radio(SDR) concept is mainly limited by *** on bandpass sampling(BPS) theory,a flexible digital frontend(DFE) platform for SDR receiver is *** order to increase the processing speed,Gigabit Ethernet was applied in the platform at speed of 5×10~8 bit/*** appropriate design of interpolant according to the position of input RF signals,multi-band receiving can be realized in the platform with suppression more than 35 d B without changing hardware.

关键词： software defined radio(SDR) digital frontend bandpass sampling

Strangulated small bowel hernia through the port site:A case report

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World Journal of Gastroenterology 2008年第44期14卷 6881-6883页

作者： jun Hyun Lee Wook kim Department of Surgery Holy Family HospitalCollege of MedicineThe Catholic University of KoreaBucheon 420-717South Korea

Port site hernia develops through a fascial or peritoneal layer that was inadequate or not repaired. It is a rare complication of laparoscopic surgery which may lead to serious problems. Here,we present a 77-year-old female,diagnosed with a small bowel hernia through a 10-mm port site. We had performed ten cases of laparoscopy-assisted distal gastrectomy before this case. The patient complained of left lower abdominal pain with a palpable mass. Abdominal CT showed an incarcerated small bowel hernia and the patient underwent segmental resection of the strangulated small bowel through a minimally extended port site incision.

关键词： Port site hernia Strangulated small bowel Minimally extended port site incision

A Rapid Adaptation Approach for Dynamic Air‑Writing Recognition Using Wearable Wristbands with Self‑Supervised Contrastive Learning

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Nano-Micro Letters 2025年第2期17卷 417-431页

作者： Yunjian Guo Kunpeng Li Wei Yue Nam‑Young kim Yang Li Guozhen Shen Jong‑Chul Lee Department of Electronic Convergence Engineering Kwangwoon UniversitySeoul 01897South Korea Radio Frequency Integrated Circuit(RFIC)Bio Centre Kwangwoon UniversitySeoul 01897South Korea Department of Electronic Engineering Kwangwoon UniversitySeoul 01897South Korea School of Microelectronics Shandong UniversityJinan 250101People’s Republic of China State Key Laboratory of Integrated Chips and Systems Fudan UniversityShanghai 200433People’s Republic of China School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijing 100081People’s Republic of China

Wearable wristband systems leverage deep learning to revolutionize hand gesture recognition in daily *** existing approaches that often focus on static gestures and require extensive labeled data,the proposed wearable wristband with selfsupervised contrastive learning excels at dynamic motion tracking and adapts rapidly across multiple *** features a four-channel sensing array composed of an ionic hydrogel with hierarchical microcone structures and ultrathin flexible electrodes,resulting in high-sensitivity capacitance *** wireless transmission from a Wi-Fi module,the proposed algorithm learns latent features from the unlabeled signals of random wrist ***,only few-shot labeled data are sufficient for fine-tuning the model,enabling rapid adaptation to various *** system achieves a high accuracy of 94.9%in different scenarios,including the prediction of eight-direction commands,and air-writing of all numbers and *** proposed method facilitates smooth transitions between multiple tasks without the need for modifying the structure or undergoing extensive task-specific *** utility has been further extended to enhance human–machine interaction over digital platforms,such as game controls,calculators,and three-language login systems,offering users a natural and intuitive way of communication.

关键词： Wearable wristband Self-supervised contrastive learning Dynamic gesture Air-writing Human-machine interaction