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Cytoplasmic FKBPs are involved in molting and metamorphosis through regulating the nuclear localization of EcR

Insect Science 2024年第3期31卷 759-772页

作者： Xian Zhang Qiao-Ran Wang Qian Wu jun gu Li-hua huang guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology School of Life SciencesSouth China Normal UniversityGuangzhouChina guangmeiyuan R&D Center Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied TechnologySouth China Normal UniversityMeizhouChina

Molting and metamorphosis are important physiological processes in insects that are tightly controlled by ecdysone receptor(EcR)through the 20-hydroxyecdysone(20E)signaling *** is a steroid nuclear receptor(SR).Several FK506-binding proteins(FKBPs)have been identified from the mammal SR complex,and are thought to be involved in the subcellular trafficking of ***,their roles in insects are poorly *** explore whether FKBPs are involved in insect molting or metamorphosis,we injected an FKBP inhibitor(FK506)into a lepidopteran insect,Spodoptera litura,and found that molting was inhibited in 61.11%of the larvae,and that the time for larvae to pupate was significantly extended.A total of 10 FKBP genes were identified from the genome of *** and were clustered into 2 distinct groups,according to their subcellular localization,with FKBP13 and FKBP14 belonging to the endoplasmic reticulum(ER)group and with the other members belonging to the cytoplasmic(Cy)*** the CyFKBPs were significantly upregulated in the prepupal or pupal stages,with the opposite being observed for the ER group ***506 completely blocked the transfer of EcR to the nucleus under 20E induction,and significantly downregulated the transcriptional expression of many 20E signaling genes.A similar phenomenon was observed after RNA interference of2 CyFKBPs(FKBP45 and FKBP12b),but not for *** together,our data indicate that the cytoplasmic FKBPs,especially FKBP45 and FKBP12b,mediate the nuclear localization of EcR,thereby regulating the 20E signaling and ultimately affecting molting and metamorphosis in insects.

关键词： EcR FKBP metamorphosis molting RNAi subcellular localization

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Prediction of liquid circulation flow rate in RH degasser:improvement of decarburization at low atmospheric pressure

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Journal of Iron and Steel Research(International) 2024年第7期31卷 1661-1667页

作者： gu-jun Chen Sheng-ping He College of Materials Science and Engineering Yangtze Normal UniversityChongqing 400044China College of Materials Science and Engineering Chongqing UniversityChongqing 400044China

The two-fluid model coupled with population balance model was used for simulating the gas-liquid flow in the Ruhrstahl-Heraeus(RH)*** predicted circulation flow rate was compared with that measured from a water model experiment to validate the mathematical ***,influence of snorkel immersion depth on liquid circulation flow rate was numerically investigated under an atmospheric pressure of 101 and 84 kPa,*** result indicates that the circulation flow rate of the RH degasser in the high-altitude area was severely reduced because of the decrease in atmospheric ***,increasing the snorkel immersion depth from 0.5 to 0.7 m can compensate for the decrease in atmospheric *** test result indicates that decarburization rate is significantly enhanced by increasing the snorkel immersion *** optimization,the percentage of heats with a final carbon content less than 0.002 wt.%is significantly increased from 22.0%to 96.4%.

关键词： RH degasser Two-fluid model Population balance model-Circulation flow rate Decarburization Snorkel immersion depth

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Volume of fluid simulation of single argon bubble dynamics in liquid steel under RH vacuum conditions

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Journal of Iron and Steel Research(International) 2024年第4期31卷 828-837页

Single argon bubble dynamics in liquid steel under Ruhrstahl-Heraeus(RH)vacuum conditions were simulated using the volume of fluid method,and the ideal gas law was used to consider bubble growth due to heat transfer and pressure *** simulation with a constant bubble density was also performed to validate the numerical method,and the predicted terminal bubble shape and velocity were found to agree with those presented in the Grace diagram and calculated by drag correlation,*** simulation results under RH conditions indicate that the terminal bubble shape and velocity cannot be *** primary bubble growth occurs within a rising distance of 0.3 m owing to heating by the high-temperature liquid steel;subsequently,the bubble continues to grow under equilibrium with the hydrostatic *** the initial diameter is 8-32 mm,the bubble diameter and rising velocity near the liquid surface are 80-200 mm and 0.5-0.8 m/s,*** bubble rises rectilinearly with an axisymmetric shape,and the shape evolution history includes an initial sphere,(dimpled)ellipsoid,and spherical cap with satellite bubbles.

关键词： Bubble dynamics Liquid steel Volume of fluid Bubble growth Bubble shape Rising velocity

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Impact of atmospheric circulations on droughts and drought propagation over China

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Science China Earth Sciences 2024年第8期67卷 2633-2648页

作者： Ziye gu Lei gu Jiabo YIN Wei FANG Lihua XIONG jun guO Ziyue ZENG jun XIA School of Civil and Hydraulic Engineering Huazhong University of Science and TechnologyWuhan 430074China State Key Laboratory of Water Resources Engineering and Management Wuhan 430072China Changjiang River Scientific Research Institute Wuhan 430010China

The GRACE satellite mission provides a new approach for monitoring,tracking,and assessing drought conditions by detecting changes in Earth's gravitational fields and inversing signals of terrestrial water storage *** studies of terrestrial water storage anomalies related droughts paid rare attention to the behind atmospheric physical mechanisms,nor quantified the risk propagation patterns between terrestrial water storage deficits and hydrological or agricultural *** this study,we first extract terrestrial water storage(TWS) droughts,hydrological droughts,and agricultural droughts by using multiple variables including TWS from the GRACE/GRACE-FO satellites,runoff and soil moisture from the ERA5-Land reanalysis *** then identify key atmospheric and oceanic oscillation indices affecting water deficits by employing machine learning *** characterize the joint distributions between drought duration and severity by using the Copula function and quantify the risk propagation of hydrological and agricultural droughts to TWS *** results show that:(1) From 2002 to 2021,there is a significant decrasing trend of TWS in China;the WPIO group atmospheric circulation indices(sea surface temperature index within the Western Pacific and Indian Ocean) contributes the most to ***,the sea surface temperature anomalies within the NINO 3.4 region as well as the Western Pacific Warm Pool area index show significantly positive correlation relationships with TWS in southern China;(2) The northwestern China,the Yangtze River basin,and the downstream of the Pearl River basin are the hotspots of TWS ***,the hotspots of hydrological droughts locate in northwestern China and the hotspots of agricultural droughts locate in South China and eastern Tibetan Plateau;(3) The elastic coefficients of hydrological droughts propagating to TWS droughts are higher than those of agricultural droughts,indicating that the TWS droughts

关键词： GRACE satellites Drought Drought propagation Atmospheric circulation Copula function

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Optimal Model Average Prediction in Orthogonal Kriging Models

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Journal of Systems Science & Complexity 2024年第3期37卷 1080-1099页

作者： WANG jun HE Jiabei LIANG hua LI Xinmin School of Mathematics and Statistics Qingdao UniversityQingdao 266071China Department of Statistics George Washington UniversityWashington DC 20052USA

The main objective of this paper is to consider model averaging methods for kriging *** paper proposes a Mallows model averaging procedure for the orthogonal kriging model and demonstrate the asymptotic optimality of the model averaging estimators in terms of mean square *** studies are conducted to evaluate the performance of the proposed method and compare it with the competitors to demonstrate its *** authors also analyse a real dataset for an illustration.

关键词： Asymptotic optimality Mallows criterion optimal model averaging orthogonal kriging model

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The essential roles of m^(6)A modification in osteogenesis and common bone diseases

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Genes & Diseases 2024年第1期11卷 335-345页

作者： Yuxi gu Yidan Song Yihua Pan jun Liu State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases Department of OrthodonticsWest China Hospital of StomatologySichuan UniversityChengduSichuan 610041China

N6-methyladenosine(m^(6)A)is the most prevalent modification in the eukaryotic transcriptome and has a wide range of functions in coding and noncoding *** affects the fate of the modified RNA,including its stability,splicing,and translation,and plays an important role in post-transcriptional *** play a key role in supporting and pro-tecting muscles and other organs,facilitating the movement of the organism,ensuring blood production,*** diseases such as osteoarthritis,osteoporosis,and bone tumors are serious public health *** processes of bone development and osteogenic differen-tiation require the precise regulation of gene expression through epigenetic mechanisms including histone,DNA,and RNA *** a reversible dynamic epigenetic mark,m^(6)A modifications affect nearly every important biological process,cellular component,and molecular function,including skeletal development and *** recent years,studies have shown that m^(6)A modification is involved in osteogenesis and bone-related *** this review,we summarized the proteins involved in RNA m^(6)A modification and the latest progress in elucidating the regulatory role of m^(6)A modification in bone formation and stem cell direc-tional *** also discussed the pathological roles and potential molecular mech-anisms of m^(6)A modification in bone-related diseases like osteoporosis and osteosarcoma and suggested potential areas for new strategies that could be used to prevent or treat bone de-fects and bone diseases.

关键词： Bone diseases m^(6)A modification Osteogenesis Regulatory role Stem cells

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Compressed Data Separation via ℓ_(q)-Split Analysis with ℓ_(∞)-Constraint

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Acta Mathematica Sinica,English Series 2024年第7期40卷 1655-1673页

作者： Ming Yang gu Song Li jun Hong Lin School of Mathematical Science Zhejiang UniversityHangzhou310027P.R.China Center for Data Science Zhejiang UniversityHangzhou310027P.R.China

In this paper,we study compressed data separation(CDS)problem,i.e.,sparse data separation from a few linear random *** propose the nonconvex ℓ_(q)-split analysis with ℓ_(∞)-constraint and 0 详细信息

In this paper,we study compressed data separation(CDS)problem,i.e.,sparse data separation from a few linear random *** propose the nonconvex ℓ_(q)-split analysis with ℓ_(∞)-constraint and 0

关键词： Data separation ℓ_(q)-split analysis Dantzig selector frames restricted isometry property compressed sensing

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Clumpy metal concentrations in elliptical galaxies NGC 4374 and NGC 4636

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Research in Astronomy and Astrophysics 2010年第3期10卷 220-226页

作者： Hai-guang Xu jun-hua gu Li-Yi gu Zhong-Li Zhang Yu Wang Tao An Department of Physics Shanghai Jiao Tong University Shanghai 200240 China Max-Planck Institut fur Astrophysik D-85740 Garching Germany Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China

We present a high spatial resolution study of metal distributions in the nearby, gas-rich elliptical galaxies NGC 4374 and NGC 4636 with the Chandra ACIS archive data. We define the hardness ratio HRFeL as the ratio of the emission in 0.65- 1.4 keV to that in 0.3-0.6 keV and 1.4-3.5 keV （after the magnesium and silicon lines are excluded）, and HRcont as the ratio of the emission in 1.4-3.5keV to that in 0.3- 0.6 keV, so that the HRFeL and HRcont maps can be used to trace the iron abundance and gas temperature distributions, respectively. By applying the a Trous wavelet algorithm to the obtained emission hardness ratio maps, we reveal that the HRFeL distributions are highly irregular, exhibiting strong spatial variations on 0.1-1 Re scales, which do not follow the HRcont distributions. Since the effect of temperature variation is small, we conclude that most of the high-HRFeL regions are very likely to possess higher abundances than the ambient gas. We also find that these high-HRFeL substructures are not associated with either the LMXB or globular cluster populations, thus their origins should be related to AGN activity or mergers.

关键词： galaxies: elliptical and lenticular cD -- galaxies: individual (NGC 4374 NGC 4636) -- galaxies: ISM -- ISM: abundances -- X-rays: galaxies

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The radio environment of the 21 Centimeter Array:RFI detection and mitigation

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Research in Astronomy and Astrophysics 2016年第2期16卷 135-144页

作者： Yah huang Xiang-Ping Wu Qian Zheng jun-hua gu Haiguang Xu National Astronomical Observatories Chinese Academy of SciencesBeijing 100012China School of Chemical and Physical Sciences Victoria University of WellingtonWellingtonNew Zealand Department of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China

Detection and mitigation of radio frequency interference （RFI） is the first and also the key step for data processing in radio observations, especially for ongoing low frequency radio experiments towards the detection of the cosmic dawn and epoch of reionization （EoR）. In this paper we demonstrate the tech- nique and efficiency of RFI identification and mitigation for the 21 Centimeter Array （21CMA）, a radio interferometer dedicated to the statistical measurement of EoR. For terrestrial, man-made RFI, we concen- trate mainly on a statistical approach by identifying and then excising non-Gaussian signatures, in the sense that the extremely weak cosmic signal is actually buried under thermal and therefore Gaussian noise. We also introduce the so-called visibility correlation coefficient instead of conventional visibility, which allows a further suppression of rapidly time-varying RFI. Finally, we briefly discuss removals of the sky RFI, the leakage of sidelobes from off-field strong radio sources with time-invariant power and a featureless spec- trum. It turns out that state of the art technique should allow us to detect and mitigate RFI to a satisfactory level in present low frequency interferometer observations such as those acquired with the 21CMA, and the accuracy and efficiency can be greatly improved with the employment of low-cost, high-speed computing facilities for data acquisition and processing.

关键词： dark ages, reionization, first stars -- instrumentation interferometers -- methods data anal-ysis observational -- techniques: interferometric

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A Chandra study of the massive, distant galaxy cluster SDSS J0150–1005

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Research in Astronomy and Astrophysics 2013年第10期13卷 1155-1162页

作者： Zhen-Zhen Qin Hai-guang Xu Jing-Ying Wang jun-hua gu Department of Physics Shanghai Jiao Tong University National Astronomical Observatories Chinese Academy of Sciences

We present a study of a fossil cluster,SDSS J0150–1005（z 0.364）,with high spatial resolution based on the imaging spectroscopic analysis of Chandra *** Chandra X-ray image shows a relaxed and symmetric morphology,which indicates that SDSS J0150–1005 is a well-developed galaxy cluster with no sign of a recent *** to the isothermal model,its global gas temperature is 5.73±0.80 keV,and the virial mass is 6.23±1.34×1014M⊙.Compared with the polytropic temperature model,the mass calculated based on the isothermal model is overestimated by 49%±*** central gas entropy,S0.1 r200=143.9±18.3 keV cm2,is significantly lower than the average value of normal galaxy clusters with similar *** results indicate that SDSS J0150–1005 formed during an early epoch.

关键词： galaxies:clusters:general galaxies:evolution galaxies:halos—intergalactic medium X-rays:galaxies:clusters

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