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Study on Shear Strength Characteristics of Basalt-Concrete Bonding Interface Based on in-situ Direct Shear Test

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Journal of Earth Science 2024年第2期35卷 553-567页

作者： Peng Xia Xinli hu Chunye Ying Shuangshuang Wu Chu Xu Xuan Wang hao Chen Hang Duan College of Harbour and Coastal Engineering Jimei UniversityXiamen361021China Faculty of Engineering China University of GeosciencesWuhan430074China China Three Gorges Construction Group Ltd.Beijing100038China

In rock engineering,the shear strength of the basalt-concrete bonding interface is a key factor affecting the shear performance of hydroelectric dam foundations,embedded rock piles and rock *** this study,30 sets of in-situ direct shear tests were conducted on the basalt-concrete bond interface in the Baihetan dam area to investigate the shear strength characteristics of the basalt-concrete bonding *** bonding interface contains two states,i.e.,the bonding interface is not sheared,termed as se(symbolic meaning see Table 1);the bonding interface is sheared with rupture surface,termed as *** effects of lithology,Joints structure,rock type grade and concrete compressive strength on the shear strength of the concrete-basalt contact surface were *** test results show that the shear strength of the bonding interface(s_(e)&s_(i))of columnar jointed basalt with concrete is greater than that of the bonding interface(s_(e)&s_(i))of non-columnar jointed one with the same rock type *** the rock type grade isⅢ_(2),fcol is 1.22 times higher than fncol and ccol is 1.13 times greater than *** shear strength parameters of the basalt-concrete bonding interface differ significantly for different *** cohesion of the bonding interface(s_(i))of cryptocrystalline basalt with concrete is 2.05 times higher than that of the bonding interface(s_(i))of breccia lava with concrete under the same rock type grade *** type grade has a large influence on the shear strength of the non-columnar jointed basalt-concrete bonding interface(s_(e)&s_(i)).cnol increases by 33%when the grade of rock type rises fromⅢ_(1)toⅡ_(1).the rock type grade has a greater effect on bonding interface(s_(i))cohesion than the coefficient of *** the rock type grade is reduced fromⅢ_(2)toⅢ_(1),f_(ncol)′increases by 2%and c_(ncol)′improves by 44%.The shear strength of the non-columnar jointed basalt-concrete bonding interface(s_(e)&s_(i))increases wit

关键词： direct shear test basalt-concrete bonding interface shear strength parameters engineering geogolgy

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Hapln1 promotes dedifferentiation and proliferation of iPSC-derived cardiomyocytes by promoting versican-based GDF11 trapping

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Journal of Pharmaceutical Analysis 2024年第3期14卷 335-347页

作者： Ding-jun hao Yue Qin Shi-Jie Zhou Bu-huai Dong jun-Song Yang Peng Zou Li-Ping Wang Yuan-Ting Zhao Department of Spine Surgery Honghui HospitalXi'an Jiaotong UniversityXi'an710054China Department of Anesthesiology Honghui HospitalXi'an Jiaotong UniversityXi'an710054China Department of Cardiovascular Medicine Honghui HospitalXi'an Jiaotong UniversityXi'an710054China State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy West China HospitalSichuan UniversityChengdu610041China

Hyaluronan and proteoglycan link protein 1(Hapln1)supports active cardiomyogenesis in zebrafish hearts,but its regulation in mammal cardiomyocytes is *** study aimed to explore the potential regulation of Hapln1 in the dedifferentiation and proliferation of cardiomyocytes and its therapeutic value in myocardial infarction with human induced pluripotent stem cell(hiPSC)-derived cardiomyocytes(CMs)and an adult mouse model of myocardial ***-CMs and adult mice with myocardial infarction were used as in vitro and in vivo models,*** single-cell RNA sequencing data were retrieved for bioinformatic *** results showed that recombinant human Hapln1(rhHapln1)promotes the proliferation of hiPSC-CMs in a dose-dependent *** a physical binding protein of Hapln1,versican interacted with Nodal growth differentiation factor(NODAL)and growth differentiation factor 11(GDF11).GDF11,but not NODAL,was expressed by ***11 expression was unaffected by rhHapln1 ***,this molecule was required for rhHapln1-mediated activation of the transforming growth factor(TGF)-β/Drosophila mothers against decapentaplegic protein(SMAD)2/3 signaling in hiPSC-CMs,which stimulates cell dedifferentiation and *** mouse Hapln1(rmHapln1)could induce cardiac regeneration in the adult mouse model of myocardial *** addition,rmHapln1 induced hiPSC-CM *** conclusion,Hapln1 can stimulate the dedifferentiation and proliferation of iPSC-derived cardiomyocytes by promoting versican-based GDF11 trapping and subsequent activation of the TGF-β/SMAD2/3 signaling ***1 might be an effective hiPSC-CM dedifferentiation and proliferation agent and a potential reagent for repairing damaged hearts.

关键词： Hapln1 Versican GDF11 iPSC-CMs Cardiomyocyte proliferation

Self-Assembled Protein Hybrid Nanofibrils for Photosynthetic Hydrogen Evolution

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CCS Chemistry 2024年第3期6卷 812-823页

作者： Weijian Chen Xiantao hu Andi hu Luyang Ji Yiming huang hao Heng Fude Feng Shu Wang Department of Polymer Science and Engineering School of Chemistry and Chemical EngineeringNanjing UniversityJiangsuNanjing 210023 Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190

In artificial photosynthesis systems,synthetic diiron complexes are popular[FeFe]-hydrogenase mimics,which are attractive for the fabrication of photocatalyst-protein hybrid structures to amplify hydrogen(H2)generation ***,constructing a highly bionic and efficient catalytic hybrid system is a major ***,we designed an ideal hybrid nanofibrils system that incorporates the crucial components:(1)a[FeFe]-H2ase mimic,which has a three-arm architecture(named triFeFe)for more interaction sites and higher catalytic activity and(2)uniform hybrid nanofibrils as the biological environment in which cysteine-catalyst coordination and the hydrogen-bonding network play a vital role in both catalyst binding and hydrogen evolution reaction *** assembled hybrid nanofibrils achieve efficient H2 generation with a turnover number of 2.3×103,outperforming previously reported diiron catalyst-protein hybrid ***,the hybrid nanofibrils work with photosynthetic thylakoids to produce H2,without extra photosensitizers or electron shuttle proteins,which advances the bioengineering of living systems for solar-driven biofuel production.

关键词： hybrid photocatalyst in situ assembly amyloid fibrils photosynthetic hydrogen evolution thylakoid

Extreme drought with seasonal timing consistently promotes CH_(4) uptake through inconsistent pathways in a temperate grassland, China

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Journal of Arid Land 2024年第6期16卷 768-778页

作者： ZHANG Wenwen PAN Yue WEN Fuqi FU Juanjuan hao Yanbin hu Tianming YANG Peizhi College of Grassland Agriculture Northwest A&F UniversityYangling 712100China Binzhou Institute of Technology Weiqiao-UCAS(University of Chinese Academy of Sciences)Science and Technology ParkBinzhou 256606China College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China

Methane(CH_(4))is a potent greenhouse gas that has a substantial impact on global warming due to its substantial influence on the greenhouse *** extreme precipitation events,such as drought,attributable to global warming that caused by greenhouse gases,exert a profound impact on the intricate biological processes associated with CH_(4) ***,the timing of extreme drought occurrence emerges as a pivotal factor influencing CH_(4) uptake,even when the degree of drought remains ***,it is still unclear how the growing season regulates the response of CH_(4) uptake to extreme *** an effort to bridge this knowledge gap,we conducted a field manipulative experiment to evaluate the impact of extreme drought on CH_(4) uptake during early,middle,and late growing stages in a temperate steppe of Inner Mongolia Autonomous Region,*** result showed that all extreme drought consistently exerted positive effects on CH_(4) uptake regardless of seasonal ***,the magnitude of this effect varied depending on the timing of season,as evidenced by a stronger effect in early growing stage than in middle and late growing ***,the pathways of CH_(4) uptake were different from seasonal *** drought affected soil physical-chemical properties and aboveground biomass(AGB),consequently leading to changes in CH_(4) *** structural equation model showed that drought both in the early and middle growing stages enhanced CH_(4) uptake due to reduced soil water content(SWC),leading to a decrease in NO_(3)–-N and an increase in pmoA ***,drought in late growing stage primarily enhanced CH_(4) uptake only by decreasing *** results suggested that seasonal timing significantly contributed to regulate the impacts of extreme drought pathways and magnitudes on CH_(4) *** findings can provide substantial implications for understanding how extreme droughts affect CH_(4) uptake and improve the prediction of

关键词： extreme climate greenhouse gas methane methanotrophs soil inorganic nitrogen

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Heterogeneous engineering of MnSe@NC@ReS2 core-shell nanowires for advanced sodium-/potassium-ion batteries

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Rare Metals 2024年第8期43卷 3713-3723页

作者： Sheng-jun Lu Jin-Yi Lin Cai-Hong Wang Yu-Fei Zhang Yi Zhang hao-Sen Fan College of Materials Science and Metallurgy Engineering Guizhou University School of Energy Science and Engineering Nanjing Tech University School of Chemistry and Chemical Engineering Guangzhou University

Sodium-ion batteries（SIBs） and potassium-ion batteries（PIBs） have been attracting great attentions and widely been exploited due to the abundant sodium/potassium ***,the preparation of high-powered anode materials for SIBs/PIBs plays a decisive role for the commercial applications of SIBs/PIBs in the *** selenides are a class of potential anode materials for SIBs/PIBs because of their small band gap and high electrical *** this work,MnSe and ReS2core-shell nanowires connecting by polydopamine derived carbon nanotube（MnSe@NC@ReS2） have been successfully synthesized from growing ReS2nanosheets array on the surface of MnSe@NC nano wires,which present excellent Na+/K+storage *** applied as SIBs anode,the specific capacity of 300 mAh·g-1was maintwined after 400 cycles at the current density of 1.0 A·***,it could also keep 120 mAh·g-1specific capacity after 900 cycles at 1.0 A·g-1for the anode of *** heterogeneous engineering and one-dimensional-two-dimensional（1D-2D） hybrid strategies could provide an ideal strategy for the synthesis of new hetero-structured anode materials with outstanding battery performance for SIBs and PIBs.

关键词： Heterogeneous engineering Core–shell nanowires MnSe@NC@ReS 2 nanowires Na + batteries K + batteries

Scutellarein Ameliorated Chondrocyte Inflammation and Osteoarthritis in Rats

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Current Medical Science 2024年第2期44卷 355-368页

作者： Shao-ze JING Shu-han YANG Yun-kun QU Hai-hu hao hua WU Department of Orthopedics Third Hospital of Shanxi Medical UniversityShanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalTaiyuan 030032China Department of Orthopedics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective:Osteoarthritis(OA)is a degenerative joint disorder characterized by the gradual degradation of joint cartilage and local *** study aimed to investigate the anti-OA effect of scutellarein(SCU),a single-unit flavonoid compound obtained from Scutellaria barbata ***,in ***:The extracted rat chondrocytes were treated with SCU and IL-1β.The chondrocytes were divided into control group,IL-1βgroup,IL-1β+SCU 50µmol/L group,and IL-1β+SCU 100µmol/L *** of rat chondrocytes was observed by toluidine blue and safranin O ***-8 method was used to detect the cytotoxicity of ***,qRT-PCR,Western blotting,immunofluorescence,SAβ-gal staining,flow cytometry,and bioinformatics analysis were applied to evaluate the effect of SCU on rat chondrocytes under IL-1β***,anterior cruciate ligament transection(ACL-T)was used to establish a rat OA *** changes were detected by safranin O/fast green,hematoxylin-eosin(HE)staining,and ***:SCU protected cartilage and exhibited anti-inflammatory effects via multiple ***,it could enhance the synthesis of extracellular matrix in cartilage cells and inhibit its *** addition,SCU partially inhibited the nuclear factor kappa-B/mitogen-activated protein kinase(NF-κB/MAPK)pathway,thereby reducing inflammatory cytokine production in the joint ***,SCU significantly reduced IL-1β-induced apoptosis and senescence in rat chondrocytes,further highlighting its potential role in OA *** vivo experiments revealed that SCU(at a dose of 50 mg/kg)administered for 2 months could significantly delay the progression of cartilage damage,which was reflected in a lower Osteoarthritis Research Society International(OARSI)score,and reduced expression of matrix metalloproteinase 13(MMP13)in ***:SCU is effective in the therapeutic management of OA and could serve as a potential candidate f

关键词： scutellarein osteoarthritis apoptosis mitogen-activated protein kinase(MAPK) nuclear factor kappa-B(NF-κB)

Research progress of slippage characteristic and gas film stability enhancement methods on biomimetic hydrophobic surfaces

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Journal of Hydrodynamics 2024年第1期36卷 87-101页

作者： Meng-zhuo Zhang Hai-bao hu Liu-zhen Ren Lu-yao Bao jun Wen Luo Xie School of Marine Science and Technology Northwestern Polytechnical UniversityXi’an710072China Research and Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen518063China

The biomimetic hydrophobic surface is a potentially efficient underwater drag reduction method and the drag reduction mechanism of this kind of surface comes from the interfacial *** now,it is a hotspot to grasp the slippage characteristic and explore slippage enhancement *** paper not only summarizes our numerical simulation and experimental results of slippage characteristic at the solid-liquid interface(SLI)of hydrophobic surfaces(HS)and the gas-liquid interface(GLI)of superhydrophobic surfaces(SHS)in recent years,but also introduces some innovative methods that can effectively improve the gas film stability and drag reduction effect of ***,we used the molecular dynamics(MD)simulation method to figure out the effect of the solid-liquid interaction strength,the system temperature and the shear rate on the slippage of SLI,and expound their action mechanism from molecular ***,by MD and multibody dissipative particle dynamics(MDPD)method,the slippage behavior at the GLI was studied under the influence of the microstructure size and the flow driving *** proposed a new kind of hybrid slip boundary condition model to describe the slippage characteristic on *** addition,we found through experiment that a three-dimensional backflow will appear on the GLI under the interfacial adsorption of surfactants,and the backflow direction will reverse with the change of GLI ***,we put forward the wettability step structure and gas injection method to enhance the stability and drag reduction effect of the gas film on SHS.

关键词： Hydrophobic surface superhydrophobic surface interfacial slip underwater drag reduction

Improving chitosan-based composite membrane by introducing a novel hybrid functional nano-hydroxyapatite with carboxymethyl cellulose and phytic acid

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Frontiers of Chemical Science and Engineering 2024年第6期18卷 1-15页

作者： Liuyun Jiang Yingjun Ma Shuo Tang Yuqing Wang Yan Zhang Shengpei Su Xiang hu jun He National&Local Joint Engineering Laboratory for New Petro-chemical Materials and Fine Utilization of Resources Key Laboratory of Chemical Biology&Traditional Chinese Medicine Research(Ministry of Education)College of Chemistry and Chemical EngineeringHunan Normal UniversityChangsha 410081China State Key Laboratory Developmental Biology of Freshwater Fish School of Life ScienceHunan Normal UniversityChangsha 410081China hunan Provincial Key Laboratory of Regional Hereditary Birth Defects Prevention and Control Changsha Hospital for Matemal&Child Health Care Aiffiliated to Hunan Normal UniversityChangsha 410081China

A functional hybrid nano-hydroxyapatite(carboxymethyl cellulose-phytic acid-n-HA,CMC-PA-n-HA)was prepared by adding CMC and *** results of Fourier transformation infrared spectra,X-ray diffraction,thermal gravimetric analysis and dispersion experiments indicated that the addition of CMC and PA affected the morphology,crystallinity and crystal size of hybrid n-HA,and CMC endowed hybrid n-HA with excellent *** electron microscope results showed that CMC-PA-n-HA nanoparticle could be uniformly dispersed in chitosan(CS)matrix to obtain composite membrane by casting technology,so that the highest tensile strength of CMC-PA-n-HA/CS composite membrane was 69.64%and 144.45%higher than that of CS membrane and n-HA/CS composite membrane,*** angle test showed that CMC-PA-n-HA effectively improved hydrophilicity of the CS *** simulated body fluid immersion results indicated that the CMC-PA-n-HA/CS composite membrane not only exhibited good degradability but also promoted bone-like apatite *** cell proliferation experiments proved that the introduction of PA made the composite membrane have better cell adhesion and proliferation *** tests demonstrated that PA could effectively improve the antibacterial properties of the composite membrane,which is expected to be applied as guide bone tissue regeneration membrane.

关键词： nano-hydroxyapatite chitosan dispersion guide bone tissue regeneration membrane

Encoding biological metaverse: Advancements and challenges in neural fields from macroscopic to microscopic

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The Innovation 2024年第3期5卷 30-32页

作者： Yantong Cai Wenbo hu Yao Pei hao Zhao Guangchuang Yu Dermatology Hospital Southern Medical UniversityGuangzhou 266003China Department of Bioinformatics School of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China Tencent AI Lab Shenzhen 518071China State Key Laboratory of Emerging Infectious Diseases School of Public HealthThe University of Hong KongHong Kong SARChina Laboratory of Data Discovery for Health(D24H) Hong Kong Science ParkHong Kong SARChina Institute for AI Industry Research Tsinghua UniversityBeijing 100000China

Neural fields can efficiently encode three-dimensional(3D)scenes,providing a bridge between two-dimensional(2D)images and virtual *** method becomes a trendsetter in bringing the metaverse into vivo *** has initially captured the attention of macroscopic biology,as demonstrated by computed tomography and magnetic resonance imaging,which provide a 3D field of view for diagnostic biological ***,it has also opened up new research opportunities in microscopic imaging,such as achieving clearer de novo protein structure *** this method to the field of biology is particularly significant,as it is refining the approach to studying biological ***,many biologists have yet to fully appreciate the distinctive meaning of neural fields in transforming 2D images into 3D *** article discusses the application of neural fields in both microscopic and macroscopic biological images and their practical uses in biomedicine,highlighting the broad prospects of neural fields in the future biological *** stand at the threshold of an exciting new era,where the advancements in neural field technology herald the dawn of exploring the mysteries of life in innovative ways.

关键词： neural bringing innovative