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Ozone Emitted During Copying Process-A Potential Cause of Pathological Oxidative Stress and Potential Oxidative Damage in the Bodies of Operators

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Biomedical and Environmental Sciences 2003年第2期16卷 95-104页

作者： jun-fuzhou WEI-WEICHEN GUI-ZHONGTONG TheSecondAffiliatedHospital CollegeofMedicineZhejiangUniversity88JiefangRoadHangzhou310009ZhejiangChina ZhejiangProvincialHealthandEpidemicPreventionStation 17LaozhedazhiRoadHangzhou310009ZhejiangChina

To estimate the impact of copying on the indoor air quality, and to investigate whether ozone emitted during such a process induces pathological oxidative stress and potential oxidative damage in the bodies of operators. Methods 67 copying operators (CO) and 67 healthy volunteers (HV) were enrolled in a random control study, in which levels of lipoperoxide (LPO) in plasma and erythrocytes, and levels of vitamin C (VC), vitamin E (VE) and b-carotene (b-CAR) in plasma as well as activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) in erythrocytes were determined by spectrophotometric methods. Results Compared with the HV group, the average values of LPO in plasma and erythrocytes in the CO group were significantly increased (P<0.0001), while those of VC, VE and b-CAR in plasma as well as those of SOD, CAT and GPX in erythrocytes in the CO group were significantly decreased (P<0.0001). Pearson product-moment correlation analysis showed that with increase of ozone level in copying sites and duration of exposure to ozone, the values of LPO in plasma and erythrocytes in the bodies of operators were gradually increased,while those of VC, VE, b-CAR, SOD, CAT and GPX were decreased in the same manner. Odds ratio (OR) of risk of biochemical parameters reflecting potential oxidative damage of the copying operators ranged from 4.440 to 13.516, and 95 % CI of OR was from 2.113 to 34.061. Reliability coefficient () of the biochemical parameters used to reflect the potential oxidative damage of the operators was 0.8156, standardized item =0.9929, P<0.0001. Conclusion Findings in the present study suggest that there exist a series of free radical chain reactions and pathological oxidative stress induced by high dose ozone in the operators, thereby causing potential oxidative and lipoperoxidative damages in their bodies.

关键词： Ozone Oxidation Lipoperoxidation Antioxidant Antioxidase Oxidative stress Oxidative damage Copying Copying operators Copier

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Changes of Expressions of VEGF, bFGF, and Angiogenesis, and Effect of Benazepril, bFGF on Angiogenesis in Acute Myocardial Infarction Model of the Rabbits

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Biomedical and Environmental Sciences 2004年第4期17卷 442-451页

作者： DAN-YANGLI KUIZHAO jun-fuzhou PENGCHEN WEILI SecondAffiliatedHospital CollegeofMedicineZhejiangUniversity88JiefangRoadHangzhou310009ZhefiangChina TheFirstAffiliatedHospital CollegeofMedicineZhejiangUniversityHangzhou310009ZhefiangChina

Objective To explore the changes of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and angiogenesis, and the effects of bFGF, angiotensin converting enzyme inhibiter(ACEI) benazepril on the angiogenesis in acute myocardial infarction (AMI) model of rabbits, and to provide a probable evidence for the treatment of AMI. Methods AMI model was established by ligating anterior descending branch of coronary artery of Japan-Sino hybridization white rabbits. The postoperative rabbits were randomly divided into 6 groups and each group was treated with different drugs. Groups 1 and 2 were treated with normal saline (NS) for 28 and 14 days (d), group 3 and 4 with bFGF for 28 and 14 d, groups 5 with benazepril for 14 d, and group 6 with benazepril and bFGF for 14 d respectively. The rabbits were killed on the 14th or 28th d and their hearts were excised, sectioned and stained with HE, Masson trichrome to observe VEGF, bFGF and CD34 under a microscope, which were quantified with a computer-assisted morphometry. Results Compared with group 1, the granulation tissue of infarction zone (IZ) in group 2 freshened up, and the capillary density (CD) in IZ was increased (P=0.002). The CD in the IZ as well as VEGF and bFGF in groups 3 and 4 were increased respectively (P=0.011-0.037). In group 5 the changes of VEGF and bFGF were not found in the IZ and the border zone (BZ) while CD was significantly increased (35.4% and 25.6%, P=0.036 and 0.037). Compared with group 2, the CD in the IZ and BZ of group 6 was significantly increased (63.4% and 44.3% P=0.007 and 0.007), meanwhile VEGF and bFGF were increased. Compared with group 5, only VEGF was increased. Conclusion Intravenous bFGF may increase VEGF and bFGF significantly, thus promoting the angiogenesis in the IZ and BZ in cardiac infarction as VEGF and bFGF are the potent angiogenic growth factors. Benazepril may promote angiogenesis in the IZ and BZ in cardiac infarction, but its mechanism is irr

关键词： Myocardial infarction Angiogenesis Basic fibroblast growth factor Vascular endothelial growth factor Benazepril

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May Chronic Childhood Constipation Cause Oxidative Stress and Potential Free Radical Damage to Children?

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Biomedical and Environmental Sciences 2004年第3期17卷 266-272页

作者： JI-YUEWANG YE-LINGWANG SHENG-LIZHOU jun-fuzhou SecondAffiliatedHospitalCollegeofMedicine ZhejiangUniversity88JiefangRoadHangzhou310009ZhejiangChina AffiliatedChildren＇sHospital CollegeofMedicineZhejiangUniversity57ZhuganLaneHangzhou310003ZhejiangChina

Objective To investigate whether chronic childhood constipation (CCC) may cause oxidative stress and potential free radical damage to children, and to explore the mechanisms by which CCC may cause oxidative stress and potential free radical damage to chronic constipation patients (CCPs). Methods Sixty CCPs and sixty healthy child volunteers (HCVs) whose ages, gender and others were matched for the CCPs were enrolled in a randomized controlled study, in which levels of vitamin C (VC) and vitamin E (VE) in plasma as well as activities of superoxide dismutase (SOD) and catalase (CAT) in erythrocytes were determined by spectrophotometric analytical methods. Results Compared with average values of the above biochemical parameters in the HCVs group, the average values of VC and VE in plasma as well as those of SOD and CAT in erythrocytes in the CCPs group were significantly decreased (P<0.0001). Linear regression and bivariate correlation analysis showed that with prolonged course of the CCPs, the levels of VC and VE in plasma as well as the activities of SOD and CAT in erythrocytes in the CCPs were decreased gradually (P<0.0001). Conclusion The findings in the present study suggest that chronic childhood constipation causes oxidative stress and potential free radical damage to children with chronic constipation.

关键词： Chronic childhood constipation Oxidative stress Free radicals Free radical damage Antioxidant Antioxidase

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Influence of Hypertension, Lipometabolism Disorders,Obesity and Other Lifestyles on SpontaneousIntracerebral Hemorrhage

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Biomedical and Environmental Sciences 2003年第3期16卷 295-303页

作者： jun-fuzhou JI-YUEWANG YAN-ERLUO HUAI-HONGCHEN SecondAffiliatedHospitalofCollegeofMedicine ZhejiangUniversity88JiefangRoadHangzhou310009ZhejiangChina AffiliatedChildren‘sHospital MedicalCollegeZhejiangUniversity57ZhuganLaneHangzhou310003ZhejiangChina FuyangMunicipalHospitalofTraditionalChineseMedicine 4BeimenRoadFuyang311400ZhejiangChina BrainMedicineResearchInstituteofZhejiangUniversity 88JiefangRoadHangzhou310009ZhejiangChina

Objective To investigate whether hypertension, abnormal lipometabolism, obesity, cigarette smoking and alcohol drinking affect the intracerebral hemorrhagic volumes (IHV) in patients with spontaneous intracerebral hemorrhage (SIHP), and to explore the roles of these factors in spontaneous intracerebral hemorrhage (SIH). Methods Five hundred patients with acute SIH and 200 healthy adult volunteers (HAV) were enrolled in a study of independently randomized controlled design, in which the levels of systolic pressure (SP) and diastolic pressure (DP), and total cholesterol (TCH), triacylglycerols (triglycerides, TG), high density lipoprotein cholesterol (HDL-CH), low density lipoprotein cholesterol (LDL-CH) in serum as well as the level of erythrocytic membrane cholesterol (EM-CH) were measured, and the body mass index (BMI), daily cigarette smoking consumption (DCSC) and daily pure alcohol consumption (DPAC) were calculated. Results Compared with the average parameters in the HAV group, those of SP, DP, TG, LDL-CH and BMI in the SIHP group were significantly increased (P<0.0001), while those of HDL-CH and EM-CH were significantly decreased (P<0.0001). The linear regression and correlation analysis showed that with increased SP, DP, LDL-CH, BMI, DCSC, DPAC and aging as well as decreased HDL-CH and EM-CH, the IHV levels in SIHP were increased gradually (P<0.0001-0.01). The linear stepwise regression analysis suggested that there existed a close correlation among the values of SP, DP, TCH, TG, HDL-CH, LDL-CH, EM-CH, BMI, DCSC, DPAC, age and fflV of the SIH patients, and that Y = - 12.4583 + 0.1127SP -1.1977EM-CH + 0.9788LDL-CH + 0.2477BMI + 0.0382DCSC + 0.0248DP,P<0.0001-0.05. Conclusions The findings in the present study suggest that significantly increased systolic and diastolic pressure, low density lipoprotein cholesterol, body mass index and daily cigarette smoking consumption, and significantly decreased erythrocytic membrane cholesterol may be likely the main factor

关键词： Blood pressure Lipids Cigarette smoking Alcohol drinking Body mass index Spontaneous intracerebral hemorrhage Intracerebral hemorrhagic volume

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3,4-Methylenedioxymethamphetamine(MDMA)Abuse Markedly Inhibits Acetylcholinesterase Activity and Induces Severe Oxidative Damage and Liperoxidative Damage

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Biomedical and Environmental Sciences 2003年第1期16卷 53-61页

作者： jun-fuzhou YE-ZHOU LINAGZHANG HUAI-HONGCHEN DONGCAI SecondAffiliatedHospital CollegeofMedicineZhejiangUniversity88JiefangRoadHangzhou310009ZhejiangProvinceChina HangzhouMunicipalPublicSecurityBureau 35HuaguangRoadHangzhou310002ZhejiangProvinceChina. ZhejiangSurveillanceStationofDrugAbuse 88JiefangRoadHangzhou310009ZhejiangprovinceChina

Objective To investigate whether 3,4-methylenedioxymethamphetamine (MDMA) abuse produces another neurotoxicity which may significantly inhibit the acetylcholinesterase activity and result in severe oxidative damage and liperoxidative damage to MDMA abusers. Methods 120 MDMA abusers (MA) and 120 healthy volunteers (HV) were enrolled in an independent sample control design, in which the levels of lipoperoxide (LPO) in plasma and erythrocytes as well as the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX) and acetylcholinesterase (AChE) in erythrocytes were determined by spectrophotometric methods. Results Compared with the average values of biochemical parameters in the HV group, those of LPO in plasma and erythrocytes in the MA group were significantly increased (P<0.0001), while those of SOD, CAT, GPX and AChE in erythrocytes in the MA group were significantly decreased (P<0.0001). The Pearson product-moment correlation analysis between the values of AChE and biochemical parameters in 120 MDMA abusers showed that significant linear negative correlation was present between the activity of AChE and the levels of LPO in plasma and erythrocytes (P<0.0005-0.0001), while significant linear positive correlation was observed between the activity of AchE and the activities of SOD, CAT and GPX (P<0.0001). The reliability analysis for the above biochemical parameters reflecting oxidative and lipoperoxidative damages in MDMA abusers suggested that the reliability coefficient (alpha) was 0.8124, and that the standardized item alpha was 0.9453. Conclusion The findings in the present study suggest that MDMA abuse can induce another neurotoxicity that significantly inhibits acetylcholinesterase activity and aggravates a series of free radical chain reactions and oxidative stress in the bodies of MDMA abusers, thereby resulting in severe neural, oxidative and lipoperoxidative damages in MDMA abusers.

关键词： 3,4-Methylenedioxymethamphetamine MDMA Drug abuse Acetylcholinesterase Free radicals Lipoperoxide Antioxidase Oxidative stress Oxidative damage Lipoperoxidative damage

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Oxidative Stress and Free Radical Damage in Patients With Acute Dipterex Poisoning

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Biomedical and Environmental Sciences 2004年第2期17卷 223-233页

作者： jun-fuzhou WENZHOU SHU-MEIZHANG YAN-ERLUO HUAI-HONGCHEN SecondAffiliatedHospitalofCollegeofMedicine ZhejiangUniversity88JiefangRoadHangzhou310009ZhejiangChina FuyangMunicipalHospitalofTraditionalChineseMedicine 4BeimenRoadFuyang311400ZhejiangChina ZhejiangSurveillanceStationofDrugAbuse 88JiefangRoadHangzhou310009ZhejiangChina

Objective To investigate whether acute dipterex poisoning (ADP) may cause oxidative stress and free radical damage in the bodies of acute dipterex poisoning patients (ADPPs), and to explore the mechanisms by which ADP may cause oxidative stress and free radical damage. Methods Fifty ADPPs and fifty healthy adult volunteers (HAVs) whose ages, gender and others were matched with the ADPPs were enrolled in a randomized controlled study, in which concentrations of nitric oxide (NO), vitamin C (VC), vitamin E (VE) and P-carotene (P-CAR) in plasma as well as concentration of lipoperoxide (LPO), and activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX) and acetylcholinesterase (AChE) in erythrocytes were determined by spectrophotometric analytical methods. Results Compared with the average values of experimental parameters in the HAVs group, the average values of plasma NO and erythrocyte LPO in the ADPPs group were significantly increased (P<0.0001), while those of plasma VC, VE and P-CAR as well as erythrocyte SOD, CAT, GPX and AChE in the ADPPs group were significantly decreased (P<0.0001). Bivariate correlation analysis and partial correlation analysis suggested that when NO and LPO values were increased, and VC, VE, β-CAR, SOD, CAT and GPX values were decreased in the ADPPs, AChE value was decreased gradually in the ADPPs (P<0.001-0.0001). Reliability analysis of experimental parameters reflecting oxidative stress and free radical damage in the ADPPs showed that the reliability coefficient (8 items) alpha=0.6909, and the standardized item alpha=0.8574. Conclusion The findings in the present study suggest that ADP can cause oxidative stress and free radical damage, and inhibit markedly erythrocyte acetylcholinesterase activity in ADPPs.

关键词： Dipterex Dipterex poisoning Oxidative stress Free radical damage Free radicals Oxidation Lipoperoxidation Acetylcholinesterase

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Potential oxidative stress in children with chronic constipation

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World Journal of Gastroenterology 2005年第3期11卷 368-371页

作者： jun-fuzhou Jian-GuoLou Sheng-LiZhou Ji-YueWang SecondHospital CollegeofMedicineZhejiangUniversityHangzhou310009ZhejiangProvinceChina Children'sHospital CollegeofMedicineZhejiangUniversityHangzhou310003ZhejiangProvinceChina

AIM: To investigate the potential oxidative stress in children with -chronic constipation and to explore its ***: Seventy children with chronic constipation and 70 age- and sex-matched healthy children were enrolled in a randomized controlled study. Plasma levels of vitamins C and E, activities of superoxide dismutase and catalase and lipoperoxide level in erythrocytes were determined by ***: Compared with healthy children whose vitamin C,vitamin E, superoxide dismutase, catalase and lipoperoxide were 58.35±14.42 μmol/L, 27.15±6.55 μmol/L, 2 206±171U/(g· Hb), 327.3±82.2 K/(g·Hb) and 19.18±4.27 nmol/(g·Hb)respectively, the levels of vitamin C, vitamin E, the activity of superoxide dismutase, and catalase in the children with chronic constipation significantly decreased [46.59±11.51 μmol/L,20.65±4.80 μmol/L, 1943±147 U/(g·Hb) and 269.3±67.8 K/(g·Hb),respectively P＜0.01], while the lipoperoxide significantly increased [25.22±5.01 nmol/(g·Hb), P＜0.01]. With a prolonged course of disease, the levels of vitamin C, vitamin E, the activity of superoxide dismutase and catalase in the children with chronic constipation gradually decreased,while the level of lipoperoxide gradually ***: Chronic constipation can cause potential oxidative stress in children.

关键词： Chronic constipation Potential oxidative stress Spectrophotometry

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Potential Oxidative Stress in the Bodies of Electric Arc Welding Operators: Effect of Photochemical Smog

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Biomedical and Environmental Sciences 2004年第4期17卷 381-389页

作者： You-GENZHU jun-fuzhou WEI-YINGSHAN PEI-SUZHOU ANDGuI-ZHONGTONG JinhuaMunicipalPeople＇sHospital 228XinhuaStreetJinhua321000Zhejiang SecondAffiliatedHospital CollegeofMedicineZhejiangUniversity88JiefangRondHangzhou310009ZhejiangChina ZhejiangCenterforDiseaseControlandPrevention 17LaozhedazhiRoadHangzhou310009ZhejiangChina

Objective To investigate whether photochemical smog emitted during the process of electric arc welding might cause oxidative stress and potential oxidative damage in the bodies of welding operators. Methods Seventy electric arc welding operators (WOs) and 70 healthy volunteers (HVs) were enrolled in a randomized controlled study design, in which the levels of vitamin C (VC) and vitamin E (VE) in plasma as well as the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX), and the level of lipoperoxide (LPO) in erythrocytes were determined by spectrophotometry. Results Compared with the average values of the above experimental parameters in the HVs group, the average values of VC and VE in plasma as well as those of SOD, CAT and GPX in erythrocytes in the WOs group were significantly decreased (P<0.005-0.0001), while the average value of LPO in erythrocytes in the WOs group was significantly increased (P<0.0001). The findings from the partial correlation analysis on the controlling of age suggested that with a prolonged duration of exposure to photochemical smog the values of VC, VE, SOD, and GPX, except for CAT, in the WOs were decreased gradually (P<0.05-0.005), the value of LPO in the WOs was increased gradually (P<0.001), and that with the ozone dose increased in the air in each worksite VC, VE, SOD, CAT and GPX decreased (P<0.005-0.001), but LPO increased (P<0.001). The findings from the reliability analysis for the VC, VE, SOD, CAT, GPX, and LPO values which were used to reflect oxidative stress and potential oxidative damage in the WOs showed that the reliability coefficients?alpha (6 items) was 0.8021, P<0.0001, and that the standardized item alpha was 0.9577, P<0.0001. Conclusion Findings in the present study suggest that there exists an oxidative stress induced by long-term exposure to photochemical smog in the bodies of WOs, thereby causing potential oxidative and lipoperoxidative damages in their bodies.

关键词： Oxidative stress Oxidative damage Electric arc welding Welder Photochemical smog Ozone Nitrogen dioxide Oxidation Lipoperoxidation Antioxidant Antioxidase

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Synthesis and Crystal Structure of Compound〔Zn （S6）（CH3C5H4N）2〕

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Chinese Journal of Structural Chemistry 1995年第Z1期 369-372页

作者： Hong-jun (Department of Chemistry, fuzhou University, fuzhou,Fujian 350002)Sheng Tian-Lu Wu Xin-Tao (State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences,fuzhou, Fujian,350002)

ＳｙｎｔｈｅｓｉｓａｎｄＣｒｙｓｔａｌＳｔｒｕｃｔｕｒｅｏｆＣｏｍｐｏｕｎｄ〔Ｚｎ（Ｓ６）(ＣＨ３Ｃ５Ｈ４Ｎ)２〕￥ＬｉＨｏｎｇ－Ｊｕｎ(ＤｅｐａｒｔｍｅｎｔｏｆＣｈｅｍｉｓｔｒｙ，ＦｕｚｈｏｕＵｎｉｖｅｒｓｉｔｙ，Ｆ... 详细信息

ＳｙｎｔｈｅｓｉｓａｎｄＣｒｙｓｔａｌＳｔｒｕｃｔｕｒｅｏｆＣｏｍｐｏｕｎｄ〔Ｚｎ（Ｓ６）(ＣＨ３Ｃ５Ｈ４Ｎ)２〕￥ＬｉＨｏｎｇ－Ｊｕｎ(ＤｅｐａｒｔｍｅｎｔｏｆＣｈｅｍｉｓｔｒｙ，ＦｕｚｈｏｕＵｎｉｖｅｒｓｉｔｙ，Ｆｕｚｈｏｕ，Ｆｕｊｉａｎ３?..

关键词： molecular structure 3-methylpridrine zinc compound

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Synthesis and Crystal Structure of Compound 〔ZnS6(C12H8N2)〕

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Chinese Journal of Structural Chemistry 2000年第1期 11-14页

作者： CHEN Zhi\|Rong\+a\ LI Jian\|Hui\+b\ LI Hong\|jun\+a a\ (Department of Chemistry, fuzhou University, fuzhou, Fujian, 350002) b\ (Fujian Agriculture University, Fujian, 350002) SU Wei\|Ping c\ CAO Rong c c\ (State Key Laboratory of Structural Chemist

The title compound ZnS\-6(C\-\{12\}H\-8N\-2) was obtained by reaction of zinic powder with sulfur and 1,10\|phenathtroline in DMF solvent, and its structure has been determined by single crystal X\|ray diffraction analysis. The crystal data for the compound: triclinic, \$P1, Z=2, a=8.159(2), b=9.485(2), c=11.997(2), α=110.00(3)°,β=99.22(3)°, γ=100.57(3)°, V=832\+3, D\-c\$=1.748g/cm\+3, μ (M\-o K\-α )=0.2219 cm\+\{-1\}, F (000)=440. The structure was refined to \$R=0.0723\$ and \$R\-w=0.0865\$ for 1427 independent observed reflections. The tilte crystal consists of a discrete molecules, in which the core of ZnS\-2N\-2 shows a distorted tetrahedral geometry.

关键词： molecular structure phenathtroline zinic compound synthesis

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