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A randomized clinical trial investigating treatment choice in Chinese men receiving sildenafil citrate and tadalafil for treating erectile dysfunction

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Asian Journal of Andrology 2017年第4期19卷 500-504页

作者： wen-jun bai Hong-jun Li Jian-jun Jin wen-Ping Xu Sorsaburu Sebastian Xiao-Feng Wang Department of Urology Peking University People's Hospital Beijing 100044 China Department of Urology Peking Union Medical College Hospital Beijing 100730 China Department of Medical Lilly Suzhou Pharmaceutical Co. Ltd. Shanghai 200021 China Eli Lilly and Company Indianapolis Indiana 46285 USA

Sildenafil and tadalafil are efficacious and well tolerated in Chinese men with erectile dysfunction （ED）. Recent study results indicate that men with ED in China who were naive to phosphodiesterase inhibitor type 5 （PDE5） therapy prefer tadalafil 20-mg （on-demand） versus sildenafil 100-mg （on-demand）. Differences in psychosocial outcomes may help to explain treatment preference in favor of tadalafih This open-label, randomized, crossover study compared psychosocial outcomes and drug attribute choices between tadalafil and sildenafil in Chinese men with ED na＇（ve to PDE5 inhibitor therapy. Eligible patients were randomized to sequential 20-mg tadalafU/lOO-mg sildenafil （n = 190） or 100-mg sildenafil/20-mg tadalafil （n = 193） for 8 weeks each and were asked which treatment they preferred to take for the 8-week extension phase. Psychosocial outcomes were assessed using the Psychological and Interpersonal Relationship Scale （PAIRS）, Drug Attributes Questionnaire （DRAQ）, and Sexual Life Quality Questionnaire （SLQQ）. When taking tadalafil versus sildenafil, men had a higher mean endpoint score on the PAIRS Spontaneity Domain （tadalafil = 2.86 vs sildenafil = 2.72; P 〈 0.001）, and a lower mean endpoint score on the Time Concerns Domain （tadalafil = 2.41 vs sildenafil = 2.55; P 〈 0.001）. A numerical increase in the Sexual Self-Confidence Domain was observed when taking tadalafil versus sildenafil （tadalafil -- 2.76 vs sildenafil = 2.72; P= 0.102）. The most frequently chosen drug attributes explaining treatment preference were able to get an erection long after having drug, and ability to get an erection every time. SLQQ results were comparable between treatment groups. These psychosocial outcomes may explain why more Chinese men preferred tadalafil versus sildenafil for the treatment of ED in this clinical trial.

关键词： drug attributes erectile dysfunction phosphodiesterase type 5 inhibitor psychological assessment of sexual dysfunction

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An analysis of treatment preferences and sexual quality of life outcomes in female partners of Chinese men with erectile dysfunction

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Asian Journal of Andrology 2016年第5期18卷 773-779页

作者： Hong-jun Li wen-jun bai Yu-Tian Dai wen-Ping Xu Chia-Ning Wang Han-Zhong Li Department of Urology Peking Union Medical College Hospital Beijing 100730 China Department of Urology Peking University People's Hospital Beijing 100044 China Department of Andrology Nanjing Drum Tower Hospital Jiangsu 210008 China Department of Medical Lilly Suzhou Pharmaceutical Co. Ltd. Shanghai 200021 China

The impact of erectile dysfunction is distressing to both males and their female partners, but less attention has been paid to identify female partners＇ preferred treatment and sexual quality of life outcomes. The present analysis explores female partners＇ treatment preference for erectile dysfunction in Chinese Men. This was a phase 4, randomized, open-label, multicenter, crossover study in Chinese men with erectile dysfunction who were na＇fve to phosphodiesterase type 5 inhibitor treatments. Eligible patients were randomized to sequential 20-mg tadalafil/100-mg sildenafil or lO0-mg sildenafil/20-mg tadalafil for 8 weeks each. Of 418 patients, female partners of 64 patients agreed to enter the study; of 64 patients who entered the study with female partners, 63 were randomized, and 62 completed the study. Baseline demographics and disease characteristics were comparable between treatment groups. Significantly more couples preferred tadalafil compared with sildenafil overall （75.4% vs 24.6%; P〈 0.001）, and irrespective of erectile dysfunction severity at baseline （P 〈 0.005）. Significant improvements in sexual quality of life scores were reported at endpoint （Visit 8） in male patients and female partners in both tadalafil and sildenafil treatment groups （P 〈 0.001）. Significantly higher mean changes from baseline were observed for male patients in the tadalafil group compared with the sildenafil group for the erectile function （P = 0.013） and overall satisfaction （P = 0.019） International Index for Erectile Function domains and the spontaneity domain （P〈 0.001） of the Psychological and Interpersonal Relationship Scale. No major safety concerns were reported during the study. Though both treatments were effective, safe, and tolerable, more couples preferred tadalafil compared with sildenafil.

关键词： erectile dysfunction partners' preference sexual quality of life sildenafil tadalafil

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Penile augmentation with injectable hyaluronic acid gel:an alternative choice for small penis syndrome

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Asian Journal of Andrology 2022年第6期24卷 601-606页

作者： Chun-Long Zhang Yuan Quan He Li Qing Li wen-jun bai Tao Xu Xiao-Wei Zhang Department of Urology Peking University People's HospitalBeijing 100044China

There is no well-established procedure for the management of small penis syndrome(SPS),especially when psychological interventions *** study aimed at systematically evaluating the physical and psychological benefits of penile augmentation(PA)using injectable hyaluronic acid(HA)***-eight patients receiving PA with HA gel from January 2017 to March 2020 were included and followed up for 1 *** size,erectile function,and psychological burden measured by the Index of Male Genital Image(IMGI),Index of International Erectile Function(lIEF),and Beliefs about Penis Size(BPAS),respectively,were assessed at the beginning and at 1,3,6,and 12 months *** volume of HA gel injected was 21.5±3.7 *** to baseline data,flaccid penile girth and length significantly increased by 3.41±0.95 cm(P<0.01)and 2.55±0.55 cm(P<0.01)at the 1^(st)month postinjection,*** the endpoint,despite attenuations,statistically significant improvements in flaccid penis size were still obtained,namely 2.44±1.14 cm in girth(P<0.01)and 1.65±0.59 cm in length(P<0.01).Similarly,erectile penile girth statistically increased by 1.32±1.02 cm(P<0.01)at the 1^(st)month but were only 0.80±0.54 cm bigger than baseline(P

关键词： hyaluronic acid penile augmentation small penis syndrome

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An open-label, multicenter, randomized, crossover study comparing sildenafil citrate and tadalahl for treating erectile dysfunction in Chinese men na＇=＇ve to phosphodiesterase 5 .inhibitor therapy

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Asian Journal of Andrology 2015年第1期17卷 61-67,I0007,I0008页

作者： wen-jun bai Hong-jun Li Yu-Tian Dai Xue-You He Yi-Ran Huang Ji-Hong Liu Sebastian Sorsaburu Chen Ji Jian-jun Jin Xiao-Feng Wang Department of Urology People's Hospital of Peking University Beijing China Department of Urology Peking Union Medical College Hospital Beijing China Department of Andrology Nanjing Drum Tower Hospital Jiangsu China Department of Urology Chinese PLA General Hospital Beijing China Department of Urology Shanghai Renji Hospital Shanghai China Department of Urology Tongji Hospital Tengji Medical College of Huazhong University of Science and Technology Wuhan China Department of Medical Eli Lilly and Company Indianapolis IN USA Department of Medical Lilly Suzhou Pharmaceutical Co. Ltd. Shanghai China.

The study was to compare treatment preference, efficacy, and tolerability of sildenafil citrate （sildenafil） and tadalafil for treating erectile dysfunction （ED） in Chinese men na＇ive to phosphodiesterase 5 （PDE5） inhibitor therapies. This multicenter, randomized, open-label, crossover study evaluated whether Chinese men with ED preferred 20-mg tadalafil or 100-mg sildenafil. After a 4 weeks baseline assessment, 383 eligible patients were randomized to sequential 20-mg tadalafil per 100-mg sildenafil or vice versa for 8 weeks respectively and then chose which treatment they preferred to take during the 8 weeks extension. Primary efficacy was measured by Question 1 of the PDE5 Inhibitor Treatment Preference Questionnaire （PITPQ）. Secondary efficacy was analyzed by PITPQ Question 2, the International Index of Erectile Function （IIEF） erectile function （EF） domain, sexual encounter profile （SEP） Questions 2 and 3, and the Drug Attributes Questionnaire. Three hundred and fifty men （91%） completed the randomized treatment phase. Two hundred and forty-two per 350 （69.1%） patients preferred 20-mg tadalafil, and 108/350 （30.9%） preferred lO0-mg sildenafil （P 〈 0.001） as their treatment in the 8 weeks extension. Ninety-two per 242 （38%） patients strongly preferred tadalafil and 37/108 （34.3%） strongly the preferred sildenafil. The SEP2 （penetration）, SEP3 （successful intercourse）, and IIEF-EF domain scores were improved in both tadalafil and sildenafil treatment groups. For patients who preferred tadalafil, getting an erection long after taking the medication was the most reported reason for tadalafil preference. The only treatment-emergent adverse event reported by 〉 2% of men was headache. After tadalafil and sildenafil treatments, more Chinese men with ED na＇ive to PDE5 inhibitor preferred tadalafil. Both sildenafil and tadalafil treatments were effective and safe.

关键词： erectile dysfunction patient preference phosphodiesterase 5 inhibitors

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Evolution of pore systems in low-maturity oil shales during thermal upgrading--Quantified by dynamic SEM and machine learning

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Petroleum Science 2024年第3期21卷 1739-1750页

作者： jun Liu Xue bai Derek Elsworth Key Laboratory of Deep Underground Science and Engineering(Ministry of Education) Institute of New Energy and Low-Carbon TechnologySichuan UniversityChengdu610065SichuanChina International Quantum Academy Shenzhen518048GuangdongChina Shenzhen Institute of Advanced Electronic Materials Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen518055GuangdongChina Department of Energy and Mineral Engineering Pennsylvania State University ParkPA 16802USA

In-situ upgrading by heating is feasible for low-maturity shale oil,where the pore space dynamically *** characterize this response for a heated substrate concurrently imaged by *** systematically follow the evolution of pore quantity,size(length,width and cross-sectional area),orientation,shape(aspect ratio,roundness and solidity)and their anisotropy—interpreted by machine *** indicate that heating generates new pores in both organic matter and inorganic ***,the newly formed pores are smaller than the original pores and thus reduce average lengths and widths of the bedding-parallel pore ***,the average pore lengths and widths are increased in the bedding-perpendicular ***,heating increases the cross-sectional area of pores in low-maturity oil shales,where this growth tendency fluctuates at300℃.In addition,the orientation and shape of the newly-formed heating-induced pores follow the habit of the original pores and follow the initial probability distributions of pore orientation and ***,limited anisotropy is detected in pore direction and shape,indicating similar modes of evolution both bedding-parallel and *** propose a straightforward but robust model to describe evolution of pore system in low-maturity oil shales during heating.

关键词： Low-maturity oil shale Pore elongation Organic matter pyrolysis In-situthermal upgrading Scanning electron microscopy(SEM) Machine learning

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Clinical efficacy and pathological outcomes of transanal endoscopic intersphincteric resection for low rectal cancer

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 933-944页

作者： Zhi-wen Xu Jing-Tao Zhu Hao-Yu bai Xue-jun Yu Qing-Qi Hong jun You Department of Gastrointestinal Oncology Surgery The First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen 361000Fujian ProvinceChina

BACKGROUND Transanal endoscopic intersphincteric resection(ISR)surgery currently lacks sufficient clinical research and *** To investigate the clinical effectiveness of transanal endoscopic ISR,in order to promote the clinical application and development of this *** This study utilized a retrospective case series *** and pathological data of patients with lower rectal cancer who underwent transanal endoscopic ISR at the First Affiliated Hospital of Xiamen University between May 2018 and May 2023 were *** patients underwent transanal endoscopic ISR as the surgical *** conducted this study to determine the perioperative recovery status,postoperative complications,and pathological specimen charac-teristics of this group of *** This study included 45 eligible patients,with no perioperative *** overall incidence of early complications was 22.22%,with a rate of 4.44%for Clavien-Dindo grade≥III *** patients(4.4%)developed anastomotic leakage after surgery,including one case of grade A and one case of grade *** pathological examination confirmed negative circumferential resection margins and distal resection margins in all *** mean distance between the tumor lower margin and distal resection margin was found to be 2.30±0.62 *** transanal endoscopic ISR procedure consistently yielded high quality pathological *** Transanal endoscopic ISR is safe,feasible,and provides a clear anatomical *** is associated with a low incidence of postoperative complications and favorable pathological outcomes,making it worth further research and application.

关键词： Intersphincteric resection Transanal Rectal cancer Complications Endoscopic

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Stability analysis of longwall top-coal caving face in extra-thick coal seams based on an innovative numerical hydraulic support model

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International Journal of Mining Science and Technology 2024年第4期34卷 491-505页

作者： jun Guo wenbo Huang Guorui Feng Jinwen bai Lirong Li Zi Wang Luyang Yu Xiaoze wen Jie Zhang wenming Feng College of Mining Engineering Taiyuan University of TechnologyTaiyuan 030024China Key Laboratory of Shanxi Province for Mine Rock Strata Control and Disaster Prevention Taiyuan University of TechnologyTaiyuan 030024China Shanxi Coking Coal Group Co. Ltd.Taiyuan 030024China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030024China

The relationship between support and surrounding rock is of great significance to the control of surrounding rock in mining *** view of the fact that most of the existing numerical simulation methods construct virtual elements and stress servo control to approximately replace the hydraulic support problem,this paper establishes a new numerical model of hydraulic support with the same working characteristics as the actual hydraulic support by integrating numerical simulation software Rhino,Griddle and FLAC3D,which can realize the simulation of different working *** on this model,the influence mechanism of the supporting strength of hydraulic support on surrounding rock stress regulation and coal stability in front of the top coal caving face in extra thick coal seam were ***,under different support intensity,the abutment pressure of the bearing coal and the coal in front of it presents the “three-stage”evolution *** influence range of support intensity is 15%–30%.Secondly,1.5 MPa is the upper limit of impact that the support strength can have on the front coal failure ***,within a displacement range of 2.76 m from the coal wall,a support strength of1.5 MPa provides optimal control of the horizontal displacement of the coal.

关键词： Extremely thick coal seam Fully mechanized top coal caving Support strength Support-surrounding rock interaction

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Effects of surface morphology on tribological properties of Arapaima gigas scales

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Friction 2024年第7期12卷 1469-1482页

作者： Shuaijun ZHANG Pengpeng bai Xiangli wen Chengwei wen Hui CAO Wanyou YANG Yu TIAN State Key Laboratory of Tribology in Advanced Equipment Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China Key Laboratory of Bionic Engineering(Ministry of Education China)Jilin UniversityChangchun 130022China

The remarkable mechanical adaptability of arapaima(Arapaima gigas)scales has made them an important subject of ***,no research has been conducted into their tribological properties,which are crucial for the protectability and flexibility of *** this study,by combining morphological characterizations,friction experiments,and theoretical analyses,the relationship between the surface morphology and tribological properties of arapaima scales is *** results indicate that arapaima scales exhibit varying surface morphologies in different *** specifically,the exposed regions of scales feature grooves and a circulus,whereas the covered regions exhibit *** specific surface morphology of arapaima scales produces varying tribological properties across different regions and sliding *** unique tribological properties of arapaima scales influence the forces received from predator attacks and neighboring scales,directly influencing the arapaima’s protective *** study provides new insights into the mechanisms of natural flexible dermal armors,and it has potential applications in personal protective systems.

关键词： arapaima scales surface morphology tribological properties protectability

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Clinical observation of loupe-assisted intussusception vasoepididymostomy in the treatment of obstructive azoospermia(analysis of 49 case reports)

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Asian Journal of Andrology 2009年第2期11卷 193-199页

作者： Guo-Xi Zhang wen-jun bai Ke-Xin Xu Xiao-Feng Wang Ji-Chuan Zhu Department of Urology People’s HospitalBeijing UniversityBeijing 100044China

To evaluate the clinical outcomes of loupe-assisted intussusception vasoepididymostomy(VE)in the treatment of epididymal obstructive azoospermia(EOA),we retrospectively analyzed data from 49 patients with EOA who underwent two-suture longitudinal intussusception vasoepididymostomy(LIVE)between 2000 and *** data included the surgical method,postoperative motile sperm count per ejaculation,percentage of progressive motile sperm and patency and pregnancy *** were a total of 49 men undergoing scrotal exploration,and epididymal obstruction was found in all *** or unilateral anastomoses were performed in 40 and 6 men,*** postoperative courses of 42 patients were followed up for more than 6 months,and the courses of 38 patients were followed up for more than 1 *** overall patency and pregnancy rates were 71.4%and 26.3%,***,progressive motile sperm was more frequently present in those patients who had undergone anastomosis at cauda than at corpus or *** was achieved only in those patients who had undergone anastomosis at least on one side of the cauda *** think that the loupe-assisted method,with a lower overall cost and a simplified surgical procedure,can achieve satisfactory patency outcomes and pregnancy *** from this paper also suggest that paternity outcomes occur more frequently after anastomoses at cauda than at corpus or caput.

关键词： epididymal obstructive azoospermia intussusception loupe-assisted vasoepididymostomy

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Thermal and hydrological processes in permafrost slope wetlands affect thermosyphon embankment stability

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Advances in Climate Change Research 2024年第4期15卷 680-694页

作者： Bo-wen TAI Qing-bai WU Xiao-Ming XU State Key Laboratory of Frozen Soil Engineering Key Laboratory of Cryospheric Science and Frozen Soil EngineeringNorthwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China School of Engineering Science University of Chinese Academy of SciencesBeijing 100049China

To ensure the long-term service performance of infrastructure such as railways,highways,airports and oil pipelines built on permafrost slope wetland sites,it is imperative to systematically uncover the long-term heat-water changes of soil in slope wetlands environment under climate *** specifically,considering valuable field data from 2001 to 2019,the long-term heat and water changes in active layers of the slope wetland site along the Qinghai-Xizang Railway(QXR)are illustrated,the effect of thermosyphon measures in protecting the permafrost environment is evaluated,and the influences of climate warming and hydrological effects on the stability of slope wetland embankments are systematically *** permafrost at the slope wetland site is rapidly degrading,demonstrating a reduction in active layer thickness of>3.7 cm per year and a permafrost temperature warming of>0.006℃ per *** thermosiphon embankment developed by QXR has a specific cooling period;thus,to mitigate the long-term impacts of climate warming on the thermal stability of permafrost foundation,it is essential to implement strengthening measures for the thermosiphon embankment,such as adding a crushed-rock layer or sunshade board on the slope of thermosiphon embankment to creating a composite cooling ***-term seasonal groundwater seepage intensifies frost damage to the slope wetland embankment,while long-term seasonal supra-permafrost water and groundwater seepage exacerbates uneven transverse deformation of slope wetland ***-term climate warming and slope effects have altered the surface water and groundwater hydrological processes of slope wetlands,potentially leading to an increased occurrence of slope embankment *** results are crucial for improving our understanding of heat and water variation processes in the active layer of slope wetland sites located in permafrost regions and ensuring long-term service safety for the QXR.

关键词： Heat and water process Active layer Slope wetland Permafrost environment Thermosyphon embankment

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