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Nuclear Science and Techniques 2024年第1期35卷 18-33页

作者： Xi-Guang Cao Yan-Long Chang Kai Chen Emilio Ciuffoli Li-Min Duan Dong-Liang Fang Chao-Song Gao Surja K.Ghorui Peng-Chong Hu Qiang Hu Si-Yuan Huang Ze-Yu Huang Lei Lang Yu-Lan Li Zhi-Jie Li Tian-Yu Liang jun Liu Chen-Gui Lu Fa-Tai Mai Yuan Mei Hao Qiu Xiang-Ming Sun Xiao-Xing Tang Hu-Lin Wang Qian-Ming Wang Le Xiao Mu-Yun Xiao Jian-Yu Xin Nu Xu Peng Yang Yi-Chen Yang Zhen Yang Zong-Yang Yu Dong-Liang zhang jun-wei zhang Cheng-Xin Zhao Dou Zhu NνDEx-100 collaboration Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China Lanzhou University Lanzhou 730000China Central China Normal University Wuhan 430079China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Lawrence Berkeley National Laboratory BerkeleyCA 94720USA North China University of Water Resources and Electric Power Zhengzhou 450045China 不详

Observing nuclear neutrinoless double beta (0vββ) decay would be a revolutionary result in particle physics.Observing such a decay would prove that the neutrinos are their own antiparticles,help to study the absolute mass of neutrinos,explore the origin of their mass,and may explain the matter-antimatter asymmetry in our universe by lepton number violation.We propose developing a time projection chamber (TPC) using high-pressure ^(82)SeF_(6) gas and Topmetal silicon sensors for readout in the China Jinping Underground Laboratory (CJPL) to search for neutrinoless double beta decay of82Se,called the NvDEx experiment.Besides being located at CJPL with the world’s thickest rock shielding,NvDEx combines the advantages of the high Qββ(2.996 MeV) of82Se and the TPC’s ability to distinguish signal and background events using their different topological characteristics.This makes NvDEx unique,with great potential for low-background and high-sensitivity 0 vββsearches.NvDEx-100,a NvDEx experiment phase with 100 kg of SeF_(6)gas,is being built,with plans to complete installation at CJPL by 2025.This report introduces 0 vββ physics,the NvDEx concept and its advantages,and the schematic design of NvDEx-100,its subsystems,and background and sensitivity estimation.

关键词： Neutrinoless double beta decay Time projection chamber ^(82)SeF_(6) China Jinping Underground Laboratory

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Mechanism of Mingjing Granules in Treating Wet Age-Related Macular Degeneration Based on Network Pharmacology and Experimental Verification

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World Journal of Traditional Chinese Medicine 2024年第1期10卷 22-32页

作者： Xiao-Yu Li Li-Na Liang wei-jun zhang Yun Gao Qiang Chen Eye Function Laboratory Eye HospitalChina Academy of Chinese Medical SciencesBeijingChina China Evidence-Based Medicine Center for Traditional Chinese Medicine BeijingChina Center for East-West Medicine UCLA David Geffen School of MedicineLos AngelesCAUSA

Objective:To analyze the potential mechanism of Mingjing granules in the treatment of wet age-related macular degeneration(wAMD)based on the research methods of network pharmacology and molecular docking approach and to provide a new reference for the currently limited treatment of wAMD.Materials and Methods:We searched TCMSP,GeneCards,OMIM,PharmGkb,TTD,and DrugBank database to screen the main active ingredients of Mingjing granules and their therapeutic targets of wAMD.The network of active components and targets was constructed using Cytoscape3.6.1 software,which was also used for the topological analysis of target genes.The network of Protein-Protein Interactions(PPI)was mapped using the String platform.We also used R language to do the Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway for additional analysis.Molecular docking studies were finished by Chemoffice,Autodock,and Pymol.Finally,the efficacy of the Mingjing granules was examined in animal experiments,in which we used enzyme-linked immunosorbent assay to the contents of vascular endothelial growth factor(VEGF)and matrix metalloproteinase-9(MMP-9)levels in peripheral blood.Results:Active compounds,including quercetin,lignocaine,and kaempferol,were found.PPI network analysis showed that tumor necrosis factor(TNF),MMP-9,epidermal growth factor(EGF),prostaglandin-endoperoxide synthase 2(PTGS2),and caspase-3(CASP3)were related to both Mingjing granules and wAMD.GO and KEGG pathway analysis showed that these targets were mainly involving lipids and atherosclerosis,TNF,and interleukin-17(IL-17)signaling pathways.Docking studies suggested that quercetin and luteolin can fit in the binding pocket of four target proteins(CASP3,EGF,PTGS2,and TNF).In the vivo experiment,the Mingjing granules were found to be effective on the expression of VEGF and MMP-9 in peripheral blood.Conclusions:This study initially reveals the multi-constituent,multi-target,and multi-pathway mechanism of action of Mingjing granules in the treatment of wAMD and impli

关键词： Experimental verification Mingjing granules molecular docking network pharmacology wet age-related macular degeneration

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Space-frequency-polarization-division multiplexed wireless communication system using anisotropic space-time-coding digital metasurface

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National Science Review 2022年第11期9卷 149-160页

作者： jun Chen Ke Xiangyu Chen Wankai Tang Ming Zheng Chen Lei zhang Li Wang jun Yan Dai Jin Yang jun wei zhang Lijie Wu Qiang Cheng Shi Jin Tie jun Cui State Key Laboratory of Millimeter Waves Southeast University Institute of Electromagnetic Space Southeast University Frontiers Science Center for Mobile Information Communication and Security Southeast University National Mobile Communications Research Laboratory Southeast University Southeast University Wuxi Campus

In the past few years, wireless communications based on digital coding metasurfaces have gained research interest owing to their simplified architectures and low cost. However, in most of the metasurface-based wireless systems, a single-polarization scenario is used, limiting the channel capacities. To solve the problem, multiplexing methods have been adopted, but the system complexity is inevitably increased. Here,a space-frequency-polarization-division multiplexed wireless communication system is proposed using an anisotropic space-time-coding digital metasurface. By separately designing time-varying control voltage sequences for differently oriented varactor diodes integrated on the metasurface, we achieve frequency-polarization-division multiplexed modulations. By further introducing different time-delay gradients to the control voltage sequences in two polarization directions, we successfully obtain space-frequency-polarization-division multiplexed modulations to realize a wireless communication system with a new architecture. The new communication system is designed with compact dual-polarized meta-elements, and can improve channel capacity and space utilization. Experimental results demonstrate the high-performance and real-time transmission capability of the proposed communication system,confirming its potential application in multiple-user collaborative wireless communications.

关键词： polarization-division multiplexing frequency-division multiplexing space-division multiplexing space-time coding wireless communication

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Engineering heterostructured Ni@Ni(OH)_(2) core-shell nanomaterials for synergistically enhanced water electrolysis

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Green Energy & Environment 2022年第5期7卷 1024-1032页

作者： jun-wei zhang Xian-wei Lv Tie-Zhen Ren Zheng Wang Teresa J.Bandosz Zhong-Yong Yuan Hebei Provincial Key Laboratory of Green Chemical Technology&High Efficient Energy Saving School of Chemical Engineering and TechnologyHebei University of TechnologyTianjin300130China Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) School of Materials Science and EngineeringNankai UniversityTianjin300350China State Key Laboratory of High-efficiency Utilization of Coal and Green Chemical Engineering Ningxia UniversityYinchuan750021NingxiaChina Department of Chemistry and Biochemistry The City College of New YorkNY10031USA

Heterostructure engineering of electrocatalysts provides a fascinating platform to reasonably manipulate the physicochemical properties of nanomaterials and further improve their catalytic efficiency for water electrolysis.However,it still remains a huge challenge to construct welldesigned core-shell heterostructured catalysts and identify the key role of components for synergistic catalysis.Herein,a melted polymeric salt tactics was innovatively developed to synthesize heterostructured Ni@Ni(OH)_(2) core-shell nanomaterials supported on porous carbon(named Ni@Ni(OH)_(2)/PC),wherein well-defined Ni(OH)_(2)-Ni heterostructure plays a pivotal role in improving electrocatalytic activity for water reduction and oxidation.Besides,the stable porous carbon support functions as a highway for continuous electron transfer between Ni and Ni(OH)_(2),and simultaneously enables the full exposure of accessible active sites.The fabricated Ni@Ni(OH)_(2)/PC exhibits outstanding bifunctional electrocatalytic performance for overall water splitting(η_(10)=1.55 V) with a good long-time stability.This work sheds new light on the design of engineering heterostructure of active bifunctional electrocatalysts for efficient energy conversion system.

关键词： stability synergistic splitting

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Clinical outcomes of lenvatinib plus transarterial chemoembolization with or without programmed death receptor-1 inhibitors in unresectable hepatocellular carcinoma

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World Journal of Gastroenterology 2023年第10期29卷 1614-1626页

作者： Yan-Yu Wang Xu Yang Yun-Chao Wang jun-Yu Long Hui-Shan Sun Yi-Ran Li Zi-Yu Xun Nan zhang Jing-Nan Xue Cong Ning jun-wei zhang Cheng-Pei Zhu Long-Hao zhang Xiao-Bo Yang Hai-Tao Zhao Department of Liver Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of General Surgery Digestive Disease HospitalAffiliated Hospital of Zunyi Medical UniversityZunyi 563003Guizhou ProvinceChina

BACKGROUND Programmed death receptor-1(PD-1)inhibitors have been approved as secondline treatment regimen in hepatocellular carcinoma(HCC),but it is still worth studying whether patients can benefit from PD-1 inhibitors as first-line drugs combined with targeted drugs and locoregional therapy.AIM To estimate the clinical outcome of transarterial chemoembolization(TACE)and lenvatinib plus PD-1 inhibitors for patients with unresectable HCC(uHCC).METHODS We carried out retrospective research of 65 patients with uHCC who were treated at Peking Union Medical College Hospital from September 2017 to February 2022.45 patients received the PD-1 inhibitors,lenvatinib,TACE(PD-1-Lenv-T)therapy,and 20 received the lenvatinib,TACE(Lenv-T)therapy.In terms of the dose of lenvatinib,8 mg was given orally for patients weighing less than 60 kg and 12 mg for those weighing more than 60 kg.Of the patients in the PD-1 inhibitor combination group,15 received Toripalimab,14 received Toripalimab,14 received Camrelizumab,4 received Pembrolizumab,9 received Sintilimab,and 2 received Nivolumab,1 with Tislelizumab.According to the investigators’assessment,TACE was performed every 4-6 wk when the patient had good hepatic function(Child-Pugh class A or B)until disease progression occurred.We evaluated the efficacy by the modified Response Evaluation Criteria in Solid Tumors(mRECIST criteria).We accessd the safety by the National Cancer Institute Common Terminology Criteria for Adverse Events,v 5.0.The key adverse events(AEs)after the initiation of combination therapy were observed.RESULTS Patients with uHCC who received PD-1-Lenv-T therapy(n=45)had a clearly longer overall survival than those who underwent Lenv-T therapy(n=20,26.8 vs 14.0 mo;P=0.027).The median progression-free survival time between the two treatment regimens was also measured{11.7 mo[95%confidence interval(CI):7.7-15.7]in the PD-1-Lenv-T group vs 8.5 mo(95%CI:3.0-13.9)in the Lenv-T group(P=0.028)}.The objective response rates of the PD-1-Lenv-T group and Lenv-T group were 44.

关键词： Lenvatinib Programmed death receptor-1 inhibitor Immunotherapy Hepatocellular carcinoma Transarterial chemoembolization Combination therapy

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Frequency-modulated continuous waves controlled by space-time-coding metasurface with nonlinearly periodic phases

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Light(Science & Applications) 2022年第10期11卷 2424-2434页

作者： jun Chen Ke jun Yan Dai jun wei zhang Zhanye Chen Ming Zheng Chen Yunfeng Lu Lei zhang Li Wang Qun Yan Zhou Long Li Jin Shan Ding Qiang Cheng Tie jun Cui Institute of Electromagnetic Space Southeast University210096 NanjingChina State Key Laboratory of Millimeter Waves Southeast University210096 NanjingChina School of Electronic Engineering Xidian University710071 Xi'anChina

The rapid development of space-time-coding metasurfaces(STCMs)offers a new avenue to manipulate spatial electromagnetic beams,waveforms,and frequency spectra simultaneously with high efficiency.To date,most studies are primarily focused on harmonic generations and independent controls of finite-order harmonics and their spatial waves,but the manipulations of continuously temporal waveforms that include much rich frequency spectral components are still limited in both theory and experiment based on STCM.Here,we propose a theoretical framework and method to generate frequency-modulated continuous waves(FMCWs)and control their spatial propagation behaviors simultaneously via a novel STCM with nonlinearly periodic phases.Since the carrier frequency of FMCW changes with time rapidly,we can produce customized time-varying reflection phases at will by the required FMCW under the illumination of a monochromatic wave.More importantly,the propagation directions of the time-varying beams can be controlled by encoding the metasurface with different initial phase gradients.A programmable STCM prototype with a full-phase range is designed and fabricated to realize reprogrammable FMCW functions,and experimental results show good agreement with the theoretical analyses.

关键词： nonlinear continuous periodic

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Prognosis of traumatic spinal cord injury in children:Follow-up of 86 patients

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Chinese Journal of Traumatology 2023年第1期26卷 14-19页

作者： Yu-Fei Meng jun-wei zhang An-Ni Tong He-Hu Tang Jin-Zhu Bai Fang-Yong Wang Shu-jia Liu Zhen Lyu Shi-Zheng Chen Jie-Sheng Liu Yi Hong School of Rehabilitation Capital Medical UniversityBeijing100068China Department of Spine and Spinal Cord Surgery Bejing Boai HospitalChina Rehabilitation Research CenterBejing100068China Department of Rehabilitation Medicine Beijing Haidian HospitalBeijing100080China

Purpose:The long-term situation of children with spinal cord injury(SCI)was investigated,and suggestions for helping them better return to the society were provided.Methods:SCI patients less than 18 years old hospitalized in Beijing Boai Hospital from January 2011 to December 2020 were retrospectively analyzed.Information including motor function,complications,characteristic changes,self-care abilities,school attendance and social participation were collected by telephone interview and electronic questionnaire.All the answers were statistically analyzed.Results:A total of 86 cases were enrolled,77 girls and 9 boys,with a median injury age of 6 years and 2 months.The follow-up time was 3-130 months.The main cause of trauma in these children was sport injury(66.3%),the thoracic spinal cord was involved the most(91.9%),and complete SCIs accounted for the majority(76.7%).In terms of complications,children with complete SCIs were more likely to have urinary incontinence,constipation and characteristic changes(p<0.05);whereas the incomplete SCIs often have spasticity(p<0.05).As to the daily living abilities,children with incomplete lumbar SCIs were more capable to accomplish personal hygiene,transfer,and bathing independently than those with complete injuries,or cervical/thoracic SCIs,respectively(p<0.05).Moreover,children older than 9 years care more able to dress and transfer independently than the youngers(p<0.05).Wheelchair users accounted for 84.9%and more than half of them were able to propel wheelchair independently,and those who move passively in wheelchairs were mostly introverted kids(p<0.05).Almost all(93.8%)children with incomplete injuries were able to walk independently.Most(79.1%)children continued to attending school,and 41.9%participated in interest classes.Unfortunately,67.4%of the children spent less time playing with their peers than before the injury.Conclusion:SCIs impair physical structures and function of children,affect their independence in daily living,and restrict school attendance and socia

关键词： Spinal cord injury Children Spinal cord injury without radiographic abnormalities Follow-up Prognosis

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FeNi doped porous carbon as an efficient catalyst for oxygen evolution reaction

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Frontiers of Chemical Science and Engineering 2021年第2期15卷 279-287页

作者： jun-wei zhang Hang zhang Tie-Zhen Ren Zhong-Yong Yuan Teresa JBandosz Hebei Provincial Key Laboratory of Green Chemical Technology&High Efficient Energy Saving School of Chemical Engineering and TechnologyHebei University of TechnologyTianjin 300130China Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) School of Materials Science and EngineeringNankai UniversityTianjin 300350China Department of Chemistry and Biochemistry The City College of New YorkNew YorkNY 10031USA

Polymer-derived porous carbon was used as a support of iron and nickel species with an objective to obtain an efficient oxygen reduction reaction(OER)catalyst.The surface features were extensively characterized using X-ray diffraction,X-ray photoelectron spectroscopy and high-resolution transmission electron microscopy.On FeNi-modified carbon the overpotential for OER was very low(280 mV)and comparable to that on noble metal catalyst IrO_(2).The electrochemical properties have been investigated to reveal the difference between the binary alloy-and single metal-doped carbons.This work demonstrates a significant step for the development of low-cost,environmentally-friendly and highly-efficient OER catalysts.

关键词： OER polystyrene salt porous carbon FeNi alloy p/n junction

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Prognostic significance of combined preoperative fibrinogen and CA199 in gallbladder cancer patients

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World Journal of Gastroenterology 2018年第13期24卷 1451-1463页

作者： wei-Yu Xu Hao-Hai zhang Xiao-Bo Yang Yi Bai Jian-Zhen Lin jun-Yu Long Jian-Ping Xiong jun-wei zhang Xin-Ting Sang Hai-Tao Zhao Department of Liver Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

AIM To investigate the prognostic value of the combination of preoperative plasma fibrinogen and CA199 in patients with gallbladder carcinoma(GBC).METHODS The clinicopathological data of 154 GBC patients were retrospectively reviewed after surgery. A receiver operating characteristic(ROC) curve was plotted to verify the optimum cut-off values for plasma fibrinogen and CA199. Univariate and multivariate survival analyses were performed to identify the factors associated with GBC prognosis. based on the HRs calculated via multivariate survival analyses, patients with elevated plasma fibrinogen and CA199 levels were allocated a score of 2.1; those with an elevated plasma fibrinogen level only were allocated a score of 1, those with an elevated CA199 level only were allocated a score of 1.1, and those with neither of these abnormalities were allocated a score of 0.RESULTS ROC curve analysis showed that the optimum cut-off values for preoperative plasma fibrinogen and CA199 were 3.47 g/L and 25.45 U/mL, respectively. Multivariate analysis indicated that elevated preoperative plasma fibrinogen and CA199 levels were significantly correlated with worse overall survival(OS)(HR = 1.711, 95%CI: 1.114-2.627, P = 0.014, and HR = 1.842, 95%CI: 1.111-3.056, P = 0.018). When we combined these two parameters, the area under the ROC curve increased from 0.735(for preoperative plasma fibrinogen only) and 0.729(for preoperative CA199 only) to 0.765. When this combined variable was added to the multivariate analysis, the combination of plasma fibrinogen and CA199(P < 0.001), resection margin(P < 0.001) and TNM stage(P = 0.010) were independent prognostic factors for GBC.CONCLUSION The combination of plasma fibrinogen and CA199 may serve as a more efficient independent prognostic biomarker for postoperative GBC patients than either parameter alone.

关键词： Prognostic factor Plasma fibrinogen CA199 Survival Gallbladder cancer

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Laparoscopic anatomical liver resection of segment 7 using a sandwich approach to the right hepatic vein (with video)

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 217-220页

作者： Song-Feng Yu wei-Chen zhang jun Yu Department of Hepatobiliary and Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Full laparoscopic liver resection has been performed widely since it was introduced in the early 1990s.It has been expanded from initial for partial resection of the anterolateral segments to non-restriction of area of the liver[1–3].Anatomical liver resec-tion is considered to have potential superiority than non-anatomic resection in terms of tumor prognosis,thus it is more often rec-ommended in the treatment of hepatocellular carcinoma[4,5].Recently,laparoscopic segmental liver resection according to the Couinaud classification has been widely performed due to its ad-vantages in minimal invasiveness and tumor prognosis.

关键词： resection liver hepatic

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