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Persistent alterations in gray matter in COVID-19 patients experiencing sleep disturbances:a 3-month longitudinal study

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Neural Regeneration Research 2025年第10期20卷 3013-3024页

作者： Kaixuan Zhou Gaoxiong Duan Ying liu Bei Peng Xiaoyan Zhou Lixia Qin Lingyan Liang Yichen Wei Qingping Zhang Xiaocheng Li Haixia Qin Yinqi Lai Yian Lu Yan Zhang Jiazhu Huang Jinli Huang Yinfei Ouyang Bolin Bin Mingming Zhao jun liu Jianrong Yang Demao Deng Guangxi Key Laboratory of Special Biomedicine School of MedicineGuangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology the People’s Hospital of Guangxi Zhuang Autonomous RegionGuangxi Academy of Medical SciencesNanningGuangxi Zhuang Autonomous RegionChina Department of Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Guangxi Clinical Research Center for Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina

Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 *** studies have demonstrated abnormal brain structures in patients with sleep disturbances who have recovered from coronavirus disease 2019(COVID-19).However,neuroimaging studies on sleep disturbances caused by COVID-19 are scarce,and existing studies have primarily focused on the long-term effects of the virus,with minimal acute phase *** a result,little is known about the pathophysiology of sleep disturbances in the acute phase of *** address this issue,we designed a longitudinal study to investigate whether alterations in brain structure occur during the acute phase of infection,and verified the results using 3-month follow-up data.A total of 26 COVID-19 patients with sleep disturbances(aged 51.5±13.57 years,8 women and 18 men),27 COVID-19 patients without sleep disturbances(aged 47.33±15.98 years,9 women and 18 men),and 31 age-and gender-matched healthy controls(aged 49.19±17.51 years,9 women and 22 men)were included in this *** COVID-19 patients with sleep disturbances were included in a longitudinal *** found that COVID-19 patients with sleep disturbances exhibited brain structural changes in almost all brain *** cortical thicknesses of the left pars opercularis and left precuneus were significantly negatively correlated with Pittsburgh Sleep Quality Index ***,we observed changes in the volume of the hippocampus and its subfield regions in COVID-19 patients compared with the healthy *** 3-month follow-up data revealed indices of altered cerebral structure(cortical thickness,cortical grey matter volume,and cortical surface area)in the frontal-parietal cortex compared with the baseline in COVID-19 patients with sleep *** findings indicate that the sleep disturbances patients had altered morphology in the cortical an

关键词： brain structure cortical gray matter volume cortical surface area cortical thickness hippocampus magnetic resonance imaging Pittsburgh Sleep Quality Index severe acute respiratory syndrome coronavirus 2 infections sleep disturbances sub-cortical volume

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Capillary electrophoresis with electrochemiluminescence detection for the analysis of quinolone drugs and pharmacokinetics study

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Chinese Chemical Letters 2008年第8期19卷 962-964页

作者： Yan Ming liu jun tao Cao Hui Wang College of Chemistry and Chemical Engineering Xinyang Normal University Xinyang 464000 China

A novel method for the determination of two quinolone drugs norfloxacin （NOR） and levofloxacin （LVX） was described by capillary electrophoresis with electrochemiluminescence detection. The good relationship （r ≥ 0.9991） between peak area and concentration of analytes was established over two orders of magnitude. The limits of detection （LOD, S/N = 3） in standard solution are 4.8 × 10^-7 mol/L for NOR and 6.4 × 10^-7 mol/L for LVX, respectively. The limits of quantitation （LOQ, S/N = 10） in real human urine samples are 1.2 × 10^-6 mol/L for NOR and 1.4 × 10^-6 mol/L for LVX, respectively. The present method was successfully applied to the determination of NOR and LVX in human urine and the studv of oharmacokinetics of NOR.

关键词： Capillary electrophoresis Electrochemiluminescence detection Quinolone drugs Urine analysis Pharmacokinetics

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Energy-efficient collaborative target tracking algorithm using cost-reference particle filtering in wireless acoustic sensor networks

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The Journal of China Universities of Posts and Telecommunications 2009年第1期16卷 9-15,43页

作者： YU Zhi-jun WEI Jian-ming liu Hai-tao Wireless Sensor Network Research and Development Center Shanghai Institute of Microsystem and Information Technology Shanghai 200050 China

Target tracking is one of the most important applications of wireless sensor networks. Optimized computation and energy dissipation are critical requirements to save the limited resource of sensor nodes. A new robust and energy-efficient collaborative target tracking framework is proposed in this article. After a target is detected, only one active cluster is responsible for the tracking task at each time step. The tracking algorithm is distributed by passing the sensing and computation operations from one cluster to another. An event-driven cluster reforming scheme is also proposed for balancing energy consumption among nodes. Observations from three cluster members are chosen and a new class of particle filter termed cost-reference particle filter （CRPF） is introduced to estimate the target motion at the cluster head. This CRPF method is quite robust for wireless sensor network tracking applications because it drops the strong assumptions of knowing the probability distributions of the system process and observation noises. In simulation experiments, the performance of the proposed collaborative target tracking algorithm is evaluated by the metrics of tracking precision and network energy consumption.

关键词： target tracking cost-reference particle filtering energy-efficient wireless sensor networks (WSNs)

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Preparation, characterization and photocatalytic activity of N-doped TiO_2 nanocrystals

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International Journal of Minerals,Metallurgy and Materials 2009年第6期16卷 701-706页

作者： Hong-tao Gao Jing Zhou Dong-mei Dai Guang-jun liu College of Chemistry and Molecular Engineering Qingdao University of Science ＆ Technology Qingdao 266042 China Department of Chemistry Jining University Jining 273155 China

N-doped TiO2 nanocrystals were prepared using titanium alkoxide as precipitant with different proportional materials. The products were characterized by X-ray diffraction, scanning electron microscopy, transmission electron microscopy, and UV-vis diffuse reflectance spectra. It is confirmed experimentally that the photocatalytic activity of N-doped TiO2 is much higher than that of Degussa P25, when used for the degradation of crystal violet. The degradation kinetics follows an apparent first-order reaction, which is consistent with a generally observed Langmuir-Hinshelwood mechanism. The doping of TiO2 with nitrogen significantly increases the absorption in the region of visible light. The energy of the band gap of N-doped TiO2 is 2.92 eV. The better performance of N-doped TiO2 can be explained by the fact that it is also excited with longer-wavelength light.

关键词： pbotocatalyst degradation nitrogen doping TiO2 nanocrystals visible light crystal violet

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Influence of microwave treatment on grinding and dissociation characteristics of vanadium titano-magnetite

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International Journal of Minerals,Metallurgy and Materials 2019年第2期26卷 160-167页

作者： jun-peng Wang tao Jiang Ya-jing liu Xiang-xin Xue School of Metallurgy Northeastern University Key Laboratory of Liaoning Province for Recycling Science of Metallurgical Resources

The effect of microwave treatment on the grinding and dissociation characteristics of vanadium titano-magnetite(VTM) ore were investigated using scanning electron microscopy(SEM), nitrogen absorption measurements, particle size distribution measurements, X-ray diffraction(XRD) analysis, Fourier transform infrared(FT-IR) spectroscopic analysis, and magnetic separation. SEM analysis showed that microfractures appeared in the microwave-treated VTM, which is attributed to the microwaves' selective heating characteristic and the differential expansion between minerals and gangues. Nitrogen absorption showed that the microfractures were more pronounced when the microwave heating time was increased. Particle size distribution analysis showed that microwave treatment could improve the grindability of the VTM, thus increasing the weight percent of the fine-ground product. The increase in grindability was more significant with prolonged heating time. Moreover, the particle size distribution of the fine-ground product changed only slightly after the microwave treatment. XRD analysis showed that the crystallinity of the microwave-treated VTM increased with increasing microwave heating time. The magnetic separation tests revealed that the separation efficiency increased as a result of the intergranular fractures generated by microwave treatment. The Fe grade of the magnetic fraction of microwave-treated VTM was 1.72% higher than that of the raw ore. We concluded that the microwave treatment was beneficial, especially for the mineral processing characteristics.

关键词： microwave treatment vanadium titano-magnetite grinding microstructure magnetic separation

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Development of an ε-type actuator for enhancing high-speed electro-pneumatic ejector valve performance

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第11期9卷 1552-1559页

作者： Zhong XIANG Hao liu Guo-Liang tao jun MAN Wei ZHONG State Key Laboratory of Fluid Power Transmission and Control Zhejiang University Hangzhou 310027 China

A novel ε-type solenoid actuator is proposed to improve the dynamic response of electro-pneumatic ejector valves by reducing moving mass weight. A finite element analysis (FEA) model has been developed to describe the static and dynamic operations of the valves. Compared with a conventional E-type actuator, the proposed ε-type actuator reduced the moving mass weight by almost 65% without significant loss of solenoid force, and reduced the response time (RT) typically by 20%. Prototype valves were designed and fabricated based on the proposed ε-type actuator model. An experimental setup was also established to investigate the dynamic characteristics of valves. The experimental results of the dynamics of valves agreed well with simulations, indicating the validity of the FEA model.

关键词： ε-type actuator High-speed electro-pneumatic ejector valve Finite element method Dynamic simulation and experiment

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Comparison of the mechanisms of microwave roasting and conventional roasting and of their effects on vanadium extraction from stone coal

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International Journal of Minerals,Metallurgy and Materials 2015年第5期22卷 476-482页

作者： Yi-zhong Yuan Yi-min Zhang tao liu Tie-jun Chen College of Resources and Environmental Engineering Wuhan University of Science and Technology Hubei Provincial Engineering Technology Research Center of High efficient Cleaning Utilization for Shale Vanadium Resource

Experiments comparing microwave blank roasting and conventional blank roasting for typical vanadium-bearing stone coal from Hubei Province in central China, in which vanadium is present in muscovite, were conducted to investigate the effects of roasting tempera- ture, roasting time, H2SO4 concentration, and leaching time on vanadium extraction. The results show that the vanadium leaching efficiency is 84% when the sample is roasted at 800℃ for 30 min by microwave irradiation and the H2SO4 concentration, liquid/solid ratio, leaching temperature, and leaching time are set as 20vo1%, 1.5：1 mL.g-1, 95℃, and 8 h, respectively. However, the vanadium leaching efficiency achieved for the sample subjected to conventional roasting at 900℃ for 60 min is just 71% under the same leaching conditions. Scanning electron microscopy （SEM） analysis shows that the microwave roasted samples contain more cracks and that the particles are more porous compared to the conventionally roasted samples. According to the results of X-ray diffraction （XRD） and Fourier-transform infrared （FTIR） analyses, neither of these roasting methods could completely destroy the mica lattice structure under the experimental conditions; however, both methods deformed the muscovite structure and facilitated the leaching process. Comparing with conventional roasting, microwave roasting causes a greater deformation of the mineral structure at a lower temperature for a shorter roasting time.

关键词： vanadium metallurgy extraction stone coal microwave roasting leaching vanadium oxides

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A novel hybrid method for aerodynamic noise prediction of high-lift devices

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Chinese Journal of Aeronautics 2023年第9期36卷 151-161页

作者： jun tao Gang SUN Department of Aeronautics&Astronautics Fudan UniversityShanghai 200433China Key Laboratory of Aerodynamic Noise Control China Aerodynamics Research and Development CenterMianyang 621000China

Aerodynamic noise of High-Lift Devices(HLDs)is one of the main sources of airframe noise,and has immediate impacts on the airworthiness certification,environmental protection and security of commercial *** this study,a novel hybrid method is proposed for the aerodynamic noise prediction of HLD.A negative Spalart-Allmaras(S-A)turbulence model based Improved Delayed Detached Eddy Simulation(IDDES)method coupling with AFT-2017b transition model is developed,in order to elaborately simulate the complex flow field around the HLD and thus obtain the information of acoustic sources.A Farassat-Kirchhoff hybrid method is developed to filter the spurious noise sources caused by the vortex motions in solving the Ffowcs Williams-Hawkings(FW-H)equation with permeable integral surfaces,and accurately predict the far-field noise radiation of the *** results of the 30P30N HLD indicate that,the computational Sound Pressure Levels(SPLs)obtained by the Farassat-Kirchhoff hybrid method conform well with the experimental ones in the spectrum for the given observation point,and are more accurate than those obtained by the Farassat 1A *** on the hybrid method,the acoustic directivity of the HLD of a commercial aircraft is obtained,and the variation of the SPLs in the spectrum with the deflection angle of the slat is analyzed.

关键词： Aerodynamic noise Farassat-Kirchhoff hybrid method High-lift devices IDDES Negative S-A turbulence model

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新生儿坏死性小肠结肠炎病情进展的影响因素分析

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临床医学研究与实践 2018年第28期3卷 112-114页

作者：和灿琳胡浩戍俊陶刘玲奚敏云南省昆明市儿童医院云南昆明650000

目的探讨影响新生儿坏死性小肠结肠炎(NEC)病情进展的相关因素。方法选择2015年10月至2017年10月在我院确诊的102例坏死性小肠结肠炎患儿的临床资料,按照Bell分期将其分为Ⅰ期组(62例)、Ⅱ期/Ⅲ期组(40例)。对各项可能引起NEC病情进展... 详细信息

目的探讨影响新生儿坏死性小肠结肠炎(NEC)病情进展的相关因素。方法选择2015年10月至2017年10月在我院确诊的102例坏死性小肠结肠炎患儿的临床资料,按照Bell分期将其分为Ⅰ期组(62例)、Ⅱ期/Ⅲ期组(40例)。对各项可能引起NEC病情进展的相关因素进行单因素和多因素Logistic回归分析。结果单因素分析结果显示,贫血、胎龄小于37周、出生体重小于2.5 kg、合并呼吸衰竭、合并心力衰竭、母乳喂养、发病前使用益生菌及合并消化道畸形是影响NEC病情进展的相关因素(P<0.05)。多因素分析显示,贫血、胎龄、出生体重、合并呼吸衰竭、合并心力衰竭、母乳喂养、发病前口服益生菌、合并消化道畸形均与NEC的疾病进展存在相关性(P<0.05),其中贫血、胎龄、出生体重、合并呼吸衰竭、合并心力衰竭及合并消化道畸形为影响NEC进展的独立危险因素,而母乳喂养、发病前口服益生菌则为NEC进展的保护因素(P<0.05)。结论 NEC的恶化与早产、体重、合并呼吸衰竭、合并心力衰竭、母乳喂养等因素有关,采取母乳喂养并口服益生菌能够减轻NEC的严重程度。

关键词：新生儿坏死性小肠结肠炎(NFC) 影响因素

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Phase Equilibria of Hydrogen Bonding Fluid in a Slit Pore with Broken Symmetry

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Chinese Journal of Chemical Physics 2015年第3期28卷 288-294,I0001页

作者： Xiao-yu liu Jiang-tao Li Fang Gu Hai-jun Wang College of Chemistry and Environmental Science Hebei University Baoding 071002 China Chemical Biology Key Laboratory of Hebei Province Hebei University Baoding 071002 China Key Laboratory of Medical Chemistry and Molecular Diagnosis Ministry of Education BaodinE 071002 China

Phase equilibria of hydrogen bonding （HB） fluid confined in a slit pore with broken symmetry were investigated by the density functional theory incorporated with modified fundamental measure theory, where the symmetry breaking originated from the distinct interactions between fluid molecules and two walls of the slit pore. In terms of adsorption-desorption isotherms and the corresponding grand potentials, phase diagrams of HB fluid under various conditions are presented. Furthermore, through phase coexistences of laying transition and capillary condensation, the effects of HB interaction, pore width, fluid-pore interaction and the broken symmetry on the phase equilibrium properties are addressed. It is shown that these factors can give rise to apparent influences on the phase equilibria of confined HB fluid because of the competition between intermolecular interaction and fluid-pore interaction. Interestingly, a significant influence of broken symmetry of the slit pore is found, and thus the symmetry breaking can provide a new way to regulate the phase behavior of various confined fluids.

关键词： Hydrogen bonding fluid Broken symmetry Phase equilibria Density functional theory

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