检索结果-南通市图书馆

Role of deubiquitinase JOSD2 in the pathogenesis of esophageal squamous cell carcinoma

World Journal of Gastroenterology 2024年第6期30卷 565-578页

作者： Wen-Peng Wang Dan shi Duo Yun jun Hu jie-Fu Wang Jia Liu Yan-Peng Yang Ming-Rui Li jun-FengWang Da-Lu Kong Department of Colorectal Oncology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin’s Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin 300060China Department of Gastrointestinal Surgery Tianjin Nan Kai HospitalTianjin Medical UniversityTianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM RepairInstitute of Integrative Medicine for Acute Abdominal DiseasesTianjin 300100China Department of Oncology The First Hospital of HohhotHohhot 010000Inner Mongolia Autonomous RegionChina Department of Endocrinology Dazhou Central HospitalDazhou 635000Sichuan ProvinceChina

BACKGROUND Esophageal squamous cell carcinoma(ESCC)is a deadly malignancy with limited treatment ***(DUBs)have been confirmed to play a crucial role in the development of malignant ***2 is a DUB involved in con-trolling protein deubiquitination and influencing critical cellular processes in *** To investigate the impact of JOSD2 on the progression of *** Bioinformatic analyses were employed to explore the expression,prognosis,and enriched pathways associated with JOSD2 in *** transduction was utilized to manipulate JOSD2 expression in ESCC cell lines(KYSE30 and RESULTS )Preliminary research indicated that JOSD2 was highly expressed in ESCC tissues,which was associated with poor *** analysis demonstrated that JOSD2 was upregulated in ESCC cell lines compared to normal esophageal ***2 knockdown inhibited ESCC cell activity,including proliferation and colony-forming ***,JOSD2 knockdown decreased the drug resistance and migration of ESCC cells,while JOSD2 overexpression enhanced these *** vivo xenograft assays further confirmed that JOSD2 promoted tumor proliferation and drug resistance in ***,JOSD2 appears to activate the MAPK/ERK and PI3K/AKT signaling *** spectrometry was used to identify crucial substrate proteins that interact with JOSD2,which identified the four primary proteins that bind to JOSD2,namely USP47,IGKV2D-29,HSP90AB1,and *** JOSD2 plays a crucial role in enhancing the proliferation,migration,and drug resistance of ESCC,suggesting that JOSD2 is a potential therapeutic target in ESCC.

关键词： Esophageal squamous cell carcinoma JOSD2 Ubiquitination Biomarker Targeted therapy Drug resistance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Melting geodynamics reveals a subduction origin for the Purang ophiolite,Tibet,China

引用

Acta Geochimica 2024年第4期43卷 754-773页

作者： Tao Ruan Zhong-jie Bai Wei-Guang Zhu shi-Ji Zheng State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China University of Chinese Academy of Sciences Beijing 100049China

The debate regarding whether the Yarlung-Zangbo ophiolite(YZO)on the south of the Qinghai-Tibet Plateau,formed in a mid-ocean ridge(MOR)or a supra-subduction zone(SSZ)setting has remained *** we present petrological,mineralogical,and geochemical data associated with modeling melting geodynamics of the mantle peridotites from the Purang ophiolite in the western segment of the Yarlung-Zangbo Suture Zone(YZSZ)to explore its tectonic *** Purang lherzolites are characterized by the protogranular texture and have abyssal-peridotite-like mineral compositions,including low Cr^(#)(20-30)and TiO_(2) contents(<0.1wt%)in spinel,high Al_(2)O_(3)(2.9wt%-4.4wt%)and CaO(1.9wt%-3.7wt%)contents in orthopyroxene and LREE-depletion in *** of these lherzolites can be modeled by~11%dynamic melting of the DMM source with a small fraction of melt(~0.5%)entrapped within the source,a similar melting process to typical abyssal *** Purang harzburgites are characterized by the porphyroclastic texture and exhibit highly refractory mineral compositions such as high spinel Cr^(#)(40-68),low orthopyroxene Al_(2)O_(3)(<2.2wt%)and CaO(<1.1wt%)*** in these harzburgites are enriched in Sr(up to 6.0 ppm)and LREE[(Ce)N=0.02-0.4],but depleted in Ti(200 ppm,on average)and HREE[(Yb)N<2].Importantly,the more depleted samples tend to have higher clinopyroxene Sr and LREE *** observations indicate an open-system hydrous melting with a continuous influx of slab fluid at a subduction *** modeled results show that these harzburgites could be formed by 19%-23%hydrous melting with the supply rate of slab fluid at 0.1%-1%.The lower clinopyroxene V/Sc ratios in harzburgites than those in lherzolites suggest a high oxidation stage of the melting system of harzburgites,which is consistent with a hydrous melting environment for these *** is therefore concluded that the Purang ophiolite has experienced a transformat

关键词： Melting geodynamics SSZ peridotites MOR peridotites Clinopyroxene Purang ophiolite

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Tuning heterogeneous microstructures to enhance mechanical properties of nano-TiN particle reinforced Haynes 230 composites by laser powder bed fusion

引用

Rare Metals 2024年第9期43卷 4548-4565页

作者： Wen-jie Liu Hui Li Qian-Xing Yin He-jun Du School of Power and Mechanical Engineering Wuhan UniversityWuhan 430072China The Institute of Technological Sciences Wuhan UniversityWuhan 430072China School of Mechanical&Aerospace Engineering Nanyang Technological UniversitySingapore 639798Singapore

Laser powder bed fusion(LPBF)is considered to be one of the most promising additive manufacturing technologies for producing components with geometries and high geometrical precision that are unattainable by traditional *** superalloy exhibits exceptional mechanical and high-temperature performances,rendering it a prime candidate for advanced aero-engine *** the high demand for LPBF-manufactured superalloys,the superalloy is one of the materials manufactured difficultly by LPBF due to their large laser absorptivity fluctuation,poor molten pool stability and sharp temperature ***,superalloys are characterized by severe pores,undesirable coarse columnar grains and poor mechanical *** this work,the effect of nano-TiN particles on defects,molten pool characteristics and microstructure and performance of the composites were *** 4.5 wt%TiN/Haynes230 samples exhibited exceptional nanohardness and elastic modulus with maximum values reaching 5.53 GPa and 240.03 GPa,*** superior mechanical properties were attributed to the combined effects of spatter and gas pore inhibition,grain refinement and duplex nanophases ***,the stability of molten pool was enhanced,and spatter was effectively suppressed by adding nano-TiN particles,while grain refinement and columnar to equiaxed transitions were ***,the matrix exhibited a high dislocation density due to a significant hindrance of dislocation movement caused by massive nano-phases(e.g.,TiN and M_(23)C_(6)),resulting in the formation of extensive dislocation tangles and *** work offers novel insights into the role of nanoparticles reinforced superalloy composites by LPBF.

关键词： Composites Laser powder bed fusion Molten pool characteristics Microstructure Mechanical properties

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Boswellic acids: a review on its pharmacological properties, molecular mechanism and bioavailability

引用

Traditional Medicine Research 2024年第10期9卷 64-74页

作者： Na Cui Ming-jie Li Yi-Wen Wang Qian Meng Ya-jun shi Yi Ding Department of Pharmacy 3201 HospitalHanzhong 723000China Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi’an 710032China School of Pharmacy Shaanxi University of Traditional Chinese medicineXianyang 712046China

Boswellic acids is a general term for a series of pentacyclic triterpenoid compounds that are isolated from the oleogin resin of the Boswellia genus and serve as the main active *** exhibits a wide range of biological activities,such as anti-inflammatory,anti-cancer,antibacterial,antiviral,hepatoprotective,neuroprotective,anti-diabetic,and anti-thrombotic *** a result,it has gained significant recognition among practitioners of traditional Chinese and Indian *** biological effects may be associated with multiple molecular targets and signal transduction ***,the poor pharmacokinetic properties of the substance lead to lower bioavailability,which affects its *** address this issue,scientists have proposed a number of strategies,such as solid dispersions,phytosome®technologies,and novel drug delivery *** article aims to provide a comprehensive overview for boswellic acids on the phytochemistry,molecular mechanisms,potential therapeutic applications,and strategies to improve bioavailability.

关键词： boswellic acids molecular mechanism pharmacological properties bioavailability

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Gas film/regenerative composite cooling characteristics of the liquid oxygen/liquid methane (LOX/LCH4) rocket engine

引用

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第8期25卷 631-649页

作者： Xinlin LIU jun SUN Zhuohang JIANG Qinglian LI Peng CHENG jie SONG Science and Technology on Scramjet Laboratory College of Aerospace Science and EngineeringNational University of Defense TechnologyChangsha 410073China

The thermal protection of rocket engines is a crucial aspect of rocket engine *** this paper,the gas film/regenerative composite cooling of the liquid oxygen/liquid methane(LOX/LCH4)rocket engine thrust chamber was investigated.A gas film/regenerative composite cooling model was developed based on the Grisson gas film cooling efficiency formula and the one-dimensional regenerative cooling *** accuracy of the model was validated through experiments conducted on a 6 kg/s level gas film/regenerative composite cooling thrust ***,key parameters related to heat transfer performance were *** results demonstrate that the model is sufficiently accurate to be used as a preliminary design *** temperature rise error of the coolant,when compared with the experimental results,was found to be less than 10%.Although the pressure drop error is relatively large,the calculated results still provide valuable guidance for heat transfer *** addition,the performance of composite cooling is observed to be superior to regenerative *** the gas film flow rate results in higher cooling efficiency and a lower gas-side wall ***,the position at which the gas film is introduced greatly impacts the cooling *** optimal introduction position for the gas film is determined when the film is introduced from a single row of *** optimal introduction position results in a more uniform wall temperature distribution and reduces the peak ***,it is observed that a double row of holes,when compared to a single row of holes,enhances the cooling effect in the superposition area of the gas film and further lowers the gas-side wall *** results provide a basis for the design of gas film/regenerative composite cooling systems.

关键词： Liquid oxygen/liquid methane(LOX/LCH4)rocket engine Gas film cooling Regenerative cooling Heat transfer characteristics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

2D multifunctional devices:from material preparation to device fabrication and neuromorphic applications

引用

International Journal of Extreme Manufacturing 2024年第3期6卷 91-118页

作者： Zhuohui Huang Yanran Li Yi Zhang jiewei Chen jun He jie Jiang Hunan Key Laboratory of Nanophotonics and Devices School of PhysicsCentral South UniversityChangshaHunanPeople’s Republic of China Department of Applied Physics The Hong Kong Polytechnic UniversityHong Kong Special Administrative Region of ChinaPeople’s Republic of China

Neuromorphic computing systems,which mimic the operation of neurons and synapses in the human brain,are seen as an appealing next-generation computing method due to their strong and efficient computing ***-dimensional (2D) materials with dangling bond-free surfaces and atomic-level thicknesses have emerged as promising candidates for neuromorphic computing *** a result,2D neuromorphic devices may provide an ideal platform for developing multifunctional neuromorphic ***,we review the recent neuromorphic devices based on 2D material and their multifunctional *** synthesis and next micro–nano fabrication methods of 2D materials and their heterostructures are first *** recent advances of neuromorphic 2D devices are discussed in detail using different operating *** importantly,we present a review of emerging multifunctional neuromorphic applications,including neuromorphic visual,auditory,tactile,and nociceptive systems based on 2D *** the end,we discuss the problems and methods for 2D neuromorphic device developments in the *** paper will give insights into designing 2D neuromorphic devices and applying them to the future neuromorphic systems.

关键词： 2D material micro–nano fabrication multifunctional system neuromorphic electronics artificial intelligence

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Spray pyrolysis-derived W-doped MoSe_(2)/rGO paper-like microspheres:optimization of microstructure and mesostructure for enhanced lithium storage

引用

Rare Metals 2024年第7期43卷 3019-3031页

作者： Wei Wang jun-Yu Chen jie Ouyang Hong Yin Ao-jie Li Liang Chen jun-Lin Huang Yu-Can Zhu Gang-Yong Li Zhao-Hui Hou Key Laboratory of Hunan Province for Advanced Carbon-based Functional Materials Hunan Institute of Science and TechnologyYueyang 414006China School of Chemistry and Chemical Engineering Hunan Institute of Science and TechnologyYueyang414006China Hunan Province Key Laboratory of Materials Surface&Interface Science and Technology Material Science and Engineering SchoolCentral South University of Forestry and TechnologyChangsha 410004China International Iberian Nanotechnology Laboratory(INL) AvMestre Jose Veiga4715-330 BragaPortuga

Two-dimensional MoSe_(2) is a promising candidate for lithium-ion battery ***,its conductivity and lithium storage volumetric effect still need to be *** this work,W-doped MoSe_(2)/rGO paper-like microspheres are successfully prepared through ultrasonic spray pyrolysis,achieving optimization at both the microstructure and mesostructure to enhance the lithium storage performance of the ***,by utilizing the similar two-dimensional structure between MoSe_(2) and rGO,self-assembly is achieved through spray pyrolysis,resulting in a well-defined van der Waals heterostructure at the interface on the microscale,enhancing the electron and ion transfer capability of the ***,the mesoscale paper-like microsphere morphology provides additional volume expansion buffering ***,W-doping not only increases the interlayer spacing of MoSe_(2)(0.73 nm),thereby reducing the diffusion resistance of Li+,but also allow for the modulation of the energy band structure of the *** functional theory(DFT)calculations confirm that W-doped MoSe_(2)/rGO exhibits the narrowest bandgap(0.892 eV).Therefore,the composite demonstrates excellent lithium storage performance,maintaining a specific capacity of 732.9 mAh·g^(-1)after 300 cycles at a current density of 1 A·g^(-1).

关键词： Molybdenum selenide Heterostructure Microspheres Li-ion batteries Kinetics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Advances of Electrochemical and Electrochemiluminescent Sensors Based on Covalent Organic Frameworks

引用

Nano-Micro Letters 2024年第2期16卷 395-422页

作者： Yue Cao Ru Wu Yan‑Yan Gao Yang Zhou jun‑jie Zhu Key Laboratory for Organic Electronics and Information Displays(KLOEID)and Institute of Advanced Materials(IAM) Nanjing University of Posts and Telecommunications(NJUPT)Nanjing 210023People’s Republic of China State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023People’s Republic of China

Covalent organic frameworks(COFs),a rapidly developing category of crystalline conjugated organic polymers,possess highly ordered structures,large specific surface areas,stable chemical properties,and tunable pore *** the first report of boroxine/boronate ester-linked COFs in 2005,COFs have rapidly gained popularity,showing important application prospects in various fields,such as sensing,catalysis,separation,and energy *** them,COFs-based electrochemical(EC)sensors with upgraded analytical performance are arousing extensive *** this review,therefore,we summarize the basic properties and the general synthesis methods of COFs used in the field of electroanalytical chemistry,with special emphasis on their usages in the fabrication of chemical sensors,ions sensors,immunosensors,and ***,the emerged COFs in the electrochemiluminescence(ECL)realm are thoroughly covered along with their preliminary ***,final conclusions on state-of-the-art COFs are provided in terms of EC and ECL sensors,as well as challenges and prospects for extending and improving the research and applications of COFs in electroanalytical chemistry.

关键词： Covalent organic frameworks Electrochemistry Electrochemiluminescence Sensors

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Low-carbon design towards sustainable city development:Integrating glass space with natural greenery

引用

Science China(Technological Sciences) 2024年第9期67卷 2659-2674页

作者： CAO shi-jie ZHANG CunKuan WANG junQi FENG ZhuangBo CHEN Gang HAGHIGHAT Fariborz School of Architecture Southeast UniversityNanjing 210096China Jiangsu Province Engineering Research Center of Urban Heat and Pollution Control Southeast UniversityNanjing 210096China Global Centre for Clean Air Research Department of Civil and Environmental EngineeringFaculty of Engineering and Physical SciencesUniversity of SurreyGuildfordGU27XHUnited Kingdom The Third Construction Co. Ltd.of China Construction Eighth Engineering DivisionNanjing 210046China Energy and Environment Group Department of BuildingCivil and Environmental EngineeringConcordia UniversityMontrealH3G 1M8Canada

The rapid urban development has caused serious problems such as high energy consumption and carbon emissions,especially under the context of climate *** are particularly energy-intensive,generating about one third of global energyrelated carbon *** with active solutions(like mechanical systems),passive solutions offer the potential to balance energy consumption,thermal comfort,and ecological *** potential solution is the integration of green glass space(GGS)into passive building *** is a transitional building space with glass curtain walls that exhibit excellent insulation performance during ***,GGS is susceptible to overheating during summer,which limits its ***,this work proposes a strategy of integrating vertical greenery into GGS,leveraging the nature-based solution of greenery(i.e.,flourishes in summer and withers in winter)to address this seasonal challenge of *** results demonstrated that the strategic application of vertical greenery can effectively mitigate the overheating in GGS and improve comprehensive *** using full coverage of vertical greenery in a linear layout,the air temperature of GGS and cooling energy consumption were largely reduced by 8.02℃and 12.2%,respectively,while the carbon abatement was enhanced by up to 101.11 *** on a comprehensive evaluation of energy,economy,and environmental benefits,it is recommended to use a greenery configuration with 50%coverage in a vertical linear layout for *** integration of greenery into building design can mitigate adverse environmental impacts,reduce energy consumption,and contribute to the sustainable development of low-carbon cities.

关键词： low-carbon design green glass space vertical greenery greenery configuration carbon abatement

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Prediction for permeability index of blast furnace based on VMD-PSO-BP model

引用

Journal of Iron and Steel Research International 2024年第3期31卷 573-583页

作者： Xiao-jie Liu Yu-jie Zhang Xin Li Zhi-feng Zhang Hong-yang Li Ran Liu Shu-jun Chen School of Metallurgy and Energy North China University of Science and TechnologyTangshan 063210HebeiChina Chengde Branch HBIS Group Co.Ltd.Chengde 067000HebeiChina

The permeability index is one of the important production indicators to monitor the operation of blast *** is crucial to grasp the trends of changes in the new permeability index in *** the complex vibration spectrum of the permeability index,a prediction model of the permeability index based on the VMD-PSO-BP(variational mode decomposition-particle swarm optimization-back propagation)method was ***,the key factors that affect the permeability index of blast furnace were studied from multiple ***,the permeability index was divided into multiple sub-modes based on the difference of frequency bands by the VMD algorithm,and a PSO-BP prediction model was established for each ***,the prediction results of each sub-mode were summed to obtain the final *** results show that the composite prediction accuracy by using the VMD algorithm is 3%higher than that of the traditional prediction method,which has better applicability.

关键词： Big data-Blast furnace Air permeability Variational mode decomposition Particle swarm optimization Back propagation Model prediction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：